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1. 发明专利

AU2003205176A8 Enantioselective methods for preparing alpha- and beta-amino acid derivatives 未知
公开(公告)号：AU2003205176A8
公开(公告)日：2003-07-30
申请号：AU2003205176
申请日：2003-01-15
申请人： SCRIPPS RESEARCH INST , BARBAS CARLOS F , CORDOVA ARMANDO , NOTZ WOLFGANG
发明人： NOTZ WOLFGANG , CORDOVA ARMANDO , BARBAS CARLOS F
IPC分类号： C07C227/32 , C07C229/22 , C07C229/28 , C07D307/83 , C07C45/00 , C07C207/00 , C07C229/00

2. 发明专利

AU2003205176A1 ENANTIOSELECTIVE METHODS FOR PREPARING Alpha- AND Beta-AMINO ACID DERIVATIVES 未知
公开(公告)号：AU2003205176A1
公开(公告)日：2003-07-30
申请号：AU2003205176
申请日：2003-01-15
申请人： BARBAS CARLOS F , CORDOVA ARMANDO , NOTZ WOLFGANG , SCRIPPS RESEARCH INST
发明人： BARBAS CARLOS F , CORDOVA ARMANDO , NOTZ WOLFGANG
IPC分类号： C07C227/32 , C07C229/22 , C07C229/28 , C07D307/83

3. 发明专利

CA2307503A1 PEPTIDES FOR USE AS A VACCINE OR TREATMENT FOR HIV INFECTION 未知
公开(公告)号：CA2307503A1
公开(公告)日：2001-11-02
申请号：CA2307503
申请日：2000-05-02
申请人： BURTON DENNIS R , SCOTT JAMIE K , BARBAS CARLOS F III , PARREN PAUL W H I , ZWICK MICHAEL B
发明人： BURTON DENNIS R , SCOTT JAMIE K , BARBAS CARLOS F III , PARREN PAUL W H I , ZWICK MICHAEL B
IPC分类号： C07K16/10 , A61K39/42 , A61K39/395 , A61P31/18 , C12P21/00 , C12P21/08

4. 发明申请

WO2011091324A3 METHODS OF GENERATING ZINC FINGER NUCLEASES HAVING ALTERED ACTIVITY 审中-公开
标题翻译：产生具有改变活性的锌指指核的方法
公开(公告)号：WO2011091324A3
公开(公告)日：2011-12-22
申请号：PCT/US2011022154
申请日：2011-01-21
申请人： SCRIPPS RESEARCH INST , BARBAS CARLOS F , GUO JING
发明人： BARBAS CARLOS F , GUO JING
IPC分类号： C12Q1/34 , C12N9/14 , C12N15/55
CPC分类号： C12N15/1034 , C07K14/4703 , C12N9/22 , C12N15/1086 , G01N2333/922
摘要： Provided herein are zinc linger nucleases having altered, arid in particular, improved catalytic activity and methods of generating such nucleases. Accordingly, there are provided methods for identifying improved catalytic activity of a ZFN by expressing a mutated zinc finger nuclease in a cell containing a reporter construct with a toxic gene, and a zinc finger nuclease cleavage site that is recognized by the ZFN. Survival of the cell is positively correlated with catalytic activity of the ZFN; thus, libraries of mutated ZFKs may be selected for altered catalytic activity based on relative survival rates, Methods of using identified ZFNs are also provided.
摘要翻译：本文提供了具有改变，特别是改进的催化活性和产生这种核酸酶的方法的锌连环核酸酶。因此，提供了通过在含有具有毒性基因的报道构建体的细胞中表达突变的锌指核酸酶以及通过ZFN识别的锌指核酸酶切割位点来鉴定ZFN的改善的催化活性的方法。细胞存活与ZFN的催化活性呈正相关; 因此，可以基于相对存活率选择突变的ZFK文库以改变催化活性，还提供使用鉴定的ZFN的方法。

5. 发明申请

WO2010132092A3 CYTIDINE DEAMINASE FUSIONS AND RELATED METHODS 审中-公开
标题翻译： CYTIDINE DEAMINASE FUSIONS及相关方法
公开(公告)号：WO2010132092A3
公开(公告)日：2011-03-10
申请号：PCT/US2010001340
申请日：2010-05-06
申请人： SCRIPPS RESEARCH INST , BARBAS CARLOS F , KIM DAE HEE
发明人： BARBAS CARLOS F , KIM DAE HEE
IPC分类号： C12N15/62 , C07K19/00 , C12N15/52 , C12N15/63
CPC分类号： C12N15/102 , C12N9/78 , C12Y305/04005
摘要： The present invention provides fusion molecules comprising a cytidine deaminase polypeptide and a single stranded DNA binding protein. The invention also provides methods of using the fusion molecules to induce mutations in target genes or polynucleotide sequences. The invention further provides methods of evolving target proteins or polypeptides with the cytidine deaminase fusion molecules disclosed herein.
摘要翻译：本发明提供了包含胞苷脱氨酶多肽和单链DNA结合蛋白的融合分子。本发明还提供使用融合分子诱导靶基因或多核苷酸序列突变的方法。本发明还提供了本文公开的胞苷脱氨酶融合分子进化靶蛋白或多肽的方法。

6. 发明申请

WO2010093706A2 CHEMICALLY PROGRAMMED VACCINATION 审中-公开
标题翻译：化学游泳
公开(公告)号：WO2010093706A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/023770
申请日：2010-02-10
申请人： THE SCRIPPS RESEARCH INSTITUTE , BARBAS, Carlos, F.
发明人： BARBAS, Carlos, F.
IPC分类号： A61K31/216 , A61K31/351 , A61K31/397 , A61K31/4192 , A61K31/439 , A61K31/496 , A61K31/499 , A61K39/00 , C07C233/41 , C07C279/16 , C07D205/08 , C07D309/28 , C07D401/12 , C07D405/12 , C07D405/14 , C07D451/04 , C07D471/04 , C07D471/10
CPC分类号： A61K39/39 , A61K31/216 , A61K31/351 , A61K31/397 , A61K31/4192 , A61K31/439 , A61K31/496 , A61K31/499 , A61K39/0011 , A61K2039/6081 , C07C233/52 , C07C279/16 , C07C2601/16 , C07D205/08 , C07D309/28 , C07D405/12 , C07D405/14 , C07D451/04 , C07D471/04 , C07D471/10 , C07K16/2839 , C07K16/44 , C07K2317/732 , C07K2317/734 , C12N2740/16011
摘要： Provided herein is a method for chemically programmed vaccination. Methods include inducing a covalent-binding polyclonal antibody response in a subject and programming the polyclonal response with a targeting compound.
摘要翻译：本文提供了一种化学程序化接种疫苗的方法。方法包括在受试者中诱导共价结合多克隆抗体应答并用靶向化合物编程多克隆应答。

7. 发明申请

WO2008006102A3 USE OF RETRO-ALDOL REACTION TO GENERATE REACTIVE VINYL KETONE FOR ATTACHMENT TO ANITIBODY MOLECULES BY MICHAEL ADDITION REACTION FOR USE IN IMMUNOSTAINING AND IMMUNOTARGETING 审中-公开
公开(公告)号：WO2008006102A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/073046
申请日：2007-07-09
申请人： THE SCRIPPS RESEARCH INSTITUTE , SINHA, Subhash, C. , BARBAS, Carlos, F., III , LERNER, Richard, A.
发明人： SINHA, Subhash, C. , BARBAS, Carlos, F., III , LERNER, Richard, A.
IPC分类号： C12P7/26 , C07K16/00 , C12N9/02
摘要： The present invention is directed to methods for formation of a chemically programmed antibody comprising the steps of: (1) reacting a conjugate comprising a signal module covalently linked to a proadapter with a catalytic moiety selected from the group consisting of a catalytic antibody and a Fab fragment of a catalytic antibody, wherein the proadapter includes therein a precursor to a reactive moiety activated to a reactive moiety by a reaction catalyzed by the catalytic moiety; and (2) crosslinking the reactive moiety to a side chain of an amino acid residue in the active site of the catalytic moiety to produce the chemically programmed antibody. The invention also encompasses chemically programmed antibodies formed by these methods, methods for their use, and pharmaceutical compositions, as well as proadaptors and conjugates including them. Chemically programmed antibodies are useful for the treatment of cancer, particularly in metastasis.

8. 发明申请

WO2007106603A2 SPECIFIC LABELING OF PROTEINS WITH ZINC FINGER TAGS AND USE OF ZINC-FINGER-TAGGED PROTEINS FOR ANALYSIS 审中-公开
标题翻译：锌指蛋白标记蛋白的特异性标记及锌指标蛋白的分析应用
公开(公告)号：WO2007106603A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/060181
申请日：2007-01-05
申请人： THE SCRIPPS RESEARCH INSTITUTE , BARBAS, Carlos, F.
发明人： BARBAS, Carlos, F.
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/6803 , C07K1/13 , C07K2319/81 , C12Q1/6837
摘要： Fusion proteins including zinc finger tags that bind in a sequence-specific manner and a peptide, polypeptide, or protein can be prepared and expressed. Such fusion proteins can be used to generate protein arrays by binding the zinc finger tags to a DNA array. The fusion proteins can also be used to label cell surfaces with DNA tags. Fusion proteins according to the invention can be used to localize the peptide, polypeptide, or protein that is incorporated into the fusion protein by using a labeled DNA, such as a fluorescent DNA. The invention further includes vectors and host cells, as well as a method of analyzing double-stranded DNA.
摘要翻译：可以制备并表达包含以序列特异性方式结合的锌指标签和肽，多肽或蛋白质的融合蛋白。这种融合蛋白可用于通过将锌指标签与DNA阵列结合来产生蛋白质阵列。融合蛋白也可用于用DNA标签标记细胞表面。根据本发明的融合蛋白可以用于通过使用标记的DNA，例如荧光DNA来定位掺入融合蛋白的肽，多肽或蛋白质。本发明进一步包括载体和宿主细胞，以及分析双链DNA的方法。

9. 发明申请

WO2007064462A1 PHAGE PARTICLE DIAGNOSTIC REAGENTS 审中-公开
标题翻译：噬菌体诊断试剂
公开(公告)号：WO2007064462A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/044134
申请日：2006-11-14
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE SCRIPPS RESEARCH INSTITUTE , SIEGEL, Donald , BARBAS, Carlos, F., III
发明人： SIEGEL, Donald , BARBAS, Carlos, F., III
IPC分类号： C12N7/00 , C12P21/06 , G01N33/53
CPC分类号： G01N33/555 , G01N33/6854
摘要： The present invention relates to novel methods for detecting a member of a known binding pair in a sample, including a cell, where one member of the pair (termed the "receptor") is expressed by a bacteriophage, which phage is then used to detect the presence of the other member of the pair (termed the "ligand" or "target"). Rather than detecting the binding of the phage using antibody-based technology, the present invention relates to detecting marker molecule associated with the phage. In one aspect, the invention relates to identifying an antigen-bearing moiety (e.g., a red blood cell antigen) of interest present on a cell, e.g., a. red blood cell, using antibody- displaying bacteriophage, as well as detecting anti-red blood cell auto- or alloantibodies and/or complement in a sample, using antiglobulin reagent-displaying bacteriophage and detecting a marker molecule associated with the phage. In one aspect, the phenotype of the phage is not linked with the genotype of the phage.
摘要翻译：本发明涉及用于检测样品中已知结合对的成员的新方法，包括细胞，其中一对成员（称为“受体”）由噬菌体表达，然后使用该噬菌体检测该对的另一成员的存在（称为“配体”或“靶”）。本发明不是使用基于抗体的技术检测噬菌体的结合，而是检测与噬菌体相关的标记分子。一方面，本发明涉及鉴定细胞上存在的感兴趣部分（例如，红细胞抗原），例如，红细胞，使用抗体展示噬菌体，以及使用抗球蛋白试剂显示噬菌体和检测与噬菌体相关的标记分子来检测样品中的抗红细胞自身或同种异体抗体和/或补体。一方面，噬菌体的表型与噬菌体的基因型不相关。

10. 发明申请

WO2003104414A3 ARTIFICIAL TRANSCRIPTION FACTORS 审中-公开
公开(公告)号：WO2003104414A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/017946
申请日：2003-06-06
申请人： THE SCRIPPS RESEARCH INSTITUTE , BARBAS, Carlos, F. III
发明人： BARBAS, Carlos, F. III
IPC分类号： C07K19/00
摘要： Transcription regulating polypeptides that contain a plurality of DNA binding domains are provided. The polypeptides optionally contain one or more transcription regulating domains. Polynucleotides that encode the polypeptides and use of the polypeptides and polynucleotides are also provided.

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