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1. 发明授权

US06846908B2 DCR-5 bone affecting ligand 有权
标题翻译： DCR-5骨影响配体
公开(公告)号：US06846908B2
公开(公告)日：2005-01-25
申请号：US10662756
申请日：2003-09-15
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61P19/08 , C07K14/47 , C07K14/475 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/53 , G01N33/577 , C07K14/00 , C07K16/00 , C12P5/02 , C12P21/06 , C12P15/74
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞中重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

2. 发明申请

US20120114665A1 HUMAN ANTIBODIES TO HUMAN RANKL 有权
标题翻译：人类抗体对人类RANKL
公开(公告)号：US20120114665A1
公开(公告)日：2012-05-10
申请号：US13059851
申请日：2009-08-19
申请人： Joel H. Martin , Aris N. Economides , Regina Raz
发明人： Joel H. Martin , Aris N. Economides , Regina Raz
IPC分类号： A61K39/395 , C12N15/13 , A61P35/00 , C12P21/02 , A61P19/08 , C07K16/18 , C12N15/63
CPC分类号： C07K16/2875 , A61K2039/505 , C07K2317/21
摘要： Isolated human antibodies or antigen-binding fragments thereof, which specifically bind to human RANKL and block hRANKL binding to a RANK receptor, are provided. The antibodies are useful in preventing or treating disorders and/or diseases, which are associated with RANKL/RANK interactions, including bone disorders or cancer.
摘要翻译：提供了特异性结合人RANKL并阻断hRANKL与RANK受体结合的分离的人抗体或其抗原结合片段。所述抗体可用于预防或治疗与RANKL / RANK相互作用（包括骨病或癌症）相关的疾病和/或疾病。

3. 发明授权

US06660499B1 DCR5, a BMP-binding protein, and applications thereof 有权
标题翻译： DCR5，BMP结合蛋白及其应用
公开(公告)号：US06660499B1
公开(公告)日：2003-12-09
申请号：US09762960
申请日：2001-02-14
申请人： Aris N. Economides , Neil Stahl
发明人： Aris N. Economides , Neil Stahl
IPC分类号： C12P2106
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/02
摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
摘要翻译：提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。蛋白质可以用受试核酸从转化的宿主细胞重组产生。还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

4. 发明授权

US06586251B2 Methods of modifying eukaryotic cells 有权
公开(公告)号：US06586251B2
公开(公告)日：2003-07-01
申请号：US09732234
申请日：2000-12-07
申请人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , George D. Yancopoulos
发明人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , George D. Yancopoulos
IPC分类号： C12N1587
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , C12N15/907
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

5. 发明授权

US08791323B2 Hybrid antibodies comprising human variable regions and mouse constant regions produced in a genetically modified mouse 有权
标题翻译：在遗传修饰的小鼠中产生的包含人可变区和小鼠恒定区的杂交抗体
公开(公告)号：US08791323B2
公开(公告)日：2014-07-29
申请号：US11595427
申请日：2006-11-09
申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens , Aris N. Economides , David M. Valenzuela
发明人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karow , Lynn Macdonald , Sean Stevens , Aris N. Economides , David M. Valenzuela
IPC分类号： A01K67/00 , G01N33/53 , C12N15/90 , C12N15/85 , C07K16/00 , C12P21/00 , A01K67/027 , C07K16/28 , C07K16/46 , C12N15/67
CPC分类号： C12P21/00 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/05 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/10 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N15/902 , C12N15/907 , C12N2800/204
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译：一种用于工程化和利用大型DNA载体通过同源重组靶向并以任何所需方式修饰真核细胞中的内源基因和染色体基因座的方法。用于真核细胞的这些大的DNA靶向载体，称为LTVEC，衍生自克隆基因组DNA的片段，大于通常用于在真核细胞中进行同源靶向的其它方法通常使用的那些。还提供了检测真核细胞的快速和方便的方法，其中LTVEC已经正确靶向和修饰了所需的内源基因或染色体基因座（位点），以及使用这些细胞产生具有遗传修饰的生物体。

6. 发明授权

US07473557B2 Method for targeting transcriptionally active loci 有权
标题翻译：靶向转录活性位点的方法
公开(公告)号：US07473557B2
公开(公告)日：2009-01-06
申请号：US10957760
申请日：2004-10-04
申请人： Aris N. Economides , Thomas M. DeChiara , George D. Yancopoulos
发明人： Aris N. Economides , Thomas M. DeChiara , George D. Yancopoulos
IPC分类号： C12N15/00 , C12N15/87
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N15/907 , C12N2800/30 , C12N2830/00
摘要： The present invention provides a method of achieving very high targeting efficiency by utilizing targeting vectors that utilize promoter-less selection cassettes and which are engineered to targeted into transcriptionally active loci. In particular, the invention provides a method for targeting promoter-less selection cassettes into transcriptionally active loci in stem cells or other eukaryotic cells with much greater efficiency than previously observed with other methods, thus reducing the number of drug-resistant clones to be screened or eliminating the need to screen for targeted cells altogether. The invention also encompasses the DNA targeting vectors, the targeted cells, as well as non-human organisms, especially mice, created from the targeted cells.
摘要翻译：本发明提供了一种通过利用利用无启动子选择盒并被设计成靶向转录活性位点的靶向载体来实现非常高的靶向效率的方法。特别地，本发明提供了一种将无启动子选择盒定位在干细胞或其他真核细胞中的转录活性基因座的方法，其效率比先前用其它方法观察到的效率高得多，从而减少要筛选的耐药性克隆的数目无需完全筛选靶细胞。本发明还包括从靶细胞产生的DNA靶向载体，靶细胞以及非人生物，特别是小鼠。

7. 发明授权

US07285532B2 Therapeutic method for treating bone formation diseases 有权
标题翻译：治疗骨形成疾病的治疗方法
公开(公告)号：US07285532B2
公开(公告)日：2007-10-23
申请号：US10735345
申请日：2003-12-12
申请人： Aris N. Economides , Neil Stahl , David M. Valenzuela , George D. Yancopoulos
发明人： Aris N. Economides , Neil Stahl , David M. Valenzuela , George D. Yancopoulos
IPC分类号： A61K38/16
CPC分类号： C07K16/22 , A61K38/00 , A61K39/00 , C07K14/475
摘要： Methods of treating and/or inhibiting a bone morphogenetic protein (BMP)-related disorder or condition by administering a BMP antagonist to a subject suffering from a BMP-related disorder or condition such that the BMP-related disorder or condition is treated. The method is carried out with a human noggin or a human noggin deletion mutant.
摘要翻译：通过向患有BMP相关病症或病症的受试者施用BMP拮抗剂以治疗和/或抑制骨形态发生蛋白（BMP）相关障碍或病症，使得与BMP相关的病症或病症得到治疗。该方法用人noggin或人noggin缺失突变体进行。

8. 发明授权

US07205148B2 Genome mutation by intron insertion into an embryonic stem cell genome 有权
标题翻译：通过内含子插入到胚胎干细胞基因组中的基因组突变
公开(公告)号：US07205148B2
公开(公告)日：2007-04-17
申请号：US10865424
申请日：2004-06-10
申请人： Aris N. Economides , David M. Valenzuela , Samuel Davis , George Yancopoulos
发明人： Aris N. Economides , David M. Valenzuela , Samuel Davis , George Yancopoulos
IPC分类号： C12N15/87 , C12N15/05 , C12N15/00
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A61D19/04 , C12N15/907 , C12N2800/30 , C12N2830/42 , C12N2840/44
摘要： Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon does not contain the modification are provided. The methods provide for a rapid method for introducing mutations and/or modifications of any type into a mammalian cell genome.
摘要翻译：通过将内含子通过同源重组插入到基因组外显子中而在基因组外显子中产生突变的方法。此外，提供了通过将内含子通过同源重组插入到基因组外显子中而将修饰引入基因组外显子的方法，从而提供了从包含基因组外显子的基因组的基因组区域产生的成熟mRNA转录物不含修饰。所述方法提供了用于将任何类型的突变和/或修饰引入哺乳动物细胞基因组的快速方法。

9. 发明授权

US09677129B2 Method for detecting the replacement of an endogenous allele with a modified allele by homologous recombination in a mouse ES cell 有权
公开(公告)号：US09677129B2
公开(公告)日：2017-06-13
申请号：US14193393
申请日：2014-02-28
申请人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , David Frendewey , George D. Yancopoulos
发明人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , David Frendewey , George D. Yancopoulos
IPC分类号： C12Q1/68 , A01K67/027 , C12N15/90 , C12N15/79
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C12N5/0606 , C12N15/79 , C12N15/907 , C12N2510/00 , C12N2810/10 , C12Q1/6827
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

10. 发明授权

US08759105B2 Method for genetically modifying mouse embryonic stem cell by homologous recombination 有权
标题翻译：通过同源重组遗传修饰小鼠胚胎干细胞的方法
公开(公告)号：US08759105B2
公开(公告)日：2014-06-24
申请号：US11809473
申请日：2007-06-01
申请人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , David Frendewey , George D. Yancopoulos
发明人： Aris N. Economides , Andrew J. Murphy , David M. Valenzuela , David Frendewey , George D. Yancopoulos
IPC分类号： A01K67/027 , C12N15/00 , C12N15/90 , C12N15/79
CPC分类号： C12N15/85 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C12N5/0606 , C12N15/79 , C12N15/907 , C12N2510/00 , C12N2810/10 , C12Q1/6827
摘要： A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
摘要翻译：一种用于工程化和利用大型DNA载体通过同源重组靶向并以任何所需方式修饰真核细胞中的内源基因和染色体基因座的方法。用于真核细胞的这些大的DNA靶向载体，称为LTVEC，衍生自克隆基因组DNA的片段，大于通常用于在真核细胞中进行同源靶向的其它方法通常使用的那些。还提供了检测真核细胞的快速和方便的方法，其中LTVEC已经正确靶向和修饰了所需的内源基因或染色体基因座（位点），以及使用这些细胞产生具有遗传修饰的生物体。

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