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    • 2. 发明申请
    • FURANONE ENDOTHELIN ANTAGONISTS
    • FURANONE内皮素拮抗剂
    • WO1997008169A1
    • 1997-03-06
    • PCT/US1996012431
    • 1996-07-29
    • WARNER-LAMBERT COMPANYCHENG, Xue-MinDOHERTY, Annette, MarianPATT, William, ChesterREPINE, Joseph, Thomas
    • WARNER-LAMBERT COMPANY
    • C07D407/04
    • C07D407/04C07D307/58
    • Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prostatic hyperplasia (BPH), and diabetes.
    • 描述了内皮素(I)的新型非肽拮抗剂,以及其制备方法及其药物组合物,其可用于治疗高水平的内皮素,急性和慢性肾衰竭,高血压,心肌梗塞,心肌缺血,脑 血管痉挛,脑缺血,脑梗塞,肝硬化,脓毒性休克,充血性心力衰竭,内毒素性休克,蛛网膜下腔出血,心律失常,哮喘,先兆子痫,动脉粥样硬化疾病包括雷诺氏病和再狭窄,心绞痛,癌症,肺动脉高压,缺血性疾病,胃粘膜损伤 ,出血性休克,缺血性肠病,中风,良性前列腺增生(BPH)和糖尿病。
    • 6. 发明申请
    • NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY
    • 非特异性内皮素拮抗剂具有增加的水溶性
    • WO1997037985A1
    • 1997-10-16
    • PCT/US1997003929
    • 1997-03-12
    • WARNER-LAMBERT COMPANYCHENG, Xue-MinDOHERTY, Annette, MarianPATT, William, ChesterREPINE, Joseph, Thomas
    • WARNER-LAMBERT COMPANY
    • C07D307/60
    • C07D407/04C07D307/60
    • Novel nonpeptide antagonists of endothelin (I) are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating atherosclerosis, restenosis, Raynaud's phenomenon, mild or severe congestive heart failure, cerebral ischemia, cerebral infarction, embolic stroke, cerebral vasospasm, glaucoma, subarachnoid hemorrhage, hemorrhagic stroke, diabetes, gastric ulceration and mucosal damage, ischemic bowel disease, Chrohn's disease, male penile erectile dysfunction, essential or malignant hypertension, pulmonary hypertension, pulmonary hypertension after bypass, cancer, especially malignant hemangioendothelioma or prostate cancer, myocardial infarction or ischemia, acute or chronic renal failure, renal ischemia, radiocontrast-induced nephrotoxicity, endotoxic, septic, hemorrhagic shock, angina, preeclampsia, asthma, arrhythmias, benign prostatic hyperplasia, and elevated levels of endothelin.
    • 描述了内皮素(I)的新型非肽拮抗剂,以及其制备方法及其药物组合物,其可用于治疗动脉粥样硬化,再狭窄,雷诺氏现象,轻度或严重充血性心力衰竭,脑缺血,脑梗死, 栓塞性中风,脑血管痉挛,青光眼,蛛网膜下腔出血,出血性中风,糖尿病,胃溃疡和粘膜损伤,缺血性肠病,克罗恩病,男性阴茎勃起功能障碍,基本或恶性高血压,肺动脉高压,旁路后肺动脉高压,癌症 恶性血管内皮瘤或前列腺癌,心肌梗死或缺血,急性或慢性肾功能衰竭,肾缺血,放射性对照诱导的肾毒性,内毒素,败血症,出血性休克,心绞痛,先兆子痫,哮喘,心律失常,良性前列腺增生和内皮素水平升高。