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1. 发明专利

JP2017512888A 新規な陽イオン性ポリホスファゼン化合物、ポリホスファゼン−薬物コンジュゲート化合物およびその製造方法审中-公开
公开(公告)号：JP2017512888A
公开(公告)日：2017-05-25
申请号：JP2016575280
申请日：2015-03-13
申请人：シーエヌファーム・カンパニー・リミテッドCnpharm Co., Ltd. , シーエヌファーム・カンパニー・リミテッドCnpharm Co., Ltd. , ソン, ヨンソSOHN, Youn Soo , ソン, ヨンソSOHN, Youn Soo
发明人：ヨンソソン， , ヨンソソン， , ヨンジョジュン， , ヨンジョジュン， , プラカシュゴーダアヴァジ， , プラカシュゴーダアヴァジ，
IPC分类号： C08G79/025 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K47/34 , A61K47/50 , A61P35/00 , C08G65/335 , C08G81/00
CPC分类号： C08G79/025 , A61K31/337 , A61K31/4745 , A61K31/555 , A61K47/48223 , A61K47/60 , A61K47/605 , C08G81/00
摘要：本発明は、親水性のポリエチレングリコールと、スペーサ(spacer)グループとして、リシン、リシンを含むオリゴペプチド、アミノエタノール、アミノプロパノール、アミノブタノール、アミノペンタノール、およびアミノヘキサノールからなる群より選択された1種を導入した陽イオン性線状ポリホスファゼン化合物、前記化合物に疎水性薬物を化学的に結合させたポリホスファゼン−薬物コンジュゲート化合物およびその製造方法に関し、本発明の化合物は、癌組織選択性に優れ、毒性が非常に低く、抗癌剤として実用化の可能性が高い新物質である。【選択図】図12

2. 发明申请

WO2016153226A3 INORGANIC POLYMER HYBRID COLLOIDAL COMPOUND AND PREPARATION METHOD THEREFOR 审中-公开
标题翻译：无机聚合物混合胶体化合物及其制备方法
公开(公告)号：WO2016153226A3
公开(公告)日：2016-11-17
申请号：PCT/KR2016002757
申请日：2016-03-18
申请人： EWHA UNIV - IND COLLABORATION FOUND , CNPHARM CO LTD
发明人： CHOY JIN HO , CHOI GO EUN , PARK DAE HWAN , KIM HO JUN
IPC分类号： A61K47/48 , A61K9/08 , A61K47/02 , A61K47/30 , A61K49/00 , A61K51/12
CPC分类号： A61K9/08 , A61K47/02 , A61K47/30 , A61K47/50 , A61K49/00 , A61K51/12
摘要： The present invention relates to an inorganic polymer hybrid colloidal compound and a preparation method therefor and, more specifically, to: an inorganic polymer hybrid colloidal compound exhibiting uniform particle size and shape and having a zeta potential of (+) 25 mV or more or (-) 25 mV or less through the hydrothermal synthesis of an inorganic salt in the presence of a bioactive molecule; a preparation method therefor; and a pharmaceutical composition containing the same. According to the present invention, the supramolecular hybrid colloidal compound has stable colloidal physical properties, and thus can be widely utilized in an active ingredient material transfer technique in various fields such as pharmacology, medicine, cosmetics, agricultural chemicals and food.
摘要翻译：本发明涉及一种无机聚合物杂化胶体化合物及其制备方法，更具体地说，涉及：具有均匀粒径和形状，并且具有（+）25mV以上的ζ电位或（+）25mV以上的无机聚合物混合胶体化合物或（ - ）在生物活性分子存在下通过无机盐的水热合成为25mV以下; 其制备方法; 和含有该组合物的药物组合物。根据本发明，超分子混合胶体化合物具有稳定的胶体物性，因此可广泛应用于药理学，药物学，化妆品，农药，食品等各个领域的活性成分材料转移技术。

3. 发明申请

WO2012086964A2 AMPHIPHILIC CYCLIC PHOSPHAZENE TRIMER, HYDROPHOBIC PHARMACEUTICAL FORMULATION MICELLIZED BY AMPHIPHILIC CYCLIC PHOSPHAZENE TRIMER, AND PREPARATION METHODS THEREOF 审中-公开
标题翻译：两亲性环状磷杂环戊二烯三聚体，疏水性药物制剂的双亲性环状磷酸三聚体胶束化及其制备方法
公开(公告)号：WO2012086964A2
公开(公告)日：2012-06-28
申请号：PCT/KR2011009726
申请日：2011-12-16
申请人： CNPHARM CO LTD , SOHN YOUN-SOO , JUN YONG-JOO
发明人： SOHN YOUN-SOO , JUN YONG-JOO
IPC分类号： C07F9/6593 , A61K31/337 , A61P35/00
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/107 , A61K9/4833 , A61K31/337 , A61K47/24 , C07F9/65815
摘要： The present invention relates to an amphiphilic cyclic phosphazene trimer having biocompatibility and a preparation method thereof. In addition, the invention relates to a hydrophobic pharmaceutical formulation micellized by the amphiphilic cyclic phosphazene trimer and a preparation method thereof.
摘要翻译：本发明涉及一种具有生物相容性的两亲性环状磷腈三聚体及其制备方法。另外，本发明涉及一种两亲性环状磷腈三聚体胶束化的疏水性药物制剂及其制备方法。

4. 发明公开

KR20100110014A Chiral-inorganic nanohybrid materials and processes for the preparation thereof 审中-公开
标题翻译：无机无机纳米材料及其制备方法
公开(公告)号：KR20100110014A
公开(公告)日：2010-10-12
申请号：KR20090028353
申请日：2009-04-02
申请人： CNPHARM CO LTD
发明人： CHOY JIN HO , PARK DAE HWAN
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： A61K9/51 , B82Y30/00
摘要： PURPOSE: A chiral compound-inorganic nanohybrid complex and a manufacturing method thereof are provided to improve the physical and chemical stability of a single phase by using a cationic/anionic inorganic nanostructure. CONSTITUTION: A chiral compound-inorganic nanohybrid complex is manufactured by encapsulating each chiral compound with a cationic/anionic inorganic layered nanostructure marked with either chemical formula 9: (Al2-xMgx)(Si4)O10[OH]2M+n x/n, or chemical formula 10: [M2+ (1-x) N3+ x (OH)2][AChiraln-]zyH2O.
摘要翻译：目的：提供手性化合物 - 无机纳米杂交体及其制备方法，以通过使用阳离子/阴离子无机纳米结构改善单相的物理和化学稳定性。构成：手性化合物 - 无机纳米杂交复合物是通过用标记有化学式9：（Al2-xMgx）（Si4）O10 [OH] 2M + nx / n的阳离子/阴离子无机分层纳米结构包封每个手性化合物或化学式10：[M2 +（1-x）N3 + x（OH）2] [AChiraln-] zyH2O。

5. 发明公开

KR20100127000A A nanohybrid of a phenolic acid uv-screening agent with a layered metal hydroxide, a process for the preparation thereof, and a composition for uv screening comprising the same 有权
标题翻译：具有层状金属氢氧化物的酚醛紫外线屏蔽剂的纳米纤维，其制备方法和包含其的紫外线筛选的组合物
公开(公告)号：KR20100127000A
公开(公告)日：2010-12-03
申请号：KR20090045475
申请日：2009-05-25
申请人： CNPHARM CO LTD
发明人： CHOY JIN HO , PARK DAE HWAN , PARK YOON MI , BISWICK TIMOTHY
IPC分类号： B82B1/00 , B82B3/00
摘要： PURPOSE: A nanohybrid of a phenolic acid UV absorbent and a layered metal hydroxide, a producing method thereof, and an anti-ultraviolet ray composition containing thereof are provided to improve the stability of the phenolic acid UV absorbent. CONSTITUTION: A nanohybrid contains a phenolic acid UV absorbent inserted among layers of a layered metal hydroxide. The layered metal hydroxide is marked with either chemical formula 1: [M(II)1-xM(III)x(OH)2]X+(An-)X/n·yH2O, or chemical formula 2: [M(II)(OH)x'](An-)(2-x')/n·yH2O. In the chemical formulas, M(II) is a divalent metal positive ion, and M(III) is a trivalent positive ion. A producing method of the nanohybrid comprises a step of forming a phenolic acid UV absorbent and divalent metal positive ion solution, and a step of titrating the solution to obtain precipitates.
摘要翻译：目的：提供酚酸UV吸收剂和层状金属氢氧化物的纳米杂化物，其制备方法和含有它们的抗紫外线组合物，以提高酚酸UV吸收剂的稳定性。构成：纳米混合物包含插入层状金属氢氧化物层之间的酚酸UV吸收剂。层状金属氢氧化物用化学式1表示：[M（II）1-xM（III）x（OH）2] X +（An-）X / n·yH 2 O或化学式2：[M（II）（OH）X ']（安 - ）（2-X'）/ N·yH2O。在化学式中，M（II）是二价金属正离子，M（III）是三价正离子。纳米混合物的制造方法包括形成酚酸UV吸收剂和二价金属正离子溶液的步骤，以及滴定溶液以获得沉淀物的步骤。

6. 发明申请

US20210315998A1 SYNTHESIZING DRUG-ORGANIC-ACID-ANHYDRIDE CONJUGATES WITHOUT USING COUPLING REAGENT 有权
公开(公告)号：US20210315998A1
公开(公告)日：2021-10-14
申请号：US17228203
申请日：2021-04-12
申请人： CNPharm Co., Ltd.
发明人： Hojun Kim , Kwang Sik Park , Guen-Woo Jin
IPC分类号： A61K47/54 , A61K47/60
摘要： Synthesizing a drug-organic-acid-anhydride conjugate using docetaxel as a drug, including: mixing aconitic anhydride with a chlorinating reagent to produce a first mixture; dissolving the first mixture in an organic solvent to produce a dissolved mixture; stirring the dissolved mixture; evaporating the organic solvent from the dissolved mixture to produce a second mixture; washing the second mixture with an impurity remover to remove impurities and to produce an aconitic anhydride chloride solution; and mixing the docetaxel with the aconitic anhydride chloride solution to produce the drug-organic-acid-anhydride conjugate.

7. 发明申请

US20190284345A1 NOVEL CATIONIC POLYPHOSPHAZENE COMPOUND, POLYPHOSPHAZENES-DRUG CONJUGATE COMPOUND AND METHOD FOR PREPARING SAME 审中-公开
公开(公告)号：US20190284345A1
公开(公告)日：2019-09-19
申请号：US16430230
申请日：2019-06-03
申请人： CNPHARM CO., LTD.
发明人： Youn Soo Sohn , Yong Joo Jun , Prakash Gouda Avaji
IPC分类号： C08G79/025 , A61K47/58 , A61K47/60 , A61K31/337 , A61K31/555 , A61K31/4745 , C08G81/00
摘要： The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.

8. 发明专利

AU2019356373A1 Metal hydroxide complex comprising active component and modified multilayered hydroxide structure, and method for preparing same 未知
公开(公告)号：AU2019356373A1
公开(公告)日：2020-09-10
申请号：AU2019356373
申请日：2019-09-23
申请人： CNPHARM CO LTD , HYUNDAI BIOSCIENCE CO LTD
发明人： KIM HO-JUN , KIM KI-YEOK
IPC分类号： A61K8/02 , A61K8/19
摘要： Provided are a metal hydroxide complex comprising a base layer, a surface layer, and an active component, the metal hydroxide complex comprising a multilayered hydroxide structure of chemical formula 1; a metal hydroxide complex prepared by including a step of coprecipitating, through a precipitation reaction, the active component and a precursor of a metal hydroxide structure using alcohol and water; and a method for preparing same.

9. 发明授权

US11969440B2 Metal (hydr)oxide composite comprising poorly soluble drug, method for manufacturing same, and pharmaceutical composition comprising same 有权
公开(公告)号：US11969440B2
公开(公告)日：2024-04-30
申请号：US17890796
申请日：2022-08-18
申请人： WEBIOTREE CO., LTD , CNPHARM CO., LTD.
发明人： Ho Jun Kim , Geun Woo Jin , Ki Yeok Kim
IPC分类号： A61K33/08 , A61K31/167 , A61K31/337 , A61P31/14
CPC分类号： A61K33/08 , A61K31/167 , A61K31/337 , A61P31/14
摘要： The present invention relates to a metal (hydr)oxide composite comprising a poorly soluble drug, a method for manufacturing same, and a pharmaceutical composition comprising same.

10. 发明授权

US11912829B2 Cationic polyphosphazene compound, polyphosphazenes-drug conjugate compound and method for preparing same 有权
公开(公告)号：US11912829B2
公开(公告)日：2024-02-27
申请号：US17516518
申请日：2021-11-01
申请人： CNPHARM CO., LTD.
发明人： Youn Soo Sohn , Yong Joo Jun , Prakash Gouda Avaji
IPC分类号： C08G79/025 , A61K47/60 , A61K47/58 , A61K31/337 , A61K31/4745 , A61K31/555 , C08G81/00
CPC分类号： C08G79/025 , A61K31/337 , A61K31/4745 , A61K31/555 , A61K47/60 , A61K47/605 , C08G81/00
摘要： The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.

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