专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010015643A1 NEW ANTIVIRAL MODIFIED NUCLEOSIDES 审中-公开
标题翻译：新的抗病毒修饰的核苷酸
公开(公告)号：WO2010015643A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060125
申请日：2009-08-04
申请人： NOVARTIS AG , CHEN, Yen Liang , DURAISWAMY, Jeyaraj , HALLER, Sarah , KEIM, Matthias , KONDREDDI, Ravinder Reddy , YIN, Zheng
发明人： CHEN, Yen Liang , DURAISWAMY, Jeyaraj , HALLER, Sarah , KEIM, Matthias , KONDREDDI, Ravinder Reddy , YIN, Zheng
IPC分类号： C07H19/23 , A61K31/7052
CPC分类号： C07H19/23
摘要： This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections. wherein: X is CH or CR 6 ; R 1 is halogen, NR 7 R 8 or OR 9 ; R 2 is H, halogen, or NR 7 R 8 ; R 3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, each of which is optionally substituted with one or more substituents; R 4 is H, acyl or an amino acid ester; R 5 is H, acyl or an amino acid ester; R 6 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, halogen, cyano, nitro, hydroxy, alkoxy, alkylthio, amino, alkylamino, carboxy, carboxamide or alkyloxycarbonyl, each of which is optionally substituted with one or more substituents; R 7 and R 8 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, amino, alkylamino, arylamino, hydroxy, alkoxy, arylcarbonyl and alkylcarbonyl, each of which is optionally substituted with one or more substituents; and R 3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkylcarbonyl or arylcarbonyl, each of which is optionally substituted with one or more substituents;
摘要翻译：本发明涉及具有各种药用应用的新化合物，例如用于治疗和/或预防病毒感染。其中：X为CH或CR 6; R1是卤素，NR7R8或OR9; R2是H，卤素或NR7R8; R3是H，烷基，烯基，炔基，芳基，环烷基，杂环烷基或杂芳基，它们各自任选被一个或多个取代基取代; R4是H，酰基或氨基酸酯; R5是H，酰基或氨基酸酯; R6是烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，卤素，氰基，硝基，羟基，烷氧基，烷硫基，氨基，烷基氨基，羧基，羧酰胺或烷氧基羰基，其各自任选被一个或多个取代基取代; R 7和R 8独立地选自H，烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，氨基，烷基氨基，芳基氨基，羟基，烷氧基，芳基羰基和烷基羰基，其各自任选被一个或更多的取代基; R 3为H，烷基，烯基，炔基，芳基，环烷基，杂环烷基，杂芳基，烷基羰基或芳基羰基，其各自任选被一个或多个取代基取代;

IPRDB

热门服务

关于我们

友情链接

联系方式