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    • 7. 发明申请
    • 7-NITROINDOLINE DERIVATIVES AND THEIR USES
    • 7-硝基吲哚衍生物及其用途
    • WO2004085394A1
    • 2004-10-07
    • PCT/GB2004/001342
    • 2004-03-26
    • MEDICAL RESEARCH COUNCILCORRIE, John, Edgar, ThomasPAPAGEORGIOU, George
    • CORRIE, John, Edgar, ThomasPAPAGEORGIOU, George
    • C07D209/30
    • C07D209/08
    • 7-nitroindoline compounds are disclosed that comprise a triplet sensitising group such as substituted or unsubstituted benzophenone group and can be used to cage effector species. In particular, the inclusion of a triplet sensitising group linked to the 4 or 5 position of a 7-nitroindoline derivative provides compounds which can be photolysed to release the effector species with unexpectedly enhanced photolysis efficiency. The triplet sensitising group may be linked directly to the 7-nitroindoline or via a spacer group. In some examples, the triplet sensitising group and/or the spacer group can be selected to enhance other properties of the caged compound such as its solubility, spectroscopic properties or stability ( e.g. stability of the linkage between the nitroindoline moiety and the triplet sensitiser). This can help to improve the performance of the caged compound, especially in aqueous environments containing dissolved oxygen.
    • 公开了包含三重敏感基团如取代或未取代的二苯甲酮基团的7-硝基二氢吲哚化合物,并且可用于笼状效应物种。 特别地,包含与7-硝基二氢吲哚衍生物的4或5位连接的三线态敏化基团提供可以被光解以释放效应物种的化合物,其具有意想不到的增强的光解效率。 三线态敏化基团可以直接连接到7-硝基二氢吲哚或通过间隔基团。 在一些实例中,可以选择三线态敏化基团和/或间隔基团以增强笼状化合物的其它性质,例如其溶解度,光谱性质或稳定性(例如硝基二取代吲哚部分和三线态敏化剂之间的连接的稳定性)。 这有助于提高笼式化合物的性能,特别是在含有溶解氧的含水环境中。
    • 8. 发明申请
    • FLUID FILTERS
    • 流体过滤器
    • WO2004009212A3
    • 2004-04-29
    • PCT/ZA0300094
    • 2003-07-17
    • SCRAGG JOHN EDGAR
    • SCRAGG JOHN EDGAR
    • B01D33/073B01D35/147B01D36/00
    • B01D35/147B01D33/073B01D33/56B01D33/801B01D35/31B01D36/001B01D36/003
    • A filter is disclosed which comprises a housing (46.1) having an inlet (48.1) and an outlet (50.1) and a filter cartridge (44.1) having a core (54.1). A float (56.1) in the core (54.1) has a buoyancy such that it sinks in the liquid product to be filtered and floats in a liquid which contaminates the liquid product. A seat (52.1) is provided at the upper end of the core (54.1) so that, as the level of contaminant liquid in the housing (46.1) increases, the float (56.1) rises in the core (54.1) and presses against the seat (52.1) to isolate the inlet (48.1) from the outlet (50.1) and thus flow through the filter is terminated. A drain outlet is provided at the lower end of the housing (46.1) and comprises a chamber (68) and a seat (62) against which a sealing element is pressed by a spring (66). The chamber (68) is connected to the outlet (50.1) by a pipe (70). Pressing of a vacuum release button (76) opens the chamber (68) to the atmosphere which creates a suction effect that overcomes the force of the spring (66) and allows the seat (64) to move downwards allowing liquid contaminant to exit the housing (46.1) via the pipe (70) and outlet (50.1).
    • 公开了一种过滤器,其包括具有入口(48.1)和出口(50.1)的壳体(46.1)和具有芯部(54.1)的过滤器滤芯(44.1)。 芯部(54.1)中的浮子(56.1)具有浮力,使其沉入待过滤的液体产品中并漂浮在污染液体产物的液体中。 在芯部(54.1)的上端设有一个座(52.1),使得当壳体(46.1)中的污染液体的水平增加时,浮子(56.1)在芯体(54.1)中升高并压在 座(52.1)将入口(48.1)与出口(50.1)隔离,从而流过过滤器。 在壳体(46.1)的下端设有排水口,包括一个室(68)和座(62),一个密封元件被弹簧(66)挤压。 腔室68通过管道70连接到出口50.1。 按压真空释放按钮(76)将空腔(68)打开到大气中,其产生克服弹簧(66)的力的吸力作用,并允许座(64)向下移动,允许液体污染物离开壳体 (46.1)经由管道(70)和出口(50.1)。
    • 9. 发明申请
    • PROCESS FOR NITRATING PHOTOCLEAVABLE COMPOUNDS
    • 硝基化合物的制备方法
    • WO2002083639A1
    • 2002-10-24
    • PCT/GB2002/000971
    • 2002-03-08
    • MEDICAL RESEARCH COUNCILCORRIE, John, Edgar, ThomasPAPAGEORGIOU, George
    • CORRIE, John, Edgar, ThomasPAPAGEORGIOU, George
    • C07D209/08
    • C07D209/08Y02P20/55
    • A process is disclosed for nitrating photocleavable compounds comprising a photocleavable group linked to an effector moiety which are capable of releasing the effector moiety on irradiation with light or a group is capable of linkage to an effector moiety. The process employs copper (II) nitrate and acetic anhydride to nitrate substituted indolines at the 7-position. This reaction which proceeds in good yield and selectivity and can be carried out in the presence of the functional groups at the 4-position and/or the effector moiety which is typically linked via an acyl linkage to the heterocyclic nitrogen at the 1-position. These nitration conditions have the advantages of a favourable isomeric ratio of products and leaving the protecting groups intact, thereby giving additional scope for isomer separation. In a preferred embodiment, the present invention employs clay supported copper (II) nitrate ("claycop") and acetic anhydride which provides improved yield and isomeric ratio as compared to the use of homogeneous, soluble copper (II) nitrate.
    • 公开了一种用于硝化光可透洗化合物的方法,其包含连接到效应子部分的可光致发光基团,其能够在光照射下释放效应部分,或者能够与效应子部分连接。 该方法使用硝酸铜(II)和乙酸酐在7-位硝酸取代的吲哚啉。 该反应以良好的产率和选择性进行,并且可以在4-位和/或效应子部分的官能团存在下进行,效应部分通常通过酰基键与1-位上的杂环氮连接。 这些硝化条件具有有利的产物异构体比例并使保护基保持完整的优点,从而为异构体分离提供了额外的范围。 在优选的实施方案中,与使用均匀的可溶性硝酸铜(II)相比,本发明使用粘土负载的硝酸铜(II)(“claycop”)和乙酸酐,其提供改善的产率和异构体比例。