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1. 发明公开

EP1030909A1 IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES 审中-公开
标题翻译：通过双多核苷酸是指免疫系统的活化
公开(公告)号：EP1030909A1
公开(公告)日：2000-08-30
申请号：EP99969109.0
申请日：1999-09-10
申请人： KOHN, Leonard D. , Suzuki, Koichi , Mori, Atsumi , Iishi, Ken , Klinman, Dennis M. , Rice, John M.
发明人： KOHN, Leonard D. , Suzuki, Koichi , Mori, Atsumi , Iishi, Ken , Klinman, Dennis M. , Rice, John M.
IPC分类号： C12N5/10 , C12N15/00 , A61K48/00
CPC分类号： C12N5/0656 , A61K31/4164 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , C12N5/0617 , Y02A50/407 , Y02A50/463
摘要： Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.

2. 发明专利

CA2309762A1 IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES 未知
公开(公告)号：CA2309762A1
公开(公告)日：2000-03-23
申请号：CA2309762
申请日：1999-09-10
申请人： SUZUKI KOICHI , KLINMAN DENNIS M , IISHI KEN , RICE JOHN M , MORI ATSUMI , KOHN LEONARD D
发明人： SUZUKI KOICHI , KLINMAN DENNIS M , IISHI KEN , RICE JOHN M , MORI ATSUMI , KOHN LEONARD D
IPC分类号： A61K31/4164 , C12N5/071 , C12N5/077 , C12N5/10 , A61K48/00 , C12N15/00
摘要： Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.

3. 发明申请

WO2004098491A3 METHOD OF PREVENTING INFECTIONS FROM BIOTERRORISM AGENTS WITH IMMUNOSTIMULATORY CpG OLIGONUCLEOTIDES 审中-公开
标题翻译：使用免疫抑制剂CpG寡核苷酸来预防生物降解药物感染的方法
公开(公告)号：WO2004098491A3
公开(公告)日：2007-02-22
申请号：PCT/US0334523
申请日：2003-10-31
申请人： US GOV HEALTH & HUMAN SERV , KLINMAN DENNIS M , IVINS BRUCE , VERTHELYI DANIELA
发明人： KLINMAN DENNIS M , IVINS BRUCE , VERTHELYI DANIELA
IPC分类号： C12Q1/70 , A61K20060101 , A61K6/00 , A61K9/00 , A61K31/00 , A61K31/711 , A61K31/7125 , A61K39/00 , A61K39/02 , A61K39/07 , A61K39/12 , A61K39/38 , A61K39/385 , A61K39/39 , A61K45/00 , A61K47/00 , A61K48/00 , A61P31/04 , C12Q1/68
CPC分类号： A61K39/39 , A61K9/0019 , A61K31/711 , A61K31/7125 , A61K39/07 , A61K48/00 , A61K2039/55561 , A61K2039/57
摘要： The present disclosure relates to a method of preventing or treating an infection caused by a bioterrorism agent, specifically to a method of increasing an immune response to a bioterrorism agent using an oligodeoxynucleotide including a CpG motif, and a method of enhancing the immunogenicity of a vaccine against a bioterrorism agent using an oligodeoxynucleotide including a CpG motif.
摘要翻译：本公开涉及预防或治疗由生物恐怖剂引起的感染的方法，具体涉及使用包含CpG基序的寡脱氧核苷酸增加对生物恐怖剂的免疫应答的方法，以及增强疫苗免疫原性的方法针对使用包含CpG基序的寡脱氧核苷酸的生物恐怖剂。

4. 发明申请

WO0061151A3 OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE 审中-公开
标题翻译：寡核苷酸及其用于诱导免疫应答
公开(公告)号：WO0061151A3
公开(公告)日：2001-04-26
申请号：PCT/US0009839
申请日：2000-04-12
申请人： US HEALTH , KLINMAN DENNIS , ISHII KEN , VERTHELYI DANIELA
发明人： KLINMAN DENNIS , ISHII KEN , VERTHELYI DANIELA
IPC分类号： A61K31/7088 , A61K39/008 , A61K39/39 , A61K45/06 , C07H21/00 , A61K31/70
CPC分类号： C07H21/04 , A61K31/7088 , A61K38/00 , A61K39/008 , A61K39/39 , A61K45/06 , A61K2039/55561 , C07H21/00 , C12N15/117 , C12N2310/17 , Y10T428/2989 , A61K2300/00
摘要： The present invention provides a substantially pure or isolated oligodeoxynucleotide of at least about 10 nucleotides comprising a sequence represented by either the formula: 5' N1N2N3T-CpG-WN4N5N6 3' wherein the central CpG motif is unmethylated, W is A or T, and N1, N2, N3, N4, N5, and N6 are any ncleotides, or the formula: 5' RY-CpG-RY 3' wherein the central CpG motif is unmethylated, R is A or G, and Y is C or T, as well as an oligodeoxynucleotide delivery complex and a pharmacological composition comprising the present inventive oligodeoxynucleotide, and a method of inducing an immune response by administering the present inventive oligodeoxynucleotide to a host.
摘要翻译：本发明提供至少约10个核苷酸的基本上纯的或分离的寡脱氧核苷酸，其包含由以下通式表示的序列：5'N1N2N3T-CpG-WN4N5N6 3'，其中中心CpG基序未甲基化，W为A或T，N1为，N 2，N 3，N 4，N 5和N 6是任何核苷酸，或下式：5'RY-CpG-RY 3'，其中中心CpG基序是未甲基化的，R是A或G，Y是C或T，以及作为寡脱氧核苷酸递送复合物和包含本发明的寡脱氧核苷酸的药物组合物，以及通过将本发明的寡脱氧核苷酸施用于宿主来诱导免疫应答的方法。

5. 发明申请

WO2011109422A8 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2011109422A8
公开(公告)日：2011-10-27
申请号：PCT/US2011026727
申请日：2011-03-01
申请人： US HEALTH , KLINMAN DENNIS , SHIROTA HIDEKAZU
发明人： KLINMAN DENNIS , SHIROTA HIDEKAZU
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： A61K47/549
摘要： Methods for inducing an immune response to a tumor in a subject are disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the CpG ODN is a K-type or a D-type CpG ODN. Methods for treating a tumor in a subject are also disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the tumor cells are autologous. In additional embodiments, the tumor is a lymphoma, cervical cancer, prostate cancer, breast cancer, colon cancer or a lung cancer.
摘要翻译：本文公开了在受试者中诱导针对肿瘤的免疫应答的方法。这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。在一些实施方案中，CpG ODN是K型或D型CpG ODN。本文还公开了治疗受试者中的肿瘤的方法。这些方法包括选择患有肿瘤的受试者并将与CpG寡脱氧核糖核苷酸（ODN）缀合的治疗有效量的凋亡肿瘤细胞给予受试者。在一些实施方案中，肿瘤细胞是自体的。在另外的实施方案中，肿瘤是淋巴瘤，宫颈癌，前列腺癌，乳腺癌，结肠癌或肺癌。

6. 发明申请

WO2009143292A9 METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES 审中-公开
标题翻译：用寡核苷酸处理肺炎的方法
公开(公告)号：WO2009143292A9
公开(公告)日：2010-03-04
申请号：PCT/US2009044739
申请日：2009-05-20
申请人： US GOV HEALTH & HUMAN SERV , KLINMAN DENNIS M , SATO TAKASHI
发明人： KLINMAN DENNIS M , SATO TAKASHI
IPC分类号： A61K31/7088 , A61P11/00 , A61P29/00
CPC分类号： A61K31/7088

7. 发明申请

WO2004012669A3 METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES 审中-公开
标题翻译：用CPG寡核苷酸抑制剂治疗炎性脑病的方法
公开(公告)号：WO2004012669A3
公开(公告)日：2006-02-02
申请号：PCT/US0324205
申请日：2003-07-31
申请人： US GOV HEALTH & HUMAN SERV , KLINMAN DENNIS M , ZEUNER RAINALD , VERTHELYI DANIELA , GURSEL IHSAN , GURSEL MAYDA
发明人： KLINMAN DENNIS M , ZEUNER RAINALD , VERTHELYI DANIELA , GURSEL IHSAN , GURSEL MAYDA
IPC分类号： A61K38/00 , A61K45/06 , C12N15/117 , A61K39/00 , A61K45/00 , A61K47/00
CPC分类号： C12N15/117 , A61K31/7088 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译：本公开涉及抑制免疫应答的寡脱氧核苷酸。公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗炎症性关节病的方法。

8. 发明申请

WO0015768A9 IMMUNE ACTIVATION BY DOUBLE-STRANDED POLYNUCLEOTIDES 审中-公开
标题翻译：双重多核苷酸的免疫激活
公开(公告)号：WO0015768A9
公开(公告)日：2000-08-31
申请号：PCT/US9920782
申请日：1999-09-10
申请人： KOHN LEONARD D , SUZUKI KOICHI , MORI ATSUMI , IISHI KEN , KLINMAN DENNIS M , RICE JOHN M
发明人： KOHN LEONARD D , SUZUKI KOICHI , MORI ATSUMI , IISHI KEN , KLINMAN DENNIS M , RICE JOHN M
IPC分类号： A61K31/4164 , C12N5/071 , C12N5/077 , C12N5/10 , A61K48/00 , C12N15/00
CPC分类号： C12N5/0656 , A61K31/4164 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , C12N5/0617
摘要： Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.
摘要翻译：双链多核苷酸激活免疫识别分子的表达。多核苷酸可以具有最小长度并且激活不是由不一定与多核苷酸相关的核苷酸序列编码的分子的表达。本发明提供了一种简单而特异的系统来激活主要组织相容性复合体（MHC）的I类和/或II类分子的表达，并允许调节MHC分子在抗原呈递细胞和其他细胞表面上的表达免疫细胞。还提供了用于筛选，鉴定和分离增加或减少该活化的化合物的系统。

9. 发明申请

WO2009143292A2 METHOD OF TREATING PNEUMOCONIOSIS WITH OLIGODEOXYNUCLEOTIDES 审中-公开
标题翻译：用寡核苷酸处理肺炎的方法
公开(公告)号：WO2009143292A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044739
申请日：2009-05-20
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , KLINMAN, Dennis, M. , SATO, Takashi
发明人： KLINMAN, Dennis, M. , SATO, Takashi
IPC分类号： A61K31/7088 , A61P11/00 , A61P29/00
CPC分类号： A61K31/7088
摘要： Methods are disclosed for treating, preventing or reducing the risk of developing occupational lung diseases, such as pneumoconiosis. In several embodiments, the methods include administering a therapeutically effective amount of the suppressive ODN to a subject having or at risk of developing a pneumoconiosis, thereby treating or inhibiting the pneumoconiosis. In several examples, thee subject can have or be at risk of developing silicosis, asbestosis or berryliosis. The method can include selecting a subject exposed to, or at risk of exposure to, inorganic particles, including, but not limited to silica, asbestos, berrylium, coal dust, or bauxite.
摘要翻译：公开了治疗，预防或降低发展职业性肺部疾病如肺尘埃沉着病的风险的方法。在几个实施方案中，所述方法包括向具有或具有发生肺尘埃沉着病风险的受试者施用治疗有效量的抑制性ODN，从而治疗或抑制肺尘埃沉着病。在几个例子中，您的受试者可能有或有发生矽肺，石棉沉滞症或bellyliosis的风险。该方法可以包括选择暴露于或有暴露于无机颗粒的风险的对象，包括但不限于二氧化硅，石棉，铍，煤粉或铝土矿。

10. 发明申请

WO2003040308A3 USE OF STERICALLY STABILIZED CATIONIC LIPOSOMES TO EFFICIENTLY DELIVER CPG OLIGONUCLEOTIDES IN VIVO 审中-公开
公开(公告)号：WO2003040308A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/024235
申请日：2002-07-29
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , KLINMAN, Dennis, M. , GURSEL, Ihsan , ISHII, Ken, J. , KAWAKAMI, Koji , JOSHI, Bharat, H. , PURI, Raj, K.
发明人： KLINMAN, Dennis, M. , GURSEL, Ihsan , ISHII, Ken, J. , KAWAKAMI, Koji , JOSHI, Bharat, H. , PURI, Raj, K.
IPC分类号： A61K48/00
摘要： Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapsulating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.

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