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1. 发明专利

GB441597A Addressing and like series-printing apparatus 未知
公开(公告)号：GB441597A
公开(公告)日：1936-01-22
申请号：GB1527535
申请日：1935-05-25
申请人： EDWARD ALLEN HOPPER
IPC分类号： B41L47/46
摘要： 441,597. Addressing and like machines. HOPPER, E. A., Oakhurst, Linden Avenue, Herne Bay. May 25, 1935, No. 15275. [Class 100 (ii)] Stencils D are fed from a container a to printing position by means of a block B adapted to be reciprocated by hand, an inking roller E mounted in an extension a of the container being raised to printing level by the block B when . a stencil is fed forward into contact with an impression roller C. The block B slides within a box A rigid with the container a , the end b of the block being slightly lower than the remaining part so that a stencil drops down when the end b is below the container, and having inclines for engaging the spindle of the roller E. During the return stroke of the block B after printing, the used stencil is left behind on ledges F and is discharged on the next forward stroke.

2. 发明专利

GB368913A Addressing and duplicating apparatus 未知
公开(公告)号：GB368913A
公开(公告)日：1932-03-17
申请号：GB198831
申请日：1931-01-21
申请人： EDWARD ALLEN HOPPER
IPC分类号： B41L47/18
摘要： 368,913. Addressing and like machines. HOPPER, E. A., Oakhurst, Linden Avenue, Herne Bay, Kent. Jan. 21, 1931, No. 1988. [Class 100 (ii).] Stencils E are fed in succession from a container a by means of a reciprocating slide B carrying, on an inclined surface b, a movable block C adapted to receive the lowermost stencil. During the forward movement of the slide, the block C engages a stationary pin F whereby the stencil is raised into contact with an impression roller J carried, as shown, by arms j fixed to the container. The pin F then enters a groove G in the side of the block C and allows forward movement thereof to an extent limited by the end of an aligned groove b in the slide B. The stencil rests on an ink-pad D mounted on top of the block C. During the return stroke of the slide, the block C strikes against the side a of the container so that the stencil falls off and the block returns to normal position. The pin F actuates the block through a flap H which lifts on the return stroke.

3. 发明申请

US20110046146A9 Phosphodiesterase 4 inhibitors 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US20110046146A9
公开(公告)日：2011-02-24
申请号：US11602283
申请日：2006-11-21
申请人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
发明人： Richard Schumacher , William Brubaker , Michael De Vivo , Hans-Jurgen Hess , Allen Hopper , Ashok Tehim , Ruiping Liu , Axel Unterbeck
IPC分类号： A61K31/505 , A61K31/4965 , A61K31/44 , A61K31/426 , A61K31/47 , A61K31/381 , A61K31/34 , A61K31/137
CPC分类号： C07D213/74 , A61K31/137 , A61K31/16 , A61K31/34 , A61K31/381 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/505 , C07C217/92 , C07C229/60 , C07D211/26 , C07D213/38 , C07D213/61 , C07D213/80 , C07D215/12 , C07D217/22 , C07D241/12 , C07D277/28 , C07D307/20 , C07D307/52 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07F7/1804
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R1, R2, R3and R4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物具有式I：其中R 1，R 2，R 3和R 4如本文所定义。

4. 发明申请

US20100010017A1 CERTAIN THIENOPYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS 审中-公开
标题翻译：某些作为磷酸二酯酶抑制剂的三烯酰基嘧啶衍生物
公开(公告)号：US20100010017A1
公开(公告)日：2010-01-14
申请号：US12494057
申请日：2009-06-29
申请人： Ruiping Liu , Mark Phillip Arrington , Allen Hopper , Ashok Tehim
发明人： Ruiping Liu , Mark Phillip Arrington , Allen Hopper , Ashok Tehim
IPC分类号： A61K31/519 , A61P25/28 , A61P25/00 , A61P7/12
CPC分类号： C07D495/04
摘要： Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., psychoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.
摘要翻译：某些噻吩并嘧啶衍生物可用于抑制PDE10酶，因此可用于治疗精神病或神经系统综合征，例如精神病，强迫症和/或帕金森病，以及例如治疗由 PDE10活动。

5. 发明授权

US07576080B2 Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors 失效
标题翻译：某些噻吩并嘧啶衍生物作为磷酸二酯酶10抑制剂
公开(公告)号：US07576080B2
公开(公告)日：2009-08-18
申请号：US11317907
申请日：2005-12-22
申请人： Ruiping Liu , Mark Phillip Arrington , Allen Hopper , Ashok Tehim
发明人： Ruiping Liu , Mark Phillip Arrington , Allen Hopper , Ashok Tehim
IPC分类号： C07D413/12 , C07D495/04 , A61K31/519 , A61K31/5355 , A61P25/18 , A61P25/28
CPC分类号： C07D495/04
摘要： Certain thienopyrimidine derivatives are useful for the inhibition of PDE10 enzymes, and thus are useful for treating psychiatric or neurological syndromes, e.g., pyschoses, obsessive-compulsive disorder and/or Parkinson's disease, as well as, for example, treating a disease state modulated by PDE10 activity.
摘要翻译：某些噻吩并嘧啶衍生物可用于抑制PDE10酶，因此可用于治疗精神病学或神经系统综合征，例如睡眠障碍，强迫症和/或帕金森病，以及例如治疗由 PDE10活动。

6. 发明授权

US07495017B2 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US07495017B2
公开(公告)日：2009-02-24
申请号：US11797151
申请日：2007-05-01
申请人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号： A61K31/415 , A61K31/4439 , C07D231/12 , C07D401/04
CPC分类号： C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要： Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
摘要翻译：通过芳基和杂芳基吡唑化合物实现选择性PDE4抑制。与化合物如咯利普兰相比，化合物表现出改善的PDE4抑制，并且在抑制其他类型的PDE时显示出选择性。

7. 发明申请

US20080119495A1 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
公开(公告)号：US20080119495A1
公开(公告)日：2008-05-22
申请号：US11956871
申请日：2007-12-14
申请人： Ruiping LIU , Hans-Jurgen Ernst Hess , Allen Hopper , Ashok Tehim , Yajing Rong
发明人： Ruiping LIU , Hans-Jurgen Ernst Hess , Allen Hopper , Ashok Tehim , Yajing Rong
IPC分类号： A61K31/52 , A61P25/00 , A61P31/18 , A61P9/00 , A61P29/00
CPC分类号： C07D473/40
摘要： PDE4 inhibition is achieved by novel compounds of the Formula I: wherein R1 and R2 are as defined herein.

8. 发明申请

US20070203197A1 Phosphodiesterase 4 inhibitors 失效
公开(公告)号：US20070203197A1
公开(公告)日：2007-08-30
申请号：US11797151
申请日：2007-05-01
申请人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号： A61K31/4439 , A61K31/416 , A61K31/415 , C07D405/02 , C07D403/02
CPC分类号： C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要： Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

9. 发明授权

US07235579B2 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US07235579B2
公开(公告)日：2007-06-26
申请号：US10270724
申请日：2002-10-16
申请人： Ruiping Liu , Mike De Vivo , Hans-Jurgen Ernst Hess , Allen Hopper , Erik Kuester , Ashok Tehim
发明人： Ruiping Liu , Mike De Vivo , Hans-Jurgen Ernst Hess , Allen Hopper , Erik Kuester , Ashok Tehim
IPC分类号： A61K31/40 , C09D409/00
CPC分类号： C07D207/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: wherein R1, R2, and R3 are as defined herein.
摘要翻译：选择性PDE4抑制由4-（取代的 - 苯基）-2-吡咯烷酮化合物实现。与化合物如咯利普兰相比，化合物表现出改善的PDE4抑制，并且显示关于抑制其它类别的PDE的选择性。本发明的化合物具有式I：其中R 1，R 2和R 3如本文所定义。

10. 发明授权

US07226930B2 Phosphodiesterase 4 inhibitors 失效
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：US07226930B2
公开(公告)日：2007-06-05
申请号：US10825611
申请日：2004-04-16
申请人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
发明人： Allen Hopper , Erik Kuester , Robert Dunn , Richard Conticello
IPC分类号： A61K31/437 , A61K31/4155 , C07D231/54 , C07D471/06
CPC分类号： C07D403/04 , C07D231/12 , C07D231/56 , C07D307/20 , C07D405/04 , C07D405/12 , C07D409/12
摘要： Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.
摘要翻译：通过芳基和杂芳基吡唑化合物实现选择性PDE4抑制。与化合物如咯利普兰相比，化合物表现出改善的PDE4抑制，并且在抑制其他类型的PDE时显示出选择性。

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