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1. 发明申请

WO2007096259A1 HYDANTOIN BASED KINASE INHIBITORS 审中-公开
标题翻译：基于HYDANTOIN的激酶抑制剂
公开(公告)号：WO2007096259A1
公开(公告)日：2007-08-30
申请号：PCT/EP2007/051313
申请日：2007-02-12
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
发明人： CHEN, Shaoqing , HUBY, Nicholas John Silvester , KONG, Norman , MISCHKE, Steven Gregory , MOLITERNI, John Anthony , WANG, Hong , ZHANG, Zhuming
IPC分类号： C07D233/76 , C07D233/78 , A61K31/4166 , A61K31/4178
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula (I), pharmaceutical compositions containing said compounds, methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及式（I）化合物，含有所述化合物的药物组合物，其制备方法及其用途。该化合物可用于治疗以MEK多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。

2. 发明申请

WO2011064141A1 SULTAM DERIVATIVES 审中-公开
标题翻译： SULTAM衍生物
公开(公告)号：WO2011064141A1
公开(公告)日：2011-06-03
申请号：PCT/EP2010/067790
申请日：2010-11-19
申请人： F. HOFFMANN-LA ROCHE AG , ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
发明人： ANDERSON, Kevin William , GILLESPIE, Paul , HUBY, Nicholas John Silvester , KONG, Norman , ROBERTS, John Lawson , ROSSMAN, Pamela Loreen , SO, Sung-Sau
IPC分类号： C07D275/06 , A61K31/425 , A61P35/00
CPC分类号： C07D275/06
摘要： The present invention relates to compounds according to formula (1), and pharmaceutically-acceptable salts thereof, wherein R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein.
摘要翻译：本发明涉及式（1）化合物及其药学上可接受的盐，其中R 2，R 3，R 4，R 5和R 6如本文所定义。

3. 发明申请

WO2009080523A1 SUBSTITUTED HYDANTOINS AS MEK KINASE INHIBITORS 审中-公开
标题翻译：作为MEK激酶抑制剂的替代的HYDANTOINS
公开(公告)号：WO2009080523A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/067221
申请日：2008-12-10
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , HUBY, Nicholas, John, Silvester , KONG, Norman , MOLITERNI, John, Anthony , MORALES, Omar, Jose
发明人： CHEN, Shaoqing , HUBY, Nicholas, John, Silvester , KONG, Norman , MOLITERNI, John, Anthony , MORALES, Omar, Jose
IPC分类号： C07D233/74 , C07D233/78 , C07D417/14 , A61K31/4166 , A61P35/00
CPC分类号： C07D233/74 , C07D233/78 , C07D417/14
摘要： The present invention relates to compounds of the formula (I) methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及式（I）化合物的制备方法及其用途。该化合物可用于治疗以MEK多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。

4. 发明申请

WO2006018188A3 SUBSTITUTED HYDANTOINS 审中-公开
标题翻译：取代的HYDANTOINS
公开(公告)号：WO2006018188A3
公开(公告)日：2006-05-18
申请号：PCT/EP2005008633
申请日：2005-08-09
申请人： HOFFMANN LA ROCHE , CHU XIN-JIE , FOTOUHI NADER , HUBY NICHOLAS JOHN SILVESTER , KONG NORMAN , MCDERMOTT LEE APOSTLE , MOLITERNI JOHN ANTHONY , ZHANG ZHUMING
发明人： CHU XIN-JIE , FOTOUHI NADER , HUBY NICHOLAS JOHN SILVESTER , KONG NORMAN , MCDERMOTT LEE APOSTLE , MOLITERNI JOHN ANTHONY , ZHANG ZHUMING
IPC分类号： C07D417/12 , A61K31/427 , C07D417/14
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of the formula (I), which are useful in treating diseases characterized by, the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及式（I）化合物，其可用于治疗以MEK的多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS障碍和炎症/自身免疫性疾病的疾病。

5. 发明申请

WO2013030205A1 PARP INHIBITORS 审中-公开
标题翻译： PARP抑制剂
公开(公告)号：WO2013030205A1
公开(公告)日：2013-03-07
申请号：PCT/EP2012/066721
申请日：2012-08-29
申请人： F. HOFFMANN-LA ROCHE AG , HAYNES, Nancy-Ellen , HUBY, Nicholas John Silvester , SCOTT, Nathan Robert
发明人： HAYNES, Nancy-Ellen , HUBY, Nicholas John Silvester , SCOTT, Nathan Robert
IPC分类号： C07C317/44 , C07D237/18 , A61K31/495 , A61K31/167 , A61P35/00
CPC分类号： C07C317/44 , C07C2601/08 , C07C2601/14 , C07D237/18
摘要： The present application disclosed compounds of Formula I wherein variables R 1 and R 2 are defined as described herein, which are inhibitors of PARP and provides compounds and compositions containing the compounds of Formula I. The present application further provides methods of using the disclosed PARP inhibitors for the treatment of PARP-mediated diseases and disorders.
摘要翻译：本申请公开了式I的化合物，其中变量R1和R2如本文所述定义，其是PARP的抑制剂，并提供含有式I化合物的化合物和组合物。本申请还提供了使用所公开的PARP抑制剂用于治疗PARP介导的疾病和病症。

6. 发明申请

WO2006029862A1 SUBSTITUTED HYDANTOINS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：替代治疗癌症的糖尿病
公开(公告)号：WO2006029862A1
公开(公告)日：2006-03-23
申请号：PCT/EP2005/009926
申请日：2005-09-15
申请人： F. HOFFMANN-LA ROCHE AG , GOODNOW, Robert, Alan, Jr. , HUBY, Nicholas, John, Silvester , KONG, Norman , MCDERMOTT, Lee, Apostle , MOLITERNI, John, Anthony , ZHANG, Zhuming
发明人： GOODNOW, Robert, Alan, Jr. , HUBY, Nicholas, John, Silvester , KONG, Norman , MCDERMOTT, Lee, Apostle , MOLITERNI, John, Anthony , ZHANG, Zhuming
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of the formula (I) which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及可用于治疗以MEK多动症为特征的疾病的式（I）化合物。因此，该化合物可用于治疗诸如癌症，认知和CNS障碍和炎症/自身免疫性疾病的疾病。

7. 发明申请

WO2006018188A2 SUBSTITUTED HYDANTOINS 审中-公开
标题翻译：被取代的嘌呤
公开(公告)号：WO2006018188A2
公开(公告)日：2006-02-23
申请号：PCT/EP2005/008633
申请日：2005-08-09
申请人： F. HOFFMANN-LA ROCHE AG , CHU, Xin-Jie , FOTOUHI, Nader , HUBY, Nicholas, John, Silvester , KONG, Norman , MCDERMOTT, Lee, Apostle , MOLITERNI, John, Anthony , ZHANG, Zhuming
发明人： CHU, Xin-Jie , FOTOUHI, Nader , HUBY, Nicholas, John, Silvester , KONG, Norman , MCDERMOTT, Lee, Apostle , MOLITERNI, John, Anthony , ZHANG, Zhuming
IPC分类号： C07D417/12 , C07D417/14 , A61K31/427
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of the formula (I), which are useful in treating diseases characterized by, the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及式（I）化合物，其可用于治疗以MEK活动过度为特征的疾病。因此，该化合物可用于治疗疾病，例如癌症，认知和CNS疾病以及炎症/自身免疫疾病。

8. 发明专利

GB190313333A Improvements in Blind Fittings 未知
公开(公告)号：GB190313333A
公开(公告)日：1904-04-21
申请号：GB190313333D
申请日：1903-06-15
申请人： HILL JOHN SILVESTER
发明人： HILL JOHN SILVESTER
摘要： 13,333. Hill, J. S. June 15. Window blinds.- Relates to brackets for supporting the ends of b l i n d rollers and also for guiding the cord or tape, and to roller ends. The end a', Fig. 3, of the roller A is made in one piece of metal or other material to form the pulley round which the cord is wound. The cord C is passed through a hole b in the fitting B, the sides of which form a guide for the cord. The pivot a of the roller passes through an opening b in the side of the fitting B, the side having also a recessed part b to receive the end of the roller and prevent the cord from slipping between it and the casing. In some cases the roller A has a long tubular pin or pivot a , Fig. 5, which acts as the pulley and which may have a hole or slot a for the attachment of the cord or tape. The opening b , Fig. 7, through which the cord passes, may be provided with rollers F for the cord to run on. The fittings B are provided with plates having stud holes which engage with studs on plates secured to the window frame ; the fittings may also be screwed to the window frames. The brackets for the ends of the rollers are made with recesses which cover the extreme ends of the pivots, or the pivots may form part of the brackets and fit into holes in the ends of the rollers. The pivots are made from round metal or othar material pointed or screwed at one end. Where holes are made in the ends of the rollers, ferrules may be employed instead of pivots. The fittings may be applied at the right, left, or top of the window frame.

9. 发明专利

GB2287792B Method and devices for measurement of flow speed using continuous oscillations in a thermal wave 未知
公开(公告)号：GB2287792B
公开(公告)日：1999-01-27
申请号：GB9505706
申请日：1995-03-21
申请人： BARTINGTON JOHN KEITH , BARNARD BRIAN JOHN SILVESTER
发明人： BARTINGTON JOHN KEITH , BARNARD BRIAN JOHN SILVESTER
IPC分类号： G01F1/704 , G01F1/708 , G01P5/10 , G01P5/18 , G01P5/24

10. 发明申请

WO2009021887A1 SUBSTITUTED HYDANTOINS 审中-公开
标题翻译：取代的HYDANTOINS
公开(公告)号：WO2009021887A1
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060326
申请日：2008-08-06
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Shaoqing , HUBY, Nicholas, John, Silvester , KONG, Norman , MOLITERNI, John, Anthony , MORALES, Omar, Jose
发明人： CHEN, Shaoqing , HUBY, Nicholas, John, Silvester , KONG, Norman , MOLITERNI, John, Anthony , MORALES, Omar, Jose
IPC分类号： C07D403/06 , A61K31/4184 , A61P35/00
CPC分类号： C07D403/06
摘要： This invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and R6 are described in this application. These compounds inhibit the enzymes MEK 1 and MEK 2, protein kinases that are components of the MAP kinase signal transduction pathway. As such the compounds have anti-hyperproliferative cellular activity and are thus useful in the treatment of cell proliferative disorders, such as cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中本申请中描述了R1，R2，R3，R4，R5和R6。这些化合物抑制酶MEK 1和MEK 2，作为MAP激酶信号转导途径成分的蛋白激酶。因此，这些化合物具有抗过度增殖细胞活性，因此可用于治疗细胞增殖性疾病如癌症。

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