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1. 发明申请

US20060016701A1 Point of care heparin determination system 有权
标题翻译：护理点肝素测定系统
公开(公告)号：US20060016701A1
公开(公告)日：2006-01-26
申请号：US11126887
申请日：2005-05-11
申请人： Wei Qin , Daniel Cheek , Christopher Hobot , Kelvin Bonnema , Randy Meyer , Douglas Nippoldt , Vitally Sitko , Qingshan (Sam) Ye , Narayanan Ramamurthy
发明人： Wei Qin , Daniel Cheek , Christopher Hobot , Kelvin Bonnema , Randy Meyer , Douglas Nippoldt , Vitally Sitko , Qingshan (Sam) Ye , Narayanan Ramamurthy
IPC分类号： G01N27/26
CPC分类号： G01N27/3335 , A61M1/3675 , G01N27/333 , G01N33/86
摘要： Methods and devices for point of care determination of heparin concentration in blood are described. Cartridges including protamine ion sensitive electrodes (ISEs) and reference electrodes and systems for automatically determining heparin concentration in the cartridges are provided. Some systems add blood to a protamine bolus sufficient to bind all heparin, leaving excess protamine. The excess protamine concentration can be determined by measuring the initial slope of the electrode potential rate of change, and comparing the slope to known protamine concentration slope values In some cartridges, an oscillating pressure source moves the blood-protamine mixture back and forth across the protamine ISE. Some systems also use a second blood sample having the heparin removed or degraded to create a blank reference sample. Protamine ISEs can include polyurethane polymer, DNNS ionophore, and NPOE plasticizer. The polyurethane may include hard segments and soft segments, where both hard and soft segments may include cyclic and straight chain aliphatic moieties having essentially no ester or ether groups. Some hard segments may include methylene diphenyl groups. Some reference electrodes have the same polymer, plasticizer, and ionophore as the measurement electrode, but with a different concentration of ionophore.
摘要翻译：描述了血液中肝素浓度的护理点测定方法和装置。提供了包括鱼精蛋白离子敏感电极（ISE）和用于自动确定药筒中肝素浓度的参比电极和系统的药盒。一些系统将血液添加到足以结合所有肝素的鱼精蛋白推注物，留下过量的鱼精蛋白。可以通过测量电极电位变化率的初始斜率，并将斜率与已知的精蛋白浓度斜率值进行比较来确定过量鱼精蛋白浓度。在一些药筒中，振荡压力源通过鱼精蛋白ISE来回移动血液 - 鱼精蛋白混合物。一些系统还使用除去或降解肝素以创建空白参考样品的第二血液样品。鱼精蛋白ISE可以包括聚氨酯聚合物，DNNS离子载体和NPOE增塑剂。聚氨酯可以包括硬链段和软链段，其中硬链段和软链段都可以包括基本上没有酯或醚基团的环状和直链脂族部分。一些硬链段可以包括亚甲基二苯基。一些参比电极与测量电极具有相同的聚合物，增塑剂和离子载体，但是具有不同浓度的离子载体。

2. 发明申请

US20080206880A9 BLOOD COAGULATION TEST CARTRIDGE, SYSTEM, AND METHOD 有权
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US20080206880A9
公开(公告)日：2008-08-28
申请号：US10826994
申请日：2004-04-19
申请人： Cynthia Clague , Daniel Cheek , Douglas Nippoldt
发明人： Cynthia Clague , Daniel Cheek , Douglas Nippoldt
IPC分类号： G01N33/86
CPC分类号： G01N11/162 , G01N11/14 , G01N15/042 , G01N15/05 , G01N33/4905 , G01N2015/0092 , Y10T436/111666
摘要： A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and is provided with a cartridge port for introducing a test sample into the test chamber,. Ferromagnetic agitator vane leaflets extend from an agitator pivot element supported by the test chamber pivot element intermediate the upper and lower major sides for rotational motion. The agitator vane leaflets can be swept, in response to an external magnetic field, through the test sample in the absence of coagulation. A timer is started when the agitator movement is commenced whereupon the agitator moves freely. Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的测试样品的凝固时间（例如TT，PT，aPTT和ACT）的系统和方法。具有上下侧和下侧壁的盒壳体包围具有测试室枢转元件的测试室，并且设置有用于将测试样品引入到测试室中的盒端口。铁磁搅拌器叶片叶片从由测试室枢转元件支撑的搅拌器枢轴元件延伸，位于上，下三个主要侧面以用于旋转运动。在不存在凝结的情况下，搅拌器叶片叶片可以响应于外部磁场扫过测试样品。当搅拌器运动开始时，搅拌器自由移动，启动定时器。检测到由于凝结而产生的搅拌器运动阻力，测定凝固时间。

3. 发明申请

US20080009073A1 Test Cartridge Holder for Blood Samples 有权
标题翻译：用于血液样品的试剂盒支架
公开(公告)号：US20080009073A1
公开(公告)日：2008-01-10
申请号：US11752743
申请日：2007-05-23
申请人： Michael Green , Douglas Nippoldt , William Zillmann , Brent Wallace , Jeff Rejent
发明人： Michael Green , Douglas Nippoldt , William Zillmann , Brent Wallace , Jeff Rejent
IPC分类号： G01N1/00 , B01L9/00
CPC分类号： B01L9/00 , B01L3/0293 , B01L3/508 , B01L2200/026 , B01L2300/0654 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.
摘要翻译：公开了改进的方法和装置，其使得更准确并降低了使用血液样品填充细胞的反应室的风险以进行使用柱塞技术的类型的凝血试验。提供了一种盒式存储器，其将测试盒固定在固定的直立位置，并使每个盒式电池的柱塞标志偏转，使得血液分配器可以深入人工插入反应室以填充反应室，并避免对盒的表面的污染在反应室外。优选地，盒保持器在填充期间提供反应室的照明，使得用户可以判断反应室何时被适当地填充从血液分配器分配的血液。墨盒保持器可以包括图像放大率以便于在填充反应室时观察反应室。

4. 发明申请

US20050255601A1 Blood coagulation test cartridge, system, and method 失效
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US20050255601A1
公开(公告)日：2005-11-17
申请号：US11047026
申请日：2005-01-31
申请人： Douglas Nippoldt , Cynthia Clague , Daniel Ericson
发明人： Douglas Nippoldt , Cynthia Clague , Daniel Ericson
IPC分类号： G01N33/49 , G01N33/86
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/2575
摘要： A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge comprises a blood receptacle that is open to the atmosphere into which a blood sample is to be deposited, a vacuum port that is open to atmosphere, and a spiral capillary within the test cartridge having a capillary length and cross-section area, a first capillary end of the spiral capillary open to the blood receptacle and a second capillary end of the spiral capillary open to the vacuum port, whereby the spiral capillary is closed to atmosphere. When a blood sample is deposited in the blood receptacle, a vacuum is drawn through the vacuum port and the blood is drawn through the spiral capillary until coagulation occurs. A pressure change is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的血液样品的凝固时间，例如凝血酶时间，PT，aPTT和ACT的系统和方法。测试盒包括对要沉积血液样本的大气开放的血液存储器，对大气开放的真空端口以及具有毛细管长度和横截面面积的测试盒内的螺旋毛细管，螺旋毛细管的第一毛细管端部通向血液容器，并且螺旋毛细管的第二毛细管端部通向真空端口，由此螺旋毛细管关闭到大气。当血液样本沉积在血液容器中时，真空通过真空口抽出，血液通过螺旋毛细管吸入，直到发生凝血。检测出压力变化，测定凝固时间。

5. 发明申请

US20050233460A1 Blood coagulation test cartridge, system, and method 有权
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US20050233460A1
公开(公告)日：2005-10-20
申请号：US10826994
申请日：2004-04-19
申请人： Cynthia Clague , Daniel Cheek , Douglas Nippoldt
发明人： Cynthia Clague , Daniel Cheek , Douglas Nippoldt
IPC分类号： G01N11/14 , G01N11/16 , G01N15/00 , G01N15/04 , G01N15/05 , G01N33/49 , G01N33/86
CPC分类号： G01N11/162 , G01N11/14 , G01N15/042 , G01N15/05 , G01N33/4905 , G01N2015/0092 , Y10T436/111666
摘要： A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and is provided with a cartridge port for introducing a test sample into the test chamber,. Ferromagnetic agitator vane leaflets extend from an agitator pivot element supported by the test chamber pivot element intermediate the upper and lower major sides for rotational motion. The agitator vane leaflets can be swept, in response to an external magnetic field, through the test sample in the absence of coagulation. A timer is started when the agitator movement is commenced whereupon the agitator moves freely. Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的测试样品的凝固时间（例如TT，PT，aPTT和ACT）的系统和方法。具有上下侧和下侧壁的盒壳体包围具有测试室枢转元件的测试室，并且设置有用于将测试样品引入测试室的盒端口。铁磁搅拌器叶片叶片从由测试室枢转元件支撑的搅拌器枢轴元件延伸，位于上，下三个主要侧面以用于旋转运动。在不存在凝结的情况下，搅拌器叶片叶片可以响应于外部磁场扫过测试样品。当搅拌器运动开始时，搅拌器自由移动，启动定时器。检测到由于凝结而产生的搅拌器运动阻力，测定凝固时间。

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