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1. 发明公开

EP0196662A3 Impact sensor 失效
标题翻译： IMPACT传感器
公开(公告)号：EP0196662A3
公开(公告)日：1987-08-19
申请号：EP86104485
申请日：1986-04-02
申请人： Brown, Milton F., Jr.
发明人： Brown, Milton F., Jr.
IPC分类号： H01H35/14
CPC分类号： H01H35/14
摘要： An impact sensor has a housing With an inner chamber. A first electrical contact extends from the housing and has a contact portion disposed in the chamber. A second eleotrical contact extends from the housing and is spaced from the first contact and has an aperture in the housing surrounding the contact portion. An insulating material is disposed between the contacts for maintaining electrisal isolation of the contacts. A plastically deformed conductive arcuate spring is in electrical connection with the second contact along generally the periphery of the aperture and has a first position arched away from the contact portion and a second position arched toward and engaged with the contact portion for thereby establishing electrical connection between the contacts. A mass is movably positioned in the chamber and is engageable with the spring for shifting the spring from the first to the second position upon detection of a collision.

2. 发明公开

EP0196662A2 Impact sensor 失效
标题翻译：震动传感器。
公开(公告)号：EP0196662A2
公开(公告)日：1986-10-08
申请号：EP86104485.7
申请日：1986-04-02
申请人： Brown, Milton F., Jr.
发明人： Brown, Milton F., Jr.
IPC分类号： H01H35/14
CPC分类号： H01H35/14
摘要： An impact sensor has a housing With an inner chamber. A first electrical contact extends from the housing and has a contact portion disposed in the chamber. A second eleotrical contact extends from the housing and is spaced from the first contact and has an aperture in the housing surrounding the contact portion. An insulating material is disposed between the contacts for maintaining electrisal isolation of the contacts. A plastically deformed conductive arcuate spring is in electrical connection with the second contact along generally the periphery of the aperture and has a first position arched away from the contact portion and a second position arched toward and engaged with the contact portion for thereby establishing electrical connection between the contacts. A mass is movably positioned in the chamber and is engageable with the spring for shifting the spring from the first to the second position upon detection of a collision.

3. 发明申请

WO2012064396A9 NOVEL EZRIN INHIBITORS AND METHODS OF MAKING AND USING 审中-公开
公开(公告)号：WO2012064396A9
公开(公告)日：2012-05-18
申请号：PCT/US2011/048635
申请日：2011-08-22
申请人： GEORGETOWN UNIVERSITY , BROWN, Milton, L. , PAIGE, Mikell , TORESTSKY, Jeffrey, A. , UREN, Aykut , KOSTURKO, George , BULUT, Gullay
发明人： BROWN, Milton, L. , PAIGE, Mikell , TORESTSKY, Jeffrey, A. , UREN, Aykut , KOSTURKO, George , BULUT, Gullay
IPC分类号： A61K31/47
摘要： The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

4. 发明申请

WO2012027482A3 COMPOUNDS, COMPOSITIONS AND METHODS RELATED TO PPAR ANTAGONISTS 审中-公开
标题翻译：化合物，组合物和与PPAR拮抗剂相关的方法
公开(公告)号：WO2012027482A3
公开(公告)日：2012-05-10
申请号：PCT/US2011048981
申请日：2011-08-24
申请人： UNIV GEORGETOWN , BROWN MILTON LANG , KONG YALI , LIU YONG , GLAZER ROBERT , TOMITA YORK
发明人： BROWN MILTON LANG , KONG YALI , LIU YONG , GLAZER ROBERT , TOMITA YORK
IPC分类号： C07C311/49 , A61K31/18 , A61P3/00 , A61P35/00 , C07C243/18
CPC分类号： C07C311/51 , A61K31/18 , C07C243/38 , C07C311/49 , C07D213/82 , C07D263/48 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders.
摘要翻译：公开的有关PPAR拮抗剂的化合物，组合物和方法。某些化合物对抑制PPAR有效。该组合物可用于抑制PPAR，治疗癌症和治疗代谢紊乱。

5. 发明申请

WO2012027482A2 COMPOUNDS, COMPOSITIONS AND METHODS RELATED TO PPAR ANTAGONISTS 审中-公开
标题翻译：与PPAR拮抗剂有关的化合物，组合物和方法
公开(公告)号：WO2012027482A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048981
申请日：2011-08-24
申请人： GEORGETOWN UNIVERSITY , BROWN, Milton, Lang , KONG, Yali , LIU, Yong , GLAZER, Robert , TOMITA, York
发明人： BROWN, Milton, Lang , KONG, Yali , LIU, Yong , GLAZER, Robert , TOMITA, York
IPC分类号： C07C311/49 , C07C243/18 , A61K31/18 , A61P35/00 , A61P3/00
CPC分类号： C07C311/51 , A61K31/18 , C07C243/38 , C07C311/49 , C07D213/82 , C07D263/48 , C07D413/14 , C07D471/04
摘要： Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders.
摘要翻译：公开了与PPAR拮抗剂有关的化合物，组合物和方法。某些化合物可有效抑制PPARs。该组合物可用于抑制PPARs，治疗癌症和治疗代谢紊乱。

6. 发明申请

WO2011156632A2 COMPOSITIONS AND METHODS OF TREATMENT FOR TUMORS IN THE NERVOUS SYSTEM 审中-公开
标题翻译：神经系统肿瘤组织及治疗方法
公开(公告)号：WO2011156632A2
公开(公告)日：2011-12-15
申请号：PCT/US2011/039847
申请日：2011-06-09
申请人： GEORGETOWN UNIVERSITY , BROWN, Milton, L. , JUNG, Mira, O. , DAKSHANAMURTHY, Sivanesan , HENDERSON, Fraser, C. , KONG, Yali
发明人： BROWN, Milton, L. , JUNG, Mira, O. , DAKSHANAMURTHY, Sivanesan , HENDERSON, Fraser, C. , KONG, Yali
IPC分类号： C07D473/06
CPC分类号： C07D401/14 , C07D409/14 , C07D473/06 , C07D487/04 , C07D487/08
摘要： The invention provides compounds, compositions and methods for preventing and treating tumors of the nervous system, by means of compounds that inhibit or modulate p75 neurotrophic receptors. Compounds of the invention have structures of the form G-H-I, wherein G is a small ring system reminiscent of redox-mediating moieties in metabolism, H is a linker of up to 8 atoms in length, and I is a simple end group such as a lower alkyl or small heteroaryl or heterocyclic ring system.
摘要翻译：本发明提供了通过抑制或调节p75神经营养受体的化合物来预防和治疗神经系统肿瘤的化合物，组合物和方法。本发明的化合物具有GHI形式的结构，其中G是一个小环系，使人联想到代谢中的氧化还原介导部分，H是长达8个原子的连接体，I是一个简单的端基，如较低的烷基或小的杂芳基或杂环系统。

7. 发明申请

WO2010091384A3 CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： CADHERIN-11抑制剂及其使用方法
公开(公告)号：WO2010091384A3
公开(公告)日：2011-03-24
申请号：PCT/US2010023556
申请日：2010-02-09
申请人： UNIV GEORGETOWN , BYERS STEPHEN W , DAKSHANAMURTHY SIVANESAN , GUIDRY AUVIL JAIME M , BROWN MILTON L
发明人： BYERS STEPHEN W , DAKSHANAMURTHY SIVANESAN , GUIDRY AUVIL JAIME M , BROWN MILTON L
IPC分类号： C07D241/44 , A61K31/498 , A61P29/00 , A61P35/00 , C07D213/06 , C07D221/18 , C07D307/77
CPC分类号： A61K31/498 , A61K31/343 , A61K31/44 , A61K31/473 , A61K45/06 , C07D213/30 , C07D215/14 , C07D241/42 , C07D307/77 , C07K16/18
摘要： Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
摘要翻译：本发明描述了钙黏着蛋白-11抑制剂及其预防和治疗钙粘蛋白-11相关疾病的方法。钙粘蛋白-11相关疾病包括癌症和类风湿性关节炎。

8. 发明申请

WO2010091384A2 CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF 审中-公开
标题翻译： CADHERIN-11抑制剂及其使用方法
公开(公告)号：WO2010091384A2
公开(公告)日：2010-08-12
申请号：PCT/US2010/023556
申请日：2010-02-09
申请人： GEORGETOWN UNIVERSITY , BYERS, Stephen W. , DAKSHANAMURTHY, Sivanesan , AUVIL, Jaime Guidry , BROWN, Milton L.
发明人： BYERS, Stephen W. , DAKSHANAMURTHY, Sivanesan , AUVIL, Jaime Guidry , BROWN, Milton L.
CPC分类号： A61K31/498 , A61K31/343 , A61K31/44 , A61K31/473 , A61K45/06 , C07D213/30 , C07D215/14 , C07D241/42 , C07D307/77 , C07K16/18
摘要： Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
摘要翻译：本发明描述了钙黏着蛋白-11抑制剂和预防和治疗钙粘蛋白-11相关疾病的方法。钙粘蛋白-11相关疾病包括癌症和类风湿性关节炎。

9. 发明申请

WO2010019271A1 FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION 审中-公开
标题翻译： RASSF1A表达和人癌细胞增殖的荧光调节因子
公开(公告)号：WO2010019271A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/004681
申请日：2009-08-14
申请人： GEORGETOWN UNIVERSITY , BROWN, Milton, L. , SHEIKH, Kathryn, D. , PAIGE, Mikell , BANERJEE, Partha , JAGEDEESH, Shankar
发明人： BROWN, Milton, L. , SHEIKH, Kathryn, D. , PAIGE, Mikell , BANERJEE, Partha , JAGEDEESH, Shankar
IPC分类号： C07D209/88 , A61K31/403
CPC分类号： C07D209/88 , A61K31/403 , A61K45/06 , A61K2300/00
摘要： The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound.
摘要翻译：本发明提供了治疗受试者中癌症的方法，所述方法包括施用丹磺酰咔唑化合物。

10. 发明申请

WO2003059350A1 DEVELOPMENT OF NOVEL REGULATORS OF ANGIOGENESIS 审中-公开
标题翻译：发展新生血管生成调节因子
公开(公告)号：WO2003059350A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/000593
申请日：2003-01-09
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , BROWN, Milton, L.
发明人： BROWN, Milton, L.
IPC分类号： A61K31/44
CPC分类号： A61K31/40 , A61K31/4035 , A61K31/407 , A61K31/47 , A61K31/472
摘要： The present invention is directed to novel thalidomide derivative compounds that have activity as angiogenic and arteriogenic compounds. More particularly the compounds have the general structure: (I) wherein R¿3? is selected from the group consisting oH, C¿1?-C¿6? alkyl, C¿1?-C¿6? alkenyl, C¿1?-C¿6? alkynyl and optionally substituted 5- or 6-membered rings. These compounds can be used to induce angiogenesis or arteriogenesis in a patient in need thereof.
摘要翻译：本发明涉及具有作为血管生成和动脉化合物的活性的新型沙利度胺衍生物化合物。更具体地，化合物具有以下通式结构：（I）其中R 3选自下列基团：OH，C 1 -C 6 - 烷基，C 1 -C 6 烯基，C 1 -C 6 炔基和任选取代的5或6元环。这些化合物可用于在有需要的患者中诱导血管生成或动脉生成。

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