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    • 3. 发明公开
    • KININOGENASE INHIBITORS
    • 激肽原酶抑制剂。
    • EP0652893A1
    • 1995-05-17
    • EP91915557.0
    • 1991-09-02
    • SZELKE, MichaelEVANS, David MichaelJONES, David Michael
    • SZELKE, Michael "Southview" BraishfieldEVANS, David, Michael 114 Adelaide Road St. DenysJONES, David, Michael "Sundew" Slab Lane
    • A61K38A61P9A61P25A61P29A61P37C07K5C07K14
    • C07K5/02C07K5/0227
    • Kininogenase inhibitors, optimally not exceeding the size of a hexapeptide, represented by (II), wherein A and B = amino acyl (including amino acyl analogue) the same or different forming a dipeptide group the amino acid of A carrying a terminal group and being any amino or imino-acid residue (but preferably of D-configuration) and of B being a lipophilic amino-acid residue of D- or L-configuration but not proline or a proline analogue, or a conformational analogue of said dipeptide group wherein the peptide link is replaced by -CH2-NH- ('reduced'), -CH(OH)-CH2- ('hydroxy'), -CO-CH2 ('keto'), -CH2-CH2- ('hydrocarbon') or other conformational mimic of the peptide bond and in (III) the side chain R1 is that of a basic amino acid or amino acid analogue (preferably of L-configuration), and R is H or lower alkyl(C¿1?-C4) or C?α¿ or the peptide link comprising -N(R)- is replaced leading to a conformational mimic as above; Y = a binding enhancing or carbonyl activating group preferably selected from H (when A or B must be cyclohexylalanine, preferably D if at A or L if at B) or alkyl (C¿1?-C20) or fluoroalkyl (C2-C12); substituted oxymethylene; thiomethylene; sulphoxymethylene; sulphonylmethylene; aminomethylene; hydrazino-methylene; -CH2-Het (where Het = a substituted or unsubstituted heterocycle); substituted amino (but when the resulting compound is a secondary alkylamide B must not be phenylalanine); an amino-acid group or its ester or amide; a carboxylic secondary amide or primary amide, when B must be cyclohexylalanine or adamantylalanine or other bulky lipophilic, non-aromatic amino-acid (not Ala Leu Ile Val Nva Met Nle Phe Tyr Trp Nal (1)); tertiary-carboxamide; carboxy-alkyl group or its ester or amide or amino acyl derivative.
    • 8. 发明公开
    • Apparatus for improving efficiency and emissions of combustion
    • Vorrichtung zur Verbesserung der Verbrennungseffizienz und -emissionen
    • EP2078844A2
    • 2009-07-15
    • EP09250062.8
    • 2009-01-09
    • Clack, David Michael
    • Clack, David Michael
    • F02M25/12
    • F02M25/12F02M27/02Y02T10/121
    • An apparatus improves the efficiency and emissions of a combustion process by producing sufficient amounts of ozone in the air flow to the combustion chamber to enable more complete and cleaner combustion of the fuel. The apparatus may include a plurality of cell elements disposed within a housing that is in placed in the air intake to a combustion chamber such as a diesel engine. The cell elements create an electrical plasma field that produces ozone. The apparatus may also include a scrubber in the housing to cause the air flow to have a vortex action to increase the amount of ozone that flows into the combustion chamber.
    • 一种装置通过在燃烧室的空气流中产生足够量的臭氧以使燃料更加完整和更清洁地燃烧来提高燃烧过程的效率和排放。 该装置可以包括设置在外壳内的多个电池元件,其被放置在诸如柴油发动机的燃烧室的进气口中。 电池元件产生产生臭氧的电等离子体场。 该装置还可以包括在壳体中的洗涤器,以使气流具有涡流作用以增加流入燃烧室的臭氧的量。