专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP3600340A2 RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES 审中-实审转让
公开(公告)号：EP3600340A2
公开(公告)日：2020-02-05
申请号：EP18776882.5
申请日：2018-03-31
申请人： Pei-Jia, Yang , Cheng, Jen-hao , Chen, Ying-Ja , Chen, Shu-jen , Chen, Hua-chien
发明人： Pei-Jia, Yang , Cheng, Jen-hao , Chen, Ying-Ja , Chen, Shu-jen , Chen, Hua-chien
IPC分类号： A61K31/7052 , A61K31/7105 , A61K39/00 , A61K39/02 , A61K48/00 , C07H21/02

2. 发明专利

SG11201907738UA RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES 未知
公开(公告)号：SG11201907738UA
公开(公告)日：2019-09-27
申请号：SG11201907738U
申请日：2018-03-31
申请人： PEI JIA YANG , CHENG JEN HAO , CHEN YING JA , CHEN SHU JEN , CHEN HUA CHIEN
发明人： PEI-JIA YANG , CHENG JEN-HAO , CHEN YING-JA , CHEN SHU-JEN , CHEN HUA-CHIEN
IPC分类号： A61K31/7105 , A61K31/7052 , A61K39/00 , A61K39/02 , A61K48/00 , C07H21/02
摘要： Epitopeidentification Component computation 'Mathirieleething m odel Weight assignment Peptide-level score designation Sample-level score designation Immunogenicity score designation () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT ~~~~~~~~~~~~~ 011101010VIIIOH olo HE mil mo lio (10) International Publication Number WO 2018/183980 A3 (51) International Patent Classification: A61K 31/7052 (2006.01) A61K 39/02 (2006.01) A61K 31/7105 (2006.01) A61K 48/00 (2006.01) A61K 39/00 (2006.01) C07H 21/02 (2006.01) (21) International Application Number: PCT/US2018/025597 (22) International Filing Date: 31 March 2018 (31.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,320 31 March 2017 (31.03.2017) US (72) Inventors; and (71) Applicants: PEI-JIA, Yang; 4f, No.208, Xinhu 2nd Rd, Neihu Dist, Taipei City, 114 (TW). CHENG, Jen-Hao; 4f, No.208, Xinhu 2nd Rd, Neihu Dist, Taipei City, 114 (TW). CHEN, Ying-Ja [US/ ]; 4f, No.208, Xinhu 2nd Rd, Nei- hu Dist, Taipei City, 114 (TW). CHEN, Shu-Jen [US/ ]; 2f.-1, No.69-1, Hejiang St., Zhongshan Dist., Taipei City, 104 (TW). CHEN, Hua-Chien; 4f., No. 17, Ln. 63, Sec. 2, Dunhua S. Rd. Daan Dist., Taipei City, 106 (TW). (74) Agent: KAO, Laurence; OPES IP CONSULTING CO., LTD, 4f. No.203, Sec. 1, Fuxing S. Rd., Daan Dist., Taipei City, 10666 (TW). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES Tumor 8f normal tis LIES Whole exome sequencing Variant deterrnina on Ranking FIGURE 1 (57) : This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers. [Continued on next page] WO 2018/183980 A3 MIDEDIMOMOIDEIREEMOMiliMOIHMOMMEfin GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 20 December 2018 (20.12.2018)

3. 发明专利

IL244697D0 Compositions and formulations for maintaining and increasing muscle mass, strength, and performance and methods of production and use thereof 未知
公开(公告)号：IL244697D0
公开(公告)日：2016-04-21
申请号：IL24469716
申请日：2016-03-21
申请人： PRONUTRIA INC , SILVER NATHANIEL W , HAMM LUKE , WILLIAMS ALISON , HAMILL MICHAEL J , BERRY DAVID A , CHEN YING JA , BASU SUBHAYU , ERBE DAVID , VON MALTZAHN GEOFFREY
IPC分类号： A23L33/00
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.

4. 发明申请

WO2022150063A1 HOMOLOGOUS RECOMBINATION DEFICIENCY DETERMINING METHOD AND KIT THEREOF 审中-公开
公开(公告)号：WO2022150063A1
公开(公告)日：2022-07-14
申请号：PCT/US2021/046034
申请日：2021-08-13
申请人： ACT GENOMICS (IP) CO., LTD. , CHEN, Ying-Ja , CHEN, Shu-Jen
发明人： WANG, Woei-fuh , YEH, Ya-Chi , CHEN, Chien-Hung , CHEN, Kuan-Ying , TAN, Wen-Hao
IPC分类号： C12Q1/6809 , C12Q1/6886
摘要： The present disclosure provides a method, a system and a kit for assessing the homologous recombination deficiency (HRD) status of a subject. The present disclosure further provides a method, a system and a kit for identifying a treatment based on the HRD status for the human subject.

5. 发明申请

WO2018183980A3 RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES 审中-公开
公开(公告)号：WO2018183980A3
公开(公告)日：2018-10-04
申请号：PCT/US2018/025597
申请日：2018-03-31
申请人： PEI-JIA, Yang , CHENG, Jen-Hao , CHEN, Ying-Ja , CHEN, Shu-Jen , CHEN, Hua-Chien
发明人： PEI-JIA, Yang , CHENG, Jen-Hao , CHEN, Ying-Ja , CHEN, Shu-Jen , CHEN, Hua-Chien
IPC分类号： A61K31/7052 , A61K31/7105 , A61K39/00 , A61K39/02 , A61K48/00 , C07H21/02
摘要： This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.

6. 发明申请

WO2015048342A2 COMPOSITIONS AND FORMULATIONS FOR MAINTAINING AND INCREASING MUSCLE MASS, STRENGTH, AND PERFORMANCE AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：维持和增加肌肉质量，强度和性能的组合物和制剂及其生产方法和用途
公开(公告)号：WO2015048342A2
公开(公告)日：2015-04-02
申请号：PCT/US2014/057537
申请日：2014-09-25
申请人： PRONUTRIA, INC. , SILVER, Nathaniel, W. , CHEN, Ying-ja , BERRY, David, A. , HAMILL, Michael, J. , BASU, Subhayu , HAMM, Luke , WILLIAMS, Alison , ERBE, David , VON MALTZAHN, Geoffrey
发明人： SILVER, Nathaniel, W. , CHEN, Ying-ja , BERRY, David, A. , HAMILL, Michael, J. , BASU, Subhayu , HAMM, Luke , WILLIAMS, Alison , ERBE, David , VON MALTZAHN, Geoffrey
IPC分类号： A23L1/305
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G06F19/18
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：本文提供了营养多肽。还提供了包括编码所述多肽的核酸，制备所述多肽的重组微生物，表达所述多肽的载体，使用重组微生物制备所述多肽的方法，包含所述多肽的组合物和制剂以及使用所述多肽的方法，组合物和配方。

7. 发明申请

WO2018183980A2 RANKING SYSTEM FOR IMMUNOGENIC CANCER-SPECIFIC EPITOPES 审中-公开
公开(公告)号：WO2018183980A2
公开(公告)日：2018-10-04
申请号：PCT/US2018/025597
申请日：2018-03-31
申请人： PEI-JIA, Yang , CHENG, Jen-Hao , CHEN, Ying-Ja , CHEN, Shu-Jen , CHEN, Hua-Chien
发明人： PEI-JIA, Yang , CHENG, Jen-Hao , CHEN, Ying-Ja , CHEN, Shu-Jen , CHEN, Hua-Chien
IPC分类号： G06F19/18 , A61K39/00
摘要： This disclosure relates to systems and methods that identify, predict, and rank immunogenic T-cell epitopes. In particular, this disclosure identifies epitopes that arose from disease-associated mutations, wherein the epitopes are predicted to elicit immune response from T cells. Specifically, this disclosure simultaneously considers peptide-level information, including MHC Class I and II presentation, helper and cytotoxic T cell response and sample-level information, including mutation clonality and MHC allele dosage. In some embodiment, the systems and methods are used for personalized treatment of cancers.

8. 发明申请

WO2015054507A1 NUTRITIVE POLYPEPTIDE PRODUCTION SYSTEMS, AND METHODS OF MANUFACTURE AND USE THEREOF 审中-公开
标题翻译：营养多肽生产系统及其制造方法及其应用
公开(公告)号：WO2015054507A1
公开(公告)日：2015-04-16
申请号：PCT/US2014/059923
申请日：2014-10-09
申请人： PRONUTRIA, INC. , BASU, Subhayu , CHEN, Ying-Ja , HARVEY, Caitlym , GORA, Katherine , BERRY, David, A. , YOUNG, David
发明人： BASU, Subhayu , CHEN, Ying-Ja , HARVEY, Caitlym , GORA, Katherine , BERRY, David, A. , YOUNG, David
IPC分类号： C12N9/62 , C12P21/02 , C12N15/52 , C12R1/66 , C12N9/22 , C12N15/10
CPC分类号： C12N9/62 , A23L33/18 , C12N15/80 , C12P21/02
摘要： The application concerns reagents and methods for the production of "nutritive polypeptides" in fungi, in particular, Aspergillus, where the expression of said polypeptide is increased by co-expressing in the fungal host (i) a variant nucleic acid encoding a secreted protease (in particular pepA, pepB, pepD, pepF or pepH), (ii) a "secretory pathway polypeptide (including a chaperone, like foldase, a vesicle trafficking polypeptide, a glycosylation pathway polypeptide or a protein degradation pathway) and/or, (ii) a nucleic acid encoding a Cas9 endonuclease plus a nucleic acid encoding a guide RNA (gRNA). The application is also directed to said nutritive proteins, nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, vectors for expressing the proteints, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins.
摘要翻译：本申请涉及用于在真菌（特别是曲霉属）中生产“营养多肽”的试剂和方法，其中所述多肽的表达通过在真菌宿主中共表达而增加（i）编码分泌蛋白酶的变体核酸（特别是pepA，pepB，pepD，pepF或pepH），（ii）“分泌途径多肽（包括分子伴侣，如折叠酶，囊泡运输多肽，糖基化途径多肽或蛋白质降解途径）和/或（ii ）编码Cas9核酸内切酶加编码引导RNA（gRNA）的核酸的核酸，还涉及所述营养蛋白，编码蛋白质的核酸，制备蛋白质的重组微生物，用于表达蛋白质的载体，方法使用重组微生物制备蛋白质，包含蛋白质的组合物和使用蛋白质的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式