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1. 发明专利

IL296755A Monoclonal antibodies targeting hsp70 and therapeutic uses thereof 未知
公开(公告)号：IL296755A
公开(公告)日：2022-11-01
申请号：IL29675522
申请日：2022-09-22
申请人： UNIV TEXAS , ASYLIA THERAPEUTICS , ROBERT Z ORLOWSKI , RICHARD J JONES , LAURA C BOVER , JENO GYURIS , JOHN MILLER , JAMES BERNARD MCCLORY , DARRAGH MAC CANN , WILLIAM M WINSTON JR
发明人： ROBERT Z ORLOWSKI , RICHARD J JONES , LAURA C BOVER , JENO GYURIS , JOHN MILLER , JAMES BERNARD MCCLORY , DARRAGH MAC CANN , WILLIAM M WINSTON JR
IPC分类号： A61K39/00 , A61K39/39 , A61K39/395 , A61K45/06 , A61P35/00 , C07K16/18 , C07K16/28 , C07K16/30
摘要： Provided herein are agents, such as antibodies and chimeric antigen receptors, that target HSP70. Methods of treating cancer are provided, comprising administering to a patient in need thereof an effective amount of an HSP70-targeting agent. The HSP70-specific antibody may enhance uptake of HSP70 by antigen presenting cells.

2. 发明专利

GB1081196A High voltage power transmission on circuit 未知
公开(公告)号：GB1081196A
公开(公告)日：1967-08-31
申请号：GB3272365
申请日：1965-07-30
申请人： DONALD JOHN MILLER
IPC分类号： H02J3/36
摘要： 1,081,196. Transmission line arrangements; converting. D. J. MILLER. July 20, 1966 [July 30, 1965; Oct. 4, 1965], Nos. 32723/65 and 41944/65. Headings H2F and H2H. In a high voltage D.C. system, each pole of a transmission circuit is divided into at least two separate insulated conductors connected together only at terminal or intermediate stations by means of a switch in each conductor, so that conductors may be isolated under fault conditions. Earthing switches may be also provided. Capacitors may be alternatively connected between conductors or between conductors and earth, which together with the reactance of the line form an oscillatory circuit to aid arc quenching at the switches. These capacitors may form part of harmonic filters or surge suppressors. The switches may be single pole automatic circuit breakers similar to those employed on A.C. systems.

3. 发明专利

GB855370A Plumber's drain flushing gun 未知
公开(公告)号：GB855370A
公开(公告)日：1960-11-30
申请号：GB717559
申请日：1959-03-02
申请人： MICHAEL JOHN MILLER
IPC分类号： B08B9/032 , E03C1/308
摘要： 855,370. Clearing drains. MILLER, M. J. March 2, 1959, No. 7175/59. Class 99(2). A drain flushing gun comprises a pressureresisting, metal cylinder 10 connected through a spring-pressed air valve 17 and a rubber hose to a manually-operated, piston, air pump 21. The cylinder 10 is provided at one end with an air port 37 closed by a spring-loaded valve 35, the valve rod 15 extending through a packed gland 14 in the other end of the cylinder 10 and having a pin and slot connection with a trigger lever 30 extending into and pivoted on a handle 11 welded to the cylinder end wall 12, movement of the lever 30 being limited by a stop 41 engaging the wall 42 of the handle. A pressure gauge 29, Fig. 2 (not shown), is screwed into the cylinder end wall 12. A " T " fitting 43 connected to the port 37 and incorporating a check valve 47 is connected by a hose 49 to a water faucet 50 and by a rubber cup 45 to a drain opening. The cylinder 10 is provided with air at a predetermined pressure by the pump 21 and the water faucet 50 is turned on admitting water into the fitting 43 and drain, whence a pull on the trigger lever 30 releases the air from the cylinder 10 into the fitting 43 to clear the drain by impact of the water on the obstruction therein. Alternatively, the fitting 43 is connected to the drain by a rubber hose inserted therein.

4. 发明专利

GB730610A Improved means for observing the burner flame in gas-heated appliances 未知
公开(公告)号：GB730610A
公开(公告)日：1955-05-25
申请号：GB2807252
申请日：1952-11-07
申请人： JOHN MILLER ANDERSON
IPC分类号： F24C15/04
摘要： 730,610. Sighting burner flames in stoves. ANDERSON, J. M. Oct. 5, 1953 [Nov. 7, 1952], No. 28072/52. Class 126. [Also in Group VI] In a gas-heated appliance, e.g. a thermostatically controlled deep fat-frying appliance, having a door 8, the door has a cavity 11 within which is placed a mirror or reflector 12 which forms an image of the gas burner 18 visible through a viewing window 13 placed at the top of the cavity in the door or in the casing above the,door.

5. 发明专利

GB674769A Rotary cultivator 未知
公开(公告)号：GB674769A
公开(公告)日：1952-07-02
申请号：GB2731449
申请日：1949-10-24
申请人： GORDON MCLEAN STEWART , ASHLEY JOHN MILLER
IPC分类号： A01B33/02
摘要： 674,769. Rotary cultivators. STEWART, G. M., and MILLER, A. J. Oct. 24, 1949, No. 27314/49. Class 6(i) A rotary cultivator, of the type having a power-driven transverse rotor 12, is provided with a shield 13, 31, 41 surrounding the rotor, the shield being made in several parts, some of which are adjustable towards or away from the rotor axis. The device is mounted on a frame 11 pivoted at the rear of a tractor 10. The front part, 13, of the shield is secured at its lower end to a curved plate 29 pivoted to a rod 25 which is movable longitudinally by a lever 28, to vary the distance between the shield and rotor axis. The upper end of the portion 13 is pivoted at 14 to a lever 15. Both the lever 15 and its fulcrum 16 are movable by hand levers 17, 22. A spring 23 urges the screen towards the rotor axis. The rear part 31 of the shield is pivoted at 32 to the frame 11, and can be fixed to a bracket 34 in various angular settings. Its lower end carries a relatively-slidable tailpiece 35. A set of blades 37, pivoted to the inside of the shield, can be set at various angles of inclination thereto, and serves to comminute the rearwardly-flung soil. A curtain of pivoted rods 46 serves a similar purpose. The central part, 41, of the shield, is counterweighted at 44 and can be swung up to permit the escape of large clods. A hopper 45, for seed or fertiliser may be mounted in the opening, or other soil treating appliances may be mounted therein. A blade (not shown) may be mounted at the bottom of the section 13 to cut vegetation. The plate 29 causes the whole structure to rise on meeting obstructions.

6. 发明专利

GB656101A An improved rotary cultivator 未知
公开(公告)号：GB656101A
公开(公告)日：1951-08-15
申请号：GB2217248
申请日：1948-08-23
申请人： GORDON MCLEAN STEWART , ASHLEY JOHN MILLER
IPC分类号： A01B33/08
摘要： 656,101. Rotary cultivators. STEWART, G. M., and MILLER, A. J. Aug. 23, 1948, No. 22172. Convention date. Sept. 14, 1947. [Class 6(i)] Rotary cultivator drawn behind a tractor has the rotor mounted in a frame comprising two spaced radius arms directly attached to the tractor, the arms being independently pivotable and having limited movement relative to each other in the vertical plane. A tractor 6 has a rear-axle casing 7 and a belt-drive pulley 8. Attached to the tractor is a cultivator frame comprising two spaced radius arms 9, 10 independently mounted on the tractor. The arm 9 has an inbent section 9' with a trunnion bearing 11 pivoted about an anchor 12 on the tractor. This bearing allows pivotal movement of the arm 9 in a vertical plane and limited movement in a horizontal plane. The radius arm 10 carries a box sub-frame comprising a transverse member 13 joined to a vertical plate 14, Fig. 2, by a member 15, vertical posts 16, 17 and rails 18, 19 supporting steel side plates 20, 21 to complete the box structure. The box-frame is attached to bearing boxes 26, 27 secured on the axle casing 7. Drag links 28, 29 connect the bearing boxes to the side frames of the tractor. The arm 10 pivots freely in a vertical plane but is restrained in the horizontal plane. A relative vertical movement is limited by an extension 13 1 of the crossmember 13 in engagement with adjustable set-screws on the arm 9. The rotor shaft 34 is mounted in bearing blocks 35 incorporating self-aligning bearings permitting relative movement of the arms 9, 10. A shield 36 covers the rotor 33, which is driven from the tractor pulley 8 through belts 37, 40, speed reduction and reverse gearing being housed in the box-frame. The working depth of the rotor is controlled by flexibly and adjustably mounted ground wheels 50, 51. A transverse girder 52 is mounted above the radius arms 9, 10 by leaf springs 53, 54 secured to the arms by vertical links 55 and rods 56 fitted with an adjustment nut 57. Each land wheel is carried on a castor action strut 58 mounted in a bracket 59 slidable on the girder and clamped in position. The wheels are adjusted vertically by a pin passed into apertures in the struts 58. Excessive upward flexing of the springs 53, 54 is prevented by links 62 pivoted to the radius arms and fitted with adjustable collars 63. To assist the land wheels in controlling the depth of cut, a skid 66 is pivotally mounted on the radius arm 9 and its setting adjusted by a strut 68.

7. 发明专利

GB654818A Improvements in, or relating to, electric lighting dynamos for pedal cycles and likeroad vehicles 未知
公开(公告)号：GB654818A
公开(公告)日：1951-06-27
申请号：GB3212648
申请日：1948-12-13
申请人： FREDERICK JOHN MILLER , NORMAN VICTOR MILLER
IPC分类号： B62J6/12
摘要： 654,818. Dynamo driving arrangements. MILLER, F. J., and MILLER, N. V. Dec. 13, 1948, No. 32126. [Class 35] A cycle lighting dynamo is supported outside the wheel hub by the wheel spindle and is driven at a speed greater than that of the wheel through gearing in the wheel - hub. The casing 10 of the imbricated pole generator is integral with a discshaped carrier 1 secured on the spindle 3 by a nut 3a. A cup-shaped housing 5 carrying the spokeflange 7 carries a spring- pressed plunger 16 controlled by a cam-lever 20 so that it can be made to engage a resilient driving block 15 on a toothed driving-wheel 13 rotating freely on the spindle and meshing with a pinion 12 on the dynamo spindle. The driving gear may be of fibre and the driving block has a chamfered engaging surface to reduce chatter between the gear teeth owing to the uneven torque of the generator at low speeds. The plunger casing 17 is fixed on a resilient cushion 18 to reduce noise. In a modification the driving block 15 may be replaced by a ring secured to the wheel 13 and having a series of projections for engagement by the pin 16, and, if desired, belted instead of toothed gearing may be used.

8. 发明专利

GB521613A Improvements in, or relating to, electric torches 未知
公开(公告)号：GB521613A
公开(公告)日：1940-05-27
申请号：GB3404038
申请日：1938-11-23
申请人： FREDERICK JOHN MILLER
IPC分类号： F21L4/00 , F21V13/00 , F21Y101/00
摘要： 521,613. Electric battery lamps. MILLER, F. J. Nov. 23, 1938, Nos. 34040/38 and 29411/39. [Class 39 (ii)] A battery torch is adapted for use as a night light by providing the lens. cap or the casing with lateral openings d opposite the bulb c the openings being covered or uncovered by a sliding or rotatable sleeve g. The rotatable sleeve has openings corresponding to those in the cap or casing. The lens cap a 4 , Fig. 10, may slide out to open up a lateral hole d 4 in the casing or it may rotate to bring an aperture in it into alignment with one in the casing.

9. 发明专利

GB414748A Improvements in and relating to copper alloys and articles made therefrom 未知
公开(公告)号：GB414748A
公开(公告)日：1934-08-13
申请号：GB126033
申请日：1933-01-13
申请人： HENRY WINDER BROWNSDON , MAURICE COOK , HERBERT JOHN MILLER , ICI LTD
IPC分类号： C22C9/06 , E06C1/20
摘要： An alloy consisting essentially of copper, nickel, aluminium, and manganese, having an aluminium content of 0,5-5 per cent, preferably 1-3 per cent, a nickel content of 1,5-15 per cent and equal to about 3-4 times the aluminium content, and a manganese content of 0,5-15 per cent is hardened by rapid cooling from a temperature of the order of 900 DEG C. followed by reheating at about 300-600 DEG C. The treated alloys are stated to retain their strength and hardness at relatively high temperatures. The alloy may be subjected to cold working after the rapid cooling and prior to the reheating. A locomotive fire-box may be made from an alloy containing 87,5 per cent copper, 5 per cent manganese, 6 per cent nickel, and 1,5 per cent aluminium, the fire box being made after the alloy has been quenched from 900 DEG C., and reheating for about 2 hours at 500-600 DEG C. being effected when the fire-box has reached or almost reached its final stage of fabrication. According to the first Provisional Specification the alloy may also contain zinc and the nickel content need not be as high as 3-4 times the aluminium content. Specifications 200,961, [Class 82 (i)], 386,017 and 402,796 are referred to.

10. 发明专利

GB385714A Improvements in, or relating to, taps or valves 未知
公开(公告)号：GB385714A
公开(公告)日：1933-01-05
申请号：GB3205831
申请日：1931-11-19
申请人： FREDERICK JOHN MILLER
IPC分类号： F16K41/00
摘要： 385,714. Delivery taps. MILLER, F. J., 9, Stonehouse Road, Sutton Coldfield. Nov. 19, 1931, No. 32058. [Class 135.] Closure members; casings.-A domestic &c. water delivery tap comprises an integral vertical cylindrical nozzle a with a coned upper end a forming a valve seat for a complementary coned facing member b formed integrally on a screwed spindle b, the facing member being large enough to overhang the nozzle so that water is deflected downwards towards exit orifices in the chamber a, said orifices being of greater cross-sectional area than the passage in the nozzle, and formed in the partition or diaphragm supporting the nozzle. A modification is shown in which the water supply pipe is disposed vertically below the valve casing instead of horizontal as shown at a .

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