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    • 1. 发明申请
    • NANOPOROUS LOW-K FILMS WITH INFILTRATED POROSITY
    • 具有渗透孔隙度的纳米低K膜
    • WO2007047822A3
    • 2009-05-07
    • PCT/US2006040848
    • 2006-10-18
    • ADVANCED TECH MATERIALSVESYCK DANIEL JBILODEAU STEVEN MXU CHONGYINGCHEN PHILIP S HROEDER JEFFREY F
    • VESYCK DANIEL JBILODEAU STEVEN MXU CHONGYINGCHEN PHILIP S HROEDER JEFFREY F
    • C08J9/26C08J9/28H01L21/00H01L21/02
    • C23C16/56B82Y30/00C23C16/30
    • A reinforced porous dielectric material having porosity including pores at least partially closed by an infilled material. The material in one application includes a siloxane such as octamethylcyclotetrasiloxane (OMCTS), tetramethylcyclotetrasiloxane (TMCTS), or CH3(EtO2)SiCHCH2O (DEOMORS), which is infiltrated with a hydrocarbon, such as propylene, ethylene, dimethylsilane or divinyldimethylsilane, and thereafter subjected to conditions for immobilizing the infiltrated material, for reinforcement and enhanced strength and mechanical integrity of the dielectric material. By appropriate choice of infiltrating conditions, the porosity of the dielectric material can be partially filled at the neck regions of the pores, to form closed pore structure having voids that reduce the dielectric constant of the overall material. In a specific application, the infilled material is a ring compound that is self- cross-linked and/or reactively bonded to the wall surface of the dielectric material porosity.
    • 一种具有孔隙率的增强的多孔电介质材料,包括至少部分由填充材料封闭的孔。 一种应用中的材料包括诸如丙烯,乙烯,二甲基硅烷或二乙烯基二甲基硅烷等烃类渗透的诸如八甲基环四硅氧烷(OMCTS),四甲基环四硅氧烷(TMCTS)或CH 3(EtO 2)SiCHCH 2 O(DEOMORS)的硅氧烷, 用于固定渗透材料的条件,用于增强和提高电介质材料的强度和机械完整性。 通过适当选择渗透条件,电介质材料的孔隙率可以部分地填充在孔的颈部区域,以形成具有减小整个材料的介电常数的空隙的闭孔结构。 在具体应用中,填充材料是与电介质材料孔隙率的壁表面自交联和/或反应性结合的环化合物。
    • 4. 发明申请
    • COMPOSITIONS AND METHODS FOR ENHANCING CELL REPROGRAMMING
    • 增强细胞重编程的组合物和方法
    • WO2010033920A2
    • 2010-03-25
    • PCT/US2009057692
    • 2009-09-21
    • WHITEHEAD BIOMEDICAL INSTYOUNG RICHARD ABILODEAU STEVENKAGEY MICHAEL
    • YOUNG RICHARD ABILODEAU STEVENKAGEY MICHAEL
    • C12N5/0696C12N2501/065
    • The invention provides compositions and methods of use to enhance reprogramming of mammalian cells. Certain compositions and methods of the invention are of use to enhance generation of induced pluripotent stem cells by reprogramming somatic cells. Certain compositions and methods of the invention are of use to enhance reprogramming of pluripotent mammalian cells to a differentiated cell type. Certain compositions and methods of the invention are of use to enhance reprogramming of differentiated mammalian cells of a first cell type to differentiated mammalian cells of a second differentiated cell type. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that enhances or contributes to reprogramming mammalian cells. Certain of the inventive compositions and methods relate to inhibiting histone methylation.
    • 本发明提供了用于增强哺乳动物细胞重编程的组合物和方法。 本发明的某些组合物和方法可用于通过重编程体细胞来增强诱导多能干细胞的产生。 本发明的某些组合物和方法可用于增强多能哺乳动物细胞重编程为分化细胞类型。 本发明的某些组合物和方法可用于增强第一种细胞类型的分化哺乳动物细胞重编程为第二分化细胞类型的分化哺乳动物细胞。 重编程的体细胞可用于多种目的,包括治疗或预防个体的医疗状况。 本发明还提供了鉴定增强或有助于重编程哺乳动物细胞的试剂的方法。 某些本发明的组合物和方法涉及抑制组蛋白甲基化。