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1. 发明申请

US20060035928A1 Combination therapeutic compositions and methods of use 失效
标题翻译：组合治疗组合物和使用方法
公开(公告)号：US20060035928A1
公开(公告)日：2006-02-16
申请号：US11258817
申请日：2005-10-26
申请人： Juan Jaen , Jin-Long Chen
发明人： Juan Jaen , Jin-Long Chen
IPC分类号： A61K31/47 , A61K31/165
CPC分类号： A61K45/06 , A61K31/00 , A61K31/165 , A61K31/47 , Y10S514/866 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
摘要翻译：本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。组合物涉及式I化合物和抗糖尿病药如磺酰脲类，双胍类，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药首先交付，然后是式I的化合物。

2. 发明申请

US20050215608A1 Bis-aryl thiazole derivatives 失效
标题翻译：双芳基噻唑衍生物
公开(公告)号：US20050215608A1
公开(公告)日：2005-09-29
申请号：US10481218
申请日：2002-06-27
申请人： M. Amaral , Jin-Long Chen , Juan Jaen , David Johnston , Paul Rafferty
发明人： M. Amaral , Jin-Long Chen , Juan Jaen , David Johnston , Paul Rafferty
IPC分类号： A61K31/427 , C07D417/04
CPC分类号： C07D417/04 , A61K31/427
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases.
摘要翻译：提供了可用于治疗或预防解偶联蛋白介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物调节UCP3的表达和/或活性。本发明组合物特别可用于治疗肥胖症和II型糖尿病以及相关疾病。

3. 发明授权

US06566089B1 Cell-based drug screens for regulators of gene expression 失效
公开(公告)号：US06566089B1
公开(公告)日：2003-05-20
申请号：US08866942
申请日：1997-05-31
申请人： Bei Shan , R. Marc Learned , M. Catherine Amaral , Steven L. McKnight , Fabienne Charles de la Brousse , Jin-Long Chen
发明人： Bei Shan , R. Marc Learned , M. Catherine Amaral , Steven L. McKnight , Fabienne Charles de la Brousse , Jin-Long Chen
IPC分类号： C12Q132
CPC分类号： G01N33/5023 , A01K2217/072 , C12N15/8509 , C12N2510/00 , C12N2830/008 , C12Q1/6897 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N2500/00
摘要： The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell comprising a knock-in mutant of a targeted native allele encoding a reporter of gene expression, wherein the expression of the reporter is under the control of the gene expression regulatory sequences of the native allele, with a candidate agent under conditions whereby but for the presence of the agent, the reporter is expressed at a first expression level; and, (b) measuring the expression of the reporter to obtain a second expression level, wherein a difference between the first and second expression levels indicates that the candidate agent modulates gene expression.

4. 发明授权

US5807740A Regulators of UCP2 gene expression 失效
标题翻译： UCP2基因表达调控因子
公开(公告)号：US5807740A
公开(公告)日：1998-09-15
申请号：US846012
申请日：1997-04-25
申请人： M. Catherine Amaral , Jin-Long Chen
发明人： M. Catherine Amaral , Jin-Long Chen
IPC分类号： C12N15/09 , A61K48/00 , C07K14/47 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/85 , C12Q1/02 , C12Q1/68 , C12N1/00 , C12N15/11 , C12N15/63
CPC分类号： C12N15/85 , C07K14/4702 , A61K48/00 , C12N2830/00 , C12N2830/85
摘要： The invention relates to regulators of UCP2 gene transcription, including novel UCP2 transcriptional promoters. UCP2 gene promoters are used in diagnosis and pharmaceutical development. In particular, transfected cells comprising UCP2 gene promoters operably linked to a reporter are used in high-throughput pharmaceutical screens.
摘要翻译：本发明涉及UCP2基因转录调控因子，包括新型UCP2转录启动子。 UCP2基因启动子用于诊断和药物开发。特别地，包含与报告物可操作地连接的UCP2基因启动子的转染细胞用于高通量药物筛选。

5. 发明申请

US20080113449A1 Novel receptors 审中-公开
标题翻译：新型受体
公开(公告)号：US20080113449A1
公开(公告)日：2008-05-15
申请号：US11971360
申请日：2008-01-09
申请人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
发明人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
IPC分类号： G01N33/566 , C07K16/28 , C07K14/705 , C07H21/04
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
摘要翻译：本发明提供新型受体的分离的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。

6. 发明申请

US20070141644A1 Novel Receptors 审中-公开
标题翻译：新的受体
公开(公告)号：US20070141644A1
公开(公告)日：2007-06-21
申请号：US11680133
申请日：2007-02-28
申请人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
发明人： Hui Tian , Kang Dai , Jin-Long Chen , Jiagang Zhao , Gene Cutler
IPC分类号： G01N33/53 , C07K16/28
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.
摘要翻译：本发明提供了分离的新型受体的核酸和氨基酸序列，这种受体的抗体，检测这种核酸和受体的方法，以及筛选受体调节剂的方法。

7. 发明申请

US20060264481A1 Therapeutic modulation of PPARgamma activity 审中-公开
标题翻译： PPARγ活性的治疗调节
公开(公告)号：US20060264481A1
公开(公告)日：2006-11-23
申请号：US11493131
申请日：2006-07-25
申请人： Jin-Long Chen
发明人： Jin-Long Chen
IPC分类号： A61K31/44 , A61K31/40 , A61K31/325 , A61K31/277 , A61K31/195 , A61K31/18
CPC分类号： A61K31/425 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/325 , A61K31/40 , A61K31/44 , A61K31/505
摘要： Modulators of PPARγ activity are used in methods of treating and/or preventing conditions such as osteoporosis, Alzheimer's disease, psoriasis and acne, and cancer.
摘要翻译： PPARgamma活性的调节剂用于治疗和/或预防诸如骨质疏松症，阿尔茨海默病，牛皮癣和痤疮以及癌症的病症的方法。

8. 发明授权

US6110322A Prevention of ground fault interrupts in a semiconductor processing system 失效
标题翻译：防止半导体处理系统中的接地故障中断
公开(公告)号：US6110322A
公开(公告)日：2000-08-29
申请号：US036536
申请日：1998-03-06
申请人： Hong Bee Teoh , James Jin-Long Chen , Cuong C. Nguyen , Hanh D. Nguyen
发明人： Hong Bee Teoh , James Jin-Long Chen , Cuong C. Nguyen , Hanh D. Nguyen
IPC分类号： H05B3/00 , C23C16/46 , C23C16/511 , C23F1/02 , H01L21/00 , H01L21/205 , H01L21/68 , H01L21/683
CPC分类号： H01L21/67103 , C23C16/4586 , H01L21/6719 , H01L21/68742 , H01L21/68785
摘要： A pedestal heating system provided for heating a pedestal disposed in the processing chamber of a substrate processing system. A pedestal heating system according to the present invention includes: a heater power supply, a transformer, coupled to the heater power supply, a heater element coupled to the transformer, and an RF ground electrode. The transformer is configured to reduce leakage current from the heater element to various elements of the substrate processing system by localizing current leakage loops. The heater element and RF ground electrode are disposed within the pedestal. Preferably, the transformer is simply an isolation transformer. Where an RF energy source is used, such as in a plasma CVD processing system, an EMI filter may be coupled between the transformer and the heater element, or at another point in the power supply chain to prevent feed-through of RF energy to other of the substrate processing system's subsystems, or other sensitive electronic circuitry coupled to the facility's power supply.
摘要翻译：一种基座加热系统，用于加热设置在基板处理系统的处理室中的基座。根据本发明的基座加热系统包括：耦合到加热器电源的加热器电源，变压器，耦合到变压器的加热器元件和RF接地电极。变压器被配置为通过定位电流泄漏回路来减少从加热元件到基板处理系统的各种元件的泄漏电流。加热器元件和RF接地电极设置在基座内。优选地，变压器仅仅是隔离变压器。在诸如在等离子体CVD处理系统中使用RF能量源的地方，EMI滤波器可以耦合在变压器和加热器元件之间，或者在电源链中的另一点处，以防止将RF能量馈送到其它的衬底处理系统的子系统或耦合到设施的电源的其他敏感电子电路。

9. 发明授权

US5952469A Murine UCP3 polypeptides 失效
公开(公告)号：US5952469A
公开(公告)日：1999-09-14
申请号：US172528
申请日：1998-10-14
申请人： Ning Zhang , M. Catherine Arnaral , Jin-Long Chen
发明人： Ning Zhang , M. Catherine Arnaral , Jin-Long Chen
IPC分类号： C12N15/09 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/075 , A61K38/00
摘要： The invention provides methods and compositions relating to a novel family of UCP3 polypeptides and related nucleic acids involved in metabolic regulation. The polypeptides may be produced recombinantly from transformed host cells from the disclosed mUCP3 encoding nucleic acids or purified from mammalian cells. The invention provides isolated mUCP3 hybridization probes, knock-out/in constructs and primers capable of specifically hybridizing with the disclosed mUCP3 genes, mUCP3-specific binding agents such as specific antibodies, animals and cells modified with the subject mUCP3 nucleic acids, and methods of making and using the subject compositions in the biopharmaceutical industry.

10. 发明授权

US07939551B2 Combination therapeutic compositions 失效
标题翻译：组合治疗组合物
公开(公告)号：US07939551B2
公开(公告)日：2011-05-10
申请号：US11258817
申请日：2005-10-26
申请人： Juan C. Jaen , Jin-Long Chen
发明人： Juan C. Jaen , Jin-Long Chen
IPC分类号： A61K31/44 , A61K31/70 , A61K31/425 , A61K31/155
CPC分类号： A61K45/06 , A61K31/00 , A61K31/165 , A61K31/47 , Y10S514/866 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
摘要翻译：本发明提供了使用组合疗法治疗糖尿病的药物组合物和方法。组合物涉及式I化合物和抗糖尿病药如磺酰脲，双胍，格列酮，α-葡糖苷酶抑制剂，钾通道拮抗剂，醛糖还原酶抑制剂，胰高血糖素拮抗剂，RXR的激活剂，胰岛素治疗或其它抗肥胖剂。所述方法包括施用式I化合物与抗糖尿病药物的组合，其中两种成分以同时方式递送，其中首先给予式I化合物，然后是抗糖尿病药，以及其中抗糖尿病药首先交付，然后是式I的化合物。

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