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1. 发明申请

WO2004015060A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗性多肽，编码其的核酸及其使用方法
公开(公告)号：WO2004015060A3
公开(公告)日：2004-10-07
申请号：PCT/US0224492
申请日：2002-08-02
申请人： CURAGEN CORP , ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , KHRAMTSOV NIKOLAI V , LI LI , MACDOUGALL JOHN R , PENA CAROL E A , PEYMAN JOHN A , PATTURAJAN MEERA , SHIMKETS RICHARD A , SMITHSON GLENNDA , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
发明人： ANDERSON DAVID W , BOLDOG FERENC L , CASMAN STACIE J , EDINGER SHLOMIT R , GANGOLLI ESHA A , GERLACH VALERIE L , GORMAN LINDA , GUO XIAOJIA , KHRAMTSOV NIKOLAI V , LI LI , MACDOUGALL JOHN R , PENA CAROL E A , PEYMAN JOHN A , PATTURAJAN MEERA , SHIMKETS RICHARD A , SMITHSON GLENNDA , SPYTEK KIMBERLY A , VERNET CORINE A M , VOSS EDWARD Z , ZHONG MEI
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C12N15/12 , C07K14/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

2. 发明申请

WO2004015060A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗用多肽，编码核酸及使用方法
公开(公告)号：WO2004015060A2
公开(公告)日：2004-02-19
申请号：PCT/US2002/024492
申请日：2002-08-02
申请人： CURAGEN CORPORATION , ANDERSON, David, W. , BOLDOG, Ferenc, L. , CASMAN, Stacie, J. , EDINGER, Shlomit, R. , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, linda , GUO, Xiaojia , KHRAMTSOV, Nikolai, V. , LI, Li , MACDOUGALL, John, R. , PENA, Carol, E., A. , PEYMAN, John, A. , PATTURAJAN, Meera , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , VERNET, Corine, A, M. , VOSS, Edward, Z. , ZHONG, Mei
发明人： ANDERSON, David, W. , BOLDOG, Ferenc, L. , CASMAN, Stacie, J. , EDINGER, Shlomit, R. , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, linda , GUO, Xiaojia , KHRAMTSOV, Nikolai, V. , LI, Li , MACDOUGALL, John, R. , PENA, Carol, E., A. , PEYMAN, John, A. , PATTURAJAN, Meera , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , VERNET, Corine, A, M. , VOSS, Edward, Z. , ZHONG, Mei
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白质受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及与多肽免疫特异性结合的抗体，以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

3. 发明申请

WO2003102159A3 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2003102159A3
公开(公告)日：2003-12-11
申请号：PCT/US2003/017573
申请日：2003-06-04
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BAUMGARTNER, Jason, C. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , DHANABAL, Mohanraj , EDINGER, Shlomit, R. , ELLERMAN, Karen , ETTENBERG, Seth , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GROSSE, William, M. , GUNTHER, Erik , GUO, Xiaojia , GUSEV, Vladimir, Y. , HERRMANN, John, L. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LAROCHELLE, William, J. , LI, Li , LIANG, Hongping , LOW, Kenneth , MACDOUGALL, John, R. , MACLACHLAN, Timothy , MALYANKAR, Uriel, M. , MCQUEENEY, Kelly , MEZICK, Amanda, J. , MILLER, Charles, E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , PEYMAN, John, A. , QIAN, Xiaozhong , RASTELLI, Luca , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , STONE, David, J. , SUKUMARAN, Sujatha , SZEKERES, Edward, S., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , WOLENC, Adam, R. , ZHONG, Mei , ZHONG, Haihong
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BAUMGARTNER, Jason, C. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , DHANABAL, Mohanraj , EDINGER, Shlomit, R. , ELLERMAN, Karen , ETTENBERG, Seth , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GORMAN, Linda , GROSSE, William, M. , GUNTHER, Erik , GUO, Xiaojia , GUSEV, Vladimir, Y. , HERRMANN, John, L. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LAROCHELLE, William, J. , LI, Li , LIANG, Hongping , LOW, Kenneth , MACDOUGALL, John, R. , MACLACHLAN, Timothy , MALYANKAR, Uriel, M. , MCQUEENEY, Kelly , MEZICK, Amanda, J. , MILLER, Charles, E. , MILLET, Isabelle , PADIGARU, Muralidhara , PATTURAJAN, Meera , PEYMAN, John, A. , QIAN, Xiaozhong , RASTELLI, Luca , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SMITHSON, Glennda , SPYTEK, Kimberly, A. , STONE, David, J. , SUKUMARAN, Sujatha , SZEKERES, Edward, S., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , WOLENC, Adam, R. , ZHONG, Mei , ZHONG, Haihong
IPC分类号： C12Q1/68
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

4. 发明申请

WO2003085124A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003085124A3
公开(公告)日：2003-10-16
申请号：PCT/US2003/009775
申请日：2003-04-01
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P. II , BENTO, Patricia , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CRABTREE-BOKOR, Julie, R. , EDINGER, Shlomit, R. , ELLERMAN, Karen , FERNANDES, Elma, R. , GERLACH, Valerie, L. , GROSSE, William, M. , GUNTHER, Erik , GUSEV, Vladimir, Y. , HEYES, Melvyn, P. , LEPLEY, Denise, M. , LI, Li , MACDOUGALL, John, R. , MALYANKAR, Uriel, M. , MILLET, Isabelle , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SHIMKETS, Richard, D. , SMITHSON, Glennda , STONE, David, J. , VERNET, Corine, A. M. , VOSS, Edward, Z.
发明人： ALSOBROOK, John, P. II , BENTO, Patricia , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CRABTREE-BOKOR, Julie, R. , EDINGER, Shlomit, R. , ELLERMAN, Karen , FERNANDES, Elma, R. , GERLACH, Valerie, L. , GROSSE, William, M. , GUNTHER, Erik , GUSEV, Vladimir, Y. , HEYES, Melvyn, P. , LEPLEY, Denise, M. , LI, Li , MACDOUGALL, John, R. , MALYANKAR, Uriel, M. , MILLET, Isabelle , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SHIMKETS, Richard, D. , SMITHSON, Glennda , STONE, David, J. , VERNET, Corine, A. M. , VOSS, Edward, Z.
IPC分类号： C07K14/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

5. 发明申请

WO2003083046A3 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2003083046A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/010142
申请日：2003-04-01
申请人： CURAGEN CORPORATION , ANDERSON, David, W. , BENTO, Patricia , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , FURTAK, Katarzyna , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUNTHER, Erik , HEYES, Melvyn, P. , LI, Li , SPYTEK, Kimberly, A. , STONE, David, J. , ZHONG, Mei , MALYANKAR, Uriel, M. , EDINGER, Shlomit, R. , PATTURAJAN, Meera , ROTHENBERG, Mark, E. , SMITHSON, Glennda
发明人： ANDERSON, David, W. , BENTO, Patricia , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , FURTAK, Katarzyna , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUNTHER, Erik , HEYES, Melvyn, P. , LI, Li , SPYTEK, Kimberly, A. , STONE, David, J. , ZHONG, Mei , MALYANKAR, Uriel, M. , EDINGER, Shlomit, R. , PATTURAJAN, Meera , ROTHENBERG, Mark, E. , SMITHSON, Glennda
IPC分类号： A61K38/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

6. 发明申请

WO03004687A8 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白质和编码相同的核酸
公开(公告)号：WO03004687A8
公开(公告)日：2003-05-08
申请号：PCT/US0221361
申请日：2002-07-03
申请人： CURAGEN CORP , ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
发明人： ANDERSON DAVID W , BERGHS CONSTANCE , BOLDOG FERENC L , BURGESS CATHERINE E , CASMAN STACIE J , CATTERTON ELINA
IPC分类号： C07K14/47 , C12Q
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。本发明还公开了与疾病相关的治疗性小分子。本发明进一步公开了用于诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

7. 发明申请

WO0210216A3 PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：蛋白质和核酸编码相同
公开(公告)号：WO0210216A3
公开(公告)日：2003-05-08
申请号：PCT/US0124225
申请日：2001-07-30
申请人： CURAGEN CORP , PADIGARU MURALIDHARA , MEZES PETER , MISHRA VISHNU , BURGESS CATHERINE , CASMAN STACIE , GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , GERLACH VALERIE L , MACDOUGALL JOHN R , SMITHSON GLENNDA
发明人： PADIGARU MURALIDHARA , MEZES PETER , MISHRA VISHNU , BURGESS CATHERINE , CASMAN STACIE , GROSSE WILLIAM M , ALSOBROOK JOHN P II , LEPLEY DENISE M , GERLACH VALERIE L , MACDOUGALL JOHN R , SMITHSON GLENNDA
IPC分类号： C12N15/09 , A61K31/7052 , A61K38/00 , A61K39/395 , A61K48/00 , A61P1/16 , A61P3/04 , A61P3/10 , A61P3/14 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P13/12 , A61P17/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/22 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07H21/04 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N9/00 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , A61K38/17 , G01N33/50 , G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further disclosed therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.
摘要翻译：本文公开了编码多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明进一步公开了用于诊断，治疗和预防涉及这些人核酸和蛋白质中的任一种的病症的治疗，诊断和研究方法。

8. 发明申请

WO2003023001A3 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2003023001A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028538
申请日：2002-09-09
申请人： CURAGEN CORPORATION , AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , CHANT, John, S. , CHAUDHURI, Amitabha , CRABTREE, Julie , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GIOT, Loic , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir, Y. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LEACH, Martin, D. , LEPLEY, Denise, M. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel, M. , MILLER, Charles, E. , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J., Jr. , TWOMLOW, Nancy , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
发明人： AGEE, Michele, L. , ALSOBROOK, John, P., II , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , CHANT, John, S. , CHAUDHURI, Amitabha , CRABTREE, Julie , DIPIPPO, Vincent, A. , EDINGER, Shlomit, R. , EISEN, Andrew , ELLERMAN, Karen , GANGOLLI, Esha, A. , GERLACH, Valerie, L. , GIOT, Loic , GORMAN, Linda , GUO, Xiaojia , GUSEV, Vladimir, Y. , JI, Weizhen , KEKUDA, Ramesh , KHRAMTSOV, Nikolai, V. , LEACH, Martin, D. , LEPLEY, Denise, M. , LI, Li , LIU, Xiaohong , MALYANKAR, Uriel, M. , MILLER, Charles, E. , OOI, Chean, Eng , ORT, Tatiana , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RIEGER, Daniel, K. , ROTHENBERG, Mark, E. , SHENOY, Suresh, G. , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , TAUPIER, Raymond, J., Jr. , TWOMLOW, Nancy , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZERHUSEN, Bryan, D. , ZHONG, Mei
IPC分类号： A61K38/00 , C07K1/00
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

9. 发明申请

WO2003003984A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO2003003984A2
公开(公告)日：2003-01-16
申请号：PCT/US2002/021268
申请日：2002-07-03
申请人： CURAGEN CORPORATION , FERNANDES, Elma, R. , VERNET, Corine, A., M. , SHIMKETS, Richard, A. , ANDERSON, David, W. , PADIGARU, Muralidhara , BOLDOG, Ferenc, L. , LI, Li , SHENOY, Suresh, G. , CASMAN, Stacie, J. , RASTELLI, Luca , ALSOBROOK, John, P., II , BURGESS, Catherine, E. , GROSSE, William, M. , GUSEV, Vladimir, Y. , JI, Weizhen , LEPLEY, Denise, M. , LIU, Xiaohong , MEZICK, Amanda, J. , PATTURAJAN, Meera , SHEN, Lei , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , SZEKERES, Edward, S., Jr. , TAUPIER, Raymond, J., Jr. , TCHERNEV, Velizar, T. , ZERHUSEN, Bryan, D. , VOSS, Edward, Z.
发明人： FERNANDES, Elma, R. , VERNET, Corine, A., M. , SHIMKETS, Richard, A. , ANDERSON, David, W. , PADIGARU, Muralidhara , BOLDOG, Ferenc, L. , LI, Li , SHENOY, Suresh, G. , CASMAN, Stacie, J. , RASTELLI, Luca , ALSOBROOK, John, P., II , BURGESS, Catherine, E. , GROSSE, William, M. , GUSEV, Vladimir, Y. , JI, Weizhen , LEPLEY, Denise, M. , LIU, Xiaohong , MEZICK, Amanda, J. , PATTURAJAN, Meera , SHEN, Lei , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , SZEKERES, Edward, S., Jr. , TAUPIER, Raymond, J., Jr. , TCHERNEV, Velizar, T. , ZERHUSEN, Bryan, D. , VOSS, Edward, Z.
IPC分类号： A61K
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving anyone of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防涉及任何这些新型人核酸和蛋白质的病症的治疗，诊断和研究方法。

10. 发明申请

WO2002098917A3 HUMAN PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
公开(公告)号：WO2002098917A3
公开(公告)日：2002-12-12
申请号：PCT/US2002/022049
申请日：2002-02-12
申请人： CURAGEN CORPORATION , GUO, Xiaojia , FERNANDES, Elma , LI, Li , KEKUDA, Ramesh , LIU, Yi , LEITE, Mario , SPYTEK, Kimberly, A. , JI, Weizhen , CASMAN, Stacie, J. , BOLDOG, Ference, L. , PATTURAJAN, Meera , VERNET, Corine, A.M. , BALLINGER, Robert, A. , MALYANKAR, Uriel, M. , TCHERNEV, Velizar, T. , BLALOCK, Angela, D. , GUSEV, Vladimir, Y. , RASTELLI, Luca , MEZES, Peter, D. , ELLERMAN, Karen , HEYES, Melvyn , HERRMANN, John, L. , SHIMKETS, Richard, A. , IOIME, Noelle , PENA, Carol, E., A. , SHENOY, Suresh, G. , TAUPIER, Raymond, J., Jr. , GERLACH, Valerie , GORMAN, Linda
发明人： GUO, Xiaojia , FERNANDES, Elma , LI, Li , KEKUDA, Ramesh , LIU, Yi , LEITE, Mario , SPYTEK, Kimberly, A. , JI, Weizhen , CASMAN, Stacie, J. , BOLDOG, Ference, L. , PATTURAJAN, Meera , VERNET, Corine, A.M. , BALLINGER, Robert, A. , MALYANKAR, Uriel, M. , TCHERNEV, Velizar, T. , BLALOCK, Angela, D. , GUSEV, Vladimir, Y. , RASTELLI, Luca , MEZES, Peter, D. , ELLERMAN, Karen , HEYES, Melvyn , HERRMANN, John, L. , SHIMKETS, Richard, A. , IOIME, Noelle , PENA, Carol, E., A. , SHENOY, Suresh, G. , TAUPIER, Raymond, J., Jr. , GERLACH, Valerie , GORMAN, Linda
IPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving anyone of these novel human nucleic acids and proteins.

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