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1. 发明申请

WO2009036014A2 MEDICAL DEVICES WITH TRIGGERABLE BIOADHESIVE MATERIAL 审中-公开
标题翻译：具有可触发生物材料的医疗器械
公开(公告)号：WO2009036014A2
公开(公告)日：2009-03-19
申请号：PCT/US2008075787
申请日：2008-09-10
申请人： BOSTON SCIENT SCIMED INC , TENNEY BARRON W , RANADE SHIRIRANG V , VALINT PAUL L , HELMUS MICHAEL N , XU YIXIN
发明人： TENNEY BARRON W , RANADE SHIRIRANG V , VALINT PAUL L , HELMUS MICHAEL N , XU YIXIN
IPC分类号： A61L31/14 , A61L31/16
CPC分类号： A61L31/145 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416
摘要： Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.
摘要翻译：本文描述的是可植入医疗装置，其包括生物相容性聚合物，其包含可触发的生物粘合性质，其允许该装置粘附于身体组织。可以通过暴露于刺激物来触发或激活聚合物的可触发生物粘附性质。此外，本发明涉及制造包括生物相容性聚合物的可植入医疗器械的方法，所述生物相容性聚合物包含允许该器件粘附于身体组织的可触发的生物粘合性质。

2. 发明申请

WO2006099409A3 DRUG RELEASE REGIONS WITH POLYCYCLIC-STRUCTURE-CONTAINING POLYMERS 审中-公开
标题翻译：含多结构聚合物的药物释放区
公开(公告)号：WO2006099409A3
公开(公告)日：2007-03-22
申请号：PCT/US2006009111
申请日：2006-03-14
申请人： BOSTON SCIENT SCIMED INC , RANADE SHRIRANG V , HELMUS MICHAEL N , RICHARD ROBERT E
发明人： RANADE SHRIRANG V , HELMUS MICHAEL N , RICHARD ROBERT E
IPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16
CPC分类号： A61L27/50 , A61L27/54 , A61L29/14 , A61L29/16 , A61L31/14 , A61L31/16 , A61L2300/602
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain polymeric release regions that control the release of one or more therapeutic agents. The polymeric release regions, in turn, contain one or more polymers that contain one or more rigid, nonplanar polycyclic molecular structures. The therapeutic agent is disposed beneath or within the polymeric release region.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含控制一种或多种治疗剂的释放的聚合物释放区域。聚合物释放区域又包含一种或多种含有一个或多个刚性非平面多环分子结构的聚合物。治疗剂设置在聚合物释放区域的下方或内部。

3. 发明申请

WO2006047191A1 MEDICAL IMPLANT WITH AVERAGE SURFACE CHARGE DENSITY 审中-公开
标题翻译：具有平均表面电荷密度的医用植入物
公开(公告)号：WO2006047191A1
公开(公告)日：2006-05-04
申请号：PCT/US2005/037630
申请日：2005-10-10
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HELMUS, Michael, N.
发明人： HELMUS, Michael, N.
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/0077 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2230/0013 , A61F2250/0001 , A61F2250/0067 , A61N1/32
摘要： A medical device for implantation into a host organism is disclosed. The device comprises a surface adapted for contact with body tissue of the host organism and an electrode disposed on at least a portion of the surface. Also the device comprises a power source in direct or indirect electrical communication with the electrode. The power source is capable of providing a current to the electrode to create an average surface charge density on the surface that is effective to promote the biocompatibility of the surface with the body tissue or create other desired biological effects.
摘要翻译：公开了用于植入宿主生物体的医疗装置。该装置包括适于与宿主生物体的身体组织接触的表面和设置在该表面的至少一部分上的电极。该装置还包括与电极直接或间接电连通的电源。电源能够向电极提供电流以在表面上产生有效促进表面与身体组织的生物相容性或产生其他期望的生物效应的平均表面电荷密度。

4. 发明申请

WO2005090656A1 DRY SPUN STYRENE-ISOBUTYLENE COPOLYMERS 审中-公开
标题翻译：干燥苯乙烯 - 异丁烯共聚物
公开(公告)号：WO2005090656A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/008595
申请日：2005-03-15
申请人： SCIMED LIFE SYSTEMS, INC. , HELMUS, Michael, N. , TENNEY, Barron
发明人： HELMUS, Michael, N. , TENNEY, Barron
IPC分类号： D01F6/42
CPC分类号： D01F6/30 , D01F6/42 , Y10T442/2525
摘要： According to an aspect of the present invention, a fiber comprising a styrene-isobutylene copolymer is formed by via a dry spinning process. Specific examples of copolymers for the practice of the present invention include copolymers comprising a polyisobutylene block and a polystyrene block, for instance, a polystyrene-polyisobutylene-polystyrene triblock copolymer. Other aspects of the present invention relate to medical articles which comprise the above dry spun fibers. Specific examples include medical articles comprising a woven region formed from the dry spun fibers, and medical articles comprising a non-woven region formed from the dry spun fibers.
摘要翻译：根据本发明的一个方面，通过干法纺丝法形成包含苯乙烯 - 异丁烯共聚物的纤维。用于实施本发明的共聚物的具体实例包括包含聚异丁烯嵌段和聚苯乙烯嵌段的共聚物，例如聚苯乙烯 - 聚异丁烯 - 聚苯乙烯三嵌段共聚物。本发明的其它方面涉及包含上述干纺纤维的医疗制品。具体实例包括包含由干燥纺丝纤维形成的织造区域的医疗制品和包含由干燥纺丝纤维形成的无纺织物区域的医疗制品。

5. 发明申请

WO9938547A3 ENHANCED BIOCOMPATIBILITY COATINGS FOR MEDICAL IMPLANTS 审中-公开
标题翻译：增强医用植入物的生物相容性涂层
公开(公告)号：WO9938547A3
公开(公告)日：1999-09-23
申请号：PCT/US9901766
申请日：1999-01-28
申请人： BAXTER INT , HELMUS MICHAEL , SCOTT MICHAEL J
发明人： HELMUS MICHAEL , SCOTT MICHAEL J
IPC分类号： A61L33/10 , A61L33/00
CPC分类号： A61L33/0017
摘要： Enhanced biocompatibility coatings for medical implants and acute exposure medical devices are disclosed in conjunction with methods for their production and use. The biocompatible coatings are particularly advantageous when used in conjunction with high surface area materials such as porous resins, fabrics and textiles and comprise ionically bound complexes of at least one anticlotting compound and at least one quaternary ammonium compound having greater than 0.15 and less than 40 IU of anticlotting compound per CM . The coatings are produced by forming a solution of the complex having a concentration greater than 0.005 % and less than 1.5 % w/v which is applied to the surface and allowed to dry. The coatings reduce the propensity for thrombus deposition without impairing healing and tissue ingrowth into the device.
摘要翻译：结合生产和使用的方法公开了用于医学植入物和急性暴露医疗装置的增强的生物相容性涂层。当与高表面积材料如多孔树脂，织物和织物结合使用时，生物相容性涂层是特别有利的，并且包含至少一种抗凝栓化合物和至少一种季铵化合物的离子结合配合物，所述配合物具有大于0.15且小于40IU 每个CM 2的抗凝栓化合物。通过形成浓度大于0.005％且小于1.5％w / v的复合物的溶液施用于表面并使其干燥来制备涂层。涂层降低了血栓沉积的倾向，而不会损害装置内的愈合和组织向内生长。

6. 发明申请

WO2007111801A3 MEDICAL DEVICES HAVING NANOPOROUS COATINGS FOR CONTROLLED THERAPEUTIC AGENT DELIVERY 审中-公开
公开(公告)号：WO2007111801A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/004704
申请日：2007-02-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , TENNEY, Barron , XU, Yixin , HELMUS, Michael, N.
发明人： TENNEY, Barron , XU, Yixin , HELMUS, Michael, N.
IPC分类号： A61L29/16 , A61L31/16
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to perform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

7. 发明申请

WO2006083698A3 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES HAVING OPTIMAL SURFACE ENERGY 审中-公开
标题翻译：具有最佳表面能量的可植入或插入式医疗器械
公开(公告)号：WO2006083698A3
公开(公告)日：2007-05-10
申请号：PCT/US2006002853
申请日：2006-01-26
申请人： BOSTON SCIENT SCIMED INC , HELMUS MICHAEL N , VALINT PAUL JR , RANADE SHRIRANG V
发明人： HELMUS MICHAEL N , VALINT PAUL JR , RANADE SHRIRANG V
IPC分类号： A61L27/34 , A61L27/26 , A61L27/50 , A61L31/10
CPC分类号： A61L27/26 , A61L27/50
摘要： An implantable or insertable medical device is provided that contains at least one polymeric region which comes into contact with a subject upon implantation or insertion of the device into the subject. The polymeric region(s) contain at least one bulk polymer moiety and at least one surface-active polymer moiety that (a) is covalently attached to the bulk polymer moiety/moieties or admixed with the bulk polymer moiety/moieties and (b) is provided in an amount that is effective in providing the polymeric region(s) with a critical surface energy that is between 20 dynes/cm and 30 dynes/cm upon implantation or insertion of the device into the subject.
摘要翻译：提供了可植入或可插入的医疗装置，其包含至少一个聚合物区域，所述至少一个聚合物区域在将装置植入或插入受试者时与受试者接触。聚合物区域包含至少一个本体聚合物部分和至少一个表面活性聚合物部分，（a）共价连接到本体聚合物部分/部分或与本体聚合物部分/部分混合，（b）提供的量可以有效地提供聚合物区域在植入或插入该受试者时在20达因/厘米至30达因/厘米之间的临界表面能。

8. 发明申请

WO2006063158A3 USE OF SUPERCRITICAL FLUIDS TO INCORPORATE BIOLOGICALLY ACTIVE AGENTS INTO NANOPOROUS MEDICAL ARTICLES 审中-公开
公开(公告)号：WO2006063158A3
公开(公告)日：2006-06-15
申请号：PCT/US2005/044462
申请日：2005-12-08
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HELMUS, Michael, N.
发明人： HELMUS, Michael, N.
IPC分类号： A61L27/54 , A61L31/16
摘要： The present invention is directed to a method in which a supercritical fluid that comprises a carrier fluid and a biologically active agent is brought into contact with medical article that comprises a nanoporous surface region. A variety of medical articles may be used in the practice of the present invention, including implantable or insertable medical devices such as bone plates, joint prostheses, vascular grafts, stent grafts, stents, catheters, guide wires, balloons, filters, vascular patches, shunts, and coils, among others. The nanoporous surface region may be, for example, metallic, ceramic, or polymeric in nature. Examples of biologically active agents include antirestenotic agents and agents that promote tissue adhesion, among others. Carbon dioxide is one of many carrier fluids that may be employed.

9. 发明申请

WO2006063158A2 USE OF SUPERCRITICAL FLUIDS TO INCORPORATE BIOLOGICALLY ACTIVE AGENTS INTO NANOPOROUS MEDICAL ARTICLES 审中-公开
标题翻译：使用超临界流体将生物活性成分纳入纳米科医学文章
公开(公告)号：WO2006063158A2
公开(公告)日：2006-06-15
申请号：PCT/US2005044462
申请日：2005-12-08
申请人： BOSTON SCIENT SCIMED INC , HELMUS MICHAEL N
发明人： HELMUS MICHAEL N
IPC分类号： A61L27/54 , A61L31/16
CPC分类号： A61L31/14 , A61L27/50 , A61L29/146 , A61L31/146
摘要： The present invention is directed to a method in which a supercritical fluid that comprises a carrier fluid and a biologically active agent is brought into contact with medical article that comprises a nanoporous surface region. A variety of medical articles may be used in the practice of the present invention, including implantable or insertable medical devices such as bone plates, joint prostheses, vascular grafts, stent grafts, stents, catheters, guide wires, balloons, filters, vascular patches, shunts, and coils, among others. The nanoporous surface region may be, for example, metallic, ceramic, or polymeric in nature. Examples of biologically active agents include antirestenotic agents and agents that promote tissue adhesion, among others. Carbon dioxide is one of many carrier fluids that may be employed.
摘要翻译：本发明涉及包含载体流体和生物活性剂的超临界流体与包括纳米多孔表面区域的医疗制品接触的方法。可以在本发明的实践中使用各种医疗制品，包括可植入或可插入的医疗装置，例如骨板，关节假体，血管移植物，支架移植物，支架，导管，导丝，球囊，过滤器，血管斑块，分流器和线圈等。纳米多孔表面区域可以是例如金属，陶瓷或聚合物。生物活性剂的实例包括抗再狭窄剂和促进组织粘附等的试剂。二氧化碳是可以使用的许多载体流体之一。

10. 发明申请

WO2005107828A3 IMPLANTABLE OR INSERTABLE MEDICAL ARTICLES HAVING COVALENTLY MODIFIED, BIOCOMPATIBLE SURFACES 审中-公开
标题翻译：具有共同修饰，生物化学表面的可植入或不可剥离的医疗用品
公开(公告)号：WO2005107828A3
公开(公告)日：2006-01-12
申请号：PCT/US2005013212
申请日：2005-04-20
申请人： BOSTON SCIENT SCIMED INC , HELMUS MICHAEL N , RANADE SHRIRANG V
发明人： HELMUS MICHAEL N , RANADE SHRIRANG V
IPC分类号： A61F2/00 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L27/28 , A61L31/08
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2400/18
摘要： Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between (20) and (30) dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced throboresistance, relative to other surfaces.
摘要翻译：可植入或可插入的医疗装置包括通过共价地将分子种类（或分子种类的组合）共价连接到其上的表面区域。选择分子种类使得所得到的改性表面区域具有在（20）和（30）达因/厘米之间的临界表面能。在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已被证明显示出增强的生物相容性，包括相对于其它表面增强的阻抗。

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