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1. 发明申请

WO2003027231A2 POLYNUCLEOTIDE ENCODING A NOVEL PLECKSTRIN HOMOLOGY DOMAIN AND PROLINE RICH DOMAIN CONTAINING ADAPTER PROTEIN, PMN29 审中-公开
标题翻译：多核苷酸编码一个新的PLECKSTRIN同源域和包含适应蛋白的多核苷酸，PMN29
公开(公告)号：WO2003027231A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/028235
申请日：2002-09-04
申请人： BRISTOL-MYERS SQUIBB COMPANY , FINGER, Joshua, N. , PEREZ-VILLAR, Juan, J. , RAJASHEKAR, Rudy , YANG, Guchen , KIENER, Peter, A.
发明人： FINGER, Joshua, N. , PEREZ-VILLAR, Juan, J. , RAJASHEKAR, Rudy , YANG, Guchen , KIENER, Peter, A.
IPC分类号： C12N
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding PMN29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PMN29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码PMN29多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型PMN29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明申请

WO2002077173A2 POLYNUCLEOTIDE ENCODING A NOVEL IMMUNOGLOBULIN SUPERFAMILY MEMBER, APEX4, AND VARIANTS AND SPLICE VARIANTS THEREOF 审中-公开
标题翻译：编码一种新型免疫抑制蛋白超家族成员，APEX4及其变体及其变体的多核苷酸
公开(公告)号：WO2002077173A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/008721
申请日：2002-03-22
申请人： BRISTOL-MYERS SQUIBB COMPANY , FINGER, Joshua
发明人： FINGER, Joshua
IPC分类号： C12N
CPC分类号： C07K14/70503
摘要： The present invention provides novel polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of APEX4 polypeptides, APEX4v1 and APEX4sv1, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel APEX4, APEX4v1, and APEX4sv1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码APEX4多肽，其片段和同系物的新型多核苷酸。本发明还提供分别编码APEX4多肽，APEX4v1和APEX4sv1的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型APEX4，APEX4v1和APEX4sv1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明申请

WO2002066494A3 IDENTIFICATION AND CLONING OF A NOVEL HUMAN GENE, RET16, INVOLVED IN THE INTRACELLULAR SIGNALING CASCADE 审中-公开
公开(公告)号：WO2002066494A3
公开(公告)日：2002-08-29
申请号：PCT/US2002/005162
申请日：2002-02-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , TODDERUD, C., Gordon , FINGER, Joshua, N. , RILLEMA, Jill
发明人： TODDERUD, C., Gordon , FINGER, Joshua, N. , RILLEMA, Jill
IPC分类号： C12N15/00
摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.

4. 发明申请

WO02066494A8 IDENTIFICATION AND CLONING OF A NOVEL HUMAN GENE, RET16, INVOLVED IN THE INTRACELLULAR SIGNALING CASCADE 审中-公开
标题翻译：鉴定和克隆新型人类基因RET16参与细胞内信号分析
公开(公告)号：WO02066494A8
公开(公告)日：2003-10-23
申请号：PCT/US0205162
申请日：2002-02-15
申请人： SQUIBB BRISTOL MYERS CO , TODDERUD C GORDON , FINGER JOSHUA N , RILLEMA JILL
发明人： TODDERUD C GORDON , FINGER JOSHUA N , RILLEMA JILL
IPC分类号： G01N33/50 , A61K38/00 , A61P1/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/04 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07K
CPC分类号： C07K14/47
摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译：本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。

5. 发明申请

WO02077173A3 POLYNUCLEOTIDE ENCODING A NOVEL IMMUNOGLOBULIN SUPERFAMILY MEMBER, APEX4, AND VARIANTS AND SPLICE VARIANTS THEREOF 审中-公开
标题翻译：编码一种新型免疫抑制蛋白超家族成员，APEX4及其变体及其变体的多核苷酸
公开(公告)号：WO02077173A3
公开(公告)日：2003-04-03
申请号：PCT/US0208721
申请日：2002-03-22
申请人： SQUIBB BRISTOL MYERS CO , FINGER JOSHUA
发明人： FINGER JOSHUA
IPC分类号： C07K14/705 , C07H21/00 , C12N1/20 , C12N15/74 , C12P21/06 , C12P15/87
CPC分类号： C07K14/70503
摘要： The present invention provides novel polynucleotides encoding APEX4 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of APEX4 polypeptides, APEX4v1 and APEX4sv1, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel APEX4, APEX4v1, and APEX4sv1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码APEX4多肽，其片段和同系物的新型多核苷酸。本发明还提供分别编码APEX4多肽，APEX4v1和APEX4sv1的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型APEX4，APEX4v1和APEX4sv1多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

6. 发明申请

WO2002066494A2 IDENTIFICATION AND CLONING OF A NOVEL HUMAN GENE, RET16, INVOLVED IN THE INTRACELLULAR SIGNALING CASCADE 审中-公开
标题翻译：鉴定和克隆新型人类基因RET16参与细胞内信号分析
公开(公告)号：WO2002066494A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/005162
申请日：2002-02-15
申请人： BRISTOL-MYERS SQUIBB COMPANY , TODDERUD, C., Gordon , FINGER, Joshua, N. , RILLEMA, Jill
发明人： TODDERUD, C., Gordon , FINGER, Joshua, N. , RILLEMA, Jill
IPC分类号： C07K
CPC分类号： C07K14/47
摘要： The present invention describes a newly discovered polynucleotide encoding a protein involved in the cell signaling cascade, called RET16, cloned, isolated and identified from TNF-alpha stimulated human microvascular endothelial cells, as well as mouse and rat RET16 orthologs thereof. Also described are the RET16 polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or polypeptide of the present invention. Methods for screening for modulators, particularly inhibitors, of the human RET16 protein, and use of the RET16 polynucleotide and polypeptide for therapeutics and diagnostics are described.
摘要翻译：本发明描述了一种新发现的多核苷酸，其编码参与由TNF-α刺激的人微血管内皮细胞以及小鼠和大鼠RET16直系同源物克隆，分离和鉴定的细胞信号级联的称为RET16的蛋白质。还描述了与本发明的多核苷酸和/或多肽相关的RET16多肽序列，表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。描述了用于筛选人RET16蛋白的调节剂，特别是抑制剂的方法，以及RET16多核苷酸和多肽用于治疗和诊断的用途。

7. 发明申请

WO2005054518A2 COMPOSITIONS AND THEIR USES DIRECTED TO BONE GROWTH MODULATORS 审中-公开
标题翻译：组合物及其用于骨生长调节剂的用途
公开(公告)号：WO2005054518A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/041019
申请日：2004-12-06
申请人： ISIS PHARMACEUTICALS, INC. , BENNETT, Frank, C. , BUTLER, Madeline, M. , DEAN, Nicholas, M. , DOBIE, Kenneth, W. , FINGER, Joshua , JAIN, Ravi , McKAY, Robert , MONIA, Brett, P. , MYERS, Kathleen
发明人： BENNETT, Frank, C. , BUTLER, Madeline, M. , DEAN, Nicholas, M. , DOBIE, Kenneth, W. , FINGER, Joshua , JAIN, Ravi , McKAY, Robert , MONIA, Brett, P. , MYERS, Kathleen
IPC分类号： C12Q1/68
CPC分类号： C07H21/04
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of a bone growth modulator in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译：本文公开了用于调节细胞，组织或动物中的骨生长调节剂的表达的化合物，组合物和方法。还提供了目标验证的方法。还提供了公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

8. 发明申请

WO2005028633A3 MODULATION OF RANKL EXPRESSION 审中-公开
标题翻译： RANKL表达调控
公开(公告)号：WO2005028633A3
公开(公告)日：2008-11-06
申请号：PCT/US2004030736
申请日：2004-09-17
申请人： ISIS PHARMACEUTICALS INC , BAKER BRENDA F , BENNETT FRANK C , DOBIE KENNETH W , MYERS KATHLEEN , FINGER JOSHUA , COWSERT LEX M
发明人： BAKER BRENDA F , BENNETT FRANK C , DOBIE KENNETH W , MYERS KATHLEEN , FINGER JOSHUA , COWSERT LEX M
IPC分类号： C07H21/02 , A61K48/00 , C07H21/04 , C12N20060101
CPC分类号： C07H21/02 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/345
摘要： Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.
摘要翻译：提供化合物，组合物和方法用于调节RANKL的表达。组合物包含针对编码RANKL的核酸的寡核苷酸。提供了使用这些化合物调节RANKL表达和用于诊断和治疗与RANKL表达相关的疾病的方法。

9. 发明申请

WO2005028633A2 MODULATION OF RANKL EXPRESSION 审中-公开
标题翻译： RANKL表达调控
公开(公告)号：WO2005028633A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030736
申请日：2004-09-17
申请人： ISIS PHARMACEUTICALS, INC. , BAKER, Brenda, F. , BENNETT, Frank, C. , DOBIE, Kenneth, W. , MYERS, Kathleen , FINGER, Joshua , COWSERT, Lex, M.
发明人： BAKER, Brenda, F. , BENNETT, Frank, C. , DOBIE, Kenneth, W. , MYERS, Kathleen , FINGER, Joshua , COWSERT, Lex, M.
IPC分类号： C12N
CPC分类号： C07H21/02 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/345
摘要： Compounds, compositions and methods are provided for modulating the expression of RANKL. The compositions comprise oligonucleotides, targeted to nucleic acid encoding RANKL. Methods of using these compounds for modulation of RANKL expression and for diagnosis and treatment of disease associated with expression of RANKL are provided.
摘要翻译：提供化合物，组合物和方法用于调节RANKL的表达。组合物包含针对编码RANKL的核酸的寡核苷酸。提供了使用这些化合物调节RANKL表达和用于诊断和治疗与RANKL表达相关的疾病的方法。

10. 发明申请

WO03027231A3 POLYNUCLEOTIDE ENCODING ADAPTER PROTEIN, PMN29 审中-公开
标题翻译：多核苷酸编码适配蛋白，PMN29
公开(公告)号：WO03027231A3
公开(公告)日：2003-10-16
申请号：PCT/US0228235
申请日：2002-09-04
申请人： SQUIBB BRISTOL MYERS CO , FINGER JOSHUA N , PEREZ-VILLAR JUAN J , RAJASHEKAR K REDDY , YANG GUCHEN , KIENER PETER A
发明人： FINGER JOSHUA N , PEREZ-VILLAR JUAN J , RAJASHEKAR K REDDY , YANG GUCHEN , KIENER PETER A
IPC分类号： C07K14/705 , C12N15/12 , A61K38/16 , A61K38/17 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/18 , C12N1/00 , C12N5/10 , C12N15/11 , C12N15/63 , C12Q1/68
CPC分类号： C07K14/705
摘要： The present invention provides novel polynucleotides encoding PMN29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PMN29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码PMN29多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型PMN29多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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