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1. 发明申请

WO2010104855A2 APPARATUS AND METHOD FOR MAGNETIC RESONANCE IMAGING WITH HIGH SPATIAL AND TEMPORAL RESOLUTIONS 审中-公开
标题翻译：具有高空间和时间分辨率的磁共振成像装置和方法
公开(公告)号：WO2010104855A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/026666
申请日：2010-03-09
申请人： THE JOHNS HOPKINS UNIVERSITY , THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , HERZKA, Daniel, Alfredo , DERBYSHIRE, John, Andrew
发明人： HERZKA, Daniel, Alfredo , DERBYSHIRE, John, Andrew
IPC分类号： A61B5/055
CPC分类号： G01R33/563 , A61B5/0205 , A61B5/0402 , A61B5/055 , A61B5/08 , A61B5/1102 , A61B5/113 , A61B5/4836 , A61B5/7207 , A61B5/7257 , A61B5/7285 , A61B18/20 , A61B2018/00577 , A61B2018/00994 , A61B2576/00 , G01R33/36 , G01R33/385 , G01R33/4808 , G01R33/4824 , G01R33/56308 , G01R33/56325 , G01R33/5676
摘要： A magnetic resonance imaging (MRI) system, comprising a magnetic resonance imaging scanner. The MR scanner comprises a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation, the subject represented by a spatial distribution of magnetizations; a radio frequency (RF) coil system configured to irradiate a plurality of radio frequency (RF) pulses into a region of interest of the subject and to detect a plurality of RF response signals emitted from the region of interest; a gradient coil system configured to provide a perturbation of the main magnetic field B0 using a gradient pulse sequence that causes the RF response signals to encode the spatial distribution of magnetizations in a Fourier domain on a plurality of read-out paths; and a controller in communication with the RF coil system and the gradient coil system to synchronously provide the RF coil system with the plurality of RF pulses and the gradient coil system with the gradient pulse sequence. The gradient pulse sequence comprises a navigator pulse that causes one of the plurality of RF response signals to encode the spatial distribution of magnetizations in the Fourier domain on a pre-determined navigator path that represents a fixed projection of the region of interest of the subject, the pre-determined navigator path is suitable to be in a direction different from directions of the read-out paths, and the fixed projection of the subject is capable of tracking a motion of the subject.
摘要翻译：磁共振成像（MRI）系统，包括磁共振成像扫描仪。 MR扫描仪包括主磁体，为观察对象提供基本上均匀的主磁场B0，该对象由磁化的空间分布表示; 射频（RF）线圈系统，被配置为将多个射频（RF）脉冲照射到所述对象的感兴趣区域中并且检测从所述感兴趣区域发射的多个RF响应信号; 梯度线圈系统，被配置为使用梯度脉冲序列来提供主磁场B0的扰动，所述梯度脉冲序列使RF响应信号在多个读出路径上的傅立叶域中的磁化空间分布进行编码; 以及与RF线圈系统和梯度线圈系统通信的控制器，以使RF线圈系统同时向梯形线圈系统提供具有梯度脉冲序列的多个RF脉冲和梯度线圈系统。梯度脉冲序列包括导航器脉冲，其导致所述多个RF响应信号中的一个RFF响应信号将傅立叶域中的磁化的空间分布编码在预定导航器路径上，所述导航器路径表示所述对象感兴趣区域的固定投影，预定导航器路径适合于与读出路径的方向不同的方向，并且被摄体的固定投影能够跟踪被摄体的运动。

2. 发明申请

WO2010104855A3 APPARATUS AND METHOD FOR MAGNETIC RESONANCE IMAGING WITH HIGH SPATIAL AND TEMPORAL RESOLUTIONS 审中-公开
标题翻译：具有高空间和时间分辨率的磁共振成像装置和方法
公开(公告)号：WO2010104855A3
公开(公告)日：2011-01-13
申请号：PCT/US2010026666
申请日：2010-03-09
申请人： UNIV JOHNS HOPKINS , US GOV HEALTH & HUMAN SERV , HERZKA DANIEL ALFREDO , DERBYSHIRE JOHN ANDREW
发明人： HERZKA DANIEL ALFREDO , DERBYSHIRE JOHN ANDREW
IPC分类号： A61B5/055
CPC分类号： G01R33/563 , A61B5/0205 , A61B5/0402 , A61B5/055 , A61B5/08 , A61B5/1102 , A61B5/113 , A61B5/4836 , A61B5/7207 , A61B5/7257 , A61B5/7285 , A61B18/20 , A61B2018/00577 , A61B2018/00994 , A61B2576/00 , G01R33/36 , G01R33/385 , G01R33/4808 , G01R33/4824 , G01R33/56308 , G01R33/56325 , G01R33/5676
摘要： A magnetic resonance imaging (MRI) system, comprising a magnetic resonance imaging scanner. The MR scanner comprises a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation, the subject represented by a spatial distribution of magnetizations; a radio frequency (RF) coil system configured to irradiate a plurality of radio frequency (RF) pulses into a region of interest of the subject and to detect a plurality of RF response signals emitted from the region of interest; a gradient coil system configured to provide a perturbation of the main magnetic field B0 using a gradient pulse sequence that causes the RF response signals to encode the spatial distribution of magnetizations in a Fourier domain on a plurality of read-out paths; and a controller in communication with the RF coil system and the gradient coil system to synchronously provide the RF coil system with the plurality of RF pulses and the gradient coil system with the gradient pulse sequence. The gradient pulse sequence comprises a navigator pulse that causes one of the plurality of RF response signals to encode the spatial distribution of magnetizations in the Fourier domain on a pre-determined navigator path that represents a fixed projection of the region of interest of the subject, the pre-determined navigator path is suitable to be in a direction different from directions of the read-out paths, and the fixed projection of the subject is capable of tracking a motion of the subject.
摘要翻译：磁共振成像（MRI）系统，包括磁共振成像扫描仪。 MR扫描仪包括主磁体，为观察对象提供基本上均匀的主磁场B0，该对象由磁化的空间分布表示; 射频（RF）线圈系统，被配置为将多个射频（RF）脉冲照射到所述对象的感兴趣区域中并且检测从所述感兴趣区域发射的多个RF响应信号; 梯度线圈系统，被配置为使用梯度脉冲序列来提供主磁场B0的扰动，所述梯度脉冲序列使RF响应信号在多个读出路径上的傅立叶域中的磁化空间分布进行编码; 以及与RF线圈系统和梯度线圈系统通信的控制器，以使RF线圈系统同时向梯形线圈系统提供具有梯度脉冲序列的多个RF脉冲和梯度线圈系统。梯度脉冲序列包括导航器脉冲，其导致所述多个RF响应信号中的一个RFF响应信号将傅立叶域中的磁化的空间分布编码在预定导航器路径上，所述预定导航器路径表示所述对象感兴趣区域的固定投影，预定导航器路径适合于与读出路径的方向不同的方向，并且被摄体的固定投影能够跟踪被摄体的运动。

3. 发明申请

WO2006077529A3 SYSTEM FOR CONTROLLING TRAVERSAL OF AN INGESTED CAPSULE 审中-公开
标题翻译：用于控制投入胶囊的跟踪系统
公开(公告)号：WO2006077529A3
公开(公告)日：2007-10-11
申请号：PCT/IB2006050159
申请日：2006-01-16
申请人： KONINKL PHILIPS ELECTRONICS NV , TROVATO KAREN I , OUWERKERK MARTIN , HERZKA DANIEL , NAAMAT JUDY RUTH
发明人： TROVATO KAREN I , OUWERKERK MARTIN , HERZKA DANIEL , NAAMAT JUDY RUTH
IPC分类号： A61M31/00 , A61B5/07 , A61B18/20 , A61B19/02
CPC分类号： A61B5/4839 , A61B1/00016 , A61B1/00055 , A61B1/00059 , A61B1/00082 , A61B1/00147 , A61B1/00156 , A61B1/041 , A61B5/06 , A61B5/065 , A61B5/073 , A61B5/411 , A61B18/20 , A61B34/70 , A61B34/72 , A61M2025/105
摘要： A treatment system (1600, 1900) is provided for traversing the alimentary tract. The system (1600, 1900) includes an ingestible capsule, which includes a gas pressurizing module (1602)) providing a gas and at least one balloon (1604, 1901) in fluid communication with the gas pressurization module (1602). The capsule further includes an exhaust channel (1610) in fluid communication with a respective balloon of the at least one balloon (1604, 1901), and a depressurizing closure member (1608) for selectively controlling flow of gas between the balloon (1604, 1901) and the ambient surroundings of the capsule. The system further includes control circuitry (906) for controlling the depressurizing closure member (1608).
摘要翻译：提供用于穿过消化道的处理系统（1600,1900）。系统（1600,1900）包括提供气体的可摄入胶囊，其包括气体加压模块（1602））和与气体加压模块（1602）流体连通的至少一个气囊（1604,1901）。胶囊还包括与至少一个气囊（1604,1901）的相应球囊流体连通的排气通道（1610）和用于选择性地控制气囊（1604,1901）之间的气体流动的减压闭合构件（1608））和胶囊的周围环境。该系统还包括用于控制减压关闭构件（1608）的控制电路（906）。

4. 发明申请

WO2006082564A1 MR MULTI-SLICE STEADY STATE FREE PRECESSION IMAGING 审中-公开
标题翻译：多尺度稳定状态无偿预成像
公开(公告)号：WO2006082564A1
公开(公告)日：2006-08-10
申请号：PCT/IB2006/050347
申请日：2006-02-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HERZKA, Daniel , WINKELMANN, Richard
发明人： HERZKA, Daniel , WINKELMANN, Richard
IPC分类号： G01R33/561 , G01R33/54
CPC分类号： G01R33/4835 , G01R33/4833 , G01R33/5611 , G01R33/5613
摘要： In a coherent magnetic resonance imaging method, a plurality of slices (70, 72; 170, 172) are each prepared (74, 76) in a steady spin state. Time domain multiplexed readouts (80, 82) are performed. Each readout acquires magnetic resonance data corresponding to one of the steady spin state slices. Radio frequency excitation pulses (120, 122) are interleaved with the time domain multiplexed readout pulses (102, 112) to maintain the steady spin states of the slices. The acquired magnetic resonance data are reconstructed (62) to produce reconstructed images corresponding to the plurality of slices.
摘要翻译：在相干磁共振成像方法中，在稳定自旋状态下，各自准备多个切片（70,72,170,172）（74,76）。执行时域多路复用读出（80,82）。每个读出器获取对应于稳态自旋状态切片之一的磁共振数据。射频激励脉冲（120,122）与时域多路复用的读出脉冲（102,112）进行交织，以维持切片的稳定自旋状态。所获取的磁共振数据被重建（62）以产生对应于多个切片的重建图像。

5. 发明申请

WO2010092493A1 PLACENTAL CALCIFICATION MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：电磁共振成像
公开(公告)号：WO2010092493A1
公开(公告)日：2010-08-19
申请号：PCT/IB2010/050103
申请日：2010-01-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HERZKA, Daniel, A. , FERNANDEZ, Anna, T.
发明人： HERZKA, Daniel, A. , FERNANDEZ, Anna, T.
IPC分类号： G01R33/54
CPC分类号： G01R33/54 , G01R33/4816 , G01R33/50 , G01R33/5602
摘要： A method comprises acquiring at least one magnetic resonance image of a placenta using an ultra-short echo time (UTE) pulse sequence; and processing the at least one magnetic resonance image to generate information indicative of placental calcification. In apparatus embodiments, a gynecology module (20) comprises a digital processor configured to cause a magnetic resonance imaging scanner (10, 12, 14, 16) to acquire at least one magnetic resonance image of a placenta and to process the at least one magnetic resonance image to generate information indicative of placental calcification.
摘要翻译：一种方法包括使用超短回波时间（UTE）脉冲序列获取胎盘的至少一个磁共振图像; 以及处理所述至少一个磁共振图像以产生指示胎盘钙化的信息。在装置实施例中，妇科模块（20）包括数字处理器，其被配置为使得磁共振成像扫描仪（10,12,14,16）获取胎盘的至少一个磁共振图像，并且处理所述至少一个磁性共振图像以产生指示胎盘钙化的信息。

6. 发明申请

WO2007124244A1 BLACK-BLOOD STEADY-STATE FREE PRECESSION MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：黑血病稳定状态自由前导磁共振成像
公开(公告)号：WO2007124244A1
公开(公告)日：2007-11-01
申请号：PCT/US2007/065839
申请日：2007-04-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HERZKA, Daniel, A. , DERBYSHIRE, John, A.
发明人： HERZKA, Daniel, A. , DERBYSHIRE, John, A.
IPC分类号： G01R33/561
CPC分类号： G01R33/5613 , G01R33/5607 , G01R33/5614
摘要： In an imaging method, periodic maintenance radio frequency pulses (α, -α) are applied to maintain a steady state magnetic resonance excitation in an imaging region. Readout (66) of imaging data from the imaging region is performed during selected intervals between maintenance radio frequency pulses. A spatially selective blood signal suppression sequence (62, 62') is performed during selected other intervals between maintenance radio frequency pulses. The blood signal suppression sequence suppresses a blood signal in a suppression region different from the imaging region. The blood signal suppression sequence has substantially no zero the moment applied magnetic field gradient.
摘要翻译：在成像方法中，施加周期性维持射频脉冲（a，-a）以在成像区域中保持稳态磁共振激励。在维护射频脉冲之间的选定间隔期间执行来自成像区域的成像数据的读出（66）。在维持射频脉冲之间的选定的其他间隔期间执行空间选择性血液信号抑制序列（62,62'）。血液信号抑制序列抑制与成像区域不同的抑制区域中的血液信号。血液信号抑制序列在施加磁场梯度的瞬间基本上不为零。

7. 发明申请

WO2006077529A2 SYSTEM AND METHOD FOR CONTROLLING TRAVERSAL OF AN INGESTED CAPSULE 审中-公开
标题翻译：用于控制投入胶囊的横向的系统和方法
公开(公告)号：WO2006077529A2
公开(公告)日：2006-07-27
申请号：PCT/IB2006/050159
申请日：2006-01-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , TROVATO, Karen, I. , OUWERKERK, Martin , HERZKA, Daniel , NAAMAT, Judy Ruth
发明人： TROVATO, Karen, I. , OUWERKERK, Martin , HERZKA, Daniel , NAAMAT, Judy Ruth
CPC分类号： A61B5/4839 , A61B1/00016 , A61B1/00055 , A61B1/00059 , A61B1/00082 , A61B1/00147 , A61B1/00156 , A61B1/041 , A61B5/06 , A61B5/065 , A61B5/073 , A61B5/411 , A61B18/20 , A61B34/70 , A61B34/72 , A61M2025/105
摘要： A treatment system (1600, 1900) is provided for traversing the alimentary tract. The system (1600, 1900) includes an ingestible capsule, which includes a gas pressurizing module (1602)) providing a gas and at least one balloon (1604, 1901) in fluid communication with the gas pressurization module (1602). The capsule further includes an exhaust channel (1610) in fluid communication with a respective balloon of the at least one balloon (1604, 1901), and a depressurizing closure member (1608) for selectively controlling flow of gas between the balloon (1604, 1901) and the ambient surroundings of the capsule. The system further includes control circuitry (906) for controlling the depressurizing closure member (1608).
摘要翻译：提供用于穿过消化道的处理系统（1600,1900）。系统（1600,1900）包括提供气体的可摄入胶囊，其包括气体加压模块（1602））和与气体加压模块（1602）流体连通的至少一个气囊（1604,1901）。胶囊还包括与至少一个气囊（1604,1901）的相应球囊流体连通的排气通道（1610）和用于选择性地控制气囊（1604,1901）之间的气体流动的减压闭合构件（1608））和胶囊的周围环境。该系统还包括用于控制减压关闭构件（1608）的控制电路（906）。

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