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1. 发明专利

FR479589A 未知
公开(公告)号：FR479589A
公开(公告)日：1916-04-12
申请号：FR479589D
申请日：1915-08-24
申请人： ELES L HENINGER , DAVID REED JR
发明人： HENINGER ELES L , JR DAVID REED
IPC分类号： B65D81/07 , B65D85/32

2. 发明专利

GB189712804A Improvements in Window Sash Holders. 未知
公开(公告)号：GB189712804A
公开(公告)日：1897-07-10
申请号：GB189712804D
申请日：1897-05-24
申请人： PETTIT WINFIELD SCOTT , PETTIT DAVID REED , SUTTON EDWIN DEVAUL
发明人： PETTIT WINFIELD SCOTT , PETTIT DAVID REED , SUTTON EDWIN DEVAUL
摘要： 12,804. Pettit, W. S., Pettit, D. R., and Sutton, E. D. May 24. Window holders. -Rollers 7, mounted between lugs 6 of springs 5 fitted in recesses in the sash stiles, bear against the frame, and hold the sash in any required position.

3. 发明专利

GB189704263A Improvements in and connected with Boiler Furnaces. 未知
公开(公告)号：GB189704263A
公开(公告)日：1897-05-29
申请号：GB189704263D
申请日：1897-02-17
申请人： PECK WILLIAM HENRY , PATTERSON DAVID REED W
发明人： PECK WILLIAM HENRY , PATTERSON DAVID REED W
摘要： 4263. Peck, W. H., and Patterson, D. R. W. Feb. 17. Steam - generator furnaces and furnace flues ; settings, casings, and external flues.-Consists mainly in the application to a boiler of a firebrick or similar heat-resisting casing f, which is supported on the side walls of the setting and on longitudinal partitions k and arches h , h . The casing is made in sections as shown, and a small space is left between it and the boiler. It serves to protect the boiler from the flames and to equalize the heat, while, becoming highly heated, it aids the consumption of smoke. The supporting-partitions form the walls of flues or passages to which air is supplied by ducts o, o, and which communicate with a secondary combustion chamber or " retort " m. The improvements are stated to be specially applicable in cases where powdered fuel is fed to the furnace by a blast, but ordinary coal, oil, or gas may be used as fuel, and the invention may be applied to Cornish and similar boilers, as well as to the externally-fired multitubular boiler shown, in which case a heat-resisting lining to the flue replaces the casing f.

4. 发明申请

WO2014137993A1 METHODS FOR USE IN A CALIBRATION-FREE ABSORBANCE SENSOR FOR MEASURING pH AND pCO2 审中-公开
标题翻译：用于测量pH和pCO2的无校准吸收传感器的方法
公开(公告)号：WO2014137993A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/020159
申请日：2014-03-04
申请人： MARKLE, David Reed
发明人： MARKLE, David Reed
IPC分类号： G01N21/59
CPC分类号： G01N21/80
摘要： A method is disclosed that includes illuminating, with broadband light, a sensor molecule disposed in operative contact with an analyte. The sensor molecule is reversibly bindable to the analyte. The method further includes measuring the absorbance of the transmitted light through the sensor molecule at each of two different wavelengths to determine a first absorbance value and a second absorbance value. The method further includes calculating a ratio of the first absorbance value to the second absorbance value, and calculating the concentration of the analyte based at least in part on the ratio.
摘要翻译：公开了一种方法，其包括用宽带光照射与被分析物有效接触的传感器分子。传感器分子可逆地与分析物结合。该方法还包括测量在两个不同波长的每一个处通过传感器分子的透射光的吸光度，以确定第一吸光度值和第二吸光度值。该方法还包括计算第一吸光度值与第二吸光度值的比率，以及至少部分地基于比率来计算分析物的浓度。

5. 发明申请

WO2014137990A1 IMPLEMENTATION OF A CALIBRATION-FREE ABSORBANCE SENSOR FOR MEASURING pH 审中-公开
标题翻译：用于测量pH的无校准吸收传感器的实现
公开(公告)号：WO2014137990A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/020150
申请日：2014-03-04
申请人： MARKLE, David Reed
发明人： MARKLE, David Reed
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/14503 , A61B5/14539 , A61B5/1495
摘要： An analyte sensor includes a first optical fiber having a first end and a second end. The analyte sensor further includes a second optical fiber having a first end and a second end, and a gap between the first end and the second end. The analyte sensor further includes a sensor material disposed in the gap and a source of excitation light selectively optically coupleable to each of the first end of the first optical fiber and the first end of the second optical fiber. The analyte sensor further includes a luminescent material disposed at the second end of the first optical fiber and the second end of the second optical fiber. The analyte sensor further includes a sensor selectively optically coupleable to the first end of the first optical fiber and the first end of the second optical fiber.
摘要翻译：分析物传感器包括具有第一端和第二端的第一光纤。分析物传感器还包括具有第一端和第二端以及第一端和第二端之间的间隙的第二光纤。分析物传感器还包括设置在间隙中的传感器材料和激发光源，其选择性地可耦合到第一光纤的第一端和第二光纤的第一端中的每一个。分析物传感器还包括设置在第一光纤的第二端和第二光纤的第二端的发光材料。分析物传感器还包括选择性地光耦合到第一光纤的第一端和第二光纤的第一端的传感器。

6. 发明申请

WO2005030148A3 TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS 审中-公开
公开(公告)号：WO2005030148A3
公开(公告)日：2005-04-07
申请号：PCT/US2004/031743
申请日：2004-09-27
申请人： CENOMED, INC. , HELTON, David, Reed , FICK, David, Brian , SHARP, Jason, Paul , PFADENHAUER, Ernest, H.
发明人： HELTON, David, Reed , FICK, David, Brian , SHARP, Jason, Paul , PFADENHAUER, Ernest, H.
IPC分类号： A61P25/00
摘要： Compositions comprising tetrahydroindolone derivatives in which the tetrahydroindolone moiety is covalently linked to a substituted arylpiperazine moiety and methods for treating neurological and psychiatric conditions using such compositions are disclosed.

7. 发明申请

WO2004058057A1 SENSOR DEVICE FOR MONITORING PERFUSION OF TISSUE 审中-公开
标题翻译：用于监测组织刺激的传感器装置
公开(公告)号：WO2004058057A1
公开(公告)日：2004-07-15
申请号：PCT/GB2003/005675
申请日：2003-12-31
申请人： DIAMETRICS MEDICAL LIMITED , MARKLE, David, Reed
发明人： MARKLE, David, Reed
IPC分类号： A61B5/00
CPC分类号： A61B5/6848 , A61B5/01 , A61B5/14539 , A61B5/1459 , A61B5/6849
摘要： A sensor device for monitoring perfusion of tissue (M) has a base portion (2) and at least a first elongate probe member (3, 4, 5), the base portion and the first probe member being so arranged that, in use, the base portion can be positioned in abutment with a surface of said tissue whilst the first probe member extends into said tissue. The device further comprises a first optical sensor (24, 25, 26) housed within said first probe member for determining a first analyte in said tissue, and a second optical sensor (24, 25, 26) for determining a second analyte in said tissue. The device is suitable for use in relatively dense tissue, for example, muscle, and may in particular be suitable for use in the myocardium.
摘要翻译：用于监测组织（M）的灌注的传感器装置具有基部（2）和至少第一细长探针构件（3,4,5），所述基部和第一探针构件被布置成使得在使用中，基部可以定位成与所述组织的表面邻接，同时第一探针构件延伸到所述组织中。所述装置还包括容纳在所述第一探针部件内用于确定所述组织中的第一分析物的第一光学传感器（24,25,26）和用于确定所述组织中的第二分析物的第二光学传感器（24,25,26）。该装置适用于相对致密的组织，例如肌肉，并且可特别适用于心肌。

8. 发明申请

WO1996005175A1 SYNTHETIC EXCITATORY AMINO ACIDS 审中-公开
标题翻译：合成激素氨基酸
公开(公告)号：WO1996005175A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010319
申请日：1995-08-14
申请人： ELI LILLY AND COMPANY , HELTON, David, Reed , MONN, James, Allen , SCHOEPP, Darryle, Darwin , TIZZANO, Joseph, Patrick
发明人： ELI LILLY AND COMPANY
IPC分类号： C07D235/02
CPC分类号： C07D235/02 , A61K31/00 , A61K31/198 , A61K31/215 , C07C62/38 , C07C69/757 , C07C229/50 , C07C2602/18 , Y10S514/81 , Y10S514/811 , Y10S514/812 , Y10S514/813
摘要： The present invention provides novel compounds that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders.
摘要翻译：本发明提供影响某些兴奋性氨基酸受体的新化合物，并且可用于治疗神经障碍和精神障碍。

9. 发明申请

WO2005030148A2 TETRAHYDROINDOLONE DERIVATIVES FOR TREATMENT OF NEUROLOGICAL CONDITIONS 审中-公开
标题翻译：用于治疗神经病学条件的四氢吲哚酮衍生物
公开(公告)号：WO2005030148A2
公开(公告)日：2005-04-07
申请号：PCT/US2004031743
申请日：2004-09-27
申请人： CENOMED INC , HELTON DAVID REED , FICK DAVID BRIAN , SHARP JASON PAUL , PFADENHAUER ERNEST H
发明人： HELTON DAVID REED , FICK DAVID BRIAN , SHARP JASON PAUL , PFADENHAUER ERNEST H
IPC分类号： A61K20060101 , A61K31/33 , A61K31/496 , A61K31/506 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , C07D209/00 , C07D209/04 , A61K
CPC分类号： A61K31/33 , A61K31/496 , A61K31/506 , C07D209/08
摘要： Compositions comprising tetrahydroindolone derivatives in which the tetrahydroindolone moiety is covalently linked to a substituted arylpiperazine moiety and methods for treating neurological and psychiatric conditions using such compositions are disclosed.
摘要翻译：公开了包含四氢吲哚酮衍生物的组合物，其中四氢吲哚酮部分与取代的芳基哌嗪部分共价连接，并且使用这些组合物治疗神经和精神病症的方法。

10. 发明申请

WO1996007405A1 EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS 审中-公开
标题翻译：激素氨基酸受体拮抗剂
公开(公告)号：WO1996007405A1
公开(公告)日：1996-03-14
申请号：PCT/US1995010031
申请日：1995-08-07
申请人： ELI LILLY AND COMPANY , ARNOLD, Macklin, Brian , BLEISCH, Thomas, J. , HELTON, David, Reed , KALLMAN, Mary, Jeanne , ORNSTEIN, Paul, Leslie , SCHOEPP, Darryle, Darwin , TIZZANO, Joseph, Patrick
发明人： ELI LILLY AND COMPANY
IPC分类号： A61K31/19
CPC分类号： C07D311/80 , C07C62/12 , C07C62/18 , C07C62/22 , C07C62/26 , C07D211/34 , C07D233/76
摘要： The present invention provides compounds of formula (I) in which R is as defined in the specification, or a pharmaceutically acceptable metabolically labile ester or amide thereof, or a pharmaceutically acceptable salt thereof, which are useful as antagonists of one or more of the actions of L-glutamate at metabotropic excitatory amino acid receptors.
摘要翻译：本发明提供式（I）化合物，其中R如说明书中所定义，或其药学上可接受的代谢不稳定的酯或酰胺或其药学上可接受的盐，其可用作一种或多种作用的拮抗剂的代谢型兴奋性氨基酸受体的L-谷氨酸。

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