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1. 发明申请

WO2007016132A3 OPHTHALMIC DEVICE LATERAL POSITIONING SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：眼科装置横向定位系统及相关方法
公开(公告)号：WO2007016132A3
公开(公告)日：2007-03-22
申请号：PCT/US2006028936
申请日：2006-07-26
申请人： ALCON REFRACTIVE HORIZONS INC , CAMPIN JOHN A , BOWES JOHN J
发明人： CAMPIN JOHN A , BOWES JOHN J
IPC分类号： A61B3/15 , A61F9/01
CPC分类号： A61F9/008 , A61B3/14 , A61B3/145 , A61B3/152 , A61F9/007 , A61F2009/00872
摘要： A system and method for determining a lateral position of an eye relative to an ophthalmic device are disclosed. One embodiment of the method includes receiving data comprising an image of a surface of an eye. An edge feature in the image is located, wherein the edge feature is in a known relationship to a pupil of the eye. The image is mapped from the edge feature to laterally define the pupil, and a center of the pupil is determined using the pupil definition. The pupil center comprises a location from which to achieve a preferred lateral eye position relative to an ophthalmic device. An embodiment of the system of this invention can include a processor and a software package executable by the processor, the software package adapted to cause the processor to carry out the method steps.
摘要翻译：公开了一种用于确定眼睛相对于眼科装置的侧向位置的系统和方法。该方法的一个实施例包括接收包括眼睛表面的图像的数据。定位图像中的边缘特征，其中边缘特征与眼睛的瞳孔处于已知关系。从边缘特征映射图像以横向定义瞳孔，并使用瞳孔定义确定瞳孔的中心。瞳孔中心包括相对于眼科装置实现优选的侧眼位置的位置。本发明的系统的实施例可以包括处理器和可由处理器执行的软件包，该软件包适于使处理器执行方法步骤。

2. 发明申请

WO2007079076A3 DETERMINING OPTIMAL POSITIONING OF OPHTHALMIC DEVICES BY USE OF IMAGE PROCESSING AND AUTOFOCUSING TECHNIQUES 审中-公开
标题翻译：通过图像处理和自动绘图技术确定眼科装置的最佳定位
公开(公告)号：WO2007079076A3
公开(公告)日：2007-08-30
申请号：PCT/US2006049264
申请日：2006-12-21
申请人： ALCON REFRACTIVE HORIZONS INC , CAMPIN JOHN A , BOWES JOHN J
发明人： CAMPIN JOHN A , BOWES JOHN J
IPC分类号： A61F9/01 , A61B3/10
CPC分类号： A61F9/00802 , A61B3/0075 , A61B3/0083 , A61B3/10 , A61B3/145 , A61F2009/00872 , G06T7/571 , G06T2207/30041
摘要： A system (200) or method of positioning an ophthalmic device relative to an eye is provided. The method first obtains a series of images of an eye. In these series of images, the distance between the ophthalmic device and the eye is varied while the region of the eye image remains substantially the same. It is possible then to process these images to determine the high frequency content associated with each image. By comparing the high frequency content associated with each image, it is possible to determine which image has the largest amount of high frequency content. The high frequency content is maximized when the image is the sharpest. An optimally focused image will have the largest amount of high frequency content . By examining the high frequency content associate with the series of images is impossible to adjust the relative position and distance between the eye and the ophthalmic device to the distance associated with the image having the largest amount of high frequency content (i.e., optimally focused) .
摘要翻译：提供了一种相对于眼睛定位眼科装置的系统（200）或方法。该方法首先获得一系列的眼睛图像。在这些系列图像中，眼睛装置与眼睛之间的距离是变化的，而眼睛图像的区域保持基本相同。然后可以处理这些图像以确定与每个图像相关联的高频内容。通过比较与每个图像相关联的高频内容，可以确定哪个图像具有最大量的高频内容。当图像最清晰时，高频内容最大化。最佳聚焦图像将具有最大量的高频内容。通过检查与该系列图像相关联的高频内容不可能将眼睛和眼科装置之间的相对位置和距离调整为与具有最大量的高频内容（即，最佳聚焦）的图像相关联的距离。

3. 发明申请

WO2007078553A2 MODIFICATION OF LASER ABLATION TREATMENT PRESCRIPTION USING CORNEAL MECHANICAL PROPERTIES AND ASSOCIATED METHODS 审中-公开
标题翻译：使用角膜机械性质和相关方法进行激光治疗的修改
公开(公告)号：WO2007078553A2
公开(公告)日：2007-07-12
申请号：PCT/US2006046676
申请日：2006-12-07
申请人： ALCON REFRACTIVE HORIZONS INC , SACHAROFF ALEX
发明人： SACHAROFF ALEX
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00806 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088
摘要： A method of the present invention is directed to improving an outcome of a surgical procedure on a patient cornea. The method includes the steps of measuring a mechanical parameter of a cornea of an eye and determining a laser-surgery prescription for the cornea to improve a visual parameter therefor. The prescription is then adjusted based upon the measured mechanical parameter of the cornea.
摘要翻译：本发明的方法涉及改善对患者角膜的外科手术的结果。该方法包括以下步骤：测量眼睛的角膜的机械参数并确定角膜的激光手术处方以改善其视觉参数。然后根据测量的角膜的机械参数调整处方。

4. 发明申请

WO2005063154A9 HYBRID EYE TRACKING SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：混合眼动跟踪系统及相关方法
公开(公告)号：WO2005063154A9
公开(公告)日：2005-09-01
申请号：PCT/US2004043130
申请日：2004-12-23
申请人： ALCON REFRACTIVE HORIZONS INC , GRAY GARY , CAMPIN JOHN A , BOTT STEVEN E , GIBBS DAVID MICHAEL , PETTIT GEORGE H
发明人： GRAY GARY , CAMPIN JOHN A , BOTT STEVEN E , GIBBS DAVID MICHAEL , PETTIT GEORGE H
IPC分类号： A61B18/20 , A61F9/008 , A61F9/01
CPC分类号： A61F9/008 , A61B18/20 , A61B2018/00636 , A61F9/00804 , A61F2009/00846 , A61F2009/00872
摘要： A system and method for tracking ocular changes during a surgical procedure include directing an eye-safe optical beam toward an undilated, unparalyzed eye. A reflected optical beam is detected, and measurements are performed based upon data contained in the reflected optical beam of at least one geometric parameter of the eye at a predetermined frequency, and from them is calculated a change in the at least one geometric parameter. The calculated change is used to dynamically adjust the directing of laser beam shots during the surgery.
摘要翻译：用于在外科手术过程中跟踪眼睛变化的系统和方法包括将眼睛安全的光束引向未被剥离的未分析的眼睛。检测反射光束，并且基于预定频率的眼睛的至少一个几何参数的反射光束中包含的数据进行测量，并且根据它们计算至少一个几何参数的变化。计算出的变化用于在手术过程中动态调整激光束拍摄的指导。

5. 发明申请

WO2008131321A9 ADAPTIVE WAVEFRONT MODULATION SYSTEM AND METHOD FOR REFRACTIVE LASER SURGERY 审中-公开
标题翻译：自适应波前调节系统及其激光激光手术方法
公开(公告)号：WO2008131321A9
公开(公告)日：2010-11-04
申请号：PCT/US2008060976
申请日：2008-04-21
申请人： ALCON REFRACTIVE HORIZONS INC , PETTIT GEORGE H , CAMPIN JOHN A
发明人： PETTIT GEORGE H , CAMPIN JOHN A
IPC分类号： A61B3/103 , A61F9/01
CPC分类号： A61B3/1015 , A61B3/1035 , A61B3/107 , A61F9/008 , A61F9/00806 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088
摘要： A method for improving an accuracy of a prescription for laser-ablation corneal treatment includes the step of receiving a set of raw data comprising Hartmann-Shack image data obtained from a plurality of aberrometer measurements of a patient eye. The Hartmann-Shack data can include, for example, a dot pattern image for each measurement. A set of reconstructed wavefront data calculated from the set of raw data for the plurality of aberrometer measurements is also received. Data on a selected component of the set of raw data and in the set of reconstructed wavefront data are compared. If the selected component data differ more than a predetermined amount between the raw data and the reconstructed wavefront data, the raw data can be further manipulated prior to undertaking laser ablation. In addition, these data are removed from consideration for inclusion in the database of treatment outcomes.
摘要翻译：用于提高激光消融角膜处理的处方精度的方法包括接收包括从患者眼睛的多个像差计测量获得的Hartmann-Shack图像数据的一组原始数据的步骤。 Hartmann-Shack数据可以包括例如每个测量的点图案图像。还接收从多个像差计测量的原始数据集合计算出的一组重建波阵面数据。比较原始数据集合和重建波阵面数据集中的选定分量上的数据。如果所选择的分量数据在原始数据和重构的波前数据之间的预定量不同，则可以在进行激光烧蚀之前进一步操纵原始数据。此外，这些数据从考虑中被删除，以纳入治疗结果数据库。

6. 发明申请

WO2009086065A3 VIRTUAL MICROSCOPE SYSTEM FOR MONITORING THE PROGRESS OF CORNEAL ABLATIVE SURGERY AND ASSOCIATED METHODS 审中-公开
标题翻译：用于监测角膜消融术的进展的虚拟显微系统及相关方法
公开(公告)号：WO2009086065A3
公开(公告)日：2009-08-27
申请号：PCT/US2008087616
申请日：2008-12-19
申请人： ALCON REFRACTIVE HORIZONS INC , LEBLANC RICHARD
发明人： LEBLANC RICHARD
IPC分类号： A61B3/13 , A61F9/007 , A61F9/01 , G02B21/00 , G02B21/06 , G02B21/22 , G02B21/36
CPC分类号： G02B21/22 , A61B3/132 , A61F9/00804 , A61F2009/00872 , G02B21/0012
摘要： A system for visualizing an eye of a patient during corneal surgery includes a processor and a first and second camera in signal communication with the processor. The cameras are positionable for focusing on a cornea positioned for surgery. A first and a second display and optics therefor are in signal communication with the processor and are positionable for viewing through a first and a second eyepiece of a stereo microscope, respectively. Software is resident on the processor for receiving a first and second corneal image from the first and second cameras, for processing the received first and second images for display, and for transmitting the processed first and second images to the first and the second displays, respectively, via the display optics. The displays can then be viewed by a surgeon through the microscope at least during the surgery.
摘要翻译：用于在角膜手术期间使患者的眼睛可视化的系统包括处理器以及与处理器进行信号通信的第一和第二照相机。这些相机可定位用于聚焦于定位手术的角膜。第一显示器和第二显示器及其光学器件与处理器进行信号通信并且可分别定位为通过立体显微镜的第一和第二目镜进行观看。软件驻留在处理器上，用于接收来自第一和第二照相机的第一和第二角膜图像，用于处理所接收的第一和第二图像以供显示，并且用于将处理后的第一和第二图像分别发送到第一和第二显示器，通过显示光学器件。外科医生至少在手术过程中可以通过显微镜观察显示器。

7. 发明申请

WO2008014368A3 PATIENT SUPPORT STRUCTURE FOR OPHTHALMIC PROCEDURES AND ASSOCIATED METHODS 审中-公开
标题翻译：眼科手术患者支持结构及相关方法
公开(公告)号：WO2008014368A3
公开(公告)日：2008-06-19
申请号：PCT/US2007074400
申请日：2007-07-26
申请人： ALCON REFRACTIVE HORIZONS INC , DOWNES GEORGE RICHARD III , MCNEILL PATRICK , TOENNIES ROLAND
发明人： DOWNES GEORGE RICHARD III , MCNEILL PATRICK , TOENNIES ROLAND
IPC分类号： A61F9/007 , A61G13/12
CPC分类号： A61G13/12 , A61F9/008 , A61F2009/0035 , A61F2009/00855 , A61G13/121 , A61G13/1245 , A61G13/1295 , A61G2203/34 , A61G2203/46 , A61G2210/90 , G16H50/50
摘要： A system (10) is provided that includes a patient support structure (200) for performing laser ophthalmic surgery thereon. The patient support structure includes a movable platform having a headrest area (205) and a patient identification device integrated into the platform. The identification device (13) is adapted to receive a signal from a patient-borne device '(201) and is operable to communicate with a processor (14) for automatically confirming patient identity. A temperature and a humidity sensor are positioned adjacent the headrest area. A heatable cushion (40) is provided for heating at least a portion of the patient positionable on the platform. A calibration stage (29) is also provided for calibrating a patient head position, wherein the calibration means is integral to the structure and positioned adjacent the headrest area. The platform can be moved from a first position for entry/exit and/or for flap cutting and a second position for performing a corneal ablation.
摘要翻译：提供了一种系统（10），其包括用于在其上执行激光眼科手术的患者支撑结构（200）。患者支撑结构包括具有头枕区域（205）和集成到平台中的患者识别装置的可移动平台。识别装置（13）适于接收来自患者设备（201）的信号，并且可操作以与处理器（14）通信以自动确认患者身份。温度和湿度传感器位于头枕区域附近。提供可加热衬垫（40），用于加热位于平台上的患者的至少一部分。还提供了用于校准患者头部位置的校准台（29），其中所述校准装置与所述结构成一体并且邻近所述头枕区域定位。平台可以从用于进入/离开的第一位置和/或用于皮瓣切割的第一位置和用于执行角膜消融的第二位置移动。

8. 发明申请

WO2005063154A3 HYBRID EYE TRACKING SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：混合眼动跟踪系统及相关方法
公开(公告)号：WO2005063154A3
公开(公告)日：2005-11-24
申请号：PCT/US2004043130
申请日：2004-12-23
申请人： ALCON REFRACTIVE HORIZONS INC , GRAY GARY , CAMPIN JOHN A , BOTT STEVEN E , GIBBS DAVID MICHAEL , PETTIT GEORGE H
发明人： GRAY GARY , CAMPIN JOHN A , BOTT STEVEN E , GIBBS DAVID MICHAEL , PETTIT GEORGE H
IPC分类号： A61B18/20 , A61F9/008 , A61F9/01
CPC分类号： A61F9/008 , A61B18/20 , A61B2018/00636 , A61F9/00804 , A61F2009/00846 , A61F2009/00872
摘要： A system (10) and method for tracking ocular changes (12, 13) during a surgical procedure include directing an eye-safe optical beam (21) toward an undilated, unparalyzed eye (90). A reflected optical beam (23) is detected (22), and measurements (17) are performed based upon data contained in the reflected optical beam of at least one geometric parameter of the eye at a predetermined frequency (105), and from them is calculated a change in the at least one geometric parameter (106). The calculated change is used to dynamically adjust the directing of laser beam shots (14) during the surgery.
摘要翻译：用于在外科手术过程中跟踪眼睛变化（12,13）的系统（10）和方法包括将眼睛安全的光束（21）引向朝向未被剥离的未分析的眼睛（90）。检测反射光束（23），并且基于预定频率（105）的眼睛的至少一个几何参数的反射光束中包含的数据执行测量（17），并且从它们是计算所述至少一个几何参数（106）中的变化。计算出的变化用于在手术过程中动态调整激光束射击（14）的引导。

9. 发明公开

EP1520411A4 IMAGE DEINTERLACING SYSTEM FOR REMOVING MOTION ARTIFACTS AND ASSOCIATED METHODS 有权
标题翻译： BILDESCHUTTELUNGSSYSTEM ZUM ENTFERNEN VON BEWEGUNGSARTEFAKTEN UND ZUGEORDNETE VERFAHREN
公开(公告)号：EP1520411A4
公开(公告)日：2005-08-03
申请号：EP03728497
申请日：2003-04-22
申请人： ALCON REFRACTIVE HORIZONS INC
发明人： GRAY GARY PAUL
IPC分类号： H04N7/01 , H04N5/44 , H04N7/12 , H04N11/00 , H04N11/20
CPC分类号： H04N7/012
摘要： Deinterlacing is applied to a composite video image that includes alternating even and odd rows of pixels. The even rows form a first image; the odd rows, a second image; these are recorded at different times, introducing a possibility of motion artifact. A first average horizontal intensity difference is computed (105) between the first image and the second image. The first image is offset (106) by one pixel in each horizontal direction to form a horizontally offset image, and another average horizontal intensity difference is computed (107). A minimum average intensity difference is determined (110) from a comparison of the average horizontal intensity differences. The first image is shifted (113) in a horizontal direction determined to achieve the minimum average horizontal intensity difference, and the horizontally shifted first image is combined (114) with the second image to form an imiproved composite image. An analogous series of steps is carried out in a vertical direction.
摘要翻译：将隔行扫描应用于包含偶数行和奇数行像素的复合视频图像。偶数行形成第一个图像; 奇数行，第二个图像; 这些记录在不同的时间，引入运动伪影的可能性。在第一图像和第二图像之间计算（105）第一平均水平强度差。第一图像在每个水平方向上偏移（106）一个像素以形成水平偏移图像，并计算另一平均水平亮度差（107）。根据平均水平强度差的比较确定（110）最小平均强度差。第一图像在确定为实现最小平均水平强度差的水平方向上被移位（113），并且水平移动的第一图像与第二图像组合（114）以形成非模型化合成图像。在垂直方向上执行类似的一系列步骤。

10. 发明专利

BRPI0614619B8 sistema e métodos associados de posicionamento de dispositivo oftálmico 未知
公开(公告)号：BRPI0614619B8
公开(公告)日：2021-06-22
申请号：BRPI0614619
申请日：2006-07-26
申请人： ALCON REFRACTIVE HORIZONS INC , ALCON REFRACTIVEHORIZONS LLC
发明人： JOHN A CAMPIN , JOHN J BOWES
IPC分类号： A61B3/10
摘要： sistema e métodos associados de posicionamento de dispositivo oftálmico. a presente invenção refere-se a um sistema e um método para determinar uma posição ótima de um olho, relativa a um dispositivo oftálmico, são descritos. uma concretização do método inclui receber dados compreendendo uma imagem de uma superfície de um olho, com o olho em uma primeira posição relativa a um dispositivo oftálmico. uma característica de borda na imagem é localizada, e um cálculo de agudeza na característica de borda é feito, usando um algoritmo predeterminado para obter um valor de agudeza. a superfície do olho é então ajustada a uma segunda posição, relativa ao dispositivo oftálmico, e as etapas prévias são repetidas até que o valor de agudeza seja maximizado, que é uma indicação de que uma posição do olho ótima foi obtida. uma concretização do sistema inclui um processador e um pacote de software executável pelo processador, o pacote de software adaptado para fazer os cálculos, como indicados acima. meios são também proporcionados para ajustar a superfície do olho a uma segunda posição relativa ao dispositivo oftálmico.

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