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1. 发明公开

EP1099901A2 Adjustable rotating shaft guard 有权
标题翻译： Verstellbare Schutzvorrichtungfürdrehende Welle
公开(公告)号：EP1099901A2
公开(公告)日：2001-05-16
申请号：EP00309313.5
申请日：2000-10-23
申请人： Doll, Ronald J.
发明人： Doll, Ronald J.
IPC分类号： F16P1/02
CPC分类号： F16P1/02 , Y10T74/2191
摘要： An adjustable rotating shaft guard (1) includes a base, a first guard half (12), and a second guard half (14). A bottom of the first and second guard halves are retained by the base such that they contact each other to fully cover a rotating shaft or coupler. A half sleeve (18) preferably extends outward from at least one end of the first and second guard halves (12,14). Preferably, the top of each guard half is fastened to each other. The first and second guard halves (12,14) are preferably fabricated from a high impact plastic. The bottom area of the first and second guard halves (12,14) preferably have a plurality of cutting lines (36) which provide a reference for sawing to a specific height. The half sleeves (18,20) also have a plurality of cutting lines (40) which provide a reference for sawing to a specific length. In a second embodiment, an adjustable rotating shaft guard (2) includes a first sleeve guard half (42), a second sleeve guard half (44) and two sets of two end cap halves (46,48). Each pair of end cap halves (46,48) are attached to each end of the first and second sleeve guard halves (42,44). One or both ends of the first and second sleeve halves (42,44) may be supported by an adjustable leg set. One or both ends of the first and second sleeve guard halves (42,44) may be supported by a mounting plate.
摘要翻译：可调节的转轴防护罩（1）包括底座，第一护罩半部（12）和第二护罩半部（14）。第一和第二保护半部的底部由基座保持，使得它们彼此接触以完全覆盖旋转轴或联接器。半套（18）优选地从第一和第二保护半部（12,14）的至少一端向外延伸。优选地，每个护罩半部的顶部彼此紧固。第一和第二保护半部（12,14）优选地由高冲击塑料制成。第一和第二保护半部（12,14）的底部区域优选地具有多个切割线（36），其提供用于锯切到特定高度的参考。半套（18,20）还具有多个切割线（40），其提供用于锯切到特定长度的参考。在第二实施例中，可调节的转动轴保护罩（2）包括第一套筒护罩半部（42），第二套筒护罩半部（44）和两组两个端帽半部（46,48）。每对端帽半部（46,48）连接到第一和第二套筒保护半部（42,44）的每个端部。第一和第二套筒半部（42,44）的一端或两端可以由可调节腿组支撑。第一和第二套筒保护半部（42,44）的一端或两端可由安装板支撑。

2. 发明公开

EP1099901A3 Adjustable rotating shaft guard 有权
标题翻译：对于转轴可调节保护装置
公开(公告)号：EP1099901A3
公开(公告)日：2002-10-16
申请号：EP00309313.5
申请日：2000-10-23
申请人： Doll, Ronald J.
发明人： Doll, Ronald J.
IPC分类号： F16P1/02
CPC分类号： F16P1/02 , Y10T74/2191
摘要： An adjustable rotating shaft guard (1) includes a base, a first guard half (12), and a second guard half (14). A bottom of the first and second guard halves are retained by the base such that they contact each other to fully cover a rotating shaft or coupler. A half sleeve (18) preferably extends outward from at least one end of the first and second guard halves (12,14). Preferably, the top of each guard half is fastened to each other. The first and second guard halves (12,14) are preferably fabricated from a high impact plastic. The bottom area of the first and second guard halves (12,14) preferably have a plurality of cutting lines (36) which provide a reference for sawing to a specific height. The half sleeves (18,20) also have a plurality of cutting lines (40) which provide a reference for sawing to a specific length. In a second embodiment, an adjustable rotating shaft guard (2) includes a first sleeve guard half (42), a second sleeve guard half (44) and two sets of two end cap halves (46,48). Each pair of end cap halves (46,48) are attached to each end of the first and second sleeve guard halves (42,44). One or both ends of the first and second sleeve halves (42,44) may be supported by an adjustable leg set. One or both ends of the first and second sleeve guard halves (42,44) may be supported by a mounting plate.

3. 发明申请

WO2011137219A1 INHIBITORS OF PHOSPHOINOSITIDE DEPENDENT KINASE 1 (PDK1) 审中-公开
标题翻译：磷酸化酶依赖性激酶1（PDK1）的抑制剂
公开(公告)号：WO2011137219A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034275
申请日：2011-04-28
申请人： SCHERING CORPORATION , PALIWAL, Sunil , TSUI, Hon-Chung , DOLL, Ronald, J. , LI, Ang , JIANG, May Xiaowu , RAINKA, Matthew Paul
发明人： PALIWAL, Sunil , TSUI, Hon-Chung , DOLL, Ronald, J. , LI, Ang , JIANG, May Xiaowu , RAINKA, Matthew Paul
IPC分类号： A61K31/33 , A61K31/385
CPC分类号： C07D417/04 , C07D417/14
摘要： The instant invention provides for compounds that inhibit PDK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting PDK1 activity by administering the compound to a patient in need of treatment of cancer.
摘要翻译：本发明提供抑制PDK1活性的化合物。本发明还提供了包含这种抑制化合物的组合物和通过将该化合物给予需要治疗癌症的患者来抑制PDK1活性的方法。

4. 发明申请

WO2009097233A9 IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS 审中-公开
公开(公告)号：WO2009097233A9
公开(公告)日：2009-08-06
申请号：PCT/US2009/031972
申请日：2009-01-26
申请人： SCHERING CORPORATION , ALBANY MOLECULAR RESEARCH, INC. , RAINKA, Matthew, Paul , VOSS, Matthew, Ernst , PETERSON, Lisa, Helen , FLEMING, Mike , BELANGER, David, B. , CURRAN, Patrick J. , KULKARNI, Bheemashankar, A. , YU, Tao , ZHANG, Yonglian , XIAO, Yushi , KEREKES, Angela, D. , TAGAT, Jayaram, R. , DOLL, Ronald J. , SIDDIQUI, M., Arshad
发明人： RAINKA, Matthew, Paul , VOSS, Matthew, Ernst , PETERSON, Lisa, Helen , FLEMING, Mike , BELANGER, David, B. , CURRAN, Patrick J. , KULKARNI, Bheemashankar, A. , YU, Tao , ZHANG, Yonglian , XIAO, Yushi , KEREKES, Angela, D. , TAGAT, Jayaram, R. , DOLL, Ronald J. , SIDDIQUI, M., Arshad
IPC分类号： C07D487/04 , A61P35/00 , A61K31/4985 , A61P29/00
摘要： In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.

5. 发明申请

WO2008130570A1 NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译：作为循环依赖型激酶抑制剂的新型吡唑并嘧啶
公开(公告)号：WO2008130570A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004907
申请日：2008-04-16
申请人： SCHERING CORPORATION , PHARMACOPEIA, INC. , GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald , GIRIJAVALLABHAN, Viyyoor, M. , MALLAMS, Alan , ALVAREZ, Carmen, S. , KEERTIKAR, Kartik, M. , RIVERA, Jocelyn , CHAN, Tin-Yau , MADISON, Vincent, S. , FISCHMANN, Thierry, O. , KIRSCHMEIER, Paul , BANNERJI, Rajat , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhenmin , JAMES, Ray, Anthony , PARK, Haengsoon , PARADKAR, Vidyadhar, M. , HOBBS, Douglas, W.
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald , GIRIJAVALLABHAN, Viyyoor, M. , MALLAMS, Alan , ALVAREZ, Carmen, S. , KEERTIKAR, Kartik, M. , RIVERA, Jocelyn , CHAN, Tin-Yau , MADISON, Vincent, S. , FISCHMANN, Thierry, O. , KIRSCHMEIER, Paul , BANNERJI, Rajat , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhenmin , JAMES, Ray, Anthony , PARK, Haengsoon , PARADKAR, Vidyadhar, M. , HOBBS, Douglas, W.
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K31/33 , A61K31/4965 , A61K31/497 , A61K31/519 , A61K31/535 , A61K31/555 , A61K31/56 , A61K31/655 , A61K31/675 , A61K31/7004 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

6. 发明申请

WO2008005268A1 SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF 审中-公开
标题翻译：增加P53活性的替代品PIPERIDIN及其用途
公开(公告)号：WO2008005268A1
公开(公告)日：2008-01-10
申请号：PCT/US2007/014958
申请日：2007-06-27
申请人： SCHERING CORPORATION , MA, Yao , LAHUE, Brian, R. , SHIPPS, JR., Gerald, W. , WANG, Yaolin , BOGEN, Stephane, L. , VOSS, Matthew. E. , NAIR, Latha, G. , TIAN, Yuan , DOLL, Ronald, J. , GUO, Zhuyan , STRICKLAND, Corey, O. , ZHANG, Rumin , MCCOY, Mark, A. , PAN, Weidong , SIEGEL, Elise, M. , GIBEAU, Craig, R.
发明人： MA, Yao , LAHUE, Brian, R. , SHIPPS, JR., Gerald, W. , WANG, Yaolin , BOGEN, Stephane, L. , VOSS, Matthew. E. , NAIR, Latha, G. , TIAN, Yuan , DOLL, Ronald, J. , GUO, Zhuyan , STRICKLAND, Corey, O. , ZHANG, Rumin , MCCOY, Mark, A. , PAN, Weidong , SIEGEL, Elise, M. , GIBEAU, Craig, R.
IPC分类号： C07D409/14 , C07D401/06 , C07D401/14 , A61P35/00 , A61K31/496 , A61K31/506
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法蛋白质或P53使用这些化合物或药物组合物。

7. 发明申请

WO2007139732A1 PYRAZOLO [1, 5-A] PYRIMIDINES AS CDK INHIBITORS 审中-公开
标题翻译： PYRAZOLO [1,5-A]吡啶类作为CDK抑制剂
公开(公告)号：WO2007139732A1
公开(公告)日：2007-12-06
申请号：PCT/US2007/011991
申请日：2007-05-21
申请人： SCHERING CORPORATION , GUZI, Timothy, J. , DOLL, Ronald, J. , NOMEIR, Amin, A.
发明人： GUZI, Timothy, J. , DOLL, Ronald, J. , NOMEIR, Amin, A.
IPC分类号： C07D487/04 , A61K31/52 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) which can have utility as inhibitors of cyclin dependent kinases ("CDKs") as well as methods of preparing such compounds. The compounds can have potential utility for the treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs.
摘要翻译：在其许多实施方案中，本发明提供了式（I。）的某些吡唑并[1,5-a]嘧啶化合物

8. 发明申请

WO2005077954A3 PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS 审中-公开
标题翻译：作为CYCLIN依赖性激酶抑制剂的吡唑并嘧啶衍生物
公开(公告)号：WO2005077954A3
公开(公告)日：2005-10-13
申请号：PCT/US2005003859
申请日：2005-02-08
申请人： SCHERING CORP , PHARMACOPEIA DRUG DISCOVERY , GUZI TIMOTHY J , PARUCH KAMIL , DWYER MICHAEL P , DOLL RONALD J , GIRIJAVALLABHAN VIYYOOR MOOPIL , MALLAMS ALAN , ALVAREZ CARMEN S , KEERTIKAR KARTIK M , RIVERA JOCELYN , CHAN TIN-YAU , MADISON VINCENT , FISCHMANN THIERRY O , DILLARD LAWRENCE W , TRAN VINH D , HE ZHEN MIN , JAMES RAY ANTHONY , PARK HAENGSOON , PARADKAR VIDYADHAR M , HOBBS DOUGLAS WALSH
发明人： GUZI TIMOTHY J , PARUCH KAMIL , DWYER MICHAEL P , DOLL RONALD J , GIRIJAVALLABHAN VIYYOOR MOOPIL , MALLAMS ALAN , ALVAREZ CARMEN S , KEERTIKAR KARTIK M , RIVERA JOCELYN , CHAN TIN-YAU , MADISON VINCENT , FISCHMANN THIERRY O , DILLARD LAWRENCE W , TRAN VINH D , HE ZHEN MIN , JAMES RAY ANTHONY , PARK HAENGSOON , PARADKAR VIDYADHAR M , HOBBS DOUGLAS WALSH
IPC分类号： A61K31/495 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04 , A61K31/495
摘要： In its many embodiments, the present invention provides pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为细胞周期蛋白依赖性激酶抑制剂的吡唑并[1,5-a]嘧啶化合物，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种这些化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

9. 发明申请

WO1990003364A1 MERCAPTO-ACYLAMINO ACIDS USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS AND AS ANALGESICS 审中-公开
标题翻译：用于治疗心血管疾病和作为分析物的美伐他汀
公开(公告)号：WO1990003364A1
公开(公告)日：1990-04-05
申请号：PCT/US1989004068
申请日：1989-09-25
申请人： SCHERING CORPORATION , DOLL, Ronald, James , NEUSTADT, Bernard, Ray , KOZLOWSKI, Joseph, Andrew , CLADER, John, Welch
发明人： SCHERING CORPORATION
IPC分类号： C07C323/60
CPC分类号： C07D213/82 , C07C323/60 , C07C327/22 , C07C327/26
摘要： Novel mercapto-acylamino acids of formula (I), wherein R1 is H or R5CO-; R2 is Y-C6H4-, Y-C6H4S-, Y-C6H4O-, Y-C6H4CH2S-, Y-C6H4CH2O-, naphthyl, furyl, thienyl, benzofuryl, benzothienyl, diphenylmethyl or (a); R3 is -OR6, -NR6R7 or (b); R4 is hydrogen, lower alkyl or aryl lower alkyl; R5 is lower alkyl, hydroxylower alkyl, lower alkoxy lower alkyl; (di-lower alkyl) amino lower alkyl, Y1-C6H4-lower alkyl, lower alkoxy, Y1-C6H4-, naphtyl, furyl, thienyl or pyridyl; R6 and R7 are independently hydrogen, lower alkyl or substituted lower alkyl wherein the substituents are hydroxy, lower alkoxy, lower alkoxy lower alkoxy, halogeno, halogeno lower alkoxy, amino, mono- or di-lower alkylamino, heterocycloalkyl, lower alkyl heterocycloalkyl, aryl, substituted aryl or an optionally substituted 5-6 membered saturated ring comprising 1-2 oxygen atoms as ring members; or R6 and R7 together with the nitrogen to which they are attached complete a 5-7 membered ring, wherein the ring optionally comprises a nitrogen atom, an alkyl-substituted nitrogen atom or an oxygen atom, and wherein the ring is optionally substituted on the ring carbon atoms; R8 is hydrogen, alkyl, carboxyalkyl, mercaptoalkyl, alkylthioalkyl, aminoalkyl, hydroxyalkyl, phenylalkyl, hydroxyphenylalkyl, guanidinoalkyl, imidazolylalkyl, indolylalkyl or carbamoylalkyl; n is 0-3; A is (c), (d), (e) or (f); X and X1 are a bond, -O-, -S-, or -CH2-; Y, Y1 and Y2 are hydrogen, lower alkyl, cyclolower alkyl, lower alkoxy, OH, F, Cl, Br, I, -CN, -CO2H, -CO2-lower alkyl, -CH2NH2, -CONH2 or aryl; and the pharmaceutically acceptable acid addition salts thereof useful as analgesics as well as in the treatment of hypertension and congestive heart failure and combinations of mercapto acylamino acids and atrial natriuretic factors and angiotensin converting enzyme inhibitors useful for treating hypertension and congestive heart failure are disclosed.

10. 发明申请

WO1989007102A1 NULCEOSIDETYPE COMPOUNDS WHICH ARE PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译： NULCEOSIDETYPE化合物是磷酸二酯酶抑制剂
公开(公告)号：WO1989007102A1
公开(公告)日：1989-08-10
申请号：PCT/US1989000409
申请日：1989-02-06
申请人： SCHERING CORPORATION , TULSHIAN, Deen , DOLL, Ronald, James
发明人： SCHERING CORPORATION
IPC分类号： C07D473/18
CPC分类号： C07D307/935 , C07C61/13 , C07C61/29 , C07C62/06 , C07C62/32 , C07D473/00 , C07D473/30 , C07D473/40
摘要： Compounds having an optionally-substituted purine derivative portion and a carbobicyclic or heterobicyclic portion, which compounds are useful as phosphodiesterase inhibitors, are disclosed. Also disclosed are intermediates, methods for making the inhibitors, pharmaceutical compositions and methods for treating hypertension using the compounds.

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