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1. 发明公开

EP1564210A1 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS 有权转让
标题翻译： 4-OXOCHINOLINVERBINDUNGEN UND DEREN VERWENDUNG ALS HIV-INTEGRASE-INHIBITOREN
公开(公告)号：EP1564210A1
公开(公告)日：2005-08-17
申请号：EP03811532.5
申请日：2003-11-20
申请人： Japan Tobacco Inc.
发明人： SATOH, Motohide, Japan Tobacco Inc. , KAWAKAMI, Hiroshi, Japan Tobacco Inc. , ITOH, Yoshiharu, Japan Tobacco Inc. , SHINKAI, Hisashi, Japan Tobacco Inc. , MOTOMURA, Takahisa, Japan Tobacco Inc. , ARAMAKI, Hisateru, Japan Tobacco Inc. , MATSUZAKI, Yuji, Japan Tobacco Inc. , WATANABE, Wataru, Japan Tobacco Inc. , WAMAKI, Shuichi, Japan Tobacco Inc.
IPC分类号： C07D215/56 , C07D401/06 , C07D409/06 , C07D417/06 , C07D471/04 , A61K31/47 , A61K31/4709 , A61K31/5377 , A61K31/4375 , A61P31/12 , A61P31/18 , A61P43/00
CPC分类号： A61K31/47 , A61K31/4375 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D215/56 , C07D215/58 , C07D401/06 , C07D409/06 , C07D417/06 , C07D471/04
摘要： An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I]
wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.
摘要翻译：作为活性成分的抗艾滋病毒药物，其含有下述式表示的4-氧代喹啉化合物，其中各符号如说明书中所定义，或其药学上可接受的盐。本发明的化合物具有HIV整合酶抑制作用，可用作预防或治疗AIDS的抗HIV剂。此外，通过与其它抗HIV剂如蛋白酶抑制剂，逆转录酶抑制剂等的组合使用，化合物可以变成更有效的抗HIV剂。由于该化合物对整合酶具有高的抑制活性，因此可提供对人体副作用较小的安全药剂。

2. 发明授权

EP1221301B1 Blood collection set 有权
标题翻译：采血装置
公开(公告)号：EP1221301B1
公开(公告)日：2005-08-17
申请号：EP01128985.7
申请日：2001-12-06
申请人： Becton Dickinson and Company
发明人： Crawford, Jamieson William Maclean , Livanos, Stefanie
IPC分类号： A61B5/15
CPC分类号： A61B5/15003 , A61B5/150259 , A61B5/150389 , A61B5/150503 , A61B5/150656 , A61B5/150717 , A61B5/15074 , A61B5/153 , A61M5/3257 , A61M2005/3247

3. 发明公开

EP1559716A1 PYRAZOLONAPHTHYRIDINE DERIVATIVE 有权
标题翻译：吡唑并萘啶衍生物
公开(公告)号：EP1559716A1
公开(公告)日：2005-08-03
申请号：EP03810609.2
申请日：2003-11-05
申请人： Grelan Pharmaceutical Co., Ltd.
发明人： KANAZAWA, Hashime , AOTSUKA, Tomoji , KUMAZAWA, Kentarou , ISHITANI, Kouki , NOSE, Takashi
IPC分类号： C07D471/14 , A61K31/4375 , A61K31/444 , A61P11/00 , A61P29/00 , A61P43/00
CPC分类号： A61K31/4375 , A61K31/444 , C07D471/14
摘要： The target is to provide PDE IV inhibitors which have a highly potent anti-asthmatic and/or COPD-prophylactic/therapeutic profile with unexpectedly excellent safety. A compound of the formula (1):
wherein A is phenyl, pyridyl, 1-oxypyridyl, or thienyl, which may be unsubstituted or optionally substituted with one or more members selected from the group consisting of hydroxyl, halogen, cyano, nitro, lower alkyl, lower alkoxy, lower alkylcarbonyloxy, amino, carboxyl, lower alkoxycarbonyl, carboxy-lower alkylene, lower alkoxycarbonyl-lower alkylene, lower alkylsulfonyl, lower alkylsulfonylamino, and ureido; R 1 is a group selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, nitro, lower alkoxy, amino, carboxyl, and lower alkoxycarbonyl; R 2 is hydrogen or lower alkyl; and m is an integer of 1 to 3; or a pharmaceutically acceptable salt thereof, possesses highly excellent PDE IV-specific inhibitory actions and is useful as an anti-asthmatic drug and/or a prophylactic/therapeutic drug for COPD with high safety.
摘要翻译：目标是提供PDE IV抑制剂，其具有高度有效的抗哮喘和/或COPD-预防/治疗特征，具有出乎意料的优异安全性。通式（1）的化合物：其中A是苯基，吡啶基，1-氧吡啶基或噻吩基，它们可以是未取代的或任选被一个或多个选自羟基，卤素，氰基，硝基，低级烷基，低级烷氧基，低级烷基羰氧基，氨基，羧基，低级烷氧基羰基，羧基 - 低级亚烷基，低级烷氧基羰基 - 低级亚烷基，低级烷基磺酰基，低级烷基磺酰基氨基和脲基; R1是选自氢，羟基，卤素，氰基，硝基，低级烷氧基，氨基，羧基和低级烷氧基羰基的基团; R2是氢或低级烷基; m是1至3的整数; 或其药学上可接受的盐具有非常优异的PDE IV特异性抑制作用，并且作为用于COPD的抗哮喘药和/或预防/治疗药具有高安全性。

4. 发明授权

EP1024217B1 Thermal bonding of wet cellulose based fibers 有权
标题翻译：湿的纤维素纤维的热粘结
公开(公告)号：EP1024217B1
公开(公告)日：2005-08-03
申请号：EP00101423.2
申请日：2000-01-25
申请人： Celanese Acetate, LLC.
发明人： Powers, Edward J. , Davis, Harold W. , Walden, James R.
IPC分类号： D04H1/54 , D04H3/14 , D06C15/02 , B29C43/24
CPC分类号： D04H3/14 , D04H1/54

5. 发明公开

EP1547590A1 MELANIN EXTINGUISHER 审中-公开
标题翻译：黑色素罗旭德
公开(公告)号：EP1547590A1
公开(公告)日：2005-06-29
申请号：EP03795415.3
申请日：2003-09-11
申请人： Oga Research, Incorporated
发明人： OGATA, Kazumi
IPC分类号： A61K31/28 , A61K31/315 , A61K31/16 , A61K31/185 , A61K31/22 , A61K7/00 , A61K7/48 , A61P17/00 , C07C323/52 , C07C323/60
CPC分类号： C07K5/06113 , A61K8/46 , A61K31/16 , A61K31/185 , A61K31/22 , A61K31/28 , A61K31/315 , A61K31/4015 , A61K31/404 , A61K31/4172 , A61K31/4402 , A61K2800/51 , A61Q19/02 , C07C323/52 , C07C323/60 , C07D207/16 , C07D209/14 , C07D213/75 , C07D233/26 , C07K5/0606
摘要： A melanin eliminator preparation comprising a metal chelate compound represented by the following formula (I),
wherein M denotes a metal, and R denotes hydroxyl, O-lower alkyl, an amine bonded at N, an amino acid bonded at N, or a peptide bonded at N, or a pharmacologically acceptable salt thereof.
摘要翻译：一种黑色素消除剂制剂，其包含由下式（I）表示的金属螯合物，其中M表示金属，R表示羟基，O-低级烷基，N键合的胺，N键合的氨基酸，或在N结合的肽或其药理学上可接受的盐。

6. 发明公开

EP1541575A1 NOVEL PROCESS FOR PRODUCING IMIDAZO(1,2-B)PYRIDAZINE DERIVATIVE 有权
标题翻译：维生素VERFAHREN ZUR HERSTELLUNG EINES IMIDAZO（1,2-B）PYRIDAZINDERIVATS
公开(公告)号：EP1541575A1
公开(公告)日：2005-06-15
申请号：EP03771268.4
申请日：2003-07-16
申请人： Sumitomo Chemical Takeda Agro Company, Limited
发明人： TABUCHI, Takanori , YAMAMOTO, Tetsuhiro , KAJIWARA, Takeshi B-1103, Shitinakandatsu,
IPC分类号： C07D487/04
CPC分类号： A01N47/36 , C07D487/04
摘要： A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II):
(wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I):
(wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO 2 N=CH-NR 1 R 2 ; and Z represents halogeno or OSO 2 R 3 ) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.
摘要翻译：具有与6-位碳原子键合的取代基并由式（II）表示的咪唑并[1,2-b]哒嗪-3-基磺酰胺衍生物的方法：其中R表示低级烷基，低级烷基，低级烯基或低级炔基取代的低级环烷基），该方法包括使由式（I）表示的咪唑并[1,2-b]哒嗪化合物：其中X表示任选被卤素取代的卤代或低级烷基 ; Y表示氢或SO 2 N = CH-NR 1 R 2; Z表示卤代或OSO 2 R 3）与有机金属化合物在过渡金属催化剂存在下反应。该衍生物可用作除草剂的中间体。

7. 发明公开

EP1537106A1 DIHYDROPYRAZOLOPYRIDINE COMPOUNDS 审中-公开
标题翻译：二氢吡唑并吡啶化合物
公开(公告)号：EP1537106A1
公开(公告)日：2005-06-08
申请号：EP03784497.4
申请日：2003-08-01
申请人： Mitsubishi Pharma Corporation
发明人： KOHARA, Toshiyuki,c/o MITSUBISHI PHARMA CORP. , FUKUNAGA, Kenji,c/o MITSUBISHI PHARMA CORP. , HANANO, Tokushi,c/o MITSUBISHI PHARMA CORP.
IPC分类号： C07D471/04 , A61K31/437 , A61P3/10 , A61P25/28 , A61P37/00
CPC分类号： C07D471/04
摘要： The present invention provides dihydropyrazolopyridine compounds represented by the formula (I):wherein each symbol is as defined in the specification, optically active forms thereof, and pharmaceutically acceptable salts thereof and hydrates thereof. The compounds of the present invention show a selective and strong inhibitory activity on glycogen synthase kinase-3 beta (GSK-3β), and are useful as medicaments for prevention and/or treatment of diabetes, diabetic complications and neurodegenerative diseases or as immunopotentiators.
摘要翻译：本发明提供由式（I）表示的二氢吡唑并吡啶化合物：其中各符号如说明书中所定义，其光学活性形式及其药学上可接受的盐和其水合物。本发明化合物对糖原合成酶激酶-3β（GSK-3β）显示出选择性强的抑制活性，可用作预防和/或治疗糖尿病，糖尿病并发症和神经退行性疾病或作为免疫增强剂的药物。

8. 发明公开

EP1535636A1 POROUS MEMBRANE 审中-公开
标题翻译： PORÖSEMEMBRAN
公开(公告)号：EP1535636A1
公开(公告)日：2005-06-01
申请号：EP03741308.5
申请日：2003-07-10
申请人： Kuraray Co., Ltd. , Kuraray Medical Inc.
发明人： TAKAI, Masato c/o KURARAY CO., LTD. , MATSUMOTO, Yoichi c/o KURARAY CO., LTD. , SEKIGUCHI, Kouji c/o KURARAY MEDICAL INC. , KAKIUCHI, Tomoki c/o KURARAY MEDICAL INC. , TSURUTA, Hitoshi c/o KURARAY CO., LTD. , SHIMIZU, Takao c/o KURARAY CO., LTD.
IPC分类号： A61M1/16
CPC分类号： B01D71/56 , B01D67/0009 , B01D69/08 , B01D2325/023 , B01D2325/22 , B01D2325/32
摘要： A polyamide having an equilibrium water absorption of not more than 10% is used as a main material. As a polyamide having an equilibrium water absorption of not more than 10%, for example, a polyamide comprising a dicarboxylic acid component comprising 60-100 mol% of terephthalic acid and a diamine component comprising 60-100 mol% of 1,9-nonanediamine and/or 2-methyl-1,8-octanediamine is used. As a result, a porous membrane showing extremely small dimensional change even after a hot water treatment, and particularly useful as a medical separation membrane permitting an AC sterilization treatment and the like is obtained.
摘要翻译：使用平衡吸水率不超过10％的聚酰胺作为主要材料。作为平衡吸水率为10％以下的聚酰胺，例如可列举含有60-100摩尔％对苯二甲酸的二羧酸组分和包含60-100摩尔％的1,9-壬二胺的二胺组分的聚酰胺和/或2-甲基-1,8-辛二胺。结果，即使在热水处理之后也显示出极小的尺寸变化的多孔膜，并且特别可用作允许进行AC灭菌处理的医疗分离膜等。

9. 发明授权

EP0976415B1 A needle shield for a prefillable syringe 有权
标题翻译：对于预填充注射器针头保护
公开(公告)号：EP0976415B1
公开(公告)日：2005-05-11
申请号：EP99112444.7
申请日：1999-06-30
申请人： Becton Dickinson and Company
发明人： Odell, Robert B. , Gyure, Sandor
IPC分类号： A61M5/32
CPC分类号： A61M5/3202 , A61M5/001

10. 发明授权

EP1088642B1 Method and apparatus for manufacturing a molded device 有权
标题翻译：生产模制装置的方法和设备
公开(公告)号：EP1088642B1
公开(公告)日：2005-03-30
申请号：EP00118933.1
申请日：2000-09-01
申请人： Becton Dickinson and Company
发明人： Powell, Kenneth G. , Monahan, Larry A. , Sage, Burton H., Jr.
IPC分类号： B29C45/37 , B29C33/42
CPC分类号： B29C33/405 , A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B29C33/424 , B29C45/372 , B29C2045/0094 , B29K2883/00 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C1/00111 , B81C2201/034

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