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1. 发明专利

JP2010155822A Pharmaceutical composition for preventing or treating lewis y antigen-related disease, and kit for detecting lewis y antigen 审中-公开
标题翻译：用于预防或治疗LEWIS Y抗原相关疾病的药物组合物和用于检测LEWIS Y ANTIGEN的药盒
公开(公告)号：JP2010155822A
公开(公告)日：2010-07-15
申请号：JP2009246503
申请日：2009-10-27
申请人： Guey-Yueh Shi , Hua-Lin Wu , シグエイ−ユエウ , ウーヒュア−リン
发明人： WU HUA-LIN , SHI GUEY-YUEH
IPC分类号： A61K38/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/04 , C07K14/745 , C12Q1/02 , G01N33/66 , G01N33/68
CPC分类号： A61K38/366 , G01N33/86 , G01N2333/7452
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for preventing or treating diseases resulting from Lewis Y antigen over-expression, and a method for detecting cancer cells, Gram-negative bacteria or LPS(lipopolysaccharides) which over-express the Lewis Y antigen in a sample from a subject.
SOLUTION: The pharmaceutical composition includes N-terminal lectin-like domain of thrombomodulin (TMD1) or analogues thereof. A kit including N-terminal lectin-like domain of thrombomodulin (TMD1) or labeled analogues thereof is also provided.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供用于预防或治疗由Lewis Y抗原过表达引起的疾病的药物组合物，以及用于检测过表达Lewis的革兰氏阴性细菌或LPS（脂多糖）的方法来自受试者的样品中的Y抗原。解决方案：药物组合物包括血栓调节蛋白（TMD1）的N-末端凝集素样结构域或其类似物。还提供了包括血栓调节蛋白（TMD1）的N-末端凝集素样结构域或其标记的类似物的试剂盒。版权所有（C）2010，JPO＆INPIT

2. 发明专利

ZA200800177B A composition for wound healing and use thereof 未知
公开(公告)号：ZA200800177B
公开(公告)日：2008-11-26
申请号：ZA200800177
申请日：2008-01-08
申请人： CHUAN-CHI CHIANG , HUI-PIN SU , HUA-LIN WU , GUEY-YUEH SHI
发明人： CHUAN-CHI CHIANG , HUI-PIN SU , HUA-LIN WU , GUEY-YUEH SHI
IPC分类号： C12P20090101

3. 发明授权

US07803367B2 Methods and compositions for promoting angiogenesis 有权
标题翻译：促进血管生成的方法和组合物
公开(公告)号：US07803367B2
公开(公告)日：2010-09-28
申请号：US12316194
申请日：2008-12-10
申请人： Hua-Lin Wu , Guey-Yueh Shi
发明人： Hua-Lin Wu , Guey-Yueh Shi
IPC分类号： C12N9/00
CPC分类号： A61K48/00 , A61K38/366
摘要： The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases.
摘要翻译：本发明涉及促进血管发生的组合物，用于控制细胞的DNA合成和用于控制细胞的趋化运动性。本发明还涉及一种治疗缺血性疾病的方法。

4. 发明申请

US20050106135A1 Compositions, kits and treating methods for alteration cell-cell adhesion, transport, or permeation properties of tissues 失效
标题翻译：用于组织改变细胞粘附，转运或渗透性质的组合物，试剂盒和处理方法
公开(公告)号：US20050106135A1
公开(公告)日：2005-05-19
申请号：US10938183
申请日：2004-09-10
申请人： Hua-Lin Wu , Guey-Yueh Shi , Huey-Chun Huang
发明人： Hua-Lin Wu , Guey-Yueh Shi , Huey-Chun Huang
IPC分类号： A61K31/7004 , A61K31/737 , A61K38/36 , A61K45/06 , C07K14/745 , C07K16/36 , G01N33/574 , C12Q1/68 , A61K38/48 , C12N9/74 , G01N33/53 , G01N33/567
CPC分类号： C07K16/36 , A61K31/7004 , A61K31/737 , A61K38/36 , A61K45/06 , C07K14/7455 , C07K2317/76 , G01N33/574 , A61K2300/00
摘要： The present invention relates to compositions, kits and treating methods for the alteration cell-cell adhesion, transport, or permeation properties of tissues. The present invention also relates to the application of drug(s) or peptide(s), compound or gene delivery, DNA or RNA(i), cosmetic or therapeutic use of the compositions and kits.
摘要翻译：本发明涉及用于改变组织的细胞 - 细胞粘附，转运或渗透性质的组合物，试剂盒和处理方法。本发明还涉及药物或肽，化合物或基因递送，DNA或RNA（i），组合物和试剂盒的美容或治疗用途的应用。

5. 发明授权

US09730983B2 Methods for treatment of CD14-mediated disorders and responses 有权
公开(公告)号：US09730983B2
公开(公告)日：2017-08-15
申请号：US14873880
申请日：2015-10-02
申请人： Chih-Yuan Ma , Guey-Yueh Shi , Hua-Lin Wu
发明人： Chih-Yuan Ma , Guey-Yueh Shi , Hua-Lin Wu
IPC分类号： A61K38/36 , A61K9/00
CPC分类号： A61K38/366 , A61K9/0019
摘要： A method for blocking, inhibiting and/or decreasing cluster of differentiation 14 (CD14) function, CD14-mediated cellular response and/or treating CD14-mediated pathological conditions is disclosed. The method comprises administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a recombinant protein comprising an amino acid sequence that is at least 80% identical to SEQ ID NO: 1, wherein the recombinant protein does not comprises a lectin-like domain 1 of a human thrombomodulin; and (b) a pharmaceutically acceptable vehicle, carrier, diluent, excipients, and/or salt.

6. 发明授权

US09061000B2 Pharmacological treatment of aortic aneurysm development 有权
标题翻译：主动脉瘤发展的药理治疗
公开(公告)号：US09061000B2
公开(公告)日：2015-06-23
申请号：US13733902
申请日：2013-01-04
申请人： Chao-Han Lai , Guey-Yueh Shi , Hua-Lin Wu
发明人： Chao-Han Lai , Guey-Yueh Shi , Hua-Lin Wu
IPC分类号： A61K38/36
CPC分类号： A61K38/366
摘要： A method for pharmacological prevention and suppression of aortic aneurysm development is disclosed. The method comprises administering a therapeutically effective amount of recombinant thrombomodulin to a subject in need thereof. The recombinant thrombomodulin prevents formation and/or retards progression of an aortic aneurysm.
摘要翻译：公开了用于药理学预防和抑制主动脉瘤发展的方法。该方法包括向有需要的受试者施用治疗有效量的重组血栓调节素。重组血栓调节蛋白阻止主动脉瘤的形成和/或延缓进展。

7. 发明授权

US07939567B2 Dextromethorphan-based method for treating acne 有权
标题翻译：基于右美沙芬的治疗痤疮的方法
公开(公告)号：US07939567B2
公开(公告)日：2011-05-10
申请号：US11361589
申请日：2006-02-24
申请人： Hua-Lin Wu , Guey-Yueh Shi
发明人： Hua-Lin Wu , Guey-Yueh Shi
IPC分类号： A01N33/02
CPC分类号： A61K31/485 , Y10S514/859
摘要： The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compound of dextromethorphan or naloxone or a pharmaceutically acceptable salt or an analog thereof. The compound is applied to skin or mucosal surface of the patient. The invention also relates to a method of treating inflammation caused by suppressing secretion of TNF-α, IL-6, or MCP-1 from macrophage comprising administering a patient in need of such treatment a therapeutically effective amount of NADPH oxidase inhibitor.
摘要翻译：本发明涉及一种提供杀菌剂或抑菌剂的方法，特别是用于治疗由细菌感染引起的疾病。该方法包括给予需要这种治疗的患者治疗有效量的右美沙芬或纳洛酮或其药学上可接受的盐或类似物的化合物。该化合物应用于患者的皮肤或粘膜表面。本发明还涉及一种治疗由巨噬细胞抑制TNF-α，IL-6或MCP-1分泌引起的炎症的方法，包括给予需要这种治疗的患者治疗有效量的NADPH氧化酶抑制剂。

8. 发明授权

US07820689B2 Methods and compositions for preventing or treating cardiovascular disease 有权
标题翻译：预防或治疗心血管疾病的方法和组合物
公开(公告)号：US07820689B2
公开(公告)日：2010-10-26
申请号：US11836159
申请日：2007-08-09
申请人： Hua-Lin Wu , Guey-Yueh Shi
发明人： Hua-Lin Wu , Guey-Yueh Shi
IPC分类号： A61K31/44 , A61K38/00
CPC分类号： A61K31/485
摘要： The present invention relates to a method for preventing or treating a cardiovascular disease.
摘要翻译：本发明涉及一种预防或治疗心血管疾病的方法。

9. 发明申请

US20090118189A1 Novel angiogenic composition-based methods 有权
标题翻译：基于新型血管生成成分的方法
公开(公告)号：US20090118189A1
公开(公告)日：2009-05-07
申请号：US12316194
申请日：2008-12-10
申请人： Hua-Lin Wu , Guey-Yueh Shi
发明人： Hua-Lin Wu , Guey-Yueh Shi
IPC分类号： A61K38/16
CPC分类号： A61K48/00 , A61K38/366
摘要： The invention relates to a composition for promoting angiogenesis, for controlling DNA synthesis of a cell, and for controlling chemotactic motility of a cell. The invention also relates to a method for treating ischemia diseases.
摘要翻译：本发明涉及促进血管发生的组合物，用于控制细胞的DNA合成和用于控制细胞的趋化运动性。本发明还涉及一种治疗缺血性疾病的方法。

10. 发明授权

US5876999A Preparation of novel streptokinase mutants as improved thrombolytic agents 失效
标题翻译：新型链激酶突变体作为改进溶栓剂的制备
公开(公告)号：US5876999A
公开(公告)日：1999-03-02
申请号：US568393
申请日：1995-12-06
申请人： Hua-Lin Wu
发明人： Hua-Lin Wu
IPC分类号： A61K38/00 , C07K14/315 , C12N9/70 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C07K14/3153 , A61K38/00
摘要： Mutants of streptokinase in which one or more amino acid residues in the region of Pro58-Lys59-Ser60-Lys61 were replaced by other amino acids become better fibrinolytic agents. The mutants are resistant to the hydrolytic inactivation by plasmin and are more efficient in inducing fibrinolysis of plasma clots.
摘要翻译：其中Pro58-Lys59-Ser60-Lys61区域中的一个或多个氨基酸残基被其它氨基酸替代的链激酶突变体变成更好的纤维蛋白溶解剂。突变体对纤溶酶的水解失活具有抗性，并且更有效地诱导血浆凝块的纤维蛋白溶解。

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