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    • 9. 发明申请
    • CONTROLLED RELEASE COMPOSITION
    • 控制释放组成
    • WO1989009066A1
    • 1989-10-05
    • PCT/DK1989000068
    • 1989-03-22
    • BUKH MEDITEC A/SBAR-SHALOM, DanielKINDT-LARSEN, Ture
    • BUKH MEDITEC A/S
    • A61K47/00
    • A61K9/0092A61K9/2013A61K9/2027A61K9/2031A61K9/2036Y10S514/96Y10S514/975
    • A composition for controlled delivery of an active substance into an aqueous phase by erosion at a substantially constant rate of a surface or surfaces of the composition, the composition comprising a matrix of at least one substantially water soluble crystalline polymer, one or more surface active agents dispersed in the crystalline polymer phase, at least one active substance substantially homogeneously dispersed in the crystalline polymer phase and/or located in geometrically well-defined zones within the crystalline polymer phase and/or dispersed in the surface active agent and, optionally, a filler. The surface active agent and/or the active substance substantially eliminates water diffusion in the interface between the polymer crystals. In an alternative embodiment, the composition comprises a matrix of room-temperature vulcanizing rubber (RTV rubber) in which particles of a superabsorbent polymer are substantially homogeneously distributed and at least one active substance substantially homogeneously dispersed in the matrix and/or located in geometrically well-defined zones within the matrix.
    • 通过以基本上恒定的速率的组合物的表面或表面侵蚀将活性物质控制递送到水相中的组合物,所述组合物包含至少一种基本上水溶性的结晶聚合物的基质,一种或多种表面活性剂 分散在结晶聚合物相中,至少一种活性物质基本上均匀地分散在结晶聚合物相中和/或位于结晶聚合物相内的几何定义明确的区域中和/或分散在表面活性剂和/或分散在表面活性剂中的填料 。 表面活性剂和/或活性物质基本上消除了在聚合物晶体之间的界面中的水扩散。 在替代实施方案中,组合物包含室温硫化橡胶(RTV橡胶)基质,其中超吸收性聚合物的颗粒基本上均匀分布,并且至少一种活性物质基本均匀地分散在基质中和/或位于几何上良好 矩阵内定义的区域。