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1. 发明专利

JP2012025763A Diagnostics and therapeutics for glaucoma 审中-公开
标题翻译： GLAUCOMA的诊断和治疗方法
公开(公告)号：JP2012025763A
公开(公告)日：2012-02-09
申请号：JP2011198018
申请日：2011-09-12
申请人： Alcon Inc , Univ Of Iowa Research Foundation , アルコンインクAlcon,Inc. , ユニバーシティーオブアイオワリサーチファウンデーション
发明人： CLARK ABBOT F , FINGERT JOHN , MCNATT LORETTA , STONE EDWIN M , WANG WAN-HENG
IPC分类号： A61K45/00 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K39/395 , A61K48/00 , A61P27/06 , C07K14/47 , C12N9/12 , C12N9/16 , C12N15/09 , C12N15/113 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/47 , C12N9/12 , C12Q1/485 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/5008 , G01N33/5041 , G01N33/5044 , G01N33/6893 , G01N2800/168
摘要： PROBLEM TO BE SOLVED: To provide a medicine for treating an elevated intraocular pressure such as glaucoma.SOLUTION: The invention relates to a therapeutically effective amount of compound selected from the group consisting of: a protein of an antagonist of the frizzled related protein gene product, a peptide, peptidomimetic, and small molecule; and a gene of frizzled related protein gene, antisense, ribozyme, and triplex nucleic acids or the like, for increasing or decreasing a level or biological activity of a Wnt pathway component or a frizzled related protein gene product.
摘要翻译：待解决的问题：提供治疗眼内压升高的药物，如青光眼。解决方案：本发明涉及治疗有效量的选自以下的化合物：卷曲相关蛋白质基因产物的拮抗剂的蛋白质，肽，拟肽和小分子; 以及用于增加或降低Wnt途径成分或卷曲相关蛋白质基因产物的水平或生物活性的卷曲相关蛋白基因，反义核酸酶和三链体核酸等的基因。版权所有（C）2012，JPO＆INPIT

2. 发明公开

KR20070098607A SYSTEM AND METHOD FOR USER SELECTABLE RELEASE MODALITY FOR A SURGICAL CASSETTE 审中-公开
标题翻译：用于手术CASSETTE的用户可选择释放模式的系统和方法
公开(公告)号：KR20070098607A
公开(公告)日：2007-10-05
申请号：KR20070030359
申请日：2007-03-28
申请人： ALCON INC
发明人： WILLIAMS DAVID LLOYD
IPC分类号： A61F9/007 , A61B19/00
CPC分类号： A61F9/00736 , A61B50/10 , A61B50/13 , A61B50/15
摘要： A system and a method for user selectable release modality for a surgical cassette are provided to prevent release of the cassette due to an accident, and to make the release speed balanced. A system for user selectable release modality for a surgical cassette includes the steps of: providing a user interface for enabling a user to select a cassette release mode for a surgical cassette from a cassette release mode set; and measuring whether the release request is performed. The step of releasing the surgical cassette from the surgical device according to the selected cassette release mode includes initiating and completing a cassette release process based on the measurement of whether the release request is performed. A cassette is placed on a cassette receiving vessel.
摘要翻译：提供了用于手术盒的用户选择性释放模式的系统和方法，以防止由于事故而释放盒，并且使释放速度平衡。一种用于手术盒的用户可选择释放模式的系统，包括以下步骤：提供用户界面，用于使用户能够从盒释放模式组中选择手术盒的盒释放模式; 并且测量是否执行释放请求。根据所选择的盒式磁带释放模式从手术装置释放手术盒的步骤包括基于是否执行释放请求的测量来启动和完成盒释放过程。盒式磁带放置在盒式磁带接收容器上。

3. 发明公开

KR20070098634A FLUIDIC CASSETTE DETECTION MECHANISM 审中-公开
标题翻译：流体CASSETTE检测机制
公开(公告)号：KR20070098634A
公开(公告)日：2007-10-05
申请号：KR20070030683
申请日：2007-03-29
申请人： ALCON INC
发明人： WILLIAMS DAVID LLOYD , GERRICK EDWIN K
IPC分类号： G01B21/00
CPC分类号： A61M1/0058 , A61M5/14228 , A61M5/14232 , A61M2205/12 , A61M2205/14 , F04B43/0081 , F04B43/12 , F04B49/10
摘要： A fluidic cassette detection mechanism is provided to secure the proper measurement of fluid by accurately positioning a fluidic cassette in a fluidic module. A fluidic cassette detection mechanism includes a fluidic module, a fluidic cassette(12), a detector, and a fluidic module control system. The fluidic cassette is operated to be inserted into the fluidic module and located on the surface of the fluidic module adjacent to a cassette vessel(14). The detector detects the existence of the fluidic cassette. The fluidic module control system receives a cassette detection signal from the detector, and is operated to start a closing command when receiving the detection signal. The detector includes a plurality of mechanical probes, and a plurality of optical interrupt switches. The mechanical probes are extended to the faceplate of the fluidic module. The fluidic module displaces the mechanical probes when the fluidic cassette is inserted into the fluidic module.
摘要翻译：提供流体盒检测机构以通过将流体盒精确地定位在流体模块中来确保流体的适当测量。流体盒检测机构包括流体模块，流体盒（12），检测器和流体模块控制系统。流体盒被操作以插入到流体模块中并且位于与盒式容器（14）相邻的流体模块的表面上。检测器检测流体盒的存在。流体模块控制系统从检测器接收盒检测信号，并且在接收到检测信号时被操作以开始关闭命令。检测器包括多个机械探针和多个光学中断开关。机械探针延伸到流体模块的面板。当流体盒被插入到流体模块中时，流体模块移动机械探针。

4. 发明专利

JP2014042846A Foldable device material for ophthalmology and otolaryngology 审中-公开
标题翻译：用于眼科和眼科学的折叠装置材料
公开(公告)号：JP2014042846A
公开(公告)日：2014-03-13
申请号：JP2013248836
申请日：2013-12-02
申请人： Alcon Inc , アルコン,インコーポレイテッド
发明人： FREEMAN CHARLES , SCHLUETER DOUGLAS C
IPC分类号： A61L27/00 , G02C7/04 , A61F2/16 , A61L27/16 , C08F220/12 , C08F220/30 , G02B1/04
CPC分类号： G02B1/04 , A61F2/14 , A61F2/145 , A61F2/16 , A61L27/16 , C08F220/30 , G02B1/043 , A61F11/00 , C08L33/16 , C08L33/14 , C08L33/06
摘要： PROBLEM TO BE SOLVED: To provide a foldable device material for ophthalmology and otolaryngology.SOLUTION: A soft acrylic material has an elongation of at least 150% and a high refractive index. The material is particularly useful as an intraocular lens material, including an aryl acrylic hydrophobic monomer as a single main device forming monomer material. In addition to the use as an intraocular lens material, the material is suitable for use as other ophthalmological devices or otolaryngological devices such as a contact lens, an artificial cornea, a cornea inlay or cornea ring; an otological ventilation tube, and a nose implant.
摘要翻译：要解决的问题：提供用于眼科和耳鼻喉科学的可折叠装置材料。解决方案：柔软的丙烯酸材料具有至少150％的伸长率和高折射率。该材料作为眼内透镜材料是特别有用的，其包括作为形成单体材料的单个主要装置的芳基丙烯酸类疏水性单体。除了用作眼内透镜材料之外，该材料适合用作其它眼科装置或耳鼻喉科装置，例如隐形眼镜，人造角膜，角膜嵌体或角膜环; 耳蜗通气管和鼻子植入物。

5. 发明专利

JP2013099596A Valve that is normally closed in free state 有权
标题翻译：在自由状态下正常关闭的阀
公开(公告)号：JP2013099596A
公开(公告)日：2013-05-23
申请号：JP2013021488
申请日：2013-02-06
申请人： Alcon Inc , アルコン,インコーポレイティド
发明人： WILLIAMS DAVID LLOYD
IPC分类号： A61F9/007
CPC分类号： F16K1/12
摘要： PROBLEM TO BE SOLVED: To provide a valve device comprising a valve structure in which a valve is normally closed.SOLUTION: The normally closed valve can comprise a circular valve seal face formed by the underside of a rim of an elastomeric valve boss and a circular valve seat, which is formed by the rim of a through-hole molded into, for example, a plastic cassette, such that the valve seal face, the valve seat, and the through-hole are concentric. The valve boss can be a hollow "mushroom" shaped valve boss, or a conical-shaped valve boss. If no force is applied to the inside surface of the valve boss, no fluid can pass through the valve as the valve seal face rests against the valve seat as a result of the steady free-state load created by the stretch of the valve boss over the slightly longer through-hole. When a force is applied to the inside surface of the valve boss, the valve seal face is displaced from the valve seat, allowing fluid between the valve seal face and valve seat to pass between the valve boss and the inside surface of the through-hole.
摘要翻译：要解决的问题：提供一种阀装置，其包括阀门正常关闭的阀结构。解决方案：常闭阀可包括由弹性阀凸台和圆形阀座的边缘的下侧形成的圆形阀密封面，该圆形阀座由模制成例如通孔的边缘形成。，塑料盒，使得阀密封面，阀座和通孔是同心的。阀门凸台可以是一个中空的“蘑菇”形阀门，也可以是一个锥形阀门。如果阀座的内表面没有施加力，则由于阀门凸起的拉伸产生的稳定的自由状态负载导致阀密封面靠在阀座上，所以没有流体能够通过阀门稍长的通孔。当向阀座的内表面施加力时，阀密封面从阀座移位，允许阀密封面和阀座之间的流体在阀凸台与通孔的内表面之间通过。版权所有（C）2013，JPO＆INPIT

6. 发明专利

JP2013063308A Implantable drug delivery system 审中-公开
标题翻译：可植入药物输送系统
公开(公告)号：JP2013063308A
公开(公告)日：2013-04-11
申请号：JP2012266684
申请日：2012-12-05
申请人： Alcon Inc , アルコン,インコーポレイテッド
发明人： RODSTROM THERON ROBERT
IPC分类号： A61F9/007 , A61J1/03 , A61D7/00 , A61F9/00 , A61K9/00 , A61K9/22 , A61M20060101 , A61M5/00 , A61M31/00 , A61M37/00
CPC分类号： A61F9/0017 , A61K9/0051 , Y10T29/49826
摘要： PROBLEM TO BE SOLVED: To provide an implantable compact drug delivery device which is simple, inexpensive, and easy to manufacture, and which can respond to implantation into the body of a human or animal for delivering a drug to a wide variety of locations.SOLUTION: An implantable compact drug delivery system 10 enables the transplantation of a machine into the body, thereby enabling the delivery of the drug to the wide variety of locations. The system 10 includes at least one basin 14, well and a hollow space. The basin 14, well, or the hollow space is enframed, sealed, encased, or formed in a core body 12. The basin 14, well or the hollow space within the core body or a basin encasement portion 12 is of sufficient size to contain the desired amount of a medicament needed for prolonged internal treatment of a chronic condition or disease.
摘要翻译：要解决的问题：提供一种植入式致密药物递送装置，其简单，便宜且易于制造，并且其可以响应于植入人或动物体内以将药物递送到各种各样的位置。解决方案：可植入的致密药物递送系统10使得能够将机器移植到体内，从而使得能够将药物递送到各种各样的位置。系统10包括至少一个盆14，井和中空空间。盆14，井或中空空间被固定，密封，封装或形成在芯体12中。盆体14，井或芯体内的中空空间或盆地包裹部分12具有足够的尺寸以容纳期望量的长期内部治疗慢性病或疾病所需的药物量。版权所有（C）2013，JPO＆INPIT

7. 发明专利

JP2012193209A RNAi INHIBITION OF SERUM AMYLOID FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗葡萄球菌的血清白介素的RNAi抑制
公开(公告)号：JP2012193209A
公开(公告)日：2012-10-11
申请号：JP2012157485
申请日：2012-07-13
申请人： Alcon Inc , アルコン,インコーポレイテッド
发明人： CLARK ABBOTT F , WANG WAN-HENG , MCNATT LORETTA
IPC分类号： A61K31/7088 , A61K48/00 , A61P27/02 , A61P27/06 , A61P43/00 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/30
摘要： PROBLEM TO BE SOLVED: To provide an interfering RNA that targets SAA mRNA, and thereby interferes with SAA mRNA expression.SOLUTION: There is provided RNA interference for inhibition of serum amyloid A mRNA expression in glaucoma involving SAA expression. There is provided a method for attenuating expression of the serum amyloid A mRNA in an eye of a subject including a step of administering to the eye of the subject a composition comprising an effective amount of the interfering RNA having a length of 19 to 49 nucleotides and a pharmaceutically acceptable carrier, the interfering RNA comprising a sense nucleotide sequence, an antisense nucleotide sequence, and a region of at least near-perfect contiguous complementary of at least 19 nucleotides between the sense and antisense sequences.
摘要翻译：要解决的问题：提供靶向SAA mRNA的干扰RNA，从而干扰SAA mRNA表达。解决方案：在涉及SAA表达的青光眼中，提供了用于抑制血清淀粉样蛋白A mRNA表达的RNA干扰。本发明提供一种减轻受试者眼中血清淀粉样蛋白A mRNA表达的方法，包括向受试者的眼睛施用包含有效量的长度为19至49个核苷酸的干扰RNA的组合物的步骤，以及药学上可接受的载体，所述干扰RNA包含有义核苷酸序列，反义核苷酸序列，以及有义和反义序列之间至少19个核苷酸至少近乎完美连续互补的区域。版权所有（C）2013，JPO＆INPIT

8. 发明专利

JP2012193197A RNAi-MEDIATED INHIBITION OF FRIZZLED RELATED PROTEIN-1 FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗玻璃体的相关蛋白-1的RNAi介导的抑制
公开(公告)号：JP2012193197A
公开(公告)日：2012-10-11
申请号：JP2012154550
申请日：2012-07-10
申请人： Alcon Inc , アルコン,インコーポレイテッド
发明人： CLARK ABBOTT F , WANG WAN-HENG , MCNATT LORETTA GRAVES , CHATTERTON JON E
IPC分类号： A61K31/7105 , A61K48/00 , A61P27/06 , A61P43/00 , C12N15/113
CPC分类号： C12N15/113 , A61K9/0048 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/316 , C12N2310/321 , C12N2310/351
摘要： PROBLEM TO BE SOLVED: To provide an interfering RNA that silences expression of FRP-1 mRNA.SOLUTION: There is provided RNA interference for inhibition of Frizzled related protein-1 mRNA expression, in particular, for treating a patient having glaucoma or at risk of developing the glaucoma. The method includes treating a subject having the glaucoma or at the risk of developing the glaucoma by administering the interfering RNA that silences the expression of the FRP-1 mRNA; thus interfering with the Wnt signaling pathway; and preventing a cascade of events related to the glaucoma and pre-glaucoma cellular activity. The expression of the Frizzled related protein-1 mRNA is attenuated thereby.
摘要翻译：要解决的问题：提供沉默FRP-1 mRNA表达的干扰RNA。解决方案：提供用于抑制卷曲相关蛋白-1 mRNA表达的RNA干扰，特别是用于治疗患有青光眼或有发展青光眼风险的患者。该方法包括通过施用沉默FRP-1 mRNA表达的干扰RNA来治疗患有青光眼的患者或患有发展青光眼的风险; 从而干扰Wnt信号通路; 并防止与青光眼和青光眼前细胞活动相关的事件的级联。因此，卷曲相关蛋白-1 mRNA的表达被减弱。版权所有（C）2013，JPO＆INPIT

9. 发明专利

JP2012183345A Surgical footswitch 有权
标题翻译：外科手术
公开(公告)号：JP2012183345A
公开(公告)日：2012-09-27
申请号：JP2012121275
申请日：2012-05-28
申请人： Alcon Inc , アルコン,インコーポレイティド
发明人： HORVATH CHRISTOPHER , BUCZEK MARK , ROWE T SCOTT
IPC分类号： A61B18/20 , G05G1/38
CPC分类号： G05G1/38 , A61B17/00 , A61B34/20 , A61B2017/00119 , A61B2017/00194 , A61B2017/00199 , A61B2017/00221 , A61B2017/00973 , A61C1/0023 , H01H21/26 , H01H2239/076 , H01H2300/014 , H01H2300/03 , Y02B70/3241 , Y04S20/227 , Y10T74/2054 , Y10T74/20888 , Y10T307/747
摘要： PROBLEM TO BE SOLVED: To provide a reliable footswitch that functions to communicate with a surgical system while avoiding potential hazard or a restrictive environment created by entangled cables.SOLUTION: The surgical footswitch includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator, and includes a first switch and a second switch. The wireless interface sends control signals from an encoder to a surgical controller and then instructs surgical equipment based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in a surgical theater. The internal power generator converts footswitch movement into stored energy, in order to eliminate potential failures of the footswitch during a surgery and to overcome the need to replace batteries of the footswitch.
摘要翻译：要解决的问题：提供可靠的脚踏开关，其功能与外科系统通信，同时避免潜在危险或由缠结电缆产生的限制性环境。解决方案：手术脚踏开关包括底座，踏板，编码器组件，无线接口和内部发电机，并且包括第一开关和第二开关。无线接口将编码器的控制信号发送到手术控制器，然后根据控制信号指示外科设备。这种无线接口消除了电线或系绳的缠结，这可能是外科手术室的危险。内部发电机将脚踏开关转换为储存的能量，以消除手术过程中脚踏开关的潜在故障，并克服更换脚踏开关电池的需要。版权所有（C）2012，JPO＆INPIT

10. 发明专利

JP2012071167A Surgical footswitch and method of controlling surgical apparatus 有权
标题翻译：外科手术和控制手术装置的方法
公开(公告)号：JP2012071167A
公开(公告)日：2012-04-12
申请号：JP2011268063
申请日：2011-12-07
申请人： Alcon Inc , アルコン,インコーポレイティド
发明人： HORVATH CHRISTOPHER , BUCZEK MARK , ROWE T SCOTT
IPC分类号： A61B19/00 , A61B18/00 , G05G1/38
CPC分类号： G05G1/38 , A61B17/00 , A61B34/20 , A61B2017/00119 , A61B2017/00194 , A61B2017/00199 , A61B2017/00221 , A61B2017/00973 , A61C1/0023 , H01H21/26 , H01H2239/076 , H01H2300/014 , H01H2300/03 , Y02B70/3241 , Y04S20/227 , Y10T74/2054 , Y10T74/20888 , Y10T307/747
摘要： PROBLEM TO BE SOLVED: To provide a reliable footswitch that avoids potential hazards or a regulated environment formed by a tangled cable and simultaneously functions to work on a surgical system.SOLUTION: The present invention provides a surgical footswitch that includes a base, a pedal, an encoder assembly, a wireless interface, and an internal power generator. The wireless interface passes a control signal from the encoder to the surgical console, which then directs the surgical apparatus based on the control signal. This wireless interface eliminates the tangle of wires or tethers, which may be a hazard in the surgical theater. The internal power generator translates footswitch movement into stored energy to eliminate potential failures of the footswitch during a procedure and overcome the need to replace batteries within the footswitch.
摘要翻译：要解决的问题：提供可靠的脚踏开关，以避免由缠结电缆形成的潜在危险或调节环境，同时可在外科系统上工作。解决方案：本发明提供一种外科脚踏开关，其包括底座，踏板，编码器组件，无线接口和内部发电机。无线接口将来自编码器的控制信号传递到手术控制台，然后控制信号基于控制信号引导外科装置。这种无线接口消除了电线或绳索的缠结，这可能是外科手术室的危险。内部发电机将脚踏开关移动转换为储存的能量，以消除脚踏开关在程序期间的潜在故障，并克服了更换脚踏开关内的电池的需要。版权所有（C）2012，JPO＆INPIT

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