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1. 发明授权

US08367704B2 Process for preparation of 2-methyl-2′ phenylpropionic acid derivatives and novel intermediate compounds 失效
标题翻译： 2-甲基-2'苯基丙酸衍生物和新型中间体化合物的制备方法
公开(公告)号：US08367704B2
公开(公告)日：2013-02-05
申请号：US12865234
申请日：2009-02-12
申请人： Chun-Ho Lee , Ja-Heouk Khoo , Kyoung-Chan Kwon , Hyun Ju
发明人： Chun-Ho Lee , Ja-Heouk Khoo , Kyoung-Chan Kwon , Hyun Ju
IPC分类号： A61K31/445 , C07D401/04 , C07D413/14
CPC分类号： C07D401/04 , C07C67/31 , C07C67/46 , C07C69/612
摘要： The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
摘要翻译：本发明涉及以更简化的方式制备显示抗组胺活性的2-甲基-2'-苯基丙酸衍生物的方法，中间体化合物及其制备方法。根据本发明，可以以工业规模高产率和纯度制备药学上可用的2-甲基-2'-苯基丙酸衍生物。

2. 发明申请

US20120099594A1 MEDIA DISTRIBUTION ARCHITECTURE 审中-公开
标题翻译：媒体分配架构
公开(公告)号：US20120099594A1
公开(公告)日：2012-04-26
申请号：US13278799
申请日：2011-10-21
申请人： Dannie Lau , Chun Ho Lee
发明人： Dannie Lau , Chun Ho Lee
IPC分类号： H04L12/56
CPC分类号： H04L12/2807 , H04L12/282 , H04L65/4076 , H04L65/605 , H04L65/80 , H04L2012/2841 , H04N21/4307 , H04N21/43637 , H04N21/44227 , H04N21/443 , H04N21/4516 , H04N21/485
摘要： A wired and wireless media transport technology is provided that allows for the simultaneous transmission of media to multiple zones while maintaining precise timing synchronization. A user can have a network of speakers, and independently select which ones are actively playing and have their playback synchronized. The media source can be a cell phone, tablet, stereo, set-top box, PC or other device. The media itself can be audio or video. The transmission method of media into the network can be wired, as through an auxiliary cable, or wireless as with Bluetooth or WiFi. The speakers/endpoints themselves are governed in a self-forming network. Audio is injected into the network from a source and the end-point network itself controls audio/video distribution, timing, and rendering.
摘要翻译：提供了有线和无线媒体传输技术，其允许将媒体同时传输到多个区域，同时保持精确的定时同步。用户可以拥有一个扬声器网络，并且独立地选择正在播放哪些播放器并使其播放同步。媒体来源可以是手机，平板电脑，立体声，机顶盒，PC或其他设备。媒体本身可以是音频或视频。介质进入网络的传输方式可以通过辅助电缆，或者与蓝牙或WiFi一样无线连接。扬声器/端点本身在自我形成网络中进行管理。音频从源头注入网络，端点网络本身控制音频/视频分配，定时和渲染。

3. 发明申请

US20100063041A1 NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED GAMMA RECEPTOR MODULATORS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新戊二酸衍生物作为过氧化物促进剂活化的游离体受体调节剂，其方法和包含其的药物组合物
公开(公告)号：US20100063041A1
公开(公告)日：2010-03-11
申请号：US12449979
申请日：2008-03-07
申请人： Ho-Sang Moon , Moo-Hi Yoo , Soon-Hoe Kim , Joong-In Lim , Moon-Ho Son , Mi-Kyung Kim , Chang-Yell Shin , Jin-Kwan Kim , Sang-Kuk Park , Yu-Na Chae , Hyun-Joo Shim , Sun-Ho Jeon , Hae-Sun Kim , Gil-Tae Wie , Dong-Hwan Kim , Byung-Kyu Lee , Chan-Sun Park , Byung-Nak Ahn , Eunkyung Kim , Myung-Ho Bae , Young-Ah Shin , Youn Hur , Chun-Ho Lee , Hyun-Ho Choi , Bongtae Kim , Wonee Chong
发明人： Ho-Sang Moon , Moo-Hi Yoo , Soon-Hoe Kim , Joong-In Lim , Moon-Ho Son , Mi-Kyung Kim , Chang-Yell Shin , Jin-Kwan Kim , Sang-Kuk Park , Yu-Na Chae , Hyun-Joo Shim , Sun-Ho Jeon , Hae-Sun Kim , Gil-Tae Wie , Dong-Hwan Kim , Byung-Kyu Lee , Chan-Sun Park , Byung-Nak Ahn , Eunkyung Kim , Myung-Ho Bae , Young-Ah Shin , Youn Hur , Chun-Ho Lee , Hyun-Ho Choi , Bongtae Kim , Wonee Chong
IPC分类号： A61K31/538 , C07D333/16 , A61K31/381 , C07D413/02 , A61K31/5377 , A61K31/5355 , C07D277/20 , A61K31/426 , C07D409/02 , A61K31/501 , C07D498/02 , A61P3/10 , A61P3/06
CPC分类号： C07D333/16 , C07D277/24 , C07D307/42 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.
摘要翻译：本发明提供了一种新的苯丙酸衍生物和包含其作为活性成分的PPAR-γ调节剂。本发明的苯基丙酸衍生物对PPAR-γ的功能具有调节作用，然后对PPAR介导的疾病或病症表现出降血糖，降血脂和胰岛素抵抗降低作用。因此，本发明对于糖尿病和代谢疾病具有预防性或治疗上的有效性。

4. 发明申请

US20110009636A1 PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS 失效
标题翻译：制备2-甲基-2'-苯基丙酸衍生物和新型中间体化合物的方法
公开(公告)号：US20110009636A1
公开(公告)日：2011-01-13
申请号：US12865234
申请日：2009-02-12
申请人： Chun-Ho Lee , Ja-Heouk Khoo , Kyoung-Chan Kwon , Hyun Ju
发明人： Chun-Ho Lee , Ja-Heouk Khoo , Kyoung-Chan Kwon , Hyun Ju
IPC分类号： C07D401/04 , C07C69/612 , C07C309/70 , C07C309/77 , C07C303/28 , C07C67/31 , C07D401/14
CPC分类号： C07D401/04 , C07C67/31 , C07C67/46 , C07C69/612
摘要： The present invention relates to a process for preparing 2-methyl-2′-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2′-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
摘要翻译：本发明涉及以更简化的方式制备显示抗组胺活性的2-甲基-2'-苯基丙酸衍生物的方法，中间体化合物及其制备方法。根据本发明，可以以工业规模高产率和纯度制备药学上可用的2-甲基-2'-苯基丙酸衍生物。

5. 发明申请

US20090264775A1 BLOOD VESSEL AGEING INDEX MEASURING AND ANALYZING SYSTEM, AND MEASURING AND ANALYZING METHOD THEREOF 审中-公开
标题翻译：血液老化指标测量和分析系统及其测量和分析方法
公开(公告)号：US20090264775A1
公开(公告)日：2009-10-22
申请号：US12416526
申请日：2009-04-01
申请人： Hsien-Tsai Wu , Chun-Ho Lee , Tsang-Chih Wu , An-Bang Liu
发明人： Hsien-Tsai Wu , Chun-Ho Lee , Tsang-Chih Wu , An-Bang Liu
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007
摘要： A blood vessel ageing index measuring and analyzing system includes a pressure applying unit, a measuring unit, a front end signal processing unit, and a back end signal analyzing unit. The pressure applying unit is configured to apply external pressure to a limb of a subject, or to release the limb of the subject from the external pressure. The measuring unit is configured to output a standard radial artery pulse signal and a comparative radial artery pulse signal. The front end signal processing unit is configured to process the standard and comparative radial artery pulse signals to generate a digital standard radial artery pulse signal and a digital comparative radial artery pulse signal. The back end signal analyzing unit is configured to obtain a blood vessel ageing index according to the digital standard and comparative radial artery pulse signals.
摘要翻译：血管老化指数测定分析系统包括压力施加单元，测量单元，前端信号处理单元和后端信号分析单元。压力施加单元构造成对受试者的肢体施加外部压力，或者将受试者的肢体从外部压力释放。测量单元被配置为输出标准的桡动脉脉搏信号和比较的桡动脉脉搏信号。前端信号处理单元被配置为处理标准和比较的桡动脉脉搏信号以产生数字标准桡动脉脉搏信号和数字比较桡动脉脉搏信号。后端信号分析部构成为根据数字标准和比较的桡动脉脉搏信号获得血管老化指数。

6. 发明申请

US20080120898A1 Alternative emulsified fuel and method of manufacturing the same 审中-公开
标题翻译：替代乳化燃料及其制造方法
公开(公告)号：US20080120898A1
公开(公告)日：2008-05-29
申请号：US11880461
申请日：2007-07-20
申请人： Gil-Yeop Song , Chun-Ho Lee , Jae-Kuk Kim , In-Kui Choi
发明人： Gil-Yeop Song , Chun-Ho Lee , Jae-Kuk Kim , In-Kui Choi
IPC分类号： C10L1/32
CPC分类号： C10L1/328 , C10L1/1216 , C10L1/1225
摘要： Disclosed herein is an alternative emulsified fuel. The emulsified fuel is formed by forming a mixture of 70˜80 wt % bunker-C oil and 20˜30 wt % carbide aqueous solution, followed by heating and stirring the mixture, applying ultrasonic waves of 20 kHz˜1 MHz to the mixture for 20˜30 minutes to induce ionic bonding between molecules in the mixture, and rotating the mixture at a high speed in an emulsifying machine to prevent oil-water separation of the mixture. 0.5˜2 parts by weight of calcium chloride is added as an emulsification agent to 100 parts by weight of the mixture of the bunker-C oil and carbide aqueous solution. The carbide aqueous solution contains 0.1˜1 wt % of carbide dissolved in water. The alternative emulsified fuel is useful for winter heating for horticulture or flowering plants, for drying agricultural and fisheries products, and other applications.
摘要翻译：本文公开了另一种乳化燃料。乳化燃料通过形成70〜80重量％的掩体-C油和20〜30重量％的碳酸盐水溶液的混合物形成，然后加热搅拌混合物，向混合物中施加20kHz〜1MHz的超声波 20〜30分钟，以诱导混合物中分子之间的离子键合，并在乳化机中高速旋转混合物以防止混合物油水分离。加入0.5〜2重量份氯化钙作为乳化剂至100重量份的掩体C油和碳化物水溶液的混合物中。碳化物水溶液含有0.1〜1重量％的溶解在水中的碳化物。替代的乳化燃料可用于园艺或开花植物的冬季加热，用于干燥农业和渔业产品以及其他应用。

7. 发明申请

US20050104784A1 PLANAR E-INVERTED ANTENNA 有权
标题翻译：平面电子天线
公开(公告)号：US20050104784A1
公开(公告)日：2005-05-19
申请号：US10714883
申请日：2003-11-18
申请人： Chun-Ho Lee
发明人： Chun-Ho Lee
IPC分类号： H01Q1/24 , H01Q9/42
CPC分类号： H01Q9/42 , H01Q1/24
摘要： A planar E-inverted antenna comprises a signal line connecting to a signal source for feeding a voltage signal; first and second short-circuit ends respectively connecting to a grounding area for outputting the voltage signal to the grounding area; and a radio-frequency area, being supported over the grounding area by means of the first and second short-circuit ends. The radio-frequency area and the grounding area have approximately a same length so that a signal is corresponded in radio-frequency to the length of the radio-frequency area and an electromagnetic wave of the corresponding frequency is received from the outside, the corresponded signal traveling to the grounding area via the short-circuit ends.
摘要翻译：平面E倒置天线包括连接到用于馈送电压信号的信号源的信号线; 第一和第二短路端分别连接到接地区域，以将电压信号输出到接地区域; 以及通过第一和第二短路端被支撑在接地区域上的射频区域。射频区域和接地区域具有大致相同的长度，使得信号在射频对应于射频区域的长度，并且从外部接收相应频率的电磁波，对应的信号通过短路端到达接地区域。

8. 发明申请

US20110160600A1 ERECTILE FUNCTION INDEX MEASURING AND ANALYZING SYSTEM AND MEASURING AND ANALYZING METHOD THEREOF 审中-公开
标题翻译：有效功能指标测量与分析系统及其测量及分析方法
公开(公告)号：US20110160600A1
公开(公告)日：2011-06-30
申请号：US12975877
申请日：2010-12-22
申请人： Hsien-Tsai WU , Chun-Ho Lee , Chih-Jung Chew
发明人： Hsien-Tsai WU , Chun-Ho Lee , Chih-Jung Chew
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/0402 , A61B5/4393
摘要： An erectile function index measuring and analyzing system includes a measuring device and an analyzing device. The measuring device is configured to output a standard pulse signal based upon a penile artery pulse of a subject that is measured while a penis of the subject is in a relaxed state, a first comparative pulse signal based upon a penile artery pulse that is measured after releasing the penis from external pressure larger than a systolic pressure, and a second comparative pulse signal based upon a penile artery pulse that is measured while the penis is in an erect state. The measuring device is further configured to measure heartbeat for outputting an electrocardiogram signal. According to the above signals, the analyzing device is operable to obtain a vasodilatation index, a pulse wave velocity and an erectile index to serve as erectile function indices used for determining erectile function of the subject.
摘要翻译：勃起功能指标测量和分析系统包括测量装置和分析装置。测量装置被配置为基于在被检体的阴茎处于松弛状态时测量的受试者的阴茎动脉脉冲输出标准脉冲信号，基于阴茎动脉脉搏的第一比较脉冲信号，将阴茎从大于收缩压的外部压力释放，以及基于在阴茎处于直立状态时测量的阴茎动脉脉搏的第二比较脉冲信号。测量装置还被配置为测量用于输出心电图信号的心跳。根据上述信号，分析装置可操作以获得血管扩张指数，脉搏波速度和勃起指数，以用作用于确定受试者勃起功能的勃起功能指标。

9. 发明授权

US07342027B2 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof 失效
标题翻译： 1-苯基哌啶-3-酮衍生物及其制备方法
公开(公告)号：US07342027B2
公开(公告)日：2008-03-11
申请号：US10521752
申请日：2003-07-26
申请人： Jong Wook Lee , Bong Yong Lee , Chun Ho Lee , Yun Hur , Tae Dong Han , Hyun Kyoung Ko , Suk Won Yun , Jae Young Shim , Joong In Lim , Moon Ho Son , Jae Sung Yang , Mi Kyung Kim
发明人： Jong Wook Lee , Bong Yong Lee , Chun Ho Lee , Yun Hur , Tae Dong Han , Hyun Kyoung Ko , Suk Won Yun , Jae Young Shim , Joong In Lim , Moon Ho Son , Jae Sung Yang , Mi Kyung Kim
IPC分类号： A61K31/445 , C07D451/12 , C07D401/04
CPC分类号： C07D401/12 , C07D211/62 , C07D211/74 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof.
摘要翻译：本发明提供了具有半胱氨酸蛋白酶抑制活性的1-苯基哌啶-3-酮衍生物及其药学上可接受的盐，其含有活性成分的药物组合物及其制备方法。

10. 发明申请

US20050234057A1 1-Phenylpiperidin-3-one derivatives and processes for the preparation thereof 失效
标题翻译： 1-苯基哌啶-3-酮衍生物及其制备方法
公开(公告)号：US20050234057A1
公开(公告)日：2005-10-20
申请号：US10521752
申请日：2003-07-26
申请人： Jong Lee , Bong Lee , Chun-Ho Lee , Yun Hur , Tae-Dong Han , Hyun Ko , Suk-Won Yun , Jae Shim , Joong Lim , Moon Son , Jae Sung Yang , Mi Kim
发明人： Jong Lee , Bong Lee , Chun-Ho Lee , Yun Hur , Tae-Dong Han , Hyun Ko , Suk-Won Yun , Jae Shim , Joong Lim , Moon Son , Jae Sung Yang , Mi Kim
IPC分类号： C07D211/62 , C07D211/74 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D498/04 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/497 , C07D413/02 , C07D41/02 , C07D43/02
CPC分类号： C07D401/12 , C07D211/62 , C07D211/74 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an active ingredient, and processes for the preparation thereof.
摘要翻译：本发明提供具有半胱氨酸蛋白酶抑制活性的1-苯基哌啶-3-酮衍生物及其药学上可接受的盐，其含有活性成分的药物组合物及其制备方法。

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