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1. 发明专利

JP2010011868A Molecular mimetic of meningococcal b epitope inducing functionally active antibody 有权
标题翻译：诱导功能活性抗体的男性骨关节炎病毒的分子形态
公开(公告)号：JP2010011868A
公开(公告)日：2010-01-21
申请号：JP2009238784
申请日：2009-10-15
申请人： Children's Hospital & Research Center Oakland , Novartis Vaccines & Diagnostics Inc , チルドレンズホスピタルアンドリサーチセンターオークランド , ノバルティスバクシンズアンドダイアグノスティックス,インコーポレーテッド
发明人： GRANOFF DAN , MOE GREGORY , RAPPUOLI RINO
IPC分类号： C12N15/09 , G01N33/53 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/395 , A61K39/40 , A61P31/04 , A61P43/00 , C07K1/22 , C07K2/00 , C07K14/22 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/36 , G01N33/569
CPC分类号： C07K14/22 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： PROBLEM TO BE SOLVED: To provide a medicine inducing the production of an antibody exhibiting complement-mediated bactericidal activity and/or opsonin activity. SOLUTION: Disclosed are molecular mimetics of a surface-exposed epitope on loop 4 of PorA of Neisseria meningitidis serogroup B (MenB) P1.2 serosubtype and antibodies produced against the mimetics. The mimetic is a GNA33 peptide containing an amino acid sequence QTP, and the peptide can induce the production of an antibody exhibiting complement-mediated bactericidal acitivty and/or opsonin activity against Neisseria meningitidis serogroup B bacterium. Compositions containing such molecular mimetics or the antibodies thereto can be used to prevent MenB disease, as well as for diagnosis of MenB infection. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供诱导产生具有补体介导的杀菌活性和/或调理素活性的抗体的药物。解决方案：公开了脑膜炎奈瑟氏球菌血清群B（MenB）P1.2血清型的PorA的环4上的表面暴露的表位的分子模拟物和针对模拟物产生的抗体。模拟物是含有氨基酸序列QTP的GNA33肽，并且肽可以诱导针对脑膜炎奈瑟氏球菌血清群B细菌表现出补体介导的杀菌活性和/或调理素活性的抗体的产生。含有这种分子模拟物的组合物或其抗体可用于预防MenB疾病以及MenB感染的诊断。版权所有（C）2010，JPO＆INPIT

2. 发明授权

US10028749B2 Cord collection clamp 有权
公开(公告)号：US10028749B2
公开(公告)日：2018-07-24
申请号：US14942094
申请日：2015-11-16
申请人： Children's Hospital & Research Center Oakland
发明人： Franciscus A. Kuypers
IPC分类号： A61M5/00 , A61B17/122 , A61M1/00 , A61B17/3211 , A61B10/02 , A61M1/02 , A61B5/15 , A61B17/3209 , A61B17/32 , A61B17/42
摘要： The present disclosure provides an apparatus, and methods of using same, for collecting blood from an umbilical cord in a sterile environment that includes an umbilical cord retaining assembly and a blood collection assembly rotatably connected to the umbilical cord retaining assembly. A cord cutting blade, which is carried by the blood collection assembly, functions to cut the umbilical cord when the blood collection assembly is rotated relative to the umbilical cord retaining assembly. After the umbilical cord is cut, blood flows by force of gravity into the blood collection region of the blood collection assembly to which a blood collection bag can be interconnected.

3. 发明授权

US10070984B2 Variable pressure upper torso braces and methods related thereto 有权
公开(公告)号：US10070984B2
公开(公告)日：2018-09-11
申请号：US14649197
申请日：2013-11-26
申请人： Children's Hospital & Research Center Oakland
发明人： Olajire Idowu , Sunghoon Kim
IPC分类号： A61F5/00 , A61F5/02 , A61F5/03 , A61F5/34
CPC分类号： A61F5/02 , A61F5/03 , A61F5/34
摘要： Upper torso braces to correct deformities in the upper torso of a patient are provided. The upper torso braces include a brace structure adapted to be maintained around an upper torso of an individual and to restrict outward expansion, and a variable force applicator coupled to the brace structure and positioned to contact and apply varying pressure to a target location on the upper torso. The brace structure is configured to restrict outward expansion and to provide a counteracting force for the variable force applicator during application of the variable pressure to the target location. In some instances, the upper torso braces may include a control element to adjust an amount of pressure provided by the variable force applicator to the target location. Methods of correcting a deformity on an upper torso with the upper torso braces are also provided.

4. 发明授权

US09914756B2 Non-naturally occurring factor H binding proteins (fHbp) and methods of use thereof 有权
公开(公告)号：US09914756B2
公开(公告)日：2018-03-13
申请号：US14907228
申请日：2014-08-01
申请人： Children's Hospital & Research Center Oakland
发明人： Peter T. Beernink
IPC分类号： A61K39/095 , C07K14/22 , A61K39/00
CPC分类号： C07K14/22 , A61K39/095 , A61K2039/53
摘要： Non-naturally occurring factor H binding proteins derived from variant 3 fHbp that can elicit antibodies that are bactericidal for at least one strain of N. meningitidis, and methods of use of such proteins, are provided. In certain embodiments, a non-naturally occurring factor H binding protein (fHbp) derived from a naturally occurring variant 3 fHbp is disclosed. The non-naturally fHbp may include a substitution of the histidine at position 223 of the naturally occurring variant 3 fHbp with an amino acid selected from the group consisting of arginine, lysine, phenylalanine, tyrosine, or tryptophan, wherein the numbering of position 223 is based on the numbering of the mature fHbp ID 1. The non-naturally occurring fHbp may have a lower affinity for human factor H (fH) than fHbp ID 79.

5. 发明授权

US09855184B2 Non-surgical torso deformity correction devices and methods related thereto 有权
公开(公告)号：US09855184B2
公开(公告)日：2018-01-02
申请号：US14266447
申请日：2014-04-30
申请人： Children's Hospital & Research Center Oakland
发明人： Olajire Idowu , Sunghoon Kim
IPC分类号： A61H9/00 , A61B17/02
CPC分类号： A61H9/0057 , A61B17/0281 , A61H2201/1619 , A61H2201/5064 , A61H2201/5071 , A61H2205/084
摘要： Aspects of the invention include devices and methods for correcting a torso deformity of a patient. The devices include a suction chamber for placement around the torso deformity and to provide negative pressure to the torso deformity; and a measurement component coupled to the suction chamber. The measurement component is adapted to indicate a relative distance between the torso deformity and a distal surface of the suction chamber. The methods include positioning a torso deformity correcting device around a torso deformity on a torso of a patient. The methods further include withdrawing air from the suction chamber to apply negative pressure within the suction chamber to displace the torso deformity, and setting a negative pressure level by measuring the relative distance of the torso deformity and the distal surface of the suction chamber that is indicated by the measurement component.

6. 发明申请

US20160235833A1 Chimeric Factor H Binding Proteins (fHBP) and Methods of Use 审中-公开
标题翻译：嵌合因子H结合蛋白（fHBP）和使用方法
公开(公告)号：US20160235833A1
公开(公告)日：2016-08-18
申请号：US14992872
申请日：2016-01-11
申请人： Children's Hospital & Research Center Oakland
发明人： Dan M. Granoff , Peter T. Beernink
IPC分类号： A61K39/095 , C07K16/12 , C12N15/74 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , A61K2039/70 , C07K14/22 , C07K16/1217 , C07K2317/34 , C12N15/74
摘要： Chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
摘要翻译：提供可引发对脑膜炎奈瑟氏球菌的不同fHbp变体菌株具有杀菌性的抗体的嵌合fHbps和使用方法。

7. 发明授权

US09398871B2 Devices, systems and methods for inserting a gastrointestinal body part into a patients body while measuring oxygen saturation 有权
标题翻译：用于在测量氧饱和度时将胃肠体部分插入患者体内的装置，系统和方法
公开(公告)号：US09398871B2
公开(公告)日：2016-07-26
申请号：US14327870
申请日：2014-07-10
申请人： Children's Hospital & Research Center Oakland
发明人： Olajire Idowu , Sunghoon Kim
IPC分类号： A61F2/50 , A61B5/1455 , A61B17/34 , A61B5/00 , A61B17/00 , A61B18/00
CPC分类号： A61B5/14551 , A61B5/4255 , A61B5/6846 , A61B17/3423 , A61B90/40 , A61B2017/00818 , A61B2017/00876 , A61B2018/00494 , A61B2503/045
摘要： Devices for containing exposed internal body parts during their insertion into the body of a patient are provided. The devices include a surgical pouch that comprises a measurement feature adapted to facilitate a measurement of the oxygen saturation of the exposed internal body parts. In some embodiments, the subject devices comprise an inner pouch for containing the exposed internal body parts, as well as an outer pouch that can be pressurized to exert positive pressure on the inner pouch to facilitate insertion of the internal body parts into the body of the patient. Also provided are methods for containing the exposed internal body parts of a patient and inserting the body parts into the patient, optionally using positive pressure, while monitoring the oxygen saturation of the exposed internal body parts via the measurement feature.
摘要翻译：提供用于在其插入患者体内时容纳暴露的内部身体部位的装置。这些装置包括手术袋，其包括适于便于测量暴露的内部身体部位的氧饱和度的测量特征。在一些实施例中，主体装置包括用于容纳暴露的内部主体部分的内部小袋以及可以被加压以在内部袋上施加正压力以便于将内部主体部件插入到主体部分的主体中的外部小袋患者。还提供了用于容纳患者的暴露的内部身体部分并且可选地使用正压将身体部分插入患者体内的方法，同时通过测量特征监测暴露的内部身体部位的氧饱和度。

8. 发明申请

US20150328035A1 Variable Pressure Upper Torso Braces and Methods Related Thereto 审中-公开
标题翻译：可变压力上躯干大括号及其相关方法
公开(公告)号：US20150328035A1
公开(公告)日：2015-11-19
申请号：US14649197
申请日：2013-11-26
申请人： Children's Hospital & Research Center Oakland
发明人： Olajire Idowu , Sunghoon Kim
IPC分类号： A61F5/02
CPC分类号： A61F5/02 , A61F5/03 , A61F5/34
摘要： Upper torso braces to correct deformities in the upper torso of a patient are provided. The upper torso braces include a brace structure adapted to be maintained around an upper torso of an individual and to restrict outward expansion, and a variable force applicator coupled to the brace structure and positioned to contact and apply varying pressure to a target location on the upper torso. The brace structure is configured to restrict outward expansion and to provide a counteracting force for the variable force applicator during application of the variable pressure to the target location. In some instances, the upper torso braces may include a control element to adjust an amount of pressure provided by the variable force applicator to the target location. Methods of correcting a deformity on an upper torso with the upper torso braces are also provided.
摘要翻译：提供用于矫正患者上部躯体畸形的上躯干支架。上躯干支架包括适于围绕个体的上身保持并且限制向外膨胀的支撑结构，以及可变力施加器，其联接到支架结构并且定位成接触并施加变化的压力到上部的目标位置躯干。支撑结构构造成限制向外膨胀并且在向可变压力施加到目标位置时为可变力施加器提供抵抗力。在一些情况下，上躯干支架可以包括控制元件，以将由可变力施加器提供的压力量调整到目标位置。还提供了使用上部躯干大括号校正上身畸形的方法。

9. 发明申请

US20140350336A1 Devices, Systems, and Methods for Removing Empyema from a Pleural Cavity 有权
标题翻译：用于从胸膜腔清除脓胸的装置，系统和方法
公开(公告)号：US20140350336A1
公开(公告)日：2014-11-27
申请号：US14298735
申请日：2014-06-06
申请人： Children's Hospital & Research Center Oakland
发明人： Olajire Idowu , Sunghoon Kim
IPC分类号： A61B1/00 , A61M27/00 , A61B1/05
CPC分类号： A61B1/00094 , A61B1/00165 , A61B1/05 , A61M27/00 , A61M2250/00
摘要： Pleural empyema removal devices are provided and enable the removal of empyema from the pleural cavity of a human or veterinary patient. The pleural empyema removal devices may be coupled with one or more additional devices, such as suction source, gas source, light source and/or camera source, and monitor. The devices and systems including the devices facilitate the removal of empyema from the pleural cavity of a patient while providing protections from damage to untargeted tissues. The devices, systems, and methods can be used in the treatment process to treat pleural empyema resulting from pleural effusions and infections stemming from various illnesses and disorders, such as pneumonia.
摘要翻译：提供胸膜积液除去装置，并能够从人或兽医患者的胸膜腔中除去脓胸。胸膜积液除去装置可以与一个或多个附加装置（例如抽吸源，气体源，光源和/或照相机源）和监视器耦合。包括装置的装置和系统有助于从患者的胸膜腔中除去脓肿，同时提供保护以免对非靶向组织的损伤。装置，系统和方法可用于治疗由胸膜积液引起的胸膜积液和由各种疾病和疾病如肺炎引起的感染的治疗过程。

10. 发明授权

US09872921B2 DE-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy 有权
公开(公告)号：US09872921B2
公开(公告)日：2018-01-23
申请号：US14742526
申请日：2015-06-17
申请人： Children's Hospital & Research Center Oakland
发明人： Gregory R. Moe , Charles Paul Plested
IPC分类号： C07K16/30 , A61K47/48 , A61K31/715 , A61K39/395 , A61K39/40 , C07K19/00 , A61K39/44 , A61K39/00 , A61K39/108 , A61K39/095 , C07K16/12 , C08B37/00 , C08L5/00 , C07K16/28 , A61K47/68
CPC分类号： A61K47/6851 , A61K31/715 , A61K39/0011 , A61K39/0258 , A61K39/095 , A61K39/395 , A61K39/39558 , A61K39/40 , A61K39/44 , A61K2039/6012 , A61K2039/6037 , C07K16/1217 , C07K16/28 , C07K16/3076 , C07K16/3084 , C07K19/00 , C07K2317/14 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/40 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C08B37/0063 , C08L5/00 , Y02A50/474
摘要： The present invention generally provides compositions methods and composition relating to the diagnosis and/or treatment of cancers having a cell surface de-N-acetylated sialic acid antigen, e.g., an at least partially de-N-acetylated ganglioside and/or a de-N-acetylated sialic acid-modified cell surface protein.

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