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1. 发明专利

GB201506394D0 Site-specific antibody-drug conjugates 未知
公开(公告)号：GB201506394D0
公开(公告)日：2015-05-27
申请号：GB201506394
申请日：2015-04-15
申请人： BERKEL PATRICIUS H C VAN AND HOWARD PHILIP W
摘要： Site-specific anti-body-drug conjugates are described, in particular conjugates comprising an antibody, which binds HER2 and comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

2. 发明专利

GB201406722D0 Site-specific antibody-drug conjugates 未知
公开(公告)号：GB201406722D0
公开(公告)日：2014-05-28
申请号：GB201406722
申请日：2014-04-15
申请人： BERKEL PATRICIUS H C VAN , HOWARD PHILIP W

3. 发明专利

GB201406721D0 Pyrrolobenzodiazepine-antibody conjugats 未知
公开(公告)号：GB201406721D0
公开(公告)日：2014-05-28
申请号：GB201406721
申请日：2014-04-15
申请人： BERKEL PATRICIUS H C VAN , HOWARD PHILIP W

4. 发明专利

GB201406717D0 Pyrrolobenzodiazepine-Antibody conjugates 未知
公开(公告)号：GB201406717D0
公开(公告)日：2014-05-28
申请号：GB201406717
申请日：2014-04-15
申请人： BERKEL PATRICIUS H C VAN , HOWARD PHILIP W

5. 发明专利

GB583459A Improvements in or relating to pipe joints 未知
公开(公告)号：GB583459A
公开(公告)日：1946-12-18
申请号：GB2566144
申请日：1944-12-21
申请人： HOWARD PHILIP SMITH
IPC分类号： F16L21/035
摘要： 583,459. Moulding concrete pipes. SMITH, H. P. Dec. 21, 1944, No. 25661. [Class 87 (ii)] [Also in Group XXVIII] A resilient joint ring is secured in an undercut recess in a concrete pipe by supporting the ring in a mould during the spinning or casting operation, the ring 12 being detachably engaged in an annular groove 16 in the mould 14.

6. 发明专利

GB483904A Improvements in pipe joints 未知
公开(公告)号：GB483904A
公开(公告)日：1938-04-27
申请号：GB2672937
申请日：1937-10-02
申请人： HOWARD PHILIP SMITH
IPC分类号： F16L13/10
摘要： 483,904. Pipe joints. SMITH, H. P. Oct. 2, 1937, No. 26729. [Class 99 (i)] Material for cementing a spigot and socket joint is prevented from escaping during setting by a canvas strip 12 tied around the spigot at one edge, held at the other edge by a split ring 13 and having means for expanding it into a groove in the socket. The expanding means may comprise a sleeve attached to one end of the ring and containing a spring which acts on the other end of the ring. As an alternative, the ends of the ring may be formed with right- and left-hand screwthreads that engage a sleeve by which the ends of the ring are forced apart. As a further alternative, one end of the ring may carry a sleeve into which the other end of the ring projects, the sleeve being provided with slots through which a wedge may be passed to force the ends of the ring apart. In order to prevent cockling of the canvas strip while the spigot is being introduced into the socket, a shield 24, Fig. 8, is placed between the strip and the spigot. The shield 24 is held by arms 25 that engage the socket. The shield may be constructed in sections laid one adjacent to another.

7. 发明专利

GB478845A Improvements in joints for pipes 未知
公开(公告)号：GB478845A
公开(公告)日：1938-01-26
申请号：GB2966636
申请日：1936-10-31
申请人： HOWARD PHILIP SMITH
IPC分类号： F16L37/00
摘要： 478,845. Pipe joints. SMITH, H. P. Oct. 31, 1936, Nos. 29666/36 and 3957/37. [Class 99 (i)] In a spigot-and-socket pipe joint, the spigot is centralized and secured within the socket bv an elastic member which is applied to the spigot under tension so that its cross-section is reduced; the tension on the elastic member being relieved to effect expansion of the latter after insertion of the spigot into the socket. In the joint shown in Figs. 3 and 4, the elastic member is in the form of a ring b which is located on the spigot a, so as to form a cavity c between itself and the inner end of the socket c, and is split by a tool inserted through a hole c in the socket, the cavity c , hole c and the gap b between the ends of the ring b preferably being filled with cement d. In a modification, two elastic rings are employed, the rings being either in contact with one another or else spaced to form a cement-receiving cavity. Fig. 11 shows a joint in which a length g of elastic material is lapped under tension around the spigot in one or more complete convolutions, the ends g , g2 of the length being released after assembly of the parts. The elastic member may be in the form of a ring, Fig. 13, which is formed into two loops h , h by fixing together, e.g. by vulcanization, spaced parts h, h thereof, the loop h being stretched and applied to the spigot with the loop h projecting outwards and the fixed parts h h being released when the spigot has been inserted into the socket.

8. 发明专利

GB191000185A Improvements in Pipe Joints. 未知
公开(公告)号：GB191000185A
公开(公告)日：1910-03-03
申请号：GB191000185D
申请日：1910-01-04
申请人： SMITH HOWARD PHILIP
发明人： SMITH HOWARD PHILIP
IPC分类号： F16L13/12
摘要： 185. Smith, H. P. Jan. 4. Spigot-and-socket joints held by cement.-In cement joints in which the annular space between the pipes is covered by a ring of canvas, this is fixed to the internal periphery of the socket by a spring-in metal ring. The canvas 1 preferably surrounds a metal wire ring 2, which is sprung into a groove 3 in the socket 4. The other end of the canvas is preferably formed with a pocket through which a wire 7 is inserted, and tightened round the spigot by twisting its ends together. Cement is then introduced through a hole in the socket.

9. 发明专利

GB201506399D0 Site-specific antibody-drug conjugates 未知
公开(公告)号：GB201506399D0
公开(公告)日：2015-05-27
申请号：GB201506399
申请日：2015-04-15
申请人： BERKEL PATRICIUS H C VAN AND HOWARD PHILIP W
摘要： Site-specific antibody-drug conjugates are described, in particular conjugates comprising an antibody that binds CD19 and which comprises an amino acid substitution of an interchain cysteine residue by an amino acid that is not cysteine, and pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

10. 发明专利

GB201506389D0 Site-specific antibody-drug conjugates 未知
公开(公告)号：GB201506389D0
公开(公告)日：2015-05-27
申请号：GB201506389
申请日：2015-04-15
申请人： BERKEL PATRICIUS H C VAN AND HOWARD PHILIP W
摘要： Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antibody moiety, allows for improved safety and efficacy of the ADC.

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