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1. 发明申请

US20110033935A1 RATIONALLY-DESIGNED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN DNASE HYPERSENSITIVE REGIONS OF THE HUMAN GENOME 审中-公开
标题翻译：具有人类基因组DNASE超敏感区域中识别序列的方案设计的重组
公开(公告)号：US20110033935A1
公开(公告)日：2011-02-10
申请号：US12795477
申请日：2010-06-07
申请人： Derek Jantz , Michael G. Nicholson , James J. Smith
发明人： Derek Jantz , Michael G. Nicholson , James J. Smith
IPC分类号： C12N15/09 , C12N9/16 , C12N15/55
CPC分类号： C12N9/16 , C12N9/22
摘要： Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
摘要翻译：提供合理设计的LAGLIDADG大范围核酸酶和制备这种大范围核酸酶的方法。此外，提供了使用大范围核酸酶产生重组细胞和生物体的方法，所述重组细胞和生物体具有插入基因组内有限数量基因座的所需DNA序列，以及基因治疗方法，用于治疗病原体感染和体外应用于诊断和研究。

2. 发明授权

US5729637A Method and apparatus for producing a hybrid data structure for displaying a raster image 失效
公开(公告)号：US5729637A
公开(公告)日：1998-03-17
申请号：US420827
申请日：1995-04-10
申请人： Dennis G. Nicholson , James C. King , David M. Emmett
发明人： Dennis G. Nicholson , James C. King , David M. Emmett
IPC分类号： G06K9/03 , G06K9/20 , G06K9/72 , G06T7/60 , G06T11/60 , G09G5/00 , H04N1/411 , G06K9/00
CPC分类号： G06K9/00442 , G06K9/033 , G06K9/723 , H04N1/4115 , G06K2209/01
摘要： A system for producing a raster image derived from a data structure including a data processing apparatus, a recognizer which performs recognition on an input bitmap to the data processing apparatus to detect identifiable objects within the input bitmap, a mechanism for producing a hybrid data structure including coded data corresponding to the identifiable objects and to non-identifiable objects and the input bitmap, and an output device capable of developing a visually perceptible raster image derived from the input bitmap in the hybrid data structure. The raster image is derived from the input bitmap and thus includes no misrecognition errors. It includes a method for producing a hybrid data structure for a bitmap of an image having the steps of inputting a bitmap into a digital processing apparatus, partitioning the bitmap into a hierarchy of lexical units, assigning labels to a label list for each lexical unit of a predetermined hierarchical level, where labels in the label list have an associated confidence level, and storing each lexical unit in a hybrid data structure as either an identifiable object or a non-identifiable object. The entire input bitmap or portions thereof are also stored in the hybrid data structure to be displayed.

3. 发明授权

US08064721B2 Method and apparatus for removing noise from a digital image 有权
标题翻译：从数字图像中去除噪声的方法和装置
公开(公告)号：US08064721B2
公开(公告)日：2011-11-22
申请号：US12648250
申请日：2009-12-28
申请人： Dennis G. Nicholson
发明人： Dennis G. Nicholson
IPC分类号： G06K9/40
CPC分类号： G06K9/40 , G06K2209/01 , G06T5/002 , G06T2207/30176
摘要： One embodiment of the present invention provides a system that removes noise from an image. During operation, the system first identifies blobs in the image, wherein a blob is a set of contiguous pixels which possibly represents a character or a portion of a character in the image. Next, the system analyzes the blobs to dynamically determine a “noise threshold” for the blobs. The system then removes blobs from the image which are below the noise threshold.
摘要翻译：本发明的一个实施例提供一种从图像中去除噪声的系统。在操作期间，系统首先识别图像中的斑点，其中斑点是可能表示图像中的字符或字符的一部分的连续像素的集合。接下来，系统分析斑点以动态地确定斑点的“噪声阈值”。然后，系统从图像中除去低于噪声阈值的斑点。

4. 发明授权

US07083728B2 Method for treating sludge using recycle 失效
标题翻译：使用回收处理污泥的方法
公开(公告)号：US07083728B2
公开(公告)日：2006-08-01
申请号：US10669462
申请日：2003-09-25
申请人： Terry J. Logan , Michael G. Nicholson , Neil Webster
发明人： Terry J. Logan , Michael G. Nicholson , Neil Webster
IPC分类号： C02F3/00
CPC分类号： C02F11/14 , C02F1/66 , C02F11/185 , C02F2209/005
摘要： A method and system for treating at least bioorganic, organic, wastewater, and sewage sludge using recycle. The method of producing a treated sludge product comprises the following steps: (a) forming a sludge mixture by mixing untreated sludge with at least one alkaline material in an amount sufficient to raise pH of the sludge mixture to a level of at least about 12 and to increase percent solids in the sludge mixture to at least about 40% by weight; (b) forming a dried sludge mixture by drying the sludge mixture from step (a) in a direct or indirect dryer thereby increasing the percent solids thereof to at least about 50% by weight; (c) recycling a portion of the dried sludge mixture from step (b) to step (a); and (d) pasteurizing the dried sludge mixture from step (b) at a temperature at or above about 52° C. to form a treated sludge product. Exemplary applications for the treated sludge product include an agricultural liming agent, a soil conditioner, a fertilizer, a topsoil blend ingredient, and a fuel.
摘要翻译：一种利用再循环处理至少生物有机，有机，废水和污水污泥的方法和系统。生产经处理的污泥产品的方法包括以下步骤：（a）通过将未处理的污泥与至少一种碱性物质混合形成污泥混合物，其量足以将污泥混合物的pH提高到至少约12的水平，将污泥混合物中的固体百分比增加至至少约40重量％; （b）通过在直接或间接干燥器中干燥来自步骤（a）的污泥混合物形成干燥的污泥混合物，从而将其固体百分比增加至至少约50重量％; （c）将一部分干燥的污泥混合物从步骤（b）循环到步骤（a）; 和（d）在等于或高于约52℃的温度下将来自步骤（b）的干燥的污泥混合物巴氏杀菌以形成经处理的污泥产物。经处理的污泥产品的示例性应用包括农用石灰剂，土壤调节剂，肥料，表土混合物成分和燃料。

5. 发明授权

US07025060B1 Personal breathing filter 有权
标题翻译：个人呼吸过滤器
公开(公告)号：US07025060B1
公开(公告)日：2006-04-11
申请号：US11044247
申请日：2005-01-27
申请人： Alexander J. G. Nicholson
发明人： Alexander J. G. Nicholson
IPC分类号： A62B18/08 , A62B18/10 , A61C5/14
CPC分类号： A62B23/06
摘要： A personal air filtration device has a cylindrical exhalation tube, with a one-way valve thereon. Concentric around the periphery of the exhalation tube and integrally connected to the exhalation tube rearward (proximate the user's mouth) of the one-way valve is a filter media housing. Filter media is contained between the housing and the tube. A plurality of perforations in the exhalation tube, rearward of the one way valve but forward from the housing connection ring, provide inhaled air ingress to the exhalation tube. Inhaled air forces the one-way valve closed, so that air is directed through the filter media, passes through the perforations and into the exhalation tube where the user can take in the cleansed air. The pressure of the exhaled air through the exhalation tube causes the one-way valve to open, so that exertion by the user is minimized.
摘要翻译：个人空气过滤装置具有圆柱形呼气管，其上具有单向阀。围绕呼气管的周边同心且与呼气管一体连接在单向阀的后方（靠近使用者的嘴部）是过滤介质外壳。过滤介质包含在外壳和管之间。呼吸管中的多个穿孔在单向阀的后方，但从壳体连接环向前，向呼气管提供吸入的空气进入。吸入空气迫使单向阀关闭，使得空气被引导通过过滤介质，穿过穿孔并进入呼吸管，用户可以将其吸入洁净空气中。通过呼气管呼出的空气的压力导致单向阀打开，使得使用者的疲劳最小化。

6. 发明授权

US06661919B2 Method and apparatus for producing a hybrid data structure for displaying a raster image 失效
公开(公告)号：US06661919B2
公开(公告)日：2003-12-09
申请号：US10054944
申请日：2002-01-25
申请人： Dennis G. Nicholson , James C. King
发明人： Dennis G. Nicholson , James C. King
IPC分类号： G06K934
CPC分类号： H04N1/4115 , G06K9/00442 , G06K9/033 , G06K9/723 , G06K2209/01
摘要： A system for producing a raster image derived from coded and non-coded portions of a hybrid data structure from an input bitmap including (1) a data processing apparatus, (2) a recognizer which performs recognition on an input bitmap to the data processing apparatus to detect identifiable objects within the input bitmap, (3) a mechanism for producing a hybrid data structure including coded data corresponding to the identifiable objects and non-coded data derived from portions of the input bitmap which do not correspond to the identifiable objects, and (4) an output device capable of developing a visually perceptible raster image derived from the hybrid data structure. The raster image includes raster images of the identifiable objects and raster images derived from portions of the input bitmap that do not correspond to the identifiable objects. The invention includes a method for producing a hybrid data structure for a bitmap of an image having the steps of: (1) inputting a signal comprising a bitmap into a digital processing apparatus, (2) partitioning the bitmap into a hierarchy of lexical units, (3) assigning labels to a label list for each lexical unit of a predetermined hierarchical level, where labels in the label list have an associated confidence level, and (4) storing each lexical unit in a hybrid data structure as either an identifiable object or a non-identifiable object.

7. 发明授权

US5999649A Method and apparatus for producing a hybrid data structure for displaying a raster image 失效
标题翻译：用于产生用于显示光栅图像的混合数据结构的方法和装置
公开(公告)号：US5999649A
公开(公告)日：1999-12-07
申请号：US736250
申请日：1996-10-24
申请人： Dennis G. Nicholson , James C. King
发明人： Dennis G. Nicholson , James C. King
IPC分类号： G06K9/03 , G06K9/20 , G06K9/72 , H04N1/411 , G06K9/00
CPC分类号： H04N1/4115 , G06K9/00442 , G06K9/033 , G06K9/723 , G06K2209/01
摘要： A system for producing a raster image derived from coded and non-coded portions of a hybrid data structure from an input bitmap including (1) a data processing apparatus, (2) a recognizer which performs recognition on an input bitmap to the data processing apparatus to detect identifiable objects within the input bitmap, (3) a mechanism for producing a hybrid data structure including coded data corresponding to the identifiable objects and non-coded data derived from portions of the input bitmap which do not correspond to the identifiable objects, and (4) an output device capable of developing a visually perceptible raster image derived from the hybrid data structure. The raster image includes raster images of the identifiable objects and raster images derived from portions of the input bitmap that do not correspond to the identifiable objects. This includes a method for producing a hybrid data structure for a bitmap of an image having the steps of: (1) inputting a signal comprising a bitmap into a digital processing apparatus, (2) partitioning the bitmap into a hierarchy of lexical units, (3) assigning labels to a label list for each lexical unit of a predetermined hierarchical level, where labels in the label list have an associated confidence level, and (4) storing each lexical unit in a hybrid data structure as either an identifiable object or a non-identifiable object.
摘要翻译：一种用于从输入位图生成从混合数据结构的编码和非编码部分得到的光栅图像的系统，包括：（1）数据处理装置，（2）识别器，其对数据处理装置执行对输入位图的识别以检测输入位图内的可识别对象，（3）用于产生混合数据结构的机制，该混合数据结构包括与可识别对象相对应的编码数据和从输入位图的不对应于可识别对象的部分导出的非编码数据，以及（4）能够开发从混合数据结构导出的视觉上可感知的光栅图像的输出装置。光栅图像包括可识别对象的光栅图像和从输入位图的与可识别对象不对应的部分导出的光栅图像。这包括用于产生图像位图的混合数据结构的方法，该方法具有以下步骤：（1）将包括位图的信号输入到数字处理装置中，（2）将位图分割成词汇单元的层级（ 3）将标签分配给预定分层级别的每个词汇单元的标签列表，其中标签列表中的标签具有相关联的置信度，以及（4）将混合数据结构中的每个词汇单元存储为可识别对象或不可识别的对象。

8. 发明授权

US5625711A Method and apparatus for producing a hybrid data structure for displaying a raster image 失效
标题翻译：用于产生用于显示光栅图像的混合数据结构的方法和装置
公开(公告)号：US5625711A
公开(公告)日：1997-04-29
申请号：US298655
申请日：1994-08-31
申请人： Dennis G. Nicholson , James C. King
发明人： Dennis G. Nicholson , James C. King
IPC分类号： G06K9/03 , G06K9/20 , G06K9/72 , H04N1/411 , G06K9/00
CPC分类号： H04N1/4115 , G06K9/00442 , G06K9/033 , G06K9/723 , G06K2209/01
摘要： A system for producing a raster image derived from coded and non-coded portions of a hybrid data structure from an input bitmap including (1) a data processing apparatus, (2) a recognizer which performs recognition on an input bitmap to the data processing apparatus to detect identifiable objects within the input bitmap, (3) a mechanism for producing a hybrid data structure including coded data corresponding to the identifiable objects and non-coded data derived from portions of the input bitmap which do not correspond to the identifiable objects, and (4) an output device capable of developing a visually perceptible raster image derived from the hybrid data structure. The raster image includes raster images of the identifiable objects and raster images derived from portions of the input bitmap that do not correspond to the identifiable objects. The invention includes a method for producing a hybrid data structure for a bitmap of an image having the steps of: (1) inputting a signal comprising a bitmap into a digital processing apparatus, (2) partitioning the bitmap into a hierarchy of lexical units, (3) assigning labels to a label list for each lexical unit of a predetermined hierarchical level, where labels in the label list have an associated confidence level, and (4) storing each lexical unit in a hybrid data structure as either an identifiable object or a non-identifiable object.
摘要翻译：一种用于从输入位图生成从混合数据结构的编码和非编码部分得到的光栅图像的系统，包括：（1）数据处理装置，（2）识别器，其对数据处理装置执行对输入位图的识别以检测输入位图内的可识别对象，（3）用于产生混合数据结构的机制，该混合数据结构包括与可识别对象相对应的编码数据和从输入位图的不对应于可识别对象的部分导出的非编码数据，以及（4）能够开发从混合数据结构导出的视觉上可感知的光栅图像的输出装置。光栅图像包括可识别对象的光栅图像和从输入位图的与可识别对象不对应的部分导出的光栅图像。本发明包括一种用于产生图像位图的混合数据结构的方法，该方法具有以下步骤：（1）将包括位图的信号输入到数字处理装置中，（2）将位图分割成词汇单元的层级，（3）将标签分配给预定分层级别的每个词汇单元的标签列表，其中标签列表中的标签具有相关联的置信度，以及（4）将混合数据结构中的每个词法单元存储为可识别对象或一个不可识别的对象。

9. 发明授权

US4361890A Synchronizing system 失效
标题翻译：同步系统
公开(公告)号：US4361890A
公开(公告)日：1982-11-30
申请号：US744034
申请日：1958-06-17
申请人： James H. Green, Jr. , Madison G. Nicholson, Jr.
发明人： James H. Green, Jr. , Madison G. Nicholson, Jr.
IPC分类号： H04B1/69 , H04L9/00
CPC分类号： H04B1/69
摘要： 1. In a communication system utilizing at least two independent binary coded pulse signal sequences, means for achieving and holding time synchronism between said two sequences which comprises the combination of pulse recurrence frequency searching means for controlling the pulse recurrence frequency of one of said signals relative to the other to bring said signal into synchronism with the other, and phase locking means including a periodic phase checking circuit and a phase variation correcting circuit responsive to the searching means bringing the signals into synchronism to operate on one of said signals for holding said signals in synchronism.
摘要翻译： 1.一种利用至少两个独立二进制编码脉冲信号序列的通信系统，用于实现和保持所述两个序列之间的时间同步的装置，其包括脉冲重复频率搜索装置的组合，用于控制所述信号之一的脉冲重现频率另一方面使所述信号与另一信号同步，并且相位锁定装置包括周期性相位检查电路和相位变化校正电路，所述相位变化校正电路响应于搜索装置使信号同步以对所述信号之一进行操作以保持所述信号同步。

10. 发明授权

US10662440B2 Self-limiting viral vectors encoding nucleases 有权
公开(公告)号：US10662440B2
公开(公告)日：2020-05-26
申请号：US15737918
申请日：2016-06-20
申请人： Precision BioSciences, Inc. , Derek Jantz , James Jefferson Smith , Michael G. Nicholson
发明人： Derek Jantz , James Jefferson Smith , Michael G. Nicholson
IPC分类号： C12N15/63 , C12N15/85 , C07H21/04 , C12N15/86 , C12N9/22 , A61K38/00
摘要： Disclosed herein are viral vectors for use in recombinant molecular biology techniques. In particular, the present disclosure relates to self-limiting viral vectors comprising genes encoding site-specific endonucleases as well as recognition sequences for site-specific endonucleases such that expression of the endonuclease in a cell cleaves the viral vector and limits its persistence time. In some embodiments, the viral vectors disclosed herein also carry directives to delete, insert, or change a target sequence.

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