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1. 发明申请

US20160010119A1 PROCESSES FOR THE ACIDIC, ANAEROBIC CONVERSION OF HYDROGEN AND CARBON OXIDES TO OXYGENATED ORGANIC COMPOUND 审中-公开
标题翻译：氢氧化物和碳氧化物对氧化有机化合物的厌氧转化的方法
公开(公告)号：US20160010119A1
公开(公告)日：2016-01-14
申请号：US14327249
申请日：2014-07-09
申请人： Coskata, Inc.
发明人： Robert Hickey
IPC分类号： C12P7/16 , C12P7/04 , C12P7/06
CPC分类号： C12P7/16 , C12P7/04 , C12P7/065 , Y02E50/10 , Y02E50/17
摘要： Processes for the bioconversion of syngas to oxygenated organic compound are disclosed that reliably, cost-effectively and efficiently supply sulfur nutrient to microorganisms contained in acidic, aqueous fermentation menstrua. In the processes of this invention, at least a portion of the sulfur nutrient for the population of microorganisms in the aqueous menstruum is provided as calcium sulfite, and the presence of undissolved calcium sulfite is maintained in the aqueous menstruum.
摘要翻译：公开了将合成气生物转化为含氧有机化合物的方法，其可靠地，经济有效且有效地向酸性水性发酵人体中所含微生物提供硫营养物。在本发明的方法中，水溶液中的微生物群体的硫营养物的至少一部分以亚硫酸钙形式提供，并且在水性水溶液中保持未溶解的亚硫酸钙的存在。

2. 发明申请

US20140349358A1 METHOD FOR INJECTING A FEED GAS STREAM INTO A VERTICALLY EXTENDED COLUMN OF LIQUID 审中-公开
标题翻译：将进料气流注入垂直扩展的液体柱的方法
公开(公告)号：US20140349358A1
公开(公告)日：2014-11-27
申请号：US14452366
申请日：2014-08-05
申请人： Coskata, Inc.
发明人： Robert Hickey , Mark Neville
IPC分类号： C12P7/06
CPC分类号： C12P7/065 , C12M29/06 , Y02E50/17
摘要： A process for conversion of syngas to liquid products that serve as surface acting agents uses the gas stream at a relatively low pressure to eliminate the use of a compressor. The process uses a liquid stream as the primary energy input to a gas injector that intensely mixes gas and the liquid with reduced compression costs while the presence of the liquid product maintains the gas-liquid dispersion as it flows downward to build a static pressure head. The process lowers the required gas pressure by adjusting the elevation of the gas injector such that a conduit receives the gas-liquid dispersion from the outlet of the injector and confines it as it travels downward to enter the bottom of a column of liquid. The liquid product provides a surface acting agent that prolongs the creation and duration of microbubbles in the gas-liquid dispersion.
摘要翻译：将合成气转化为用作表面作用剂的液体产物的方法使用相对较低压力的气流来消除压缩机的使用。该过程使用液体流作为气体注入器的主要能量输入，其以降低的压缩成本强烈地混合气体和液体，同时液体产物的存在在其向下流动时保持气液分散体以构建静压头。该过程通过调节气体注射器的高度来降低所需的气体压力，使得导管从喷射器的出口接收气液分散体，并在其向下行进时限制其进入液柱的底部。液体产品提供了一种表面作用剂，其延长气 - 液分散体中微泡的产生和持续时间。

3. 发明申请

US20140220649A1 METHOD FOR PRODUCING C4 OXYGENTATES BY FERMENTATION USING HIGH OXIDATION STATE SULFUR 有权
标题翻译：通过使用高氧化态硫磺生产C4氧化物的方法
公开(公告)号：US20140220649A1
公开(公告)日：2014-08-07
申请号：US14245907
申请日：2014-04-04
申请人： COSKATA, INC.
发明人： Richard E. Tobey , Toby D. Allen , Peter Martin Lokken , Andrew James Heinen , Gengsheng Chen
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12P7/40 , Y02E50/10
摘要： The invention relates to improvements in the production of butanol and butyrate by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO and the addition of an inorganic sulfur additive. It more particularly relates to the provision of an inorganic organic sulfur source to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to butanol. In one aspect the invention uses a sulfur additive comprising inorganic sulfur compounds having a +2 to a +4 sulfur oxidation state that produces sulfur oxoanions and hydrosulfur oxoanions in an aqueous fermentation medium.
摘要翻译：本发明涉及通过微生物发酵生产丁醇和丁酸酯的方法的改进，特别是通过微生物发酵包含CO和添加无机硫添加剂的基质来生产醇。更特别地涉及向发酵系统提供无机有机硫源，使得一种或多种微生物将包含CO的底物转化为丁醇。在一个方面，本发明使用包含在含水发酵培养基中产生硫氧代阴离子和硫代氧代阴离子的具有+2至+4硫氧化态的无机硫化合物的硫添加剂。

4. 发明申请

US20140206052A1 Method for production of n-butanol from syngas using syntrophic co-cultures of anaerobic microorganisms 有权
标题翻译：使用厌氧微生物的合成共培养物从合成气生产正丁醇的方法
公开(公告)号：US20140206052A1
公开(公告)日：2014-07-24
申请号：US13745155
申请日：2013-01-18
申请人： COSKATA, INC.
发明人： Mike Enzien , Rathin Datta , Richard Tobey
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , C12P7/06 , C12P7/54 , Y02E50/10 , Y02E50/17 , Y02T50/678
摘要： This invention provides methods and systems for the production of butanol. Specifically, the methods and systems of the present invention use syntrophic co-cultures for the production of butanol from syngas.
摘要翻译：本发明提供了生产丁醇的方法和系统。具体地，本发明的方法和系统使用合成共培养物从合成气生产丁醇。

5. 发明授权

US09914945B2 Processes for bioconverting syngas to oxygenated hydrocarbonaceous compounds 有权
公开(公告)号：US09914945B2
公开(公告)日：2018-03-13
申请号：US14671834
申请日：2015-03-27
申请人： Coskata, Inc.
发明人： Robert Hickey
IPC分类号： C12P7/06 , C12P7/04 , C12P7/16 , C12P7/14 , C12N1/20
CPC分类号： C12P7/16 , C12N1/20 , C12P7/04 , C12P7/065 , C12P7/14 , Y02E50/10 , Y02E50/17
摘要： Continuous processes for the anaerobic bioconversion of syngas to oxygenated hydrocarbonaceous products, in particular lower alkanols, are disclosed in which nutrients, including micronutrients, and lower carboxylate anion are recovered from at least a portion of an aqueous distillation fraction from a distillation unit operation to recover lower alkanols by using a “tight” ultrafiltration membrane. At least about 75 percent of the water permeates the ultrafiltration membrane. The tight ultrafiltration membrane rejects sufficient components that are adverse to the microorganisms used in the bioconversion that continuous fermentation operations over long durations can be achieved.

6. 发明授权

US09428755B2 Use of clostridial methyltransferases for generating novel strains 有权
公开(公告)号：US09428755B2
公开(公告)日：2016-08-30
申请号：US14592208
申请日：2015-01-08
申请人： Coskata, Inc.
发明人： Andrew Reeves
IPC分类号： C12N15/74 , C12N15/63 , C12N9/10 , C12N15/70 , C12N15/87
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
摘要： This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.

7. 发明授权

US09284538B2 Genes encoding key catalyzing mechanisms for ethanol production from syngas fermentation 有权
公开(公告)号：US09284538B2
公开(公告)日：2016-03-15
申请号：US14083007
申请日：2013-11-18
申请人： Coskata, Inc.
发明人： Andrew Reeves , Rathin Datta
IPC分类号： C12P7/06 , C12N9/12 , C12N9/10 , C12N15/52 , C12N15/74
CPC分类号： C12N9/1029 , C12N9/1217 , C12N15/52 , C12N15/74 , C12P7/065 , Y02E50/17
摘要： Gene sequences of key acetogenic clostridial species were sequenced and isolated. Genes of interest were identified, and functionality was established. Key genes of interest for metabolic catalyzing activity in clostridial species include a three-gene operon coding for CODH activity, a two-gene operon coding for PTA-ACK, and a novel acetyl coenzyme A reductase. The promoter regions of the two operons and the acetyl coA reductase are manipulated to increase ethanol production.

8. 发明申请

US20150322402A1 Syntrophic co-culture of anaerobic microorganism for production of n-butanol from syngas 审中-公开
标题翻译：用于从合成气生产正丁醇的厌氧微生物的合成共培养物
公开(公告)号：US20150322402A1
公开(公告)日：2015-11-12
申请号：US14812182
申请日：2015-07-29
申请人： Coskata, Inc.
发明人： Rathin Datta , Andrew Reeves
IPC分类号： C12N1/20 , C12P7/16
CPC分类号： C12N1/20 , C12P7/16 , Y02E50/10
摘要： This invention provides compositions for the production of butanol. Specifically, the compositions of the present invention use syntrophic co-cultures for the production of butanol from syngas.
摘要翻译：本发明提供了用于生产丁醇的组合物。具体地，本发明的组合物使用合成共培养物从合成气生产丁醇。

9. 发明申请

US20150191736A1 Use of Clostridial Methyltransferases for Generating Novel Strains 有权
标题翻译：使用梭菌甲基转移酶生产新型菌株
公开(公告)号：US20150191736A1
公开(公告)日：2015-07-09
申请号：US14592208
申请日：2015-01-08
申请人： Coskata, Inc.
发明人： Andrew Reeves
IPC分类号： C12N15/74 , C12N9/10
CPC分类号： C12N15/74 , C12N9/1007 , C12N15/63 , C12N15/70 , C12N15/87 , C12Q2521/331 , C12Y201/01072
摘要： This invention provides isolated polynucleotides encoding DNA Type I methyltransferase and uses thereof for improving transformation efficiencies of exogenous and endogenous plasmid DNA into Clostridial hosts.
摘要翻译：本发明提供编码DNA I型甲基转移酶的分离的多核苷酸及其用于提高外源和内源质粒DNA转化成梭菌宿主的转化效率的用途。

10. 发明申请

US20140228598A1 INTEGRATED PROCESSES FOR ANAEROBIC CONVERSION OF HYDROGEN AND CARBON OXIDES TO ALCOHOL 有权
标题翻译：将氢和碳氧化物转化为醇的综合方法
公开(公告)号：US20140228598A1
公开(公告)日：2014-08-14
申请号：US13942311
申请日：2013-07-15
申请人： COSKATA, INC.
发明人： Rathin Datta , Steve Calderone , Loula Sassaris Merkel
IPC分类号： C12P7/06
CPC分类号： C12P7/04 , C12P7/065 , C12P7/08 , C12P7/16 , Y02E50/10 , Y02E50/17 , Y02E50/343 , Y02E50/346 , Y02P20/125
摘要： Integrated processes are disclosed for reducing the carbon foot print related to the use of non-renewable hydrocarbon gas streams for producing alcohols by anaerobic bioconversion of reformed gas. These processes combine renewable and non-renewable gas sources of hydrogen, carbon monoxide and carbon dioxide to produce alcohol. Thus the invention found a highly a practical way to make use of non-renewable carbon oxide sources while still lowering the carbon footprint of such alcohols produced thereby, especially when combined with corn ethanol production. In the case of motor fuel use, the renewable portion of the alcohol produced in this manner provides a reduction in greenhouse gases by 50% or more when compared to gasoline.
摘要翻译：公开了一种综合方法，用于通过改性气体的厌氧生物转化来减少与用于生产醇的不可再生烃气流相关的碳脚印。这些方法将可再生和不可再生气体的氢气，一氧化碳和二氧化碳组合起来生产酒精。因此，本发明发现使用不可再生碳氧化物源的高度实用的方法，同时仍然降低由此产生的这种醇的碳足迹，特别是当与玉米乙醇生产相结合时。在使用机动车燃料的情况下，与汽油相比，以这种方式生产的醇的可再生部分使温室气体减少了50％以上。

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