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1. 发明申请

WO2010034043A1 PLATTENFALLFILM-KURZWEG VERDAMPFER 审中-公开
标题翻译： PLATE秋季电影短程蒸馏器
公开(公告)号：WO2010034043A1
公开(公告)日：2010-04-01
申请号：PCT/AT2009/000359
申请日：2009-09-17
申请人： GIG KARASEK GMBH , KARASEK, Andreas , BETHGE, Daniel
发明人： KARASEK, Andreas , BETHGE, Daniel
IPC分类号： B01D1/06 , B01D1/26 , B01D1/30 , C02F1/08 , B01D3/06 , B01D3/12
CPC分类号： B01D1/06 , B01D1/221 , B01D1/26 , B01D1/305 , B01D3/12
摘要： Ein Platten-Fallfilmverdampfer zur Fallstromverdampfung einer flüssigen Substanz, mit zumindest einer, in einem Gehäuse (1) im Wesentlichen vertikal angeordneten, beheizbaren Verdampferplatte (5), mit einer oberhalb der zumindest einen Verdampferplatte angeordneten Verteilerwanne (8), aus der die darin befindliche Substanz der Verdampferplatte unter Bildung eines an der Außenfläche der Verdampferplatte herabrinnenden Films zuführbar ist, mit einem der unteren Plattenkante zugeordneten Auffangmittel (9) für das Konzentrat, mit zumindest einem Anschluss (15, 15o, u) für ein Pumpmittel (16) zum Evakuieren des Gehäuseinnenraumes, sowie mit einer Kondensationseinrichtung zur anschließenden Kondensation des entstehenden Brüdens, wobei die Kondensationseinrichtung als zumindest eine, innerhalb des Gehäuses im Wesentlichen vertikal und parallel zu der zumindest einen Verdampferplatte (5) angeordnete Kondensationsplatte (6) ausgebildet ist, die mittels eines, ihren inneren Hohlraum durchströmenden Kühlfluidums kühlbar ist und der ein Auffangmittel (4) für von der Kondensationsplatte herabrinnendes Destillat zugeordnet ist.
摘要翻译：一种用于液体物质的下流蒸发的盘降膜蒸发器，具有至少一个垂直布置的，在一个壳体（1）基本上可加热蒸发器板（5），与所述至少一个蒸发器板上设置的分配器罐（8），从包含在其中的物质以上蒸发器板以形成还原滴蒸发器板膜的外表面上被供给，与下板的边缘收集装置中的一个相关联的（9）所述浓缩物，以用于排出内部壳体区域的至少一个连接部（15，15，U），用于泵送装置（16）和聚光装置，用于随后冷凝所得到的废蒸气，其中，所述冷凝装置被设计为至少一个，垂直和平行于所述至少一个蒸发器板（5），其布置在所述壳体内基本上冷凝板（6），其通过内部腔体的装置 ð urchströmenden冷却流体冷却，并与用于冷凝压板馏出herabrinnendes一个收集装置（4）相关联。

2. 发明申请

WO2009015955A1 STROMKOMPENSIERTE DROSSEL UND SCHALTUNGSANORDNUNG MIT EINER STROMKOMPENSIERTEN DROSSEL 审中-公开
标题翻译：电流补偿扼流电路，一个电流补偿油门
公开(公告)号：WO2009015955A1
公开(公告)日：2009-02-05
申请号：PCT/EP2008/058209
申请日：2008-06-26
申请人： EPCOS AG , KARASEK, Manfred , STRAUB, Markus
发明人： KARASEK, Manfred , STRAUB, Markus
IPC分类号： H01F17/04 , H01F27/38
CPC分类号： H01F19/08 , H01F5/00 , H01F17/045 , H01F27/02 , H01F27/346 , H01F27/385 , H01F37/00 , H01F2017/0093
摘要： Es wird eine stromkompensierte Drossel angegeben, welche mehrere Strompfade (1, 2) aufweist, die aus mehreren parallel geschalteten Wicklungen (1a, 1b, 2a, 2b) besteht, die um einen gemeinsamen Kern (3) gewickelt sind. Die Wicklungen (1a, 1b, 2a, 2b) sind bevorzugt derart alternierend auf den Kern (3) aufgewickelt, dass Wicklungen (1a, 1b, 2a, 2b) eines gemeinsamen Strompfades (1, 2) nicht direkt übereinander angeordnet sind.
摘要翻译：提供了一种具有多个电流路径中的（1，2）（1A，1B，2A，2B）的多个围绕一个共同的核心（3）并联连接的绕组的卷绕的电流补偿扼流圈。绕组（1A，1B，2A，2B）优选是这样的交替的芯（3）伤口绕组（1A，1B，2A，2B）的公共电流通路（1，2）不直接在彼此之上布置。

3. 发明申请

WO1984000098A1 METHOD FOR OBTAINING SOLID CONCENTRATED ALBUMIN FROM BLOOD ORPLA SMA OF ANIMAL ORIGIN 审中-公开
标题翻译：从动物原始血液平滑肌中获得固体浓缩的白蛋白的方法
公开(公告)号：WO1984000098A1
公开(公告)日：1984-01-19
申请号：PCT/CH1983000084
申请日：1983-06-30
申请人： BELL AG , KARASEK, Jaroslav , NYFELER, Beat , SCHINDELHOLZ, Markus
发明人： BELL AG
IPC分类号： A23J01/06
CPC分类号： A23J1/06
摘要： The blood or plasma of animal origine is heated until coagulation is effected at a temperature comprised between 75 and 100oC. Optionally, the coagulating product is maintained for a while at that temperature. Then the product is rapidly cooled to a temperature of about 0oC. The coagulated product may be slowly freezed at a temperature comprised between -5oC and -10oC and stored from a few days to one month at a temperature comprised between -5oC and -30oC. The product is finally unfreezed, crumbled up and the water released is withdrawn. Thereby a solid concentrated albumin is obtained. The concentrate obtained is microbiologically pure and due to its organoleptic characteristics is appropriate to the manufacture of food products or foodstuff for animals.

4. 发明申请

WO2016168762A3 ANTI-PACAP ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2016168762A3
公开(公告)日：2016-12-22
申请号：PCT/US2016027984
申请日：2016-04-15
申请人： ALDER BIOPHARMACEUTICALS INC , ALLISON DANIEL S , HENDRIX KATHERINE LEE , OJALA ETHAN WAYNE , FAN PEI , SMITH JEFFREY T L , LATHAM JOHN , KARASEK CHARLIE , MULLIGAN JENNY , SCALLEY-KIM MICHELLE , STEWART ERICA , RUBIN VANESSA LISBETH , BILLGREN JENS J
发明人： ALLISON DANIEL S , HENDRIX KATHERINE LEE , OJALA ETHAN WAYNE , FAN PEI , SMITH JEFFREY T L , LATHAM JOHN , KARASEK CHARLIE , MULLIGAN JENNY , SCALLEY-KIM MICHELLE , STEWART ERICA , RUBIN VANESSA LISBETH , BILLGREN JENS J , LOOMIS MARIA-CRISTINA , DUTZAR BENJAMIN H , GARCIA-MARTINEZ LEON
IPC分类号： C07K16/18 , A61K38/00 , A61P25/06
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

5. 发明申请

WO2010040324A1 MODULAR SET OF DEVICES FOR OPTICAL AMPLIFICATION OF SIGNAL BY RAMAN FIBER AMPLIFIER 审中-公开
标题翻译：拉曼光纤放大器用于光信号放大的模块化设备
公开(公告)号：WO2010040324A1
公开(公告)日：2010-04-15
申请号：PCT/CZ2009000116
申请日：2009-10-02
申请人： CESNET ZAJMOVE SDRUZENI PRAVNI , KARASEK MIROSLAV , VOJTECH JOSEF , RADIL JAN
发明人： KARASEK MIROSLAV , VOJTECH JOSEF , RADIL JAN
IPC分类号： H01S3/0941 , H04B10/29 , H01S3/094 , H01S3/102 , H01S3/30
CPC分类号： H01S3/094046 , H01S3/06754 , H01S3/0912 , H01S3/094073 , H01S3/094076 , H01S3/09408 , H01S3/094096 , H01S3/09415 , H01S3/10069 , H01S3/1022 , H01S3/302 , H01S2301/03 , H01S2301/04 , H01S2301/06
摘要： Modular set is formed by optical module (1) interconnected with control module (2) of electronic system. Optical module (1) is formed by at least two pairs (10, 11, 12, 13) of laser diodes connected in series and including Peltier cooler and thermistor, which are connected to inputs of polarizing fiber combiners (14, 15, 16, 17), and depolarized outputs of these polarizing fiber combiners are connected to inputs of a wavelengths combiner (18). Module (2) of the electronic system is formed by a control microprocessor (20) interconnected with direct current power supply source (21), with PID regulators (25) of laser diodes temperature, a display indicating temperature of individual laser diodes and current flowing through them, and a control panel. To the microprocessor (20) of the module (2) of the electronic system is connected a gate array (22) and to this gate array (22) are connected generators (23) of current impulses, which do not overlap in time, and their widths, repetition frequencies and amplitudes are adjustable, while the number of generators (23) of current impulses equals to the number of pairs (10-13) of laser diodes and their outputs are connected via power stages (24) to pairs (10-13) of laser diodes connected in series, and where to the power stages (24) is connected an analogue/digital converter (210), which is connected also to the microprocessor (20).
摘要翻译：模块化组件由光学模块（1）与电子系统的控制模块（2）相互连接而成。光学模块（1）由至少两对串联连接的激光二极管（10,11,12,13）形成，并且包括珀耳帖冷却器和热敏电阻，所述激光二极管连接到偏振光纤组合器（14,15,16， 17），并且这些偏振光纤组合器的去偏振输出端连接到波长组合器（18）的输入端。电子系统的模块（2）由与直流电源（21）互连的控制微处理器（20）形成，具有激光二极管温度的PID调节器（25），显示单个激光二极管的温度和电流流动的显示器通过他们和一个控制面板。电子系统的模块（2）的微处理器（20）连接到门阵列（22），并且该门阵列（22）连接有电流脉冲的发生器（23），其在时间上不重叠，并且它们的宽度，重复频率和振幅是可调的，而电流脉冲的发生器（23）的数量等于激光二极管的对（10-13）的数量，并且它们的输出通过功率级（24）连接到成对 -13）串联连接的激光二极管以及功率级（24）的何处连接到还连接到微处理器（20）的模拟/数字转换器（210）。

6. 发明申请

WO1995018667A1 PREVENTION OF FORMATION AND DESTRUCTION OF ORGANOHALOGEN COMPOUNDS IN INCINERATION OF WASTE MATERIALS 审中-公开
标题翻译：防止有机化合物在废弃废物中的形成和破坏
公开(公告)号：WO1995018667A1
公开(公告)日：1995-07-13
申请号：PCT/CA1995000012
申请日：1995-01-06
申请人： UNIVERSITY OF WATERLOO , NAIKWADI, Krishnat, P. , KARASEK, Francis, W.
发明人： UNIVERSITY OF WATERLOO
IPC分类号： B01D53/70
CPC分类号： A62D3/38 , A62D2101/08 , A62D2101/22 , A62D2101/28 , B01D53/70
摘要： Organohalogen compounds (OHC), including dioxins and furans, produced in waste incinerators are destroyed by introducing inorganic bases, either alone or in combination with aliphatic hydroxy compounds, into an incineration post combustion zone that contains gaseous incineration products. The destroyer compounds may also serve to inhibit the formation of OHC by catalysis at active sites on flyash produced in the incineration and also to remove acid gases from the gaseous incineration products. In this way, the concentration of OHC on flyash precipitated from the product gas stream is decreased as dioxins and acid gas concentrations in stack emissions from the incineration process also decreases.
摘要翻译：通过将无机碱单独或与脂肪族羟基化合物组合引入到含有气体焚烧产物的焚化后燃烧区中，废弃焚化炉中产生的有机卤素化合物（OHC），包括二恶英和呋喃被破坏。驱逐剂化合物还可以用于通过在焚烧中产生的飞灰上的活性位点处的催化来抑制OHC的形成，并且还从气态焚烧产物中除去酸性气体。以这种方式，从产物气流中析出的粉煤灰中的OHC浓度随二恶英浓度的降低而降低，而焚烧过程的烟囱排放中的酸性气体浓度也降低。

7. 发明专利

CZ16568U1 Snímac síly s plochou víceramennou spirální pruzinou 未知
公开(公告)号：CZ16568U1
公开(公告)日：2006-07-12
申请号：CZ200617474
申请日：2006-02-27
申请人： KARASEK PAVEL , KARASEK JOSEF
发明人： KARASEK PAVEL , KARASEK JOSEF
IPC分类号： G01G3/06

8. 发明专利

DE8421004U1 未知
公开(公告)号：DE8421004U1
公开(公告)日：1984-11-08
申请号：DE8421004
申请日：1984-07-13
申请人： ST. KARASEK & CO METALL- UND HOLZMOEBELFABRIK KARASEK, SACK & CO GMBH, WIEN, AT
IPC分类号： A47C5/12

9. 发明申请

WO2016168768A2 ANTI-PACAP ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗PACAP抗体及其用途
公开(公告)号：WO2016168768A2
公开(公告)日：2016-10-20
申请号：PCT/US2016027992
申请日：2016-04-15
申请人： ALDER BIOPHARMACEUTICALS INC , ALLISON DANIEL S , OJALA ETHAN WAYNE , FAN PEI , SMITH JEFFREY T L , LATHAM JOHN , KARASEK CHARLIE , MULLIGAN JENNY , SCALLEY-KIM MICHELLE , STEWART ERICA , HENDRICKS LEE , RUBIN VANESSA LISBETH , BILLGREN JENS J
发明人： ALLISON DANIEL S , OJALA ETHAN WAYNE , FAN PEI , SMITH JEFFREY T L , LATHAM JOHN , KARASEK CHARLIE , MULLIGAN JENNY , SCALLEY-KIM MICHELLE , STEWART ERICA , HENDRICKS LEE , RUBIN VANESSA LISBETH , BILLGREN JENS J , LOOMIS MARIA-CRISTINA , DUTZAR BENJAMIN H , GARCIA-MARTINEZ LEON
IPC分类号： C07K16/26 , A61K45/06
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757
摘要： The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific VH, VL, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.
摘要翻译：本发明涉及对PACAP具有结合特异性的拮抗性抗体及其抗原结合片段。这些抗体抑制，阻断或中和与PACAP相关的至少一种生物效应，例如血管舒张。在示例性实施方案中，这些抗体及其抗原结合片段可以包含本文所述的特异性VH，VL和CDR多肽。在一些实施方案中，这些抗体及其抗原结合片段结合和/或竞争结合人PACAP上的特定表位。本发明还涉及使用这些拮抗性抗PACAP抗体及其结合片段用于诊断，评估和治疗与PACAP相关的疾病和病症以及其中PACAP相关活性的拮抗作用如血管舒张，肥大细胞脱粒和/或神经元活化）是治疗有益的，例如头痛和偏头痛指征。

10. 发明申请

WO2016168757A1 USE OF ANTI-PACAP ANTIBODIES AND ANTIGEN BINDING FRAGMENTS THEREOF FOR TREATMENT, PREVENTION, OR INHIBITION OF PHOTOPHOBIA 审中-公开
标题翻译：使用抗PACAP抗体和抗原结合片段进行治疗，预防或抑制光合作用
公开(公告)号：WO2016168757A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027977
申请日：2016-04-15
申请人： ALDER BIOPHARMACEUTICALS, INC. , THE UNIVERSITY OF IOWA RESEARCH FOUNDATION , ALLISON, Daniel, S. , HENDRICKS, Lee , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey, T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , RUBIN, Vanessa Lisbeth , BILLGREN, Jens, J.
发明人： ALLISON, Daniel, S. , HENDRICKS, Lee , OJALA, Ethan Wayne , FAN, Pei , SMITH, Jeffrey, T.L. , LATHAM, John , KARASEK, Charlie , MULLIGAN, Jenny , SCALLEY-KIM, Michelle , STEWART, Erica , RUBIN, Vanessa Lisbeth , BILLGREN, Jens, J. , KUBURAS, Adisa , MASON, Bianca , SOWERS, Levi, P. , RUSSO, Andrew, F. , LOOMIS, Maria-Cristina , DUTZAR, Benjamin, H. , GARCIA-MARTINEZ, Leon
IPC分类号： A61P25/06 , A61K39/395
CPC分类号： C07K16/26 , A61K39/3955 , A61K39/39566 , A61K45/06 , A61K49/0004 , A61K49/0008 , A61K2039/505 , C07K16/4241 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/76 , C07K2317/92 , G01N33/5088 , G01N33/74 , G01N2333/5757 , Y02A50/383 , Y02A50/51
摘要： This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.
摘要翻译：本发明涉及筛选抗PACAP抗体或抗PACAP受体抗体及其抗原结合片段的方法，用于治疗或预防PACAP相关畏光或轻度反应的潜在用途，以及含有治疗组合物和使用抗-APP受体抗体的方法 -PACAP抗体或抗PACAP受体抗体及其抗原结合片段。

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