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1. 发明专利

JP2011141286A Compact optical detection system for microfluidic device 有权
标题翻译：用于微流体装置的紧凑光学检测系统
公开(公告)号：JP2011141286A
公开(公告)日：2011-07-21
申请号：JP2011035075
申请日：2011-02-21
申请人： Caliper Life Sciences Inc , カリパー・ライフ・サイエンシズ・インク.
发明人： RULISON AARON , WOLK JEFFREY A , LEE ERNEST C W , SLATER MICHAEL , JENSEN MORTEN J
IPC分类号： G01N21/64 , G01N21/05
CPC分类号： G01B11/002 , B01L3/5027 , B01L3/502715 , B01L2200/025 , B01L2300/0816 , G01N21/645 , G01N2021/0162 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0627 , G02B21/16
摘要： PROBLEM TO BE SOLVED: To provide an optical detection system for a microfluidic device and a dry-focus microfluidic device compatible with the compact optical detection system.
SOLUTION: The optical detection system for microfluidic devices includes an LED, a means of collimating light emitted by the LED, a means of directing the collimated light onto the microfluidic device through an objective lens, and a means of detecting a fluorescent signal emitted from the microfluidic device. In the optical detection system for microfluidic devices, the dry-focus microfluidic device includes a plurality of channels and a plurality of closed optical alignment marks having curved walls. At least one of the channels is positioned between at least two of the marks. The marks are illuminated for alignment and focusing purposes by light from an external white LED.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于微流体装置的光学检测系统和与紧凑型光学检测系统兼容的干焦微流体装置。解决方案：用于微流体装置的光学检测系统包括LED，准直由LED发射的光的装置，通过物镜将准直光引导到微流体装置的手段，以及检测荧光信号的装置从微流体装置发射。在用于微流体装置的光学检测系统中，干焦微流体装置包括多个通道和多个具有弯曲壁的闭合光学对准标记。至少一个通道位于至少两个标记之间。通过来自外部白色LED的光照亮标记以进行对准和聚焦。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2005049357A Electronic pipetter and compensation means for electrophoretic bias 审中-公开
标题翻译：电子偏移电子管和补偿装置
公开(公告)号：JP2005049357A
公开(公告)日：2005-02-24
申请号：JP2004278557
申请日：2004-09-24
申请人： Caliper Life Sciences Inc , カリパー・ライフ・サイエンシズ・インコーポレーテッドCaliper Liff Sciences Incorporated
发明人： PARCE J WALLACE , KNAPP MICHAEL R
IPC分类号： G01N27/447 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To introduce a substance into a micro fluid system. SOLUTION: The micro fluid system has a capillary channel constituted to introduce the substances into the micro fluid system from a plurality of sources, and having an end part, and a voltage source for impressing a voltage potential to an electrode of the micro fluid system. In the system, the end part of the capillary channel is brought into contact with the objective substance source, the voltage is impressed to the objective substance source, as to the electrode, the source of the spacer substance having a prescribed concentration is selected, and a voltage is impressed to the spacer substance source, as to the electrode. The system includes a process for repeating the process hereinbefore, using the different substance sources, to introduce the plurality of different substances separated by the spacer substance electrokinetically into the capillary channel, without being mixed between the different substances, and to be transported toward the micro fluid system. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：将物质引入微流体系统。解决方案：微流体系统具有毛细通道，其构成为将物质从多个源引入微流体系统，并具有端部，以及用于将电压电位施加到微电极的电压源流体系统。在该系统中，使毛细通道的端部与目标物质源接触，对物体源施加电压，对于电极，选择具有规定浓度的间隔物质的源，电极对间隔物质源施加电压。该系统包括用于重复上述过程的方法，使用不同的物质源，将间隔物物质分离的多种不同物质电动地引入毛细通道中，而不会在不同物质之间混合，并被输送到微量流体系统。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2014079252A Method and apparatus for generating thermal melting curve in microfluidic device 有权
标题翻译：用于在微流体装置中产生热熔曲线的方法和装置
公开(公告)号：JP2014079252A
公开(公告)日：2014-05-08
申请号：JP2013271633
申请日：2013-12-27
申请人： Caliper Life Sciences Inc , カリパーライフサイエンシズ,インコーポレイテッド , Canon Us Life Sciences Inc , キヤノンユー.エス. ライフサイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc.
发明人： STEVEN A SUNDBERG , KNAPP MICHAEL R , KNIGHT IVOR T , BOLES DEBORAH J , RULISON AARON , DONG WESLEY B , FABANS ANDREW , BORANKAY ALLEN , DOLON EDWARD , MOTI ROBERT , SLATER MICHAEL
IPC分类号： C12Q1/68 , G01N21/33 , G01N21/64 , G01N35/00 , G01N35/08 , G01N37/00
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： PROBLEM TO BE SOLVED: To determine the properties of biological materials on a microfluidic device.SOLUTION: The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves.
摘要翻译：要解决的问题：确定微流体装置上的生物材料的性质。解决方案：本发明提供了使用微流体技术产生分子熔融曲线的新方法和装置。

4. 发明专利

JP2013051969A Method and apparatus for generating thermal melting curves in microfluidic device 有权
标题翻译：用于在微流体装置中产生热熔融曲线的方法和装置
公开(公告)号：JP2013051969A
公开(公告)日：2013-03-21
申请号：JP2012251788
申请日：2012-11-16
申请人： Caliper Life Sciences Inc , カリパーライフサイエンシズ,インコーポレイテッド , Canon Us Life Sciences Inc , キヤノンユー.エス. ライフサイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc.
发明人： SUNDBERG STEVEN A , KNAPP MICHAEL R , KNIGHT IVOR T , BOLES DEBORAH J , RULISON AARON , DONG WESLEY B , FABANS ANDREW , BORANKAY ALLEN , DOLON EDWARD , MOTI ROBERT , SLATER MICHAEL
IPC分类号： C12Q1/68 , G01N21/64 , G01N33/58 , G01N37/00
CPC分类号： G01N25/04 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L7/52 , B01L7/525 , B01L2200/10 , B01L2300/0627 , B01L2300/0816 , B01L2300/14 , B01L2300/18 , B01L2300/1833 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , C12Q1/68 , C12Q1/6844 , C12Q1/686 , C12Q1/6862 , G01N21/33 , G01N21/6428 , Y10T436/143333 , C12Q2565/629 , C12Q2565/101 , C12Q2527/107 , C12Q2527/101
摘要： PROBLEM TO BE SOLVED: To provide novel methods and devices that employ microfluidic technology to generate molecular melt curves.SOLUTION: A method of determining the value of a physical parameter that corresponds to a reference temperature within a channel in a microfluidic device includes: flowing a fluid comprising a molecule of known Tthrough the channel; varying a physical parameter that correlates with the temperature within the channel; generating a thermal property curve for the molecule by measuring the value of a detectable property of the molecule as a function of the parameter; and determining the values of the detectable property and the parameter at the point in the thermal property curve that corresponds to the Tof the molecule.
摘要翻译：要解决的问题：提供采用微流体技术产生分子熔融曲线的新方法和装置。解决方案：确定对应于微流体装置的通道内的参考温度的物理参数的值的方法包括：使包含已知T分子的流体流动， SB>通过渠道; 改变与通道内的温度相关的物理参数; 通过测量分子的可检测性质的值作为参数的函数来产生分子的热性质曲线; 并且确定与分子的T m 对应的热性质曲线中的点处的可检测性质和参数的值。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2011081011A Reduction of migration shift assay interference 有权
标题翻译：减少移动移动测量干扰
公开(公告)号：JP2011081011A
公开(公告)日：2011-04-21
申请号：JP2010277630
申请日：2010-12-14
申请人： Caliper Life Sciences Inc , Wako Pure Chemical Industries Ltd , カリパー・ライフ・サイエンシズ・インク. , 和光純薬工業株式会社
发明人： WADA H GARRETT , KAZAKOVA IRINA G , MIKI YUTAKA , OHASHI TOSHISHIGE , KANKE FUTOSHI
IPC分类号： G01N27/447 , B01L3/00 , C12Q1/68 , G01N30/02 , G01N30/34 , G01N30/86 , G01N33/53 , G01N33/533 , G01N33/534 , G01N33/535 , G01N33/538 , G01N33/561 , G01N33/574
CPC分类号： G01N30/8644 , B01L3/5027 , B01L3/502753 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N30/02 , G01N30/34 , G01N33/5306 , G01N33/538 , G01N33/561 , B01D15/34
摘要： PROBLEM TO BE SOLVED: To provide a method and composition to reduce interference from non-specific binding sample constituents in a migration shift assay, for example. SOLUTION: Interference due to non-specific binding of sample constituents to an affinity substance (e.g., an affinity molecule or a conjugate of an affinity molecule and a charged carrier molecule) is prevented by, e.g., binding the constituents to charged polymers such as heparin sulfate. The present invention also provides a method to concentrate an analyte of interest with high concentration and to detect the analyte with high sensitivity, and further to optimize the reaction conditions for easily concentrating the analyte. Such objects of the present invention are attained, for example, by concentrating a complex of the analyte and a conjugate which is formed by bringing the analyte in a sample into contact with an affinity molecule bound to a charged carrier molecule such as DNA. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供例如在迁移移位测定中减少来自非特异性结合样品成分的干扰的方法和组合物。解决方案：通过例如将成分与带电聚合物结合，可以防止样品成分与亲和物质（例如，亲和分子或亲和分子和带电载体分子的结合物）的非特异性结合的干扰如硫酸肝素。本发明还提供了一种以高浓度浓缩感兴趣分析物并以高灵敏度检测分析物的方法，并进一步优化用于容易地浓缩分析物的反应条件。本发明的这些目的可以通过例如浓缩分析物和通过将样品中的分析物与结合到带电荷的载体分子如DNA的亲和分子接触形成的缀合物进行浓缩来实现。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2012211914A Microfluidic devices and systems incorporating cover layers 有权
标题翻译：微流体装置和系统包含盖层
公开(公告)号：JP2012211914A
公开(公告)日：2012-11-01
申请号：JP2012133822
申请日：2012-06-13
申请人： Caliper Life Sciences Inc , カリパー・ライフ・サイエンシズ・インク.
发明人： ROBERT S DUBROW , COLIN B KENNEDY , ROBERT NAGLE , DAVID CHAZAN , ERNEST C W LEE , KHUSHROO GANDHI , CALVIN Y H CHOW
IPC分类号： G01N35/08 , B01J19/00 , B01L3/00 , B81B1/00 , G01N1/18 , G01N1/34 , G01N35/02 , G01N35/10 , G01N37/00
CPC分类号： B01L3/502753 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N2001/4016
摘要： PROBLEM TO BE SOLVED: To provide microfluidic methods and devices that combine the advantages of microfluidics with improved material handling characteristics and reduced costs for manufacturing.SOLUTION: The present invention provides microfluidic devices 100 that comprise a body structure comprising at least a first microscale channel network 114 disposed therein. The body structure has a plurality of ports 106 disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. The devices also optionally include conductive coatings and membranes. The invention additionally provides methods of controlling the delivery of a composition of material into the microfluidic device 100.
摘要翻译：要解决的问题：提供将微流体学的优点与改进的材料处理特性相结合并降低制造成本的微流体方法和装置。解决方案：本发明提供了包括身体结构的微流体装置100，其包括至少设置在其中的第一微尺度通道网络114。主体结构具有设置在主体结构中的多个端口106，其中每个端口与第一通道网络中的一个或多个通道流体连通。这些装置还包括覆盖层，其包括穿过覆盖层设置的多个孔。覆盖层与主体结构配合，由此每个孔与多个端口中的单独一个对准。所述装置还可选地包括导电涂层和膜。本发明另外提供了控制材料组合物输送到微流体装置100中的方法。版权所有：（C）2013，JPO＆INPIT

7. 发明专利

JP2007108181A Electronic pipetter and compensation means for electrophoretic bias 审中-公开
标题翻译：电子偏移电子管和补偿装置
公开(公告)号：JP2007108181A
公开(公告)日：2007-04-26
申请号：JP2006278450
申请日：2006-10-12
申请人： Caliper Life Sciences Inc , カリパー・ライフ・サイエンシズ・インコーポレーテッドCaliper Liff Sciences Incorporated
发明人： PARCE J WALLACE , KNAPP MICHAEL R
IPC分类号： G01N31/20 , G01N35/08 , B01F13/00 , B01J19/00 , B01L3/00 , B01L3/02 , B81B1/00 , F04B17/00 , F04B19/00 , G01N27/26 , G01N27/447 , G01N37/00 , H02N11/00
CPC分类号： B01F13/0071 , B01F13/0084 , B01F13/0086 , B01J19/0093 , B01J2219/00891 , B01L3/021 , B01L3/502715 , B01L3/50273 , B01L3/502784 , B01L2200/027 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , F04B17/00 , F04B19/006 , G01N27/44704 , G01N27/44743 , G01N27/44791 , H02N11/006 , Y10S366/02 , Y10T436/113332 , Y10T436/2575
摘要： PROBLEM TO BE SOLVED: To provide a micro fluid system of high through-put capable of controlling directly and quickly the movement of a substance passed through a channel. SOLUTION: In the micro fluid system, at least the second channel is crossed with the first channel in substrates having at least the first channel and at least the second channel arranged on the substrates, and the first channel includes the substrate deeper than that of the second channel, and an electroendosometic fluid directing system. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供能够直接和快速地控制通过通道的物质的运动的高通量的微流体系统。解决方案：在微流体系统中，至少第二通道与具有至少第一通道的衬底中的第一通道交叉，并且至少第二通道布置在衬底上，并且第一通道包括比第第二通道，以及电内流体引导系统。版权所有（C）2007，JPO＆INPIT

8. 发明申请

WO2014137475A1 HIGH-THROUGHPUT SINGLE-CELL IMAGING, SORTING AND ISOLATION 审中-公开
标题翻译：高通量单细胞成像，分离和分离
公开(公告)号：WO2014137475A1
公开(公告)日：2014-09-12
申请号：PCT/US2014/000030
申请日：2014-03-04
申请人： CALIPER LIFE SCIENCES, INC. , CALIPER LIFE SCIENCES , INC. , BHARADWAJ, Rajiv , FATHOLLAHI, Bahram
发明人： BHARADWAJ, Rajiv , FATHOLLAHI, Bahram
IPC分类号： B01L3/00 , C12M1/00 , C12N5/00
CPC分类号： H04N5/2251 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , C12M47/04 , C12N5/0081 , C12N5/0087 , G02B21/365 , G06T7/0012 , H04N5/2256 , H04N7/18
摘要： The invention provides a method and apparatus for isolating individual target cells. The apparatus includes a body structure comprising a main channel, a collection. channel, and a waste channel fluidly coupled at a first fluid junction. A plurality of trapping channels intersect the collection channel, each trapping channel having a diameter at a location adjacent to the intersection of the trapping channel with the collection channel that is less than a diameter of an individual target cell. The apparatus also includes an imaging system configured to image individual target and non-target cells within the main channel, thereby producing imaging data; a processor configured to perform real-time, multivariate analyses of the imaging data; and a directing system configured to direct the individual target cells. A pressure source is in fluid communication with one or more of the collection channel, the waste channel, the first side channel, and the second side channel.
摘要翻译：本发明提供了一种隔离单个靶细胞的方法和装置。该装置包括主体结构，其包括主通道，集合体。通道和在第一流体结处流体耦合的废物通道。多个捕获通道与收集通道相交，每个捕获通道在与捕集通道与收集通道的交叉点相邻的位置处的直径小于单个靶细胞的直径。该装置还包括：成像系统，被配置为对主通道内的各个目标单元和非目标单元进行成像，从而产生成像数据; 处理器，被配置为执行所述成像数据的实时，多变量分析; 以及被配置为引导各个目标细胞的引导系统。压力源与收集通道，废物通道，第一侧通道和第二侧通道中的一个或多个流体连通。

9. 发明授权

US11040118B2 In-vivo reactive species imaging 有权
公开(公告)号：US11040118B2
公开(公告)日：2021-06-22
申请号：US16182941
申请日：2018-11-07
申请人： Caliper Life Sciences, Inc.
发明人： Sunetra Ray , Daniel Ansaldi , Rajendra Singh
IPC分类号： A61K49/00
摘要： The disclosure features methods that include: administering to a subject a composition that includes particles, where each one of the particles features at least one targeting group that binds to a structural entity in the subject and at least one reacting group that reacts chemically with a reactive oxygen species in the subject, and where the particle emits luminescence when the reaction occurs; detecting the luminescence emission from the particles; and displaying an image of the subject showing locations of at least some reactive oxygen species in the subject based on the detected luminescence.

10. 发明授权

US10138517B2 Manipulation of microparticles in microfluidic systems 有权
公开(公告)号：US10138517B2
公开(公告)日：2018-11-27
申请号：US15615469
申请日：2017-06-06
申请人： Caliper Life Sciences, Inc.
发明人： Tammy Burd Mehta , Anne R. Kopf-Sill , J. Wallace Parce , Andrea W. Chow , Luc J. Bousse , Michael R. Knapp , Theo T. Nikiforov , Steve Gallagher
IPC分类号： B01L3/00 , C12Q1/6874 , C07H21/02 , C07H21/04 , C12Q1/6869 , B01F13/00 , C40B60/14 , G01N27/447 , G01N35/00
摘要： An array of transportable particle sets is used in a microfluidic device for performing chemical reactions in the microfluidic device. The microfluidic device comprises a main channel and intersecting side channels, the main channel and side channels forming a plurality of intersections. The array of particle sets is disposed in the main channel, and the side channels are coupled to reagents. As the particle sets are transported through the intersections of the main channel and the side channels, reagents are flowed through the side channels into contact with each array member (or selected array members), thereby providing a plurality of chemical reactions in the microfluidic system.

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