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1. 发明专利

JPS6327744A METHOD AND DEVICE FOR GENERATING TEMPERATURE GRADIENT ENABLING CONTROL AND REPRODUCTION 失效
公开(公告)号：JPS6327744A
公开(公告)日：1988-02-05
申请号：JP16767387
申请日：1987-07-03
申请人： DIAGEN INST MOLEKULARBIO
发明人： FUORUKAA ROOZENBAUMU , DEETOREFU RIISUNAA
IPC分类号： B01D43/00 , B01D57/02 , B01L7/00 , C02F9/00 , G01N27/26 , G01N27/447 , G01N30/30 , G01N30/90

2. 发明专利

JP2001095572A METHOD AND APPARATUS FOR ISOLATING AND PURIFYING NUCLEIC ACID 失效
公开(公告)号：JP2001095572A
公开(公告)日：2001-04-10
申请号：JP2000223370
申请日：2000-07-25
申请人： DIAGEN GMBH
发明人： COLPAN METIN
IPC分类号： C12N15/09 , B01D15/00 , B01D15/04 , B01D39/00 , B01D39/16 , B01D39/20 , B01J41/04 , C12M1/00 , C12M1/12 , C12N1/08 , C12N15/10 , C12Q1/68 , G01N30/88 , G01N33/50 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To develop both a method for isolating and purifying a nucleic acid such as a plasmid or a genomic DNA from a cell and other raw materials and an apparatus for carrying out the method. SOLUTION: This method for isolating and purifying a nucleic acid comprises (a) removing cell fragments and other particles with a filter layer reducing the pore diameter viewed in the flow direction or the direction to make a sample flow and (b) then treating the resultant eluate with an anion exchanger in a buffer solution at a low ionic strength or a high ionic strength. The apparatus for isolating and purifying the nucleic acid comprises at least one filter layer 12, 20, 21 or 22 arranged on the upstream side of a layer 10 having anion exchange characteristics or a layer 11 capable of binding the nucleic acid in the respective solutions at a high ionic strength and fixed between two means 5 and 6 in the interior of a substantially cylindrical hollow unit 1 when viewed from the direction of an inlet opening 7.

3. 发明专利

JPS6372699A SEPARATION AND PURIFICATION OF VITAL MACROPOLYMER BY AFINITY CHROMATOGRAPHY 失效
公开(公告)号：JPS6372699A
公开(公告)日：1988-04-02
申请号：JP19799187
申请日：1987-08-07
申请人： DIAGEN INST MOLEKULARBIO
发明人： MEETEIN KORUPAN
IPC分类号： B01J20/281 , A61K39/00 , B01D15/08 , B01J20/32 , C07K1/16 , C07K1/22 , C07K14/52 , C07K16/00 , C07K16/06 , C12N5/00 , G01N30/88

4. 发明申请

US20160068572A1 NEW STABLE PENTADECAPEPTIDE SALTS, A PROCESS FOR PREPARATION THEREOF, A USE THEREOF IN THE MANUFACTURE OF PHARMACEUTICAL PREPARATIONS AND A USE THEREOF IN THERAPY 有权
标题翻译：新型稳定的口香糖类药物，其制备方法，在药物制剂的制造中的应用及其在治疗中的应用
公开(公告)号：US20160068572A1
公开(公告)日：2016-03-10
申请号：US14774457
申请日：2013-05-09
申请人： DIAGEN D.O.O.
发明人： Rudolf RUCMAN
IPC分类号： C07K7/08 , A61K38/10 , A23L1/30 , A61K45/06
CPC分类号： C07K7/08 , A23L33/10 , A23V2002/00 , A61K38/10 , A61K45/06 , Y02A50/463 , A61K2300/00
摘要： The present invention discloses new stable pentadecapeptide salts of formula (I): (I) SEQ ID NO 1 Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala 1 5 10 Gly Leu Val · n BAA 15 wherein n means 1, 2 or 3, and BAA means basic amino acid, a process for the preparation thereof, a process for the use thereof for the manufacture of pharmaceutical formulations in liquid and solid form and a use thereof for prevention, protection in treatment of diseases and disease conditions and for the preparation of formulations for use as food supplements.
摘要翻译：本发明公开了新的稳定的式（I）十五肽盐：（I）SEQ ID NO 1 Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala 1 5 10 Gly Leu Val·n BAA 15其中n表示1,2或 3，BAA是指碱性氨基酸，其制备方法，其用于制备液体和固体形式的药物制剂的方法及其用于预防，治疗疾病和疾病状况的保护和用于制剂用作食品添加剂。

5. 发明授权

US09850282B2 Stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy 有权
公开(公告)号：US09850282B2
公开(公告)日：2017-12-26
申请号：US14774457
申请日：2013-05-09
申请人： DIAGEN D.O.O.
发明人： Rudolf Rucman
IPC分类号： A61K38/10 , A61K45/06 , C07K7/08 , A23L1/30 , A23L33/10
CPC分类号： C07K7/08 , A23L33/10 , A23V2002/00 , A61K38/10 , A61K45/06 , Y02A50/463 , A61K2300/00
摘要： Stable pentadecapeptide salts of formula (I): (I) SEQ ID NO 1 Gly Glu Pro Pro Pro Gly Lys Pro Ala Asp Asp Ala 1 5 10 Gly Leu Val · n BAA 15 wherein n means 1, 2 or 3, and BAA means basic amino acid, a process for the preparation thereof, a process for the use thereof for the manufacture of pharmaceutical formulations in liquid and solid form and a use thereof for prevention, protection in treatment of diseases and disease conditions and for the preparation of formulations for use as food supplements are described.

6. 发明申请

US20020119478A1 Methods for detection of nucleic acid sequences in urine 审中-公开
公开(公告)号：US20020119478A1
公开(公告)日：2002-08-29
申请号：US10007607
申请日：2001-11-07
申请人： Diagen Corporation
发明人： Samuil R. Umansky , Anatoly V. Lichtenstein , Hovsep S. Melkonyan
IPC分类号： C12Q001/68 , C12P019/34
CPC分类号： C12Q1/6806 , C12Q1/6879 , C12Q1/6883 , C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , C12Q2527/125 , C12Q2525/125
摘要： Described are non-invasive methods of detecting the presence of specific nucleic acid sequences as well as nucleic acid modifications and alterations by analyzing urine samples for the presence of transrenal nucleic acids. More specifically, the present invention encompasses methods of detecting specific fetal nucleic acid sequences and fetal sequences that contained modified nucleotides by analyzing maternal urine for the presence of fetal nucleic acids. The invention further encompasses methods of detecting specific nucleic acid modifications for the diagnosis of diseases, such as cancer and pathogen infections, and detection of genetic predisposition to various diseases. The invention specifically encompasses methods of analyzing specific nucleic acid modifications for the monitoring of cancer treatment. The invention further encompasses methods of analyzing specific nucleic acids in urine to track the success of transplanted cells, tissues and organs. The invention also encompasses methods for evaluating the effects of environmental factors and aging on the genome.

7. 发明专利

JP2002187897A METHOD FOR SEPARATION OF DOUBLE-STRANDED/SINGLE- STRANDED NUCLEIC ACID STRUCTURE 审中-公开
公开(公告)号：JP2002187897A
公开(公告)日：2002-07-05
申请号：JP2001288689
申请日：2001-09-21
申请人： DIAGEN GMBH
发明人： BASTIAN HELGE , GAUCH SIMONE , COLPAN METIN , FEUSER PETRA
IPC分类号： C07H1/06 , B01J20/281 , B01J20/283 , B01J20/285 , C07H1/08 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/09 , C12N15/10 , C12Q1/68 , C12Q1/6806 , G01N30/26 , G01N30/88 , G01N30/48
摘要： PROBLEM TO BE SOLVED: To provide a method for separating a nucleic acid mixture into double- stranded and single-stranded nucleic acid fractions thereof by a chromatography. SOLUTION: This method comprises simultaneously adsorbing the nucleic acids in whole to an mineral support and then separating into the double- stranded and single-stranded nucleic acids by a fractional elution or selectively adsorbing the double-stranded or single-stranded nucleic acid of a sample to the mineral support and comprises supplying a solution prepared so as to comprise a raw material containing a nucleic acid, comprise a substance complexing an alkaline earth metal ion and contain no substance having an alcohol group to the mineral support to mainly adsorb the double-stranded nucleic acid to the mineral support and eluting the double-stranded nucleic acid adsorbed on the mineral support under the condition having a low ionic strength or with water after a washing step optionally carried out after the adsorption.

9. 发明专利

JPS63150294A SEPARATION OF LONG CHAIN NUCLEIC ACID 失效
公开(公告)号：JPS63150294A
公开(公告)日：1988-06-22
申请号：JP29594787
申请日：1987-11-24
申请人： DIAGEN INST MOLEKULARBIO
发明人： KARUSHIYUTEN HENKO , ARUNTO SHIYUTEIHERU , METEIN KORUPAN
IPC分类号： B01J20/281 , A61K38/00 , A61K39/395 , B01J20/00 , C07H1/08 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/10 , C12P19/34 , G01N30/60 , G01N30/88

10. 发明申请

WO1993011221A1 DEVICE AND PROCESS FOR ISOLATING AND PURIFYING NUCLEIC ACIDS 审中-公开
标题翻译：用于分离和纯化核酸的装置和方法
公开(公告)号：WO1993011221A1
公开(公告)日：1993-06-10
申请号：PCT/EP1992002775
申请日：1992-12-01
申请人： DIAGEN INSTITUT FUR MOLEKULARBIOLOGISCHE ... , COLPAN, Metin
发明人： DIAGEN INSTITUT FUR MOLEKULARBIOLOGISCHE ...
IPC分类号： C12N01/08
CPC分类号： C12N15/101 , B01D39/00 , C12N15/1017 , Y10T436/25375 , Y10T436/255
摘要： The description relates to a process for isolating and purifying nucleic acids like plasmide or genomic DNA from cells or other sources in which: a) the cells containing nucleic acid are disinte grated and the cell fragments removed or other nucleic acid-containing samples are treated with anion exchangers in buffer solutions of low ionic strength; b) the nucleic acids are then desorbed from the anion exchanger using a buffer of higher ionic strength in order then c) to be treated in the higher ionic-strength buffer or in the presence of lower alcohols and/or polyethylene glycol with a mineral base material with the adsorption of the nucleic acid on the surface of the mineral base, whereupon d) the nucleic acid is desorbed with water or a lower ionic-strength buffer solution. The device for implementing the process of the invention consists of a hollow body (1) with an inlet aperture (7) and an outlet aperture (8), in which a powdered first silica-gel-based material (10) is inserted into the hollow body (1) between two securing devices (5 and 6) and a second material (11) is arranged between the first material (10) and the outlet aperture, whereby the first and second materials (10, 11) have different adsorption characteristics for nucleic acids.
摘要翻译：描述涉及从细胞或其他来源分离和纯化核酸如质粒或基因组DNA的方法，其中：a）将含有核酸的细胞破碎，除去细胞片段或其他含核酸的样品用阴离子交换剂在低离子强度的缓冲溶液中; b）然后使用较高离子强度的缓冲液将核酸从阴离子交换器中解吸，然后c）在较高离子强度缓冲液中或在低级醇和/或聚乙二醇存在下与矿物碱进行处理在核酸表面吸附核酸的材料，d）核酸用水或较低离子强度的缓冲溶液解吸。用于实施本发明方法的装置包括具有入口孔（7）和出口孔（8）的中空体（1），其中将粉末状第一硅胶基材料（10）插入在第一材料（10）和出口孔之间布置有位于两个固定装置（5和6）和第二材料（11）之间的空心体（1），由此第一和第二材料（10,11）具有不同的吸附特性用于核酸。

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