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1. 发明申请

US20100179199A1 Ethanamine Compounds and Methods of Using the Same 545 有权
标题翻译：乙胺化合物及其使用方法545
公开(公告)号：US20100179199A1
公开(公告)日：2010-07-15
申请号：US12644046
申请日：2009-12-22
申请人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
发明人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
IPC分类号： A61K31/4402 , C07D213/36 , A61P25/16 , A61P25/00
CPC分类号： C07D213/38 , A61K31/4402 , C07C57/15
摘要： The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
摘要翻译：本发明涉及乙胺化合物，包含其的药物组合物，以及通过施用乙胺化合物治疗抑郁症的方法。

2. 发明授权

US07285662B2 Therapeutic heterocyclic compounds 失效
标题翻译：治疗性杂环化合物
公开(公告)号：US07285662B2
公开(公告)日：2007-10-23
申请号：US11108587
申请日：2005-04-18
申请人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
发明人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
IPC分类号： C07D413/14 , C07D407/04
CPC分类号： C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译：本文提供具有式（I）的化合物：其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。该化合物是5HT 1B和5HT 1D 1拮抗剂。

3. 发明申请

US20120277272A1 Ethanamine Compounds and Methods of Using the Same 审中-公开
标题翻译：乙胺化合物及其使用方法
公开(公告)号：US20120277272A1
公开(公告)日：2012-11-01
申请号：US13431303
申请日：2012-03-27
申请人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
发明人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
IPC分类号： A61K31/4402 , C07D213/38 , A61P25/24
CPC分类号： C07D213/38 , A61K31/4402 , C07C57/15
摘要： (S)-2-methyl-1-phenyl-2-(pyridin-2-yl)propan-1-amine, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, uses of said compound or salt for therapy of depression and other conditions, and methods of treating depression and other conditions by administering said compound or salt.
摘要翻译：（S）-2-甲基-1-苯基-2-（吡啶-2-基）丙-1-胺，其药学上可接受的盐，包含其的药物组合物，所述化合物或盐用于治疗抑郁症和其它条件和方法，通过施用所述化合物或盐来治疗抑郁症和其它病症。

4. 发明授权

US07045514B2 Therapeutic heterocyclic compounds 失效
标题翻译：治疗性杂环化合物
公开(公告)号：US07045514B2
公开(公告)日：2006-05-16
申请号：US10889350
申请日：2004-07-12
申请人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
发明人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
IPC分类号： A61K31/33 , A61K31/38 , A61K31/35 , C07D335/04 , C07D311/04
CPC分类号： C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
摘要翻译：本文提供具有式（I）的化合物：其中所述化合物可用于治疗精神障碍，包括但不限于抑郁症，广泛性焦虑症，进食障碍，痴呆症，惊恐障碍和睡眠障碍。该化合物还可用于治疗胃肠道疾病，心血管调节，运动障碍，内分泌障碍，血管痉挛和性功能障碍。该化合物是5HT 1B和5HT 1D 1拮抗剂。

5. 发明授权

US5575916A Method of processing a cheese processing waste stream 失效
标题翻译：加工干酪加工废料流的方法
公开(公告)号：US5575916A
公开(公告)日：1996-11-19
申请号：US337181
申请日：1994-11-07
申请人： Barry Brian , David A. Zopf , Lei Lu , John P. McCauley, Jr. , Michael Partsch
发明人： Barry Brian , David A. Zopf , Lei Lu , John P. McCauley, Jr. , Michael Partsch
IPC分类号： A23C21/00 , A23C9/146 , C02F1/26 , C02F1/42 , C07H1/06 , C07H3/04 , B01D11/04
CPC分类号： C02F1/26 , A23C9/1465 , C02F1/42 , C02F2103/327
摘要： A method of processing a cheese processing waste stream generated in a cheese-making process is described comprising:i) contacting a cheese processing waste stream with a solvent and extracting a sialyloligosaccharide with said solvent;ii) separating a sialyloligosaccharide containing solvent from said cheese processing waste stream; andiii) isolating a sialyloligosacchride from said sialyloligosaccharide containing solvent.
摘要翻译：描述了一种处理在干酪制备方法中产生的干酪加工废物流的方法，其包括：i）使干酪加工废物流与溶剂接触并用所述溶剂萃取唾液酸寡糖; ii）从所述干酪加工废料流中分离含唾液酸寡糖的溶剂; 和iii）从所述含唾液酸寡糖的溶剂中分离唾液酸低聚糖。

6. 发明授权

US5223479A Process for preparing alkali metal-doped fullerenes 失效
标题翻译：制备掺杂碱金属的富勒烯的方法
公开(公告)号：US5223479A
公开(公告)日：1993-06-29
申请号：US738888
申请日：1991-08-01
申请人： John P. McCauley, Jr. , Qing Zhu , Gavin Vaughan , Nicole Coustel
发明人： John P. McCauley, Jr. , Qing Zhu , Gavin Vaughan , Nicole Coustel
IPC分类号： C01B31/02
CPC分类号： B82Y30/00 , B82Y40/00 , C01B31/0206 , C01B31/0213 , Y10S505/725 , Y10S505/775 , Y10S505/81 , Y10S505/815
摘要： Superconducting, metal-doped fullerenes are provided, along with processes for their preparation in relatively high stoichiometric purity. In one embodiment, the processes provide fullerenes of the formula M.sub.3 C.sub.60 where M is an alkali metal. The processes comprise contacting C.sub.60 with alkali metal in an amount and under reaction conditions effective to produce a compound having the formula M.sub.y C.sub.60, where y is greater than 3, and contacting said M.sub.y C.sub.60 with a portion of C.sub.60 in an amount and under reaction conditions effective to produce said M.sub.3 C.sub.60.
摘要翻译：提供了超导金属掺杂的富勒烯，以及其相对高的化学计量纯度的制备方法。在一个实施方案中，该方法提供式M3C60的富勒烯，其中M是碱金属。所述方法包括使C 60与碱金属接触，其量和反应条件有效地产生具有式MyC60的化合物，其中y大于3，并将所述MyC60与C60的一部分接触，反应条件有效至生产M3C60。

7. 发明授权

US4948041A Thermostatic garden hose protection device 失效
标题翻译：恒温花园软管保护装置
公开(公告)号：US4948041A
公开(公告)日：1990-08-14
申请号：US319829
申请日：1989-03-03
申请人： John P. McCauley
发明人： John P. McCauley
IPC分类号： A01G25/00 , B05B12/10 , G05D23/02
CPC分类号： B05B12/10 , A01G25/00 , G05D23/022
摘要： A device to protect garden hoses and other fluid conduits from wear and bursting caused by pressure build-up due to heat generation particularly from the sun's rays. The device can be attached between the house spigot and hose or at the end of a hose between the hose and spray attachment. The device comprises a housing with a threaded inlet end for attachment to a hose or spigot, a central chamber containing a thermostat in a valve moveably mounted on a spring, which together are adapted to open water release holes at the outlet port end when water temperatures reach a predetermined level and close when the water temperature decreases to a second predetermined level. Sufficient openings in the device, allow full flow of fluid through the inlet port, the chamber and the outlet port and attachment, but still provides protection against pressure build-up when the hose is not in use.
摘要翻译：保护花园软管和其他流体管道的装置不会受到由于特别是太阳光线的发热而产生的压力积聚造成的磨损和破裂。该装置可以连接在房屋插口和软管之间，或者在软管和喷雾附件之间的软管末端。该装置包括具有用于附接到软管或插口的螺纹入口端的壳体，包含可移动地安装在弹簧上的阀中的恒温器的中心室，其一起适于在出口端口处打开水释放孔，当水温当水温降低到第二预定水平时达到预定水平并关闭。设备中足够的开口允许流体通过入口端口，腔室和出口端口以及附件完全流动，但是当软管不使用时仍然提供防止压力积聚的保护。

8. 发明申请

US20120115913A1 Ethanamine Compounds and Methods of Using the Same 审中-公开
标题翻译：乙胺化合物及其使用方法
公开(公告)号：US20120115913A1
公开(公告)日：2012-05-10
申请号：US13219892
申请日：2011-08-29
申请人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
发明人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P. McCauley , Lihong Shen , David Nugiel
IPC分类号： A61K31/4402 , A61P25/24 , C07D213/38
CPC分类号： C07D213/38 , A61K31/4402 , C07C57/15
摘要： The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
摘要翻译：本发明涉及乙胺化合物，包含其的药物组合物，以及通过施用乙胺化合物治疗抑郁症的方法。

9. 发明授权

US08013165B2 Ethanamine compounds and methods of using the same 545 有权
标题翻译：乙胺化合物及其使用方法545
公开(公告)号：US08013165B2
公开(公告)日：2011-09-06
申请号：US12644046
申请日：2009-12-22
申请人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P McCauley , Lihong Shen , David Nugiel
发明人： Michael Balestra , Peter Bernstein , Glen E. Ernst , William Frietze , John P McCauley , Lihong Shen , David Nugiel
IPC分类号： C07D211/70 , A01N43/40
CPC分类号： C07D213/38 , A61K31/4402 , C07C57/15
摘要： The present invention is directed to ethanamine compounds, pharmaceutical compositions comprising the same, and methods of treating depression by administering the ethanamine compound.
摘要翻译：本发明涉及乙胺化合物，包含其的药物组合物，以及通过施用乙胺化合物治疗抑郁症的方法。

10. 发明授权

US06812225B2 Therapeutic heterocyclic compounds 失效
标题翻译：治疗性杂环化合物
公开(公告)号：US06812225B2
公开(公告)日：2004-11-02
申请号：US10051776
申请日：2002-01-16
申请人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
发明人： Edward Pierson , Daniel Sohn , Markus Haeberlein , Timothy Davenport , Marc Chapdelaine , Carey Horchler , John P. McCauley
IPC分类号： A61K3137
CPC分类号： C07D231/12 , A61K31/495 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D215/50 , C07D233/56 , C07D249/08 , C07D311/24 , C07D311/58 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12
摘要： Provided herein is a compound having the formula (I): Wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.

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