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1. 发明申请

WO2013009100A3 METHOD FOR MANUFACTURING UMBILICAL CORD EXTRACT AND USAGE OF SAME 审中-公开
标题翻译：制造脐带提取物及其用途的方法
公开(公告)号：WO2013009100A3
公开(公告)日：2013-06-13
申请号：PCT/KR2012005514
申请日：2012-07-11
申请人： CHABIOMED CO LTD , SUNGKWANG MEDICAL FOUNDATION , CHABIO & DIOSTECH CO LTD , CHOI YONG SOO , KIM SUN MI , KIM HO JIN , LEE KWANG HYOUNG , CHUNG KWANG-HOE , YOON TAE KI , LEE YOUNGJUN , HAN KYUBOEM , CHUNG HYUNG MIN
发明人： CHOI YONG SOO , KIM SUN MI , KIM HO JIN , LEE KWANG HYOUNG , CHUNG KWANG-HOE , YOON TAE KI , LEE YOUNGJUN , HAN KYUBOEM , CHUNG HYUNG MIN
IPC分类号： A61K35/44 , A61K8/98 , A61K35/12 , A61P17/00 , C12N5/074
CPC分类号： C12N5/0607 , A61K8/985 , A61K35/51 , A61K2800/10 , A61Q19/00 , C12N5/0018 , C12N5/0605 , C12N2502/025 , C12N2509/00
摘要： The present invention provides a method for effectively extracting useful ingredients from an umbilical cord. The present invention provides an umbilical cord extract including the useful ingredients. The umbilical cord extract, according to the present invention, can be used as a serum substitute for cultivating ordinary cells and stem cells derived from an animal. Also, the umbilical extract, according to the present invention, can be used for a filler and a dressing for tissue restoration, and for a cosmetic composition for improving the skin. In addition, the present invention relates to a composition for a medium for separating and cultivating stem cells derived from tissue, such as an umbilical cord and fatty tissue, and to a method for separating and cultivating stem cells derived from the tissue using same.
摘要翻译：本发明提供了一种从脐带有效提取有用成分的方法。本发明提供了包含有用成分的脐带提取物。根据本发明的脐带提取物可以用作培养来自动物的普通细胞和干细胞的血清替代物。此外，根据本发明的脐带提取物可用于填充物和用于组织修复的敷料，以及用于改善皮肤的化妆品组合物。此外，本发明涉及用于分离培养源自组织如脐带和脂肪组织的干细胞的培养基的组合物，以及使用该组合物分离和培养来源于组织的干细胞的方法。

2. 发明申请

WO2009151301A3 GRAFT MATERIAL FOR WOUND TREATMENT AND TREATMENT METHOD USING VASCULAR PRECURSOR CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：用于人造胚胎干细胞衍生的血管前体细胞的治疗和治疗方法的材料
公开(公告)号：WO2009151301A3
公开(公告)日：2010-03-11
申请号：PCT/KR2009003173
申请日：2009-06-12
申请人： CHABIO & DIOSTECH CO LTD , CHUNG HYUNG MIN , LIM JOA JIN , MOON SUNG HWAN , KIM JU MI
发明人： CHUNG HYUNG MIN , LIM JOA JIN , MOON SUNG HWAN , KIM JU MI
IPC分类号： A61K35/12 , A61K35/00 , C12N5/00 , C12N5/02
CPC分类号： A61K35/44
摘要： The present invention provides a graft material for wound treatment including vascular precursor cells derived from human embryonic stem cells, wherein the vascular precursor cells are separated and enriched by differentiating human embryonic stem cells via embryoid body formation under hypoxic conditions. In addition, the present invention provides a wound treatment method using vascular precursor cells derived from embryonic stem cells, comprising: (a) a step of culturing vascular precursor cells derived from embryonic stem cells for transplantation; and (b) a step of transplating said cultured vascular precursor cells derived from embryonic stem cells into the skin of mammals.
摘要翻译：本发明提供一种用于伤口治疗的移植材料，包括源自人胚胎干细胞的血管前体细胞，其中通过在缺氧条件下通过胚状体形成分化人胚胎干细胞来分离和富集血管前体细胞。此外，本发明提供了使用源自胚胎干细胞的血管前体细胞的伤口治疗方法，其特征在于，包括：（a）培养源自胚胎干细胞移植的血管前体细胞的工序; 和（b）将源自胚胎干细胞的培养的血管前体细胞转移到哺乳动物的皮肤中的步骤。

3. 发明申请

WO2007139357A1 METHOD FOR CULTURING HUMAN EMBRYONIC STEM CELLS 审中-公开
标题翻译：培养人胚胎干细胞的方法
公开(公告)号：WO2007139357A1
公开(公告)日：2007-12-06
申请号：PCT/KR2007/002640
申请日：2007-05-31
申请人： CHABIOTECH CO., LTD. , COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , CHUNG, Hyung-Min , LEE, Soo-Hong , KIM, Si-Nae , KIM, Min-Jeong
发明人： CHUNG, Hyung-Min , LEE, Soo-Hong , KIM, Si-Nae , KIM, Min-Jeong
IPC分类号： C12N5/08 , C12N5/00
CPC分类号： C12N5/0606 , C12N2533/30 , C12N2533/52 , C12N2533/54 , C12N2533/56
摘要： The present invention relates to a method for culturing human embryonic stem cells (hESCs) in a hESC culture medium comprising a porous membrane, feeder cells being attached to a bottom of the porous membrane and a method for recovering human embryonic stem cells using the same.
摘要翻译：本发明涉及一种在包含多孔膜的hESC培养基中培养人胚胎干细胞（hESC）的方法，所述多孔膜附着有饲养细胞，并且使用该胚胎干细胞回收人胚胎干细胞的方法。

4. 发明申请

WO2012053788A2 INJECTION NEEDLE FOR INJECTING CELL AND SYRINGE HAVING SAME 审中-公开
标题翻译：用于注射细胞的注射针和具有相同的注射针
公开(公告)号：WO2012053788A2
公开(公告)日：2012-04-26
申请号：PCT/KR2011007715
申请日：2011-10-17
申请人： BYUN KI HYUN , CHABIO & DIOSTECH CO LTD , CHUNG HYUNG MIN , MOON SUNG HWAN , HONG KI SUNG
发明人： BYUN KI HYUN , CHUNG HYUNG MIN , MOON SUNG HWAN , HONG KI SUNG
IPC分类号： A61M5/32 , A61M5/158 , A61M5/178
CPC分类号： A61M5/329 , A61M5/3291
摘要： The present invention relates to an injection needle and a syringe for injecting a stem cell inside a cardiac muscular tissue necrotic from a myocardial infarction or an ischemic heart failure, and the present invention provides an injection needle for injecting a cell, the injection needle having a needle shaft wound in a spiral shape. The injection needle and the syringe of the present invention prevent the cell sap from leaking outside the epicardium after being injected into the cardiac muscular tissue, and at the same time, enhance the survival rate of the stem cell inside the necrotic cardiac muscular tissue by resuming the circulation of the blood stream in the injected stem cell.
摘要翻译：本发明涉及一种注射针头和注射器，用于从心肌梗塞或缺血性心力衰竭中将坏死的坏死肌肉组织注入干细胞，本发明提供了一种用于注射细胞的注射针，所述注射针具有针轴缠绕成螺旋状。本发明的注射针和注射器在注入心肌组织后，可防止细胞液在外膜外泄漏，同时通过恢复，提高坏死心肌组织内的干细胞的存活率注射干细胞中血流的循环。

5. 发明申请

WO2008146992A1 PROCESS FOR THE HIGH-PURITY ISOLATION OF MESENCHYMAL STEM CELLS DERIVED FROM PLACENTAL CHORIONIC PLATE MEMBRANE 审中-公开
标题翻译：高纯度分离从普通氯胺酮薄膜衍生的中胚层干细胞的方法
公开(公告)号：WO2008146992A1
公开(公告)日：2008-12-04
申请号：PCT/KR2007/005235
申请日：2007-10-24
申请人： CHABIOTECH CO., LTD. , COLLEGE OF MEDICINE POCHON CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KIM, Gi-Jin , SHIN, Kyung-Sun , NA, Kyu-Hwan , CHUNG, Hyung-Min
发明人： KIM, Gi-Jin , SHIN, Kyung-Sun , NA, Kyu-Hwan , CHUNG, Hyung-Min
IPC分类号： C12N5/08 , C12N5/06
CPC分类号： C12N5/0605 , C12N5/0668 , C12N2501/119 , C12N2501/91
摘要： The present invention provides a method for isolating mesenchymal stem cells derived from a placental chorionic plate membrane, the method including: (a) harvesting a chorionic plate membrane from a detached placenta; (b) harvesting cells present in the chorionic plate membrane obtained in step (a) by scraping; (c) adding a solution containing trypsin and ethylenediaminetetraacetate to the cells obtained in step (b) to perform an enzymatic reaction and adding a fetal bovine serum thereto to terminate the enzymatic reaction; and (d) centrifuging the reaction solution obtained in step (c) and culturing the obtained cells in a medium containing a fetal bovine serum and an antibiotic.
摘要翻译：本发明提供了一种分离源自胎盘绒膜膜的间充质干细胞的方法，所述方法包括：（a）从分离的胎盘中收获绒毛膜板; （b）通过刮擦收集在步骤（a）中获得的绒毛膜板中存在的细胞; （c）向步骤（b）中获得的细胞中加入含有胰蛋白酶和乙二胺四乙酸的溶液进行酶促反应并加入胎牛血清以终止酶促反应; 和（d）将步骤（c）中获得的反应溶液离心，并将所获得的细胞培养在含有胎牛血清和抗生素的培养基中。

6. 发明申请

WO2010140795A3 HUMAN-PLACENTA-LIKE COMPOSITION CONTAINING A HUMAN-PLACENTA-DERIVED GROWTH FACTOR AND CYTOKINES, AND COSMETIC USE THEREOF 审中-公开
标题翻译：含有人类衍生生长因子和细胞因子的人 - 类似物组合物及其化妆品用途
公开(公告)号：WO2010140795A3
公开(公告)日：2011-04-21
申请号：PCT/KR2010003435
申请日：2010-05-28
申请人： CHABIO & DIOSTECH CO LTD , CHUNG HYUNG MIN , KIM JU MI
发明人： CHUNG HYUNG MIN , KIM JU MI
IPC分类号： A61K8/64 , A61K8/98 , A61Q19/02 , A61Q19/08
CPC分类号： A61Q19/02 , A61K8/66 , A61K8/982 , A61K2800/592 , A61Q19/08
摘要： The present invention relates to a cosmetic composition restructured from a human-placenta-derived growth factor and cytokines. The present invention provides a cosmetic composition comprising, as active ingredients, 300 to 300,000 pg/ml of basic fibroblast growth factor-2 (FGF-2), 100 to 100,000 pg/ml of platelet-derived growth factor-AA (PDGF-AA), and 400 to 400,000 pg/ml of vascular endothelial growth factor (VEGF), and further comprising 40 to 40,000 pg/ml of Flt-3 Ligand, 300 to 300,000 pg/ml of RANTES (CCL5), 80 to 80,000 pg/ml of Interleukin-10 (IL-10), 80 to 80,0000 pg/ml of interferon-gamma-inducible protein-10 (IP-10), and 30 to 30,000 pg/ml of platelet-derived growth factor-BB (PDGF-BB), if needed. The present invention provides a cosmetic composition which exhibits excellent effects in wrinkle removal and skin-whitening even when applied in a small amount, as opposed to conventional cosmetic compositions containing placenta extracts in which unnecessary components are included.
摘要翻译：本发明涉及从人胎盘来源的生长因子和细胞因子重组的化妆品组合物。本发明提供一种化妆品组合物，其包含作为活性成分的300至300,000pg / ml的碱性成纤维细胞生长因子-2（FGF-2），100至100,000pg / ml的血小板衍生的生长因子AA（PDGF-AA ）和400至400,000pg / ml的血管内皮生长因子（VEGF），并且还包含40至40,000pg / ml的Flt-3配体，300至300,000pg / ml的RANTES（CCL5），80至80,000pg / ml的白细胞介素-10（IL-10），80至80,0000pg / ml的干扰素-γ诱导蛋白-10（IP-10）和30至30,000pg / ml的血小板衍生的生长因子-BB（ PDGF-BB）。本发明提供了与含有其中不含有成分的胎盘提取物的常规化妆品组合物相比，即使在少量使用时也具有优异的皱纹去除和皮肤美白效果的化妆品组合物。

7. 发明申请

WO2009035216A1 CELL DELIVERY SYSTEM FOR CELL THERAPY COMPRISING CELLS DERIVED FROM EMBRYONIC STEM CELLS 审中-公开
标题翻译：用于细胞治疗的细胞递送系统，其包含从胚胎干细胞衍生的细胞
公开(公告)号：WO2009035216A1
公开(公告)日：2009-03-19
申请号：PCT/KR2008/004722
申请日：2008-08-14
申请人： CHABIOTECH CO., LTD. , CHUNG, Hyung-Min , MOON, Sung-Hwan , KIM, Ju-Mi
发明人： CHUNG, Hyung-Min , MOON, Sung-Hwan , KIM, Ju-Mi
IPC分类号： A61K48/00
CPC分类号： A61K35/44 , A61K2035/128
摘要： The present invention provides a cell delivery system for cell therapy including cells derived from embryonic stem cells, which is formed by inserting the cells derived from embryonic stem cells into a carrier formed of matrigel. The cell delivery system is transplanted into the region of a living body, which does not directly in contact with a disease region; migration of the cells derived from embryonic stem cells from the transplanted region is inhibited by the carrier; and the cell delivery system is finally removed from the transplanted region. In the cell delivery system of the present invention, cell therapy is accomplished only by substances secreted from the cells derived from embryonic stem cells, such as cytokine, while the cells derived from embryonic stem cells are not directly in contact with a disease region. Therefore, the cell delivery system according to the present invention can avoid any formation of cancers and tumors, which may be caused from direct transplantation of cells derived from embryonic stem cells into a living body.
摘要翻译：本发明提供了用于细胞治疗的细胞递送系统，包括源自胚胎干细胞的细胞，其通过将从胚胎干细胞衍生的细胞插入由基质胶形成的载体中而形成。将细胞递送系统移植到不直接与疾病区域接触的生物体的区域中; 来自移植区域的胚胎干细胞的细胞的迁移被载体抑制; 并且最终从移植区域移除细胞递送系统。在本发明的细胞递送系统中，细胞治疗仅通过从源自胚胎干细胞（例如细胞因子）的细胞分泌的物质完成，而源自胚胎干细胞的细胞不直接与疾病区域接触。因此，根据本发明的细胞递送系统可以避免任何形成癌症和肿瘤，这可能是由从胚胎干细胞的细胞直接移植到活体中引起的。

8. 发明申请

WO2006107156A1 METHODS FOR ESTIMATING GLOBAL DNA METHYLATION IN MOUSE AND SCREENING METHODS FOR CANDIDATE ANTICANCER AGENTS USING THE SAME 审中-公开
标题翻译：用于估算小鼠全球DNA甲基化的方法和使用其的候选抗原试剂筛选方法
公开(公告)号：WO2006107156A1
公开(公告)日：2006-10-12
申请号：PCT/KR2006/001053
申请日：2006-03-22
申请人： CHABIOTECH CO., LTD. , LEE, Su-Man , JEONG, Kyoung-Sin , CHUNG, Hyung-Min , CHA, Kwang-Yul
发明人： LEE, Su-Man , JEONG, Kyoung-Sin , CHUNG, Hyung-Min , CHA, Kwang-Yul
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156
摘要： Provided are a method for estimating global DNA methylation in a mouse, which comprises measuring the degree of methylation of Bl element (SEQ ID NO: 1) in a mouse gDNA; and a screening method for a candidate anticancer agent using the same.
摘要翻译：提供了一种用于估计小鼠全球DNA甲基化的方法，其包括测量小鼠gDNA中的B1元件（SEQ ID NO：1）的甲基化程度; 以及使用其的候选抗癌剂的筛选方法。

9. 发明申请

WO2013009102A3 CARTILAGE CELL TREATING AGENT COMPRISING COLLAGEN, HYALURONIC ACID DERIVATIVE, AND STEM CELL DERIVED FROM MAMMAL UMBILICAL CORD 审中-公开
标题翻译：包含胶原蛋白，羟丙酸衍生物和从母体脐带衍生的干细胞的细胞处理剂
公开(公告)号：WO2013009102A3
公开(公告)日：2013-04-11
申请号：PCT/KR2012005518
申请日：2012-07-11
申请人： CHABIO & DIOSTECH CO LTD , CHOI YONG SOO , NOH SANG EUN , LEE YOUNGJUN , JUNG SANG YOUN , KIM SUN MI , HAN KYUBOEM , CHUNG HYUNG MIN
发明人： CHOI YONG SOO , NOH SANG EUN , LEE YOUNGJUN , JUNG SANG YOUN , KIM SUN MI , HAN KYUBOEM , CHUNG HYUNG MIN
IPC分类号： A61K35/44 , A61K31/728 , A61K35/12 , A61P19/00
CPC分类号： A61K38/39 , A61K31/728 , A61K35/51 , A61K35/545 , A61K47/36 , A61L27/26 , A61L27/3834 , A61L27/3852 , A61L27/52 , A61L2400/06 , A61L2430/06 , A61K2300/00 , C08L89/06 , C08L5/08
摘要： The present invention relates to a medical composite biomaterial. More specifically, the present invention relates to the medical composite biomaterial comprising collagen and a hyaluronic acid derivative. Also, the present invention relates to a cartilage cell treating agent using the biomaterial and stem cells derived from a mammal umbilical cord. The biomaterial does not cause an immune system reaction, has superior durability, and the cartilage cell treating agent comprising the biomaterial and the stem cells enables arthroscopic surgery, thereby reducing pain of the patient, and can effectively treat degenerative arthritis and cartilage damage.
摘要翻译：本发明涉及医用复合生物材料。更具体地，本发明涉及包含胶原和透明质酸衍生物的医用复合生物材料。此外，本发明涉及使用衍生自哺乳动物脐带的生物材料和干细胞的软骨细胞处理剂。生物材料不引起免疫系统反应，具有优异的耐久性，并且包含生物材料和干细胞的软骨细胞处理剂能够进行关节镜手术，从而减轻患者的疼痛，并可有效治疗退行性关节炎和软骨损伤。

10. 发明申请

WO2011052979A3 DE-DIFFERENTIATION METHOD OF CELLS USING NANOCARRIER, AND PREPARATION METHOD OF PLURIPOTENT STEM CELLS USING SAME 审中-公开
标题翻译：使用纳米颗粒的细胞分化方法及其使用的PLUIPOTETI干细胞的制备方法
公开(公告)号：WO2011052979A3
公开(公告)日：2011-10-27
申请号：PCT/KR2010007398
申请日：2010-10-27
申请人： CHABIO & DIOSTECH CO LTD , 3CRO INC , CHO SEONG-JE , DO JEONG-TAE , CHUNG HYUNG-MIN
发明人： CHO SEONG-JE , DO JEONG-TAE , CHUNG HYUNG-MIN
IPC分类号： C12N5/02 , B82B3/00 , C12N5/07 , C12N15/87
CPC分类号： B82Y5/00 , C12N5/00 , C12N2506/00 , C12N2531/00
摘要： The present invention relates to a de-differentiation method of cells comprising the following steps: (a) binding a de-differentiation transcription factor to a nanotube having a silicon dioxide layer to prepare a transcription factor-nanotube carrier; (b) culturing the transcription factor-nanotube carrier with cells; and (c) separating embryonic stem cell-like colonies from the cultured product obtained from step (b). Safety problems (for example, the possibility of propagation of cancer cells) caused by the use of a virus vector can be fundamentally avoided by using the preparation method of the present invention. Additionally, since protein denaturation is prevented, a sufficient amount of proteins can be supplied by the continuous release of proteins from the nanotube carrier without repeated treatment of the proteins.
摘要翻译：本发明涉及细胞的分解方法，包括以下步骤：（a）将去分化转录因子与具有二氧化硅层的纳米管结合以制备转录因子 - 纳米管载体; （b）用细胞培养转录因子 - 纳米管载体; 和（c）从步骤（b）获得的培养产物中分离胚胎干细胞样集落。通过使用本发明的制备方法，可以从根本上避免使用病毒载体引起的安全性问题（例如，癌细胞繁殖的可能性）。此外，由于蛋白质变性被阻止，通过蛋白质从纳米管载体的连续释放而不会重复处理蛋白质，可以提供足够量的蛋白质。

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