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1. 发明授权

US07351825B2 Cyclopropane compounds and pharmaceutical use thereof 失效
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US07351825B2
公开(公告)日：2008-04-01
申请号：US11011773
申请日：2004-12-15
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafumi Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D265/00 , C07D295/00 , C07D237/00 , C07D409/00 , C07D411/00 , C07D217/00 , C07D211/00 , C07D213/00 , C07D271/00 , C07D413/00 , C07D498/00 , C07D277/00 , C07D257/00 , C07D233/00 , C07D231/00 , C07D207/00 , C07D333/00 , C07D307/00 , C07D303/00 , C07D309/00 , C07D311/00
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）的环丙烷化合物：其中R 1 是 - （CH 2）2 -X-（CH 2）n - SUP> 1等，其中m和n相同或不同，并且各自为0至6，X为单键等，而A 1为取代的C _{3-14个烃环基等; R 2和R 3相同或不同，并且各自为氢原子， - （CH 2）2 N 其中p和q为 - （CH 2）2 - - - - CH 2 - 相同或不同，并且各自为0至6，X 1为单键等，而A 2为任选取代的C 3-14烷基，烃环等; R 4是-CO 2 R 9等，其中R 9是氢原子等。 ; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2 CH 2）m 12 其中m12和m12（其中m12和m12）相同或不同，各自为0至6，X 12为单键等，R 30为氢原子等; 或其前药或其药学上可接受的盐。}

2. 发明授权

US4311475A Counter ejector 失效
标题翻译：计数器喷射器
公开(公告)号：US4311475A
公开(公告)日：1982-01-19
申请号：US107083
申请日：1979-12-26
申请人： Hiroto Imai
发明人： Hiroto Imai
IPC分类号： B65H33/02 , B42C19/08 , B65H31/30 , B65H31/32 , B65H33/16 , G06M9/00 , B31B1/64 , B31B1/98
CPC分类号： B65H31/3027 , B42C19/08 , B65H31/3081 , B65H31/32 , B65H33/16 , B65H2301/42266 , B65H2301/4228 , B65H2701/1766 , Y10S414/115
摘要： A device for counting and delivering sheets which accumulates a plurality of paste-applied and folded cardboard sheets, delivered by a paste-applying and folding machine, in a hopper for delivery to a next step in batches of a prescribed number of sheets. A counter is employed to count the individual sheets as they are being accumulated in the hopper for further processing. A plurality of ledges reciprocal in a vertical direction and projectable into the sheets being accumulated in the hopper divide the sheets into batches of the prescribed number as a function of the sheets having been counted. The batches are then removed from the hopper and delivered to a binding machine which is adapted to bind the cardboard sheets as a next step.
摘要翻译：一种用于计数和传送片材的装置，其将由糊剂施加和折叠机递送的多个粘贴和折叠的纸板片堆积在料斗中，以批量递送至下一步骤。使用计数器来计数各个片材，因为它们被积聚在料斗中用于进一步处理。多个在垂直方向上往复倒下的突出部，并且可投影到堆积在料斗中的纸张中，根据已经计数的纸张的数量，将纸张分成批次。然后将批料从料斗中取出并输送到装订机，该装订机适于在下一步骤中粘合纸板。

3. 发明申请

US20100105894A1 Cyclopropane compounds and pharmaceutical use thereof 审中-公开
标题翻译：环丙烷化合物及其药物用途
公开(公告)号：US20100105894A1
公开(公告)日：2010-04-29
申请号：US12457391
申请日：2009-06-09
申请人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
发明人： Takashi Inaba , Julia Haas , Makoto Shiozaki , Nicole M. Littmann , Katsutaka Yasue , Steven W. Andrews , Atushi Sakai , Andrew M. Fryer , Takafuml Matsuo , Ellen R. Laird , Akira Suma , Yuichi Shinozaki , Yoshikazu Hori , Hiroto Imai , Tamotsu Negoro
IPC分类号： C07D243/08 , C07C229/02 , C07C307/00 , C07D409/02 , C07D231/10 , C07D401/02 , C07D261/06 , C07D333/34 , C07D241/04 , C07D271/06 , C07D257/04 , C07D295/00 , C07D215/14 , C07D205/04 , C07D413/02 , C07D241/36 , C07D413/14 , C07D223/14
CPC分类号： C07C311/29 , C07C311/13 , C07C311/20 , C07C311/22 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07C2603/08 , C07C2603/18 , C07C2603/30 , C07D205/04 , C07D207/48 , C07D209/44 , C07D211/58 , C07D211/96 , C07D213/18 , C07D213/65 , C07D213/71 , C07D213/74 , C07D213/81 , C07D213/82 , C07D217/08 , C07D231/12 , C07D233/64 , C07D237/12 , C07D239/22 , C07D243/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/107 , C07D277/26 , C07D277/36 , C07D277/82 , C07D295/26 , C07D307/79 , C07D307/91 , C07D333/18 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D401/04 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的环丙烷化合物：其中，R 1为 - （CH 2 ）m-X-（CH 2）n -Al等，其中m和n相同或不同，各自为0〜6，X为单键等，而A1为取代的C3-14烃环基，等等。; R2和R3相同或不同，各自为氢原子， - （CH2）p-X1-（CH2）q-A2等，其中p和q相同或不同，各自为0至6，X1 是单键等，A2是任选取代的C 3-14烃环基等; R4是-CO 2 R 9等，其中R9是氢原子等; 和R 20和R 21相同或不同，各自为氢原子， - （CH 2）m 12 -X 12 - （CH 2）m 12 -R 30等，其中m12和m12相同或不同，各自为0至6， X12为单键等，R30为氢原子等; 或其前药或其药学上可接受的盐。

4. 发明申请

US20100056367A1 EXHAUST GAS PURIFYING CATALYST 有权
标题翻译：排气净化催化剂
公开(公告)号：US20100056367A1
公开(公告)日：2010-03-04
申请号：US12524352
申请日：2008-01-25
申请人： Hiroto Imai
发明人： Hiroto Imai
IPC分类号： B01J23/10 , B01J23/58
CPC分类号： B01J37/0244 , B01D53/945 , B01D2255/1021 , B01D2255/1025 , B01D2255/202 , B01D2255/204 , B01D2255/20715 , B01D2255/91 , B01J21/066 , B01J23/58 , B01J23/63 , B01J35/0006 , B01J37/0242 , Y02T10/22
摘要： An exhaust gas purifying catalyst 1 has a catalyst substrate 3 and catalyst coating layers 5, 7 that are formed on the catalyst substrate 3 and contain (a) Rh, (b) Pt, (c) an alkali metal or alkaline earth element, and (d) an inorganic oxide. The catalyst coating layers 5, 7 has a layered structure including an inside layer 5 where the component (a) is substantially locally existing, and an outside layer 7 where the component (b) is substantially locally existing. The inside layer 5 also contains a zirconia oxide.
摘要翻译：废气净化催化剂1具有形成在催化剂基板3上并含有（a）Rh，（b）Pt，（c）碱金属或碱土金属元素的催化剂基板3和催化剂涂层5,7，以及（d）无机氧化物。催化剂涂层层5,7具有层状结构，其中组分（a）基本上局部存在的内层5和组分（b）基本上局部存在的外层7。内层5也含有氧化锆。

5. 发明授权

US4331053A Rotary die cutter 失效
标题翻译：旋转模切机
公开(公告)号：US4331053A
公开(公告)日：1982-05-25
申请号：US173678
申请日：1980-07-30
申请人： Hiroto Imai , Noriyuki Hoshino
发明人： Hiroto Imai , Noriyuki Hoshino
IPC分类号： B23P6/00 , B26D7/08 , B26D7/20 , B26F1/38 , B31B1/20
CPC分类号： B26D7/08 , B23P6/00 , B26D7/20 , B26F1/384 , B26D2007/202 , Y10T83/303 , Y10T83/4737 , Y10T83/4841
摘要： There is provided a rotary die cutter for effecting a punching and scribing on a sheet which is fed between a die cylinder and an anvil cylinder disposed in parallel with said die cylinder. The die cylinder is adapted to be rotated in a predetermined direction and provided on its peripheral surface with a knife and a scribing rule. The anvil cylinder is adapted to be rotated in the opposite direction to the die cylinder and provided on its peripheral surface with an anvil for receiving the knife and the scribing rule. There is a mechanism for adjusting the clearance between the die cylinder and the anvil cylinder. A blade carrier is disposed adjacent to the anvil cylinder and slidable in the axial direction of the anvil cylinder. A cutting blade capable of cutting the anvil surface is attached to the blade carrier in such a manner as to move toward and away from the axis of the anvil cylinder. A staged gear type speed changing device is interposed between the driving mechanisms for the die cylinder and the anvil cylinder for and is adapted to change the velocity of the anvil cylinder with respect to that of the die cylinder over a plurality of stages at a fine step.
摘要翻译：提供了一种旋转模切机，用于在被供给在与所述模具缸平行设置的模具缸和砧座缸之间的片材上进行冲压和划线。模具圆筒适于沿预定方向旋转，并且在其外周表面上用刀和划线规则设置。砧筒适于沿着与模具缸相反的方向旋转并且在其外周表面上设置有用于接收刀的砧座和划线规则。存在用于调节模具缸和砧筒之间的间隙的机构。叶片载体邻近砧筒设置并可在砧筒的轴向上滑动。能够切割砧座表面的切割刀片以使得朝向和远离砧座圆柱体的轴线移动的方式附接到刀片托架。分级齿轮式变速装置设置在用于模具缸和砧座缸的驱动机构之间，并且适于在多个阶段以精细步骤改变砧筒相对于模具缸的速度。

6. 发明申请

US20130065754A1 EXHAUST GAS PURIFICATION CATALYST 审中-公开
标题翻译：排气净化催化剂
公开(公告)号：US20130065754A1
公开(公告)日：2013-03-14
申请号：US13636079
申请日：2010-03-24
申请人： Yusuke Shinmyo , Nobuyuki Takagi , Hiroyuki Matsubara , Hiroto Imai , Masaya Kamada
发明人： Yusuke Shinmyo , Nobuyuki Takagi , Hiroyuki Matsubara , Hiroto Imai , Masaya Kamada
IPC分类号： B01J23/58
CPC分类号： B01J35/04 , B01D53/945 , B01D2255/1021 , B01D2255/1023 , B01D2255/1025 , B01D2255/202 , B01D2255/204 , B01D2255/9022 , B01D2255/91 , B01J23/42 , B01J23/44 , B01J23/58 , B01J23/63 , B01J35/0006 , B01J37/0244 , F01N3/0814 , F01N3/0842 , F01N3/106 , F01N2510/0682 , F01N2510/0684 , Y02T10/22
摘要： The present invention provides an exhaust gas purification catalyst which has a structure which prevents competitive adsorption of HC, CO, and NOx and enables effective utilization of an NOx storage reduction type catalyst. The exhaust gas purification catalyst of the present invention is characterized by having an NOx storage reduction type catalyst layer which contains at least one type of NOx storage material which is selected from an alkali metal or an alkali earth metal and Pt and/or Rh on a substrate and having an oxidation catalyst layer which carries Pt and/or Pd on the NOx storage reduction type catalyst layer.
摘要翻译：本发明提供一种废气净化催化剂，其具有防止HC，CO和NOx的竞争性吸附的结构，能够有效利用NOx储存还原型催化剂。本发明的排气净化催化剂的特征在于，具有NOx吸留还原型催化剂层，其含有选自碱金属或碱土金属中的至少一种NOx储存材料，Pt和/或Rh 并且具有在NOx储存还原型催化剂层上承载Pt和/或Pd的氧化催化剂层。

7. 发明申请

US20110118113A1 EXHAUST GAS PURIFYING CATALYST 审中-公开
标题翻译：排气净化催化剂
公开(公告)号：US20110118113A1
公开(公告)日：2011-05-19
申请号：US12674956
申请日：2008-08-27
申请人： Naoto Miyoshi , Yoshiteru Yazawa , Kunio Ezaki , Hiroto Imai
发明人： Naoto Miyoshi , Yoshiteru Yazawa , Kunio Ezaki , Hiroto Imai
IPC分类号： B01J21/06
CPC分类号： B01J23/63 , B01D53/9422 , B01D53/945 , B01D2255/1025 , B01D2255/2061 , B01D2255/20715 , B01D2255/91 , B01J35/0006 , B01J37/0242 , B01J37/0248 , Y02T10/22
摘要： Disclosed is an exhaust gas purifying catalyst, including Rh/Y—ZrO2 particles obtained by supporting Rh on zirconia support particles which contain yttria, wherein yttria is contained in an amount of 2˜9 mol % in the support particles. The exhaust gas purifying catalyst exhibits a superior high-temperature durability because the zirconia support can resist heat, thereby particularly increasing the structure retaining power and the thermal stability of Rh.
摘要翻译：公开了一种废气净化催化剂，其包括通过在包含氧化钇的氧化锆载体颗粒上负载Rh而获得的Rh / Y-ZrO 2颗粒，其中在载体颗粒中含有2〜9摩尔％的氧化钇。废气净化催化剂表现出优异的高温耐久性，因为氧化锆载体可以抵抗热量，从而特别提高结构保持力和Rh的热稳定性。

8. 发明申请

US20080242656A1 N-Substituted-N-Sulfonylaminocyclopropane Compounds and Pharmaceutical Use Thereof 审中-公开
标题翻译： N-取代的N-磺酰氨基环丙烷化合物及其药物用途
公开(公告)号：US20080242656A1
公开(公告)日：2008-10-02
申请号：US11765136
申请日：2007-06-19
申请人： Andrew M. Fryer , Makoto Shiozaki , Nicole M. Littmann , Takashi Inaba , Steven W. Andrews , Katsutaka Yasue , Ellen R. Laird , Masahiro Yokota , Julia Haas , Hiroto Imai , Katsuya Maeda , Yuichi Shinozaki , Yoshikazu Hori
发明人： Andrew M. Fryer , Makoto Shiozaki , Nicole M. Littmann , Takashi Inaba , Steven W. Andrews , Katsutaka Yasue , Ellen R. Laird , Masahiro Yokota , Julia Haas , Hiroto Imai , Katsuya Maeda , Yuichi Shinozaki , Yoshikazu Hori
IPC分类号： A01N43/00
CPC分类号： C07C311/20 , C07C311/51 , C07C381/06 , C07C381/08 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D209/52 , C07D211/46 , C07D211/60 , C07D213/42 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D231/14 , C07D231/20 , C07D233/90 , C07D235/14 , C07D249/10 , C07D257/04 , C07D257/06 , C07D261/18 , C07D271/07 , C07D277/56 , C07D285/06 , C07D285/08 , C07D295/088 , C07D295/13 , C07D295/15 , C07D295/185 , C07D307/68 , C07D333/18 , C07D333/34 , C07D409/12 , C07D413/04 , C07D413/12
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1) wherein R1 is —W-A1-W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21, etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体地，可以使用式（1）的N-取代-N-磺酰氨基环丙烷化合物，其中 R 1是-WA 1 -W 1 -A 2，W是 - （CH 2）2 其中W 1 - （CH 2）n - （CH 2）n - 其中W 1是 - （ CH 2 - （CH 2）n1 - - - - - （CH 2）n1 - m，m1，n和n1相同或不同，各自为0〜6，X和X 1相同或不同，分别为单键等。任选取代的C 3-14-14烃环基等，并且A 2是取代的C 3-14烃基戒指组等 R 2是 - （CH 2 CH 2）n -CO-R 8等，其中r是0 至6和R 8是C 1-6烷氧基等; R 3和R 4相同或不同，各自为氢原子，C 1-6烷基等; 和R 5是-CO 2 R 21等; R 30和R 31相同或不同，各自为氢原子等; 或其前药或其药学上可接受的盐。

9. 发明申请

US20050222146A1 N-substituted-n-sulfonylaminocyclopropane compounds and pharmaceutical use thereof 审中-公开
标题翻译： N-取代的n-磺酰氨基环丙烷化合物及其药物用途
公开(公告)号：US20050222146A1
公开(公告)日：2005-10-06
申请号：US11011781
申请日：2004-12-15
申请人： Andrew Fryer , Makoto Shiozaki , Nicole Littmann , Takashi Inaba , Steven Andrews , Katsutaka Yasue , Ellen Laird , Masahiro Yokota , Julia Haas , Hiroto Imai , Katsuya Maeda , Yuichi Shinozaki , Yoshikazu Hori
发明人： Andrew Fryer , Makoto Shiozaki , Nicole Littmann , Takashi Inaba , Steven Andrews , Katsutaka Yasue , Ellen Laird , Masahiro Yokota , Julia Haas , Hiroto Imai , Katsuya Maeda , Yuichi Shinozaki , Yoshikazu Hori
IPC分类号： A61K31/18 , A61K31/33 , A61K31/381 , A61K31/496 , A61K31/5377 , C07C311/20 , C07C311/51 , C07C381/06 , C07C381/08 , C07D207/34 , C07D209/52 , C07D211/46 , C07D211/60 , C07D213/42 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D231/14 , C07D231/20 , C07D233/90 , C07D235/10 , C07D235/14 , C07D249/10 , C07D257/04 , C07D257/06 , C07D261/18 , C07D271/06 , C07D271/07 , C07D277/56 , C07D285/06 , C07D285/08 , C07D295/088 , C07D295/092 , C07D295/13 , C07D295/15 , C07D295/185 , C07D307/68 , C07D333/18 , C07D333/34 , C07D409/12 , C07D413/02 , C07D413/04 , C07D413/12 , C07D49/02
CPC分类号： C07C311/20 , C07C311/51 , C07C381/06 , C07C381/08 , C07C2601/02 , C07C2601/14 , C07D207/34 , C07D209/52 , C07D211/46 , C07D211/60 , C07D213/42 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D231/14 , C07D231/20 , C07D233/90 , C07D235/14 , C07D249/10 , C07D257/04 , C07D257/06 , C07D261/18 , C07D271/07 , C07D277/56 , C07D285/06 , C07D285/08 , C07D295/088 , C07D295/13 , C07D295/15 , C07D295/185 , C07D307/68 , C07D333/18 , C07D333/34 , C07D409/12 , C07D413/04 , C07D413/12
摘要： The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a N-substituted-N-sulfonylaminocyclopropane compound of formula (1): wherein R1 is —W-A1—W1-A2, W is —(CH2)m—X—(CH2)n—, wherein W1 is —(CH2)m1—X1—(CH2)n1—, m, m1, n and n1 are the same or different and each is 0 to 6, X and X1 are the same or different and each is a single bond, etc., A1 is an optionally substituted C3-14 hydrocarbon ring group, etc. and A2 is a substituted C3-14 hydrocarbon ring group etc.; R2 is —(CH2)r—CO—R8, etc., wherein r is 0 to 6 and R8 is a C1-6 alkoxy group, etc.; R3 and R4 are the same or different and each is a hydrogen atom, a C1-6 alkyl group, etc.; and R5 is —CO2R21 etc.; R30 and R31 are the same or different and each is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有聚集蛋白聚糖蛋白聚糖酶抑制活性和MMP-13抑制活性的化合物，可用作骨关节炎，类风湿性关节炎等的治疗剂，更具体而言，可以使用式（1）所示的N-取代-N-磺酰氨基环丙烷化合物：其中R 1是-WA 1 -W 1 -A 2，W是 - （CH 3）其中W 1是 - （CH 2）n - 其中W 1是 - （CH 2）n1 - （CH 2）n1 - （CH 2）n1 - ，m，m1，n和n1相同或不同，各自为0〜6，X和X 1相同或不同，均为单键等。 1是任选取代的C 3-14烃环基等，而A 2是取代的C 3-14烃基，烃环组等; R 2是 - （CH 2 CH 2）n -CO-R 8等，其中r是0 至6和R 8是C 1-6烷氧基等; R 3和R 4相同或不同，各自为氢原子，C 1-6烷基等; 和R 5是-CO 2 R 21等; R 30和R 31相同或不同，各自为氢原子等; 或其前药或其药学上可接受的盐。

10. 发明授权

US4362104A Flexographic printing press 失效
标题翻译：柔版印刷机
公开(公告)号：US4362104A
公开(公告)日：1982-12-07
申请号：US155784
申请日：1980-06-02
申请人： Hiroto Imai , Sumito Arima
发明人： Hiroto Imai , Sumito Arima
IPC分类号： B41F5/24 , B41F31/02 , B41F31/00
CPC分类号： B41F5/24 , B41F31/025
摘要： Flexographic printing press for printing on the corrugated board sheets passing between the printing cylinder provided with a form plate on its peripheral surface and the receiving roll. Flexographic ink stored between a doctor roll and an anilox roll, which are rotated in the opposite directions as these rolls contact each other, is supplied to said form plate via said anilox roll to thereby carry out a printing operation. Said anilox roll is driven by said printing cylinder at same peripheral speed. Said doctor roll is driven by a speed change drive mechanism for reducing the peripheral speed of said doctor roll when the rotational speed of said anilox roll is increased, and increasing the peripheral speed of said doctor roll when the rotational speed of said anilox roll is decreased. The preferred speed change drive mechanism consists of a differential gear means having an output shaft connected to said doctor roll, a motor for driving said differential gear means and means for transmitting the force of rotation of said anilox roll to said differential gear means.
摘要翻译：柔性版印刷机，用于印刷在波纹板上，在其外周表面上设置有成形板的印刷滚筒和接收辊之间。存储在刮辊和网纹辊之间的柔性油墨通过所述网纹辊被供给到所述成形板，从而进行打印操作。所述网纹辊以相同的圆周速度由所述印刷滚筒驱动。所述刮刀辊由变速驱动机构驱动，当所述网纹辊的旋转速度增加时，用于降低所述刮刀辊的圆周速度，并且当所述网纹辊的旋转速度减小时提高所述刮刀辊的圆周速度。优选的变速驱动机构包括具有连接到所述刮刀辊的输出轴的差速齿轮装置，用于驱动所述差速齿轮装置的马达和用于将所述网纹辊的旋转力传递到所述差动齿轮装置的装置。

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