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1. 发明申请

WO2011094680A3 CLEANING AND DEWATERING FINE COAL 审中-公开
标题翻译：清洁和减少细煤
公开(公告)号：WO2011094680A3
公开(公告)日：2011-08-04
申请号：PCT/US2011/023161
申请日：2011-01-31
申请人： VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. , YOON, Roe-Hoan , ERAYDIN, Kerem , FREELAND, Chad
发明人： YOON, Roe-Hoan , ERAYDIN, Kerem , FREELAND, Chad
IPC分类号： B03B5/28 , B03B5/62
摘要： Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.
摘要翻译：通过将含有两者的水性浆液与疏水性液体混合，使混合物进行相分离，将细煤清除其矿物质杂质并脱水。所得的疏水液相包含无颗粒表面水分的煤颗粒和由煤颗粒稳定的水滴，而水相含有矿物质。通过机械方式将夹带的水滴从煤颗粒中分离出来，获得了明显减少矿物质和水分含量的洁净煤产品。废弃的疏水液体从洁净煤产品中分离出来并循环使用。该工艺也可用于通过选择性疏水化一种亲水性颗粒与另一种亲水性颗粒进行分离。

2. 发明申请

WO2003106382A3 REVERSED LIQUID CRYSTALLINE PHASES WITH NON-PARAFFIN HYDROPHOBES 审中-公开
公开(公告)号：WO2003106382A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018457
申请日：2003-06-13
申请人： LYOTROPIC THERAPEUTICS, INC.
发明人： ANDERSON, David, M.
IPC分类号： A61K9/00
摘要： Compounds which are otherwise difficult to solubilize, such as, for example, pharmaceutical actives difficult for the body to absorb, are solubilized into a composition using a solvent system that is a structured fluid. The structured fluid is a reversed cubic phase or reversed hexagonal phase material, or a combination thereof, which includes a polar solvent, a surfactant and a non-paraffinic liquid with a high octanol-water partition coefficient which does not qualify as a surfactant. The compositions thus formed are able to enhance absorption of drugs by the induction of local, transient nanopores in biomembrane absorption barriers and particularly those in which efflux mechanisms, such as those associated with P-glycoprotein and/or cytochrome 3A4, are active. The compositions and methods that are used for solubilizing pharmaceutical actives in structured fluids can simultaneously accomplish solubilization of difficultly soluble drugs and enhancement of absorption.

3. 发明申请

WO2003106382A2 REVERSED LIQUID CRYSTALLINE PHASES WITH NON-PARAFFIN HYDROPHOBES 审中-公开
标题翻译：具有非对映体疏水性的反相液晶相
公开(公告)号：WO2003106382A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018457
申请日：2003-06-13
申请人： LYOTROPIC THERAPEUTICS, INC.
发明人： ANDERSON, David, M.
IPC分类号： C07C
CPC分类号： A61K9/1274
摘要： Compounds which are otherwise difficult to solubilize, such as, for example, pharmaceutical actives difficult for the body to absorb, are solubilized into a composition using a solvent system that is a structured fluid. The structured fluid is a reversed cubic phase or reversed hexagonal phase material, or a combination thereof, which includes a polar solvent, a surfactant and a non-paraffinic liquid with a high octanol-water partition coefficient which does not qualify as a surfactant. The compositions thus formed are able to enhance absorption of drugs by the induction of local, transient nanopores in biomembrane absorption barriers and particularly those in which efflux mechanisms, such as those associated with P-glycoprotein and/or cytochrome 3A4, are active. The compositions and methods that are used for solubilizing pharmaceutical actives in structured fluids can simultaneously accomplish solubilization of difficultly soluble drugs and enhancement of absorption.
摘要翻译：否则难以溶解的化合物，例如难以吸收身体的药物活性成分，可以使用作为结构化流体的溶剂体系溶解到组合物中。结构化流体是反相立方相或反相六方相材料或其组合，其包括极限溶剂，表面活性剂和具有高辛醇 - 水分配系数的非石蜡液体，其不被认为是表面活性剂。由此形成的组合物能够通过诱导生物膜吸收屏障中的局部，瞬时纳米孔而增强药物的吸收，特别是其中外源机制（例如与P-糖蛋白和/或细胞色素3A4相关的那些）是活性的那些。用于溶解结构化流体中的药物活性物质的组合物和方法可以同时完成难溶性药物的溶解和增强吸收。

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