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    • 4. 发明授权
    • Organic polymers-separation membrane filter, and organic polymers-separation method
    • 有机聚合物分离膜过滤器和有机聚合物分离方法
    • US08945391B2
    • 2015-02-03
    • US13261013
    • 2010-04-26
    • Izumi IchinoseXinSheng Peng
    • Izumi IchinoseXinSheng Peng
    • B01D61/00B01D39/00B01D39/14A61K9/14B01D61/14B01D69/02B01D69/14B01D71/74B82Y30/00
    • B01D61/145B01D69/02B01D69/144B01D71/74B01D2323/30B82Y30/00
    • The object of the invention is to provide an organic polymers-separation membrane filter capable of physically separating organic polymers based on their molecular stereostructure difference without giving rise to chemical changes in them and without selecting their chemical compositions. The organic polymers-separation membrane filter comprising an ultrafilter membrane is characterized in that a path taken by a nano permeation pore has a narrower path portion having a width narrower than that of the rest, wherein organic polymers capable of changing in their stereostructure are passed through the path while their width is transformed into a configuration along the narrower path portion, thereby separating the organic polymers. In the ultrafilter membrane, particulate materials are mutually coupled together in its thickness and planar directions. The particulate materials comprise a protein. The particulate materials comprise protein particles deposited onto a nanostrand such that they are mutually crosslinked and integrated together. The nano permeation pore includes a mark remaining where the nanostrand is removed. The invention also provides a method for separating organic polymers capable of changing in their stereostructure, using the organic polymers-separation membrane filter.
    • 本发明的目的是提供一种有机聚合物分离膜过滤器,其能够基于其分子立体结构差异物理分离有机聚合物,而不会引起其化学变化并且不选择其化学组成。 包含超滤膜的有机聚合物分离膜过滤器的特征在于,纳米渗透孔所获得的路径具有窄于其余部分宽度的窄路径部分,其中能够改变其立体结构的有机聚合物通过 该路径的宽度被变换为沿较窄路径部分的构造,从而分离有机聚合物。 在超滤膜中,颗粒材料在其厚度和平面方向上相互耦合在一起。 颗粒材料包含蛋白质。 颗粒材料包括沉积在纳米链上的蛋白质颗粒,使得它们相互交联并整合在一起。 纳米渗透孔包括除去纳米链的剩余标记。 本发明还提供了使用有机聚合物分离膜过滤器分离能够改变其立体结构的有机聚合物的方法。
    • 6. 发明申请
    • A FLEXIBLE FREE-STANDING ULTRATHIN OR THIN PROTEIN MEMBRANE, ITS FABRICATION METHOD AND APPLICATION
    • 柔性自由超声波或薄蛋白膜,其制造方法和应用
    • US20100219120A1
    • 2010-09-02
    • US12452570
    • 2008-07-11
    • XinShen PengIzumi Ichinose
    • XinShen PengIzumi Ichinose
    • C07K1/113C07K14/805C07K14/80C12N9/04B01D61/00
    • B01D71/74B01D67/0006B01D69/122B01D69/144B01D2323/30B01D2325/04B82Y5/00Y10S977/705Y10S977/84Y10S977/89
    • [Purpose] A purpose of this invention is to provide a robust and flexible free-standing ultrathin (nano) or thin pure protein membrane which enables a rapid and simple separation (or condensation) of relatively small (M.W.=ca. 1,000 Da) molecules.[Summary] A flexible free-standing ultrathin (nano) or thin protein membrane can be fabricated by a method comprising following steps: (1) A dilute metal (Cd, Cu or Zn) nitrate or chloride solution is kept under neutral or weak basic pH to spontaneously form metal (Cd, Cu or Zn) hydroxide nanostrands; (2) The above metal (Cd, Cu or Zn) hydroxide nanostrands and protein solution are mixed to obtain composite nanofibers made of protein and the said metal hydroxide nanostrands; (3) The obtained dispersion of composite nanofibers is filtered on a filter. (4) Proteins contained in the composite nanofibers are cross-linked by bifunctional cross-linkers; and (5) Metal (Cd, Cu or Zn) hydroxide nanostrands are removed from them.
    • [目的]本发明的目的是提供一种坚固且灵活的独立超薄(纳米)或薄纯蛋白质膜,其能够快速和简单地分离(或缩合)相对小的(MW =约1,000Da)分子 。 [摘要]可以通过包括以下步骤的方法制造柔性独立的超薄(纳米)或薄蛋白膜:(1)将稀金属(Cd,Cu或Zn)硝酸盐或氯化物溶液保持在中性或弱碱性 pH自发形成金属(Cd,Cu或Zn)氢氧化物纳米链; (2)将上述金属(Cd,Cu或Zn)氢氧化物纳米链和蛋白质溶液混合,得到由蛋白质和所述金属氢氧化物纳米链制成的复合纳米纤维; (3)将所得的复合纳米纤维的分散体在过滤器上过滤。 (4)复合纳米纤维中含有的蛋白质通过双功能交联剂进行交联; 和(5)从它们中除去金属(Cd,Cu或Zn)氢氧化物纳米链。