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1. 发明申请

WO1996018606A1 NOVEL 1,3-DIALKYLUREA DERIVATIVES 审中-公开
标题翻译：新的1,3-二氯乙烯衍生物
公开(公告)号：WO1996018606A1
公开(公告)日：1996-06-20
申请号：PCT/JP1995002539
申请日：1995-12-11
申请人： SANTEN PHARMACEUTICAL CO., LTD. , KAWASHIMA, Yoichi , FUJIMURA, Ken-ichi , SUHARA, Hiroshi , YAMAMOTO, Noriyoshi , MATSUMOTO, Hiromi , MIYAWAKI, Nobuaki , FUJITA, Yuko
发明人： SANTEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07C275/18
CPC分类号： C07F9/3808 , C07C275/24 , C07C2602/08 , C07F9/4006
摘要： A compound represented by general formula (I) and salts thereof, wherein R and R represent each carboxyl, sulfo or a derivative thereof; R represents hydrogen, lower alkyl, (substituted) phenyl-lower alkyl, lower alkoxy or (substituted) phenyl-lower alkoxy; R represents lower alkyl or (substituted) phenyl-lower alkyl; and R represents a group represented by general formula (XI), (XII) or (XIII). The compound has an endopeptidase 24.11 inhibitory activity and is useful for treating cardiovascular diseases such as cardiac failure and hypertension, kidney diseases such as renal failure, gastrointestinal disorders such as diarrhea and gastric hyperacidity, endocrine-metabolic diseases such as obesity, and autoimmune diseases such as rheumatism, and for mitigating muscular pain and migraine.
摘要翻译：由通式（I）表示的化合物及其盐，其中R 1和R 5分别代表羧基，磺基或其衍生物; R 2表示氢，低级烷基，（取代的）苯基 - 低级烷基，低级烷氧基或（取代的）苯基 - 低级烷氧基; R 3表示低级烷基或（取代的）苯基 - 低级烷基; R 4表示由通式（XI），（XII）或（XIII）表示的基团。该化合物具有内肽酶24.11抑制活性，可用于治疗心血管疾病如心力衰竭和高血压，肾脏疾病如肾衰竭，胃肠道疾病如腹泻和胃酸过度，内分泌代谢疾病如肥胖症和自身免疫性疾病，如作为风湿病，以及减轻肌肉疼痛和偏头痛。

2. 发明申请

WO1989009387A1 CONCENTRATION DETECTION ELEMENT FOR SOLUTE IN AQUEOUS SOLUTION 审中-公开
标题翻译：浓度检测元素在水溶液中溶解
公开(公告)号：WO1989009387A1
公开(公告)日：1989-10-05
申请号：PCT/JP1989000350
申请日：1989-03-31
申请人： JAPAN GORE-TEX INC. , JAPAN STORAGE BATTERY CO., LTD. , FUJITA, Yuko , KUDO, Hisashi , IWANAMI, Yoshiharu , NOMI, Haruo , SHIBATA, Yoshihiko , UENO, Ryozo
发明人： JAPAN GORE-TEX INC. , JAPAN STORAGE BATTERY CO., LTD.
IPC分类号： G01N07/10
CPC分类号： G01N7/10
摘要： This invention provides a solute in an aqueous solution concentration detection element sealed airtight by a porous non-water-permeable fluororesin film or a two-layered film of a porous non-water-permeable fluororesin film and a selective vapor permeable layer or a three-layered film of a porous non-water-permeable fluororesin film, a selective vapor permeable layer and an acid vapor absorption layer, by utilizing a property that the concentration of a solute in an aqueous solution is closely associated with the vapor pressure of the aqueous solution.
摘要翻译：本发明提供一种水溶液浓度检测元件中的溶质，其通过多孔非透水性氟树脂膜或多孔非透水性氟树脂膜和选择性透气性层或三维透湿性氟树脂膜的双层膜密封而密封，通过利用水溶液中的溶质的浓度与水溶液的蒸汽压密切相关的性质，可以使用多孔非透水性氟树脂膜，选择性蒸气透过层和酸性蒸气吸收层的多层膜。

3. 发明申请

WO1998004010A1 POSITIVE ELECTRODE FOR LITHIUM BATTERY 审中-公开
标题翻译：锂电池正极
公开(公告)号：WO1998004010A1
公开(公告)日：1998-01-29
申请号：PCT/JP1996002049
申请日：1996-07-22
申请人： JAPAN STORAGE BATTERY CO., LTD. , AMINE, Khalil , YASUDA, Hideo , FUJITA, Yuko
发明人： JAPAN STORAGE BATTERY CO., LTD.
IPC分类号： H01M04/48
CPC分类号： H01M4/505 , H01M4/131 , H01M4/1391 , H01M4/485 , H01M4/525 , H01M10/052
摘要： A positive electrode active material for high voltage lithium battery which is represented by general formula LixMn2-yMyO4 (M: a 2-valency metal (Ni, Co, Fe, Mg, Zn), with 0.45
摘要翻译：由通式LixMn2-yMyO4（M：2价贵金属（Ni，Co，Fe，Mg，Zn））表示的高电压锂电池用正极活性物质，其中0.45≤y≤0.60， 0

4. 发明申请

WO1995019356A1 ENDOPEPTIDASE 24.15 INHIBITOR 审中-公开
标题翻译：内毒素24.15抑制剂
公开(公告)号：WO1995019356A1
公开(公告)日：1995-07-20
申请号：PCT/JP1995000020
申请日：1995-01-11
申请人： SANTEN PHARMACEUTICAL CO., LTD. , MITA, Shiro , RI, Kyurin , FUJITA, Yuko , ITO, Susumu
发明人： SANTEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07D277/06
CPC分类号： C07D277/06
摘要： An endopeptidase 24.15 inhibitor containing a compound represented by the general formula (I) or a salt thereof as the active ingredient, wherein R represents hydrogen, lower alkyl, hydroxy or lower alkanoyloxy; R represents hydrogen, lower alkanoyl or benzoyl; R represents hydrogen and R represents hydrogen, lower alkyl or phenylated lower alkyl, provided that R and R may be combined with each other to form a pyrrolidine ring, that the lower alkyl may be substituted by hydroxy, carboxy, mercapto, lower alkylthio, imidazolyl or indolyl, and that the phenyl of the phenylated lower alkyl may be substituted by hydroxy or lower alkoxy; R represents carboxyl which may be in the form of ester or amide; and A represents C1-C3 linear or branched alkylene. The compound has an excellent endopeptidase 24.15 inhibitory activity and is promising as an analgesic, antirheumatic, osteoporosis remedy, and dementia remedy.
摘要翻译：含有由通式（I）表示的化合物或其盐作为活性成分的内肽酶24.15抑制剂，其中R 1表示氢，低级烷基，羟基或低级烷酰氧基; R 2表示氢，低级烷酰基或苯甲酰基; R 3表示氢，R 4表示氢，低级烷基或苯基低级烷基，条件是R 3和R 4可以彼此结合形成吡咯烷环，低级烷基可以是被羟基，羧基，巯基，低级烷硫基，咪唑基或吲哚基取代，苯基低级烷基的苯基可以被羟基或低级烷氧基取代; R 5表示可以是酯或酰胺形式的羧基; A表示C1-C3直链或支链亚烷基。该化合物具有优异的内肽酶24.15抑制活性，并且有希望作为止痛，抗风湿，骨质疏松症和痴呆症。

5. 发明申请

WO1992013130A1 METHOD FOR AVOIDING PITCH TROUBLES BY USE OF THERMOSTABLE LIPASE 审中-公开
标题翻译：通过使用热稳定性脂肪来避免麻烦的方法
公开(公告)号：WO1992013130A1
公开(公告)日：1992-08-06
申请号：PCT/DK1992000025
申请日：1992-01-24
申请人： NOVO NORDISK A/S , JUJO, Paper, Co., Ltd. , MATSUKURA, Motoo , FUJITA, Yuko , ABO, Masanobu , ITAMI, Ryoko
发明人： NOVO NORDISK A/S , JUJO, Paper, Co., Ltd.
IPC分类号： D21C09/08
CPC分类号： D21C9/08 , C02F3/342 , D21C5/005 , D21H21/02
摘要： More effective prevention of pitch troubles in a process for producing mechanical pulp or in a paper-making process using mechanical pulp. A paper-making process is conducted by addition of a fatty acid glyceride hydrolysing enzyme that is resistant to temperatures above 70 DEG C to paper-making raw material or white water that is exposed to temperatures above 70 DEG C.
摘要翻译：在制造机械纸浆的方法中或在使用机械纸浆的造纸方法中更有效地防止沥青麻烦。通过加入耐高温70℃以上的脂肪酸甘油酯水解酶对造纸原料或暴露于70℃以上的白水进行造纸过程。

6. 发明申请

WO1996014293A1 NOVEL 1,3-DIALKYLUREA DERIVATIVE HAVING HYDROXYL GROUP 审中-公开
标题翻译：具有羟基的新型1,3-二氨基脲衍生物
公开(公告)号：WO1996014293A1
公开(公告)日：1996-05-17
申请号：PCT/JP1995002236
申请日：1995-11-01
申请人： SANTEN PHARMACEUTICAL CO., LTD. , KAWASHIMA, Yoichi , FUJIMURA, Ken-ichi , SUHARA, Hiroshi , MIYAWAKI, Nobuaki , FUJITA, Yuko
发明人： SANTEN PHARMACEUTICAL CO., LTD.
IPC分类号： C07C275/10
CPC分类号： C07C275/24 , C07C2601/14
摘要： A compound represented by general formula (I) and salts thereof, wherein R and R represent carboxyl optionally converted into an ester, amide or hydroxamate group; R represents lower alkyl or phenyl lower alkyl; and R represents hydrogen, lower alkyl, amino lower alkyl, lower alkylamino lower alkyl, hydroxy lower alkyl, mercapto lower alkyl, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, imidazolyl lower alkyl, indolyl lower alkyl, optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted naphthyl or optionally substituted naphthyl lower alkyl. The compound has an inhibitory effect on endopeptidase 24.11 and being useful as a remedy for cardiovascular diseases such as cardiac insufficiency and hypertension, kidney diseases such as renal insufficiency, gastrointestinal disorders such as diarrhea and gastric hyperacidity, endocrine/metabolic diseases such as obesity, and autoimmune diseases such as rheumatism, and as an analgesic agent for muscular pain, hemicrania, etc.
摘要翻译：由通式（I）表示的化合物及其盐，其中R 1和R 4表示任选转化为酯，酰胺或异羟肟基的羧基; R 2表示低级烷基或苯基低级烷基; R 3表示氢，低级烷基，氨基低级烷基，低级烷基氨基低级烷基，羟基低级烷基，巯基低级烷基，羧基低级烷基，低级烷氧基羰基低级烷基，咪唑基低级烷基，吲哚基低级烷基，任意取代的苯基，取代的苯基低级烷基，任选取代的萘基或任选取代的萘基低级烷基。该化合物对内肽酶24.11具有抑制作用，可用作心血管疾病如心功能不全和高血压，肾脏疾病如肾功能不全，胃肠疾病如腹泻和胃酸过多，内分泌/代谢疾病如肥胖症的补救措施，以及自身免疫性疾病如风湿病，以及作为肌肉疼痛，血红素等的镇痛剂。

7. 发明申请

WO1992019808A1 LIPASE-CATALYZED ESTER HYDROLYSIS 审中-公开
标题翻译：脂肪酶催化酯水解
公开(公告)号：WO1992019808A1
公开(公告)日：1992-11-12
申请号：PCT/DK1992000137
申请日：1992-04-30
申请人： NOVO NORDISK A/S , JUJO PAPER CO., LTD. , FUJITA, Yuko , AWAJI, Haruo , SHIMOTO, Hidesato , SHARYOU, Masaki
发明人： NOVO NORDISK A/S , JUJO PAPER CO., LTD.
IPC分类号： D21C90/08
CPC分类号： C12P7/6418 , C12P7/6445 , D21C5/005 , D21C9/08 , D21H21/02
摘要： Addition of a water-soluble polyelectrolyte (i.e. an anionic or cationic polymer) significantly increases the hydrolysis rate of esters in the presence of lipases. The invention provides a process for hydrolysis of water-insoluble ester in the presence of a lipase characterized by the presence of a water-soluble polyelectrolyte. The invention also provides a method of increasing the rate of hydrolysis of water-insoluble ester in the presence of a lipase by incorporation of a water-soluble polyelectrolyte.
摘要翻译：添加水溶性聚电解质（即阴离子或阳离子聚合物）可显着增加脂肪酶存在下酯的水解速率。本发明提供一种水解不溶性酯在脂肪酶存在下的水解方法，其特征在于存在水溶性聚电解质。本发明还提供了通过引入水溶性聚电解质在脂肪酶存在下提高水不溶性酯的水解速率的方法。

8. 发明专利

JPH09322877A FUTON BEATER 失效
公开(公告)号：JPH09322877A
公开(公告)日：1997-12-16
申请号：JP18262996
申请日：1996-06-06
申请人： FUJITA YUKO
发明人： FUJITA YUKO
IPC分类号： A47L13/36
摘要： PROBLEM TO BE SOLVED: To enable drying of a large fabric product such as futon outside to drive fine dirt such as dust by beating the product. SOLUTION: A handle 1 is so angled to incline a futon beating body 3 downward.

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