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1. 发明授权

US08759304B2 Compositions and methods for increasing telomerase activity 有权
标题翻译：用于增加端粒酶活性的组合物和方法
公开(公告)号：US08759304B2
公开(公告)日：2014-06-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
IPC分类号： A61K31/70 , A01N45/00 , C07J3/00
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译：本发明涉及增加细胞中端粒酶活性的方法和组合物。这样的组合物包括药物，包括局部和营养制剂。所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。

2. 发明授权

US08033037B2 Ironing station 有权
标题翻译：熨烫台
公开(公告)号：US08033037B2
公开(公告)日：2011-10-11
申请号：US12497919
申请日：2009-07-06
申请人： Lorraine L. Achterberg , James William Kendall , David M. Miller , Ronald M. Nowell, Jr. , William J. Schill, Jr. , Richard A. Sunshine , Ameresh Babu Viswanathan , Vicki Lyn Wyatt
发明人： Lorraine L. Achterberg , James William Kendall , David M. Miller , Ronald M. Nowell, Jr. , William J. Schill, Jr. , Richard A. Sunshine , Ameresh Babu Viswanathan , Vicki Lyn Wyatt
IPC分类号： D06F81/00 , D06F81/06
CPC分类号： A47B46/00 , A47B77/10 , D06F81/00 , D06F81/003
摘要： An ironing station has a cabinet defining an interior space, an accessible storage area defined within the interior space of the cabinet, an ironing board stowably mounted in the cabinet for movement between a stowed position and a use position. The ironing board can be coupled to the cabinet via a non-vertical guide rail. A handle can be coupled to the ironing board to aid a user in moving the ironing board between the stowed and use positions. A multi-position docking station can be provided on the top wall of the cabinet for receiving an iron. A cover can be provided for selectively covering the docking station.
摘要翻译：熨烫站具有限定内部空间的机柜，限定在机柜内部空间内的可访问存储区域，可收容地安装在机柜中的熨衣板，用于在收起位置和使用位置之间移动。熨衣板可以通过非垂直导轨连接到机柜。手柄可以连接到熨衣板，以帮助使用者在收起和使用位置之间移动熨衣板。可以在机柜的顶壁上设置多位置对接站，用于接收熨斗。可以提供用于选择性地覆盖坞站的盖。

3. 发明授权

US07647430B2 Remote command framework for devices 有权
标题翻译：设备的远程命令框架
公开(公告)号：US07647430B2
公开(公告)日：2010-01-12
申请号：US11038632
申请日：2005-01-19
申请人： Norman N. Ng , Michael P. Hart , David M. Miller , Jonathan Wilkins , Kenneth Fern , Markham F. MacLin , Peter S. Ford , Scott D. Sanders , Walter VonKoch
发明人： Norman N. Ng , Michael P. Hart , David M. Miller , Jonathan Wilkins , Kenneth Fern , Markham F. MacLin , Peter S. Ford , Scott D. Sanders , Walter VonKoch
IPC分类号： G06F3/00 , G06F15/16 , G06F11/00
CPC分类号： H04L12/2823 , H04L2012/2849
摘要： A robust device messaging framework is disclosed that enables a user to send commands to a device. A provisioning service is used to provision unique device identities and maps user web identities to device identities. The provisioning service also limits device per day provisioning attempts to limit denial of service attacks. A command service allows remote users to issue commands to a device, synchronize outgoing commands with incoming results, receive accurate feedback about whether a command was received, and maintain state information about the device. A device layer encrypts and stores device identities, authenticates itself with the command service, establishes a high-availability Internet connection to receive alerts that a command has issued, and reports results to the server-based command service.
摘要翻译：公开了一种强大的设备消息传递框架，使得用户能够向设备发送命令。配置服务用于提供唯一的设备身份，并将用户网络身份映射到设备身份。配置服务还限制每天的设备配置尝试限制拒绝服务攻击。命令服务允许远程用户向设备发出命令，将传出命令与传入结果进行同步，接收关于命令是否收到的准确反馈，以及维护有关设备的状态信息。设备层加密并存储设备标识，使用命令服务对其进行身份验证，建立高可用性Internet连接以接收命令发出的警报，并将结果报告给基于服务器的命令服务。

4. 发明授权

US07254545B2 Speech controls for use with a speech system 有权
标题翻译：用于语音系统的语音控制
公开(公告)号：US07254545B2
公开(公告)日：2007-08-07
申请号：US11265636
申请日：2005-11-02
申请人： Stephen R Falcon , Clement Chun Pong Yip , Dan Banay , David M Miller
发明人： Stephen R Falcon , Clement Chun Pong Yip , Dan Banay , David M Miller
IPC分类号： G10L21/00
CPC分类号： G10L15/193
摘要： Systems and methods are described for a speech system that includes one or more speech controls incorporated into one or more speech-enabled applications that run on the speech system. The controls allow applications to be developed with minimal programming effort to incorporate common speech-enabled application functions. A question control provides a customizable template for requesting information from a user. An announcer control allows a speech-enabled application to provide a user with information without having to re-create an entire announcer process each time it is used. A command control provides a simple way to attach command and control functions to speech-enabled applications. A word trainer control provides a way to associate user-selected voice tags with certain information. Providing the controls for use with speech-enabled applications ensures standardized user interfaces across multiple speech-enabled applications.
摘要翻译：描述了用于语音系统的系统和方法，该语音系统包括结合到在语音系统上运行的一个或多个支持语音的应用中的一个或多个语音控制。该控件允许以最少的编程工作来开发应用程序，以结合通用的支持语音的应用程序功能。问题控件提供用于从用户请求信息的可定制模板。播音员控制允许支持语音的应用程序向用户提供信息，而无需在每次使用时重新创建整个播音员进程。命令控制提供了一种将命令和控制功能附加到支持语音的应用程序的简单方法。字培训者控制提供了一种将用户选择的语音标签与某些信息相关联的方式。提供与语音使能应用程序一起使用的控件可确保跨多个支持语音的应用程序的标准化用户界面。

5. 发明授权

US3953220A Refractory celsian glass-ceramics 失效
$Refractory celsian glass-ceramics$
标题翻译：耐火玻璃陶瓷
公开(公告)号：US3953220A
公开(公告)日：1976-04-27
申请号：US492053
申请日：1974-07-26
申请人： David M. Miller
发明人： David M. Miller
IPC分类号： C03C10/00 , C03C3/22 , C03B32/00
CPC分类号： C03C10/0036
摘要： The present invention is concerned with the production of glass-ceramic articles wherein the crystal phase consists essentially of celsian (BaO.Al.sub.2 O.sub.3.2SiO.sub.2) with a minor amount of rutile (TiO.sub.2). Such articles consist essentially, by weight, of about 20-40% SiO.sub.2, 20-35% Al.sub.2 O.sub.3, 20-35% BaO, 5-15% PbO and/or 2-15% P.sub.2 O.sub.5, and 7-12% TiO.sub.2. Such articles can have a use temperature up to about 1250.degree.C, exhibit a coefficient of thermal expansion (room temperature to 900.degree.C) between about 35-50 .times. 10.sup.-.sup.7 /.degree.C, may demonstrate modulus of rupture values in excess of 20,000 psi, and will have a high density (about 3.1-3.5 g/cc), thereby recommending their utility as heat transfer media in a process such as that devised for extracting oil from oil-containing shale.
摘要翻译：本发明涉及玻璃陶瓷制品的生产，其中晶相基本上由具有少量金红石（TiO 2）的凝胶（BaO.Al2O3.2SiO2）组成。这些制品基本上由约20-40％SiO 2，20-35％Al 2 O 3，20-35％BaO，5-15％PbO和/或2-15％P 2 O 5和7-12％TiO 2组成。这种制品的使用温度可达1250℃左右，在35-50×10-7 /℃之间呈现出热膨胀系数（室温至900℃），可显示出断裂模数超过20,000psi，并且将具有高密度（约3.1-3.5g / cc），从而推荐其在诸如用于从含油页岩中提取油的过程中作为传热介质的实用性。

6. 发明授权

US09248020B2 Ceramic monoblock implants with osseointegration fixation surfaces 有权
标题翻译：陶瓷整体植入物与骨整合固定面
公开(公告)号：US09248020B2
公开(公告)日：2016-02-02
申请号：US13885918
申请日：2011-11-16
申请人： Oludele O. Popoola , David M. Miller , Jeffrey P. Anderson , Brian H. Thomas
发明人： Oludele O. Popoola , David M. Miller , Jeffrey P. Anderson , Brian H. Thomas
IPC分类号： A61F2/28 , A61L27/06 , A61L27/10 , A61L27/30
CPC分类号： A61F2/28 , A61L27/06 , A61L27/10 , A61L27/306
摘要： Monoblock orthopedic and/or dental implants are disclosed. The monoblock implants include a ceramic articulating surface and an osseointegrative bone-contacting surface. Methods of making such implants also disclosed.
摘要翻译：公开了单块矫形和/或牙科植入物。整体植入物包括陶瓷关节表面和骨整合骨接触表面。还公开了制造这种植入物的方法。

7. 发明授权

US08642112B2 Thermally treated ceramic coating for implants 有权
标题翻译：用于植入物的热处理陶瓷涂层
公开(公告)号：US08642112B2
公开(公告)日：2014-02-04
申请号：US12503535
申请日：2009-07-15
申请人： Joel G. Scrafton , Jeffrey P. Anderson , David M. Miller , Oludele O. Popoola
发明人： Joel G. Scrafton , Jeffrey P. Anderson , David M. Miller , Oludele O. Popoola
IPC分类号： A61L33/00
CPC分类号： A61L27/30 , A61L27/306 , A61L2430/24
摘要： A prosthetic implant having a thermally treated ceramic coating and a method of producing a coated prosthetic implant. The ceramic coating is deposited onto the prosthetic implant such as by a plasma spray coating process. The prosthetic implant is thermally treated in a low oxygen environment to increase the hardness and wear-resistance of the ceramic coating for improved articulation of the prosthetic implant.
摘要翻译：具有热处理的陶瓷涂层的假体植入物和制造涂覆的假体植入物的方法。陶瓷涂层例如通过等离子体喷涂工艺沉积到假体植入物上。假体植入物在低氧环境中被热处理以增加陶瓷涂层的硬度和耐磨性，以改善假体植入物的关节连接。

8. 发明申请

US20110071095A1 Compositions and Methods for Increasing Telomerase Activity 有权
标题翻译：增加端粒酶活性的组成和方法
公开(公告)号：US20110071095A1
公开(公告)日：2011-03-24
申请号：US12718812
申请日：2010-03-05
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Yung-hou Wong , David M. Miller-Martini
IPC分类号： A61K31/7048 , C07D307/12 , A61K31/58 , C07H17/04 , A61P17/02 , A61P29/00 , A61P1/04 , C12N5/071 , C12N5/077 , C12Q1/02 , A61P31/18 , A61P25/28 , A61P9/10 , A61P7/06 , A61P27/02 , A61P19/02 , A61P19/08
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin ailments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译：本发明涉及增加细胞中端粒酶活性的方法和组合物。这样的组合物包括药物，包括局部和营养制剂。所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病以及急性或慢性皮肤疾病中端粒酶活性增加而治疗的疾病。它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。

9. 发明申请

US20080113925A1 Compositions and Methods for Increasing Telomerase Activity 有权
标题翻译：增加端粒酶活性的组成和方法
公开(公告)号：US20080113925A1
公开(公告)日：2008-05-15
申请号：US10562374
申请日：2004-06-23
申请人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
发明人： Calvin Bruce Harley , Allison C. Chin , Tsutomu Akama , Nancy Yuk-yu Ip , Wong Yung-hou , David M. Miller-Martini
IPC分类号： A61K31/704 , A61K31/58
CPC分类号： A61K31/7048 , A61K31/56 , A61K31/58 , A61K36/481 , C07J1/00
摘要： The present invention relates to methods and compositions for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The methods and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.
摘要翻译：本发明涉及增加细胞中端粒酶活性的方法和组合物。这样的组合物包括药物，包括局部和营养制剂。所述方法和组合物可用于治疗患者的细胞或组织中例如HIV感染，各种退行性疾病和急性或慢性皮肤营养物质中端粒酶活性增加而治疗的疾病。它们也可用于增强培养细胞的复制能力，如离体细胞治疗和干细胞增殖。

10. 发明授权

US4530166A Preheating particulate material 失效
标题翻译：预热颗粒材料
公开(公告)号：US4530166A
公开(公告)日：1985-07-23
申请号：US584028
申请日：1984-02-27
申请人： David M. Miller
发明人： David M. Miller
IPC分类号： C03B3/02 , F26B3/20 , F26B3/24
CPC分类号： C03B3/023 , F26B3/205 , Y02P40/56
摘要： A process for preheating particulate material is disclosed. The process also may be used for drying the particulate. The invention uses a heat exchange method that preferably employs furnace exhaust gases. In one embodiment, glass batch is preheated before being fed to a melting furnace. The invention involves the use of glass-ceramic materials as the heat exchange media.
摘要翻译：公开了一种预热颗粒材料的方法。该方法也可用于干燥颗粒。本发明采用优选采用炉废气的热交换方法。在一个实施方案中，玻璃批料在被送入熔化炉之前被预热。本发明涉及使用玻璃 - 陶瓷材料作为热交换介质。

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