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1. 发明申请

WO2023069887A1 MUCOSAL VACCINE, METHODS OF USE AND ADMINISTRATION THEREOF 审中-公开
公开(公告)号：WO2023069887A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/078191
申请日：2022-10-17
申请人： YANG, Kejian
IPC分类号： A61K39/12
摘要： A method of vaccinating a subject against a respiratory viral infection comprises concurrently or separately administering to a subject in need thereof one of more polynucleotide vector(s) encoding a respiratory virus antigen and one or more aerosolized respiratory virus antigen(s) to induce a mucosal immune response in the subject against an infection by respiratory viral infection. In another aspect, the present application provides a mucosal vaccine kit comprising one of more polynucleotide vector(s) encoding a respiratory virus antigen, one or more aerosolized respiratory virus antigen(s).

2. 发明申请

WO2022211791A1 MODIFIED PLASMA CLOTTING FACTOR VIII AND METHOD OF USE THEREOF 审中-公开
公开(公告)号：WO2022211791A1
公开(公告)日：2022-10-06
申请号：PCT/US2021/024916
申请日：2021-03-30
申请人： AAVNERGENE INC.
发明人： WANG, Qizhao , YU, Daozhan
IPC分类号： C07K14/755 , A61P7/04 , A61K38/00
摘要： Modified hum 1. an factor VIII polypeptides with enhanced factor VIII activity are described. In some embodiments, the modified human factor VIII polypeptides comprise one or more amino acid substitutions at positions A20, T21, F57, L69, I80, L178, R199, H212, I215, R269, I310, L318, S332, R378, I610 and/or I661. Such polypeptides and viral vectors encoding such polypeptides may be used for treatment of FVIII deficiencies, such as hemophilia A.

3. 发明申请

WO2017096201A1 SENECA VALLEY VIRUS (SVV) CELLULAR RECEPTOR TARGETED ONCOTHERAPY 审中-公开
标题翻译： SENECA VALLEY VIRUS（SVV）细胞受体靶向治疗
公开(公告)号：WO2017096201A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/064679
申请日：2016-12-02
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER
发明人： MILES, Linde , POIRIER, John , RUDIN, Charles
IPC分类号： A61P35/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N2800/52
摘要： A method for selecting cancer patient for treatment with Seneca Valley Virus (SVV) by determining expression of ANTXR1 in a cancerous tissue in a cancer patient; and designating the cancer patient as a candidate for treatment with SVV if normal levels or elevated levels of ANTXR1 expression is detected in the cancerous tissue. Also a method for treating a cancer patient with SVV is disclosed.
摘要翻译：通过确定癌症患者的癌组织中ANTXR1的表达来选择用塞内卡谷病毒（SVV）治疗的癌症患者的方法; 如果在癌组织中检测到正常水平或ANTXR1表达水平升高，则将癌症患者指定为用SVV治疗的候选者。还公开了用SVV治疗癌症患者的方法。

4. 发明申请

WO2017095394A1 INTEGRATED SAMPLE PROCESSING SYSTEM 审中-公开
标题翻译：集成的样品处理系统
公开(公告)号：WO2017095394A1
公开(公告)日：2017-06-08
申请号：PCT/US2015/063232
申请日：2015-12-01
申请人： AKONNI BIOSYSTEMS, INC.
发明人： COONEY, Christopher, G. , HOLMBERG, Rebecca , BELGRADER, Phillip , QU, Peter, Qiang
IPC分类号： C12Q1/68 , C40B60/12
CPC分类号： C12Q1/6806 , G01N1/286 , G01N35/0099
摘要： An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.
摘要翻译：集成式样品净化系统包括外壳，样品容器架，过滤器支架和圆柱形磁体。样本容器架和过滤装置保持器设置在壳体中。样本容器架被配置为保持一个或多个样本容器，过滤装置保持器被配置为保持一个或多个过滤装置。圆柱形磁体邻近样品容器架并在样品容器架的外部，并且通过设置在壳体中的电动马达围绕磁体的中心纵向轴线旋转以溶解细胞。裂解细胞中感兴趣的分子使用特异性结合感兴趣分子的过滤器纯化。该系统很容易进行自动化和快速纯化和分析感兴趣的分子，如核酸和蛋白质。

5. 发明申请

WO2016061073A1 COMPOSITION AND METHOD FOR IN VIVO ENGINEERING OF CHROMOSOMAL REARRANGEMENTS 审中-公开
标题翻译：染色体重建工程的组成和方法
公开(公告)号：WO2016061073A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055286
申请日：2015-10-13
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER
发明人： VENTURA, Andrea , MADDALO, Danilo
IPC分类号： C12N15/85 , C12N15/861 , C12N15/113 , C12N15/63
CPC分类号： C12N15/102 , A01K67/0275 , A01K2217/00 , A01K2227/105 , A01K2267/0331 , C12N15/85 , C12N15/8509 , C12N2015/8572 , C12N2310/20 , C12N2750/14143
摘要： A method for inducing specific chromosomal rearrangements in vivo using the CRISPR/Cas system is disclosed. The method may be used to introduce chromosomal rearrangement in vivo and to generate animal models of human diseases, such as a mouse model of Eml4-Alk -driven non- small cell lung cancer.
摘要翻译：公开了使用CRISPR / Cas系统在体内诱导特异性染色体重排的方法。该方法可用于在体内引入染色体重排并产生人类疾病的动物模型，例如Eml4-Alk驱动的非小细胞肺癌的小鼠模型。

6. 发明申请

WO2015153870A1 METHOD AND KITS FOR IDENTIFYING OF CDK9 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于鉴定CDK9抑制剂治疗癌症的方法和工具
公开(公告)号：WO2015153870A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024057
申请日：2015-04-02
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , ST. JUDE CHILDREN'S RESEARCH HOSPITAL
发明人： LOWE, Scott, William , SHERR, Charles, J. , HUANG, Chun-Hao , LUJAMBIO, Amaia
IPC分类号： C12Q1/68 , G01N33/574 , A61K48/00 , A61K31/70 , A61K31/445
CPC分类号： A61K31/519 , A61K31/40 , A61K31/404 , A61K31/44 , A61K31/445 , A61K31/4545 , A61K31/4745 , A61K31/655 , A61K31/7048 , A61K31/7068 , A61K45/06 , C12N15/1137 , C12N2310/531 , C12N2320/10 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Y207/11022 , C12Y207/11023 , G01N33/57423 , G01N33/57426 , G01N33/57438 , G01N2333/91205 , G01N2800/52 , A61K2300/00
摘要： A method of determining sensitivity to cancer treatment includes the step of determining the presence of overexpression of MYC in a biological sample from a patient suffering from cancer, wherein the presence of overexpression of MYC indicates a sensitivity to a treatment by a CDK9 inhibitor and wherein the cancer is selected from the group consisting of carcinoma, leukemia, and lymphoma.
摘要翻译：确定对癌症治疗的敏感性的方法包括确定来自患有癌症的患者的生物样品中MYC的过表达的存在的步骤，其中MYC的过表达的存在表示对CDK9抑制剂的治疗的敏感性，并且其中癌症选自癌，白血病和淋巴瘤。

7. 发明申请

WO2015142885A3 METHOD AND KITS FOR DETERMINING SENSITIVITY TO CANCER TREATMENT 审中-公开
公开(公告)号：WO2015142885A3
公开(公告)日：2015-09-24
申请号：PCT/US2015/021014
申请日：2015-03-17
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , DANA-FARBER CANCER INSTITUTE
发明人： ROSENBERG, Jonathan, Eric , VAN ALLEN, Eliezer, Mendel , GARRAWAY, Levi, Alexander , KANTOFF, Philip, Wayne , WAGLE, Nikhil
IPC分类号： C12Q1/68
摘要： A method of increasing the efficacy of treatment for a patient suffering from urothelial carcinoma. The method comprises the steps of determining the presence or absence in a biological sample from the patient of somatic ERCC2 mutation followed by performing appropriate treatment. The absence of somatic ERCC2 mutation indicates that the urothelial carcinoma is likely to be unresponsive to cisplatin chemotherapy, and the patient then undergoes surgery to remove the carcinoma without accompanying cisplatin chemotherapy. The presence of somatic ERCC2 mutation indicates that the uroethelial carcinoma is likely to be responsive to cisplatin chemotherapy and the patient then undergoes surgery to remove the carcinoma accompanied by cisplatin chemotherapy.

8. 发明申请

WO2014026121A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS RELATED TO LACK OF BLOOD SUPPLY, SHOCK AND NEURONAL INJURIES 审中-公开
标题翻译：治疗缺乏血液供应，冲击和神经损伤的条件的方法和组合物
公开(公告)号：WO2014026121A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/054356
申请日：2013-08-09
申请人： SIMPKINS, Cuthbert, O.
发明人： SIMPKINS, Cuthbert, O.
IPC分类号： A61K38/42 , A61K31/02 , A61P25/00
CPC分类号： A61K31/4172 , A61K9/0026 , A61K9/107 , A61K47/183 , A61K47/44
摘要： A pharmaceutical composition comprising an amphiphilic emulsifier, a polar liquid carrier and, optionally, a lipid component. The amphiphilic emulsifier form free-moving, optionally lipid-carrying, micelles (LMs) in the polar liquid carrier. The pharmaceutical composition is free of hemoglobin and fluorocarbon and can be used for treating conditions related to lack of blood supply and to raise the blood pressure and correct hypovolemia.
摘要翻译：一种药物组合物，其包含两亲性乳化剂，极性液体载体和任选的脂质组分。两极乳化剂在极性液体载体中形成自由移动的，任选的含脂质的胶束（LM）。该药物组合物不含血红蛋白和碳氟化合物，可用于治疗与供血不足有关的病症，提高血压，矫正血容量不足。

9. 发明申请

WO2012078863A2 SAMPLE ANALYSIS SYSTEM 审中-公开
标题翻译：样本分析系统
公开(公告)号：WO2012078863A2
公开(公告)日：2012-06-14
申请号：PCT/US2011/063937
申请日：2011-12-08
申请人： AKONNI BIOSYSTEMS , COONEY, Christopher , BELGRADER, Phillip , BUENO, Arial , GARBER, Steve , THAKORE, Nitu, Harshendu , QU, Peter, Qiang
发明人： COONEY, Christopher , BELGRADER, Phillip , BUENO, Arial , GARBER, Steve , THAKORE, Nitu, Harshendu , QU, Peter, Qiang
IPC分类号： G01N33/53 , G01N33/48 , G01N35/08
CPC分类号： B01L3/5025 , B01L3/502715 , B01L3/50855 , B01L7/52 , B01L2200/04 , B01L2200/0678 , B01L2200/16 , B01L2300/044 , B01L2300/0636 , B01L2300/0672 , B01L2300/0819 , B01L2300/0829 , B01L2300/087 , B01L2400/0487 , B01L2400/065 , B01L2400/0683
摘要： An integrated sample analysis system is disclosed. The sample analysis system contains (1) a sample preparation/analysis module having sample purification device comprising a monolith that binds specifically to nucleic acids and a sample analysis device comprising a microarray enclosed in a reaction chamber having a hydrophilic interior surface; (2) a temperature control module comprising a thermocycler having a thermally conductive temperature-control bladder; and (3) an imaging device capable of capturing an image of the microarray in the reaction chamber.
摘要翻译：公开了一种整合的样本分析系统。样品分析系统包含（1）具有样品纯化装置的样品制备/分析模块，样品纯化装置包含与核酸特异性结合的整体柱和样品分析装置，所述样品分析装置包括封装在具有亲水性内表面的反应室中的微阵列; （2）温度控制模块，其包括具有导热温控囊的热循环仪; 和（3）能够捕获反应室中微阵列图像的成像装置。

10. 发明申请

WO2010056355A2 SPINAL FUSION DEVICE 审中-公开
标题翻译：脊髓融合装置
公开(公告)号：WO2010056355A2
公开(公告)日：2010-05-20
申请号：PCT/US2009/006124
申请日：2009-11-16
申请人： SPINAL INTEGRITY, LLC , KRUEGER, David
发明人： KRUEGER, David
IPC分类号： A61F2/44 , A61B17/70
CPC分类号： A61F2/447 , A61F2/442 , A61F2/4611 , A61F2/4684 , A61F2002/2835 , A61F2002/30056 , A61F2002/3008 , A61F2002/30387 , A61F2002/30395 , A61F2002/30401 , A61F2002/30504 , A61F2002/30538 , A61F2002/30553 , A61F2002/30556 , A61F2002/30598 , A61F2002/30616 , A61F2002/30682 , A61F2002/30774 , A61F2002/30785 , A61F2002/30797 , A61F2002/30808 , A61F2002/30841 , A61F2002/30971 , A61F2002/3098 , A61F2002/30981 , A61F2002/4475 , A61F2002/4628 , A61F2220/0025 , A61F2250/0006 , A61F2250/0008 , A61F2250/0009 , A61F2250/0032 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00047 , A61F2310/00053 , A61F2310/00059 , A61F2310/00179 , A61F2310/00407 , A61F2310/00796 , A61F2310/00976
摘要： A spinal fusion device is disclosed. The spinal fusion device includes a first endplate configured for fitting within a disc space and engaging with a first vertebra and a second endplate configured for fitting within the disc space and engaging with a second vertebra. The two endplates are separated by a single spacer that is positioned between the first endplate and the second endplate and maintains a pre-determined distance between the first endplate and the second endplate. The spacer contains an anterior end, a posterior end, a first lateral side, a second lateral side opposite to the first lateral side, a first surface that engages with the first endplate, a second surface that engages with the second endplate. Also disclosed are methods and instruments for implanting the spinal fusion device.
摘要翻译：公开了一种脊柱融合装置。所述脊柱融合装置包括第一端板和第二端板，所述第一端板构造成用于装配在椎间盘空间内并且与第一椎骨和第二端板接合，所述第一端板构造成配合在椎间盘空间内并与第二椎骨接合。两个端板由定位在第一端板和第二端板之间的单个间隔件隔开，并且保持第一端板和第二端板之间的预定距离。间隔件包括前端，后端，第一侧面，与第一侧面相对的第二侧面，与第一端板接合的第一表面，与第二端板接合的第二表面。还公开了用于植入脊柱融合装置的方法和器械。

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