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    • 2. 发明授权
    • Method for calibrating a Fourier transform ion cyclotron resonance mass spectrometer
    • 校准傅里叶变换离子回旋共振质谱仪的方法
    • US06608302B2
    • 2003-08-19
    • US09870577
    • 2001-05-30
    • Richard D. SmithChristophe D. MasselonAleksey Tolmachev
    • Richard D. SmithChristophe D. MasselonAleksey Tolmachev
    • H01J4900
    • H01J49/0009H01J49/38
    • A method for improving the calibration of a Fourier transform ion cyclotron resonance mass spectrometer wherein the frequency spectrum of a sample has been measured and the frequency (f) and intensity (I) of at least three species having known mass to charge (m/z) ratios and one specie having an unknown (m/z) ratio have been identified. The method uses the known (m/z) ratios, frequencies, and intensities at least three species to calculate coefficients A, B, and C, wherein the mass to charge ratio of a least one of the three species (m/z)i is equal to A f i + B f i 2 + C · G ⁡ ( I i ) f i Q wherein fi is the detected frequency of the specie, G(Ii) is a predetermined function of the intensity of the species, and Q is a predetermined exponent. Using the calculated values for A, B, and C, the mass to charge ratio of the unknown specie (m/z)ii is calculated as the sum of A f ii + B f ii 2 + C · G ⁡ ( I ii ) f ii Q wherein fii is the measured frequency of the unknown specie, and (Iii) is the measured intensity of the unknown specie.
    • 一种用于改进傅里叶变换离子回旋共振质谱仪的校准的方法,其中已经测量了样品的频谱,以及已知质量电荷的至少三种物质的频率(f)和强度(I)(m / z )比例,并且已经鉴定了具有未知(m / z)比的一种物质。 该方法使用至少三种物质的已知(m / z)比,频率和强度来计算系数A,B和C,其中三种物质(m / z)i中的至少一种的质荷比 等于其中fi是物种的检测频率,G(Ii)是物种强度的预定函数,Q是预定指数。 使用A,B和C的计算值,将未知物种(m / z)ii的质荷比计算为fii是未知物种的测量频率的总和,(Iii)是测量的 未知物种的强度。