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1. 发明申请

WO2018216009A1 BIOMARKERS FOR DIAGNOSIS OF LUNG CANCER 审中-公开
公开(公告)号：WO2018216009A1
公开(公告)日：2018-11-29
申请号：PCT/IL2018/050554
申请日：2018-05-22
申请人： THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD. BEN-GURION UNIVERSITY OF THE NEGEV
发明人： SHOSHAN-BARMATZ, Varda
IPC分类号： A61P35/00 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574
摘要： The present invention relates to biomarkers of lung cancer, particularly to markers that enable distinguishing between subtypes of non-small cell lung cancer (NSCLC), particularly between adenocarcinoma (AC) and squamous cell carcinoma (SCC). In particular, the present invention relates to means and methods for diagnosing, assessing the level of severity and selecting methods of treating NSCLC.

2. 发明申请

WO2018122846A1 UNIFIED BOOSTER FOR ARTILLERY MUNITION FUSES ENABLING DETONATING OF BOTH EXPLOSION AND EJECTION TYPE SHELLS 审中-公开
公开(公告)号：WO2018122846A1
公开(公告)日：2018-07-05
申请号：PCT/IL2017/051392
申请日：2017-12-27
申请人： RAFAEL ADVANCED DEFENSE SYSTEMS LTD.
发明人： WEITZ, Amir , SILBERMAN, Iris , TANANBOUM, Zach
IPC分类号： C06C7/02 , F42B3/00
摘要： A unified booster for artillery ammunition fuses, that enables initiating both explosive type shells as well as ejection type shells, wherein the booster component is installable in continuation to the detonator component and the lead charge, that are usually installed in various artillery ammunition fuses, as a part of their detonation chain, and wherein the booster component is formed as a charge of explosive material that a flyer plate is installed at its one end that from the instant of installing the booster component in the fuse and mounting the fuse at the head of the shell is turned towards the shell's charge to be initiated.

3. 发明申请

WO2014170892A1 INHIBITION OF RIP KINASES FOR TREATING LYSOSOMAL STORAGE DISEASES 审中-公开
标题翻译：用于治疗LYSOSOMAL存储疾病的RIP KINASES的抑制
公开(公告)号：WO2014170892A1
公开(公告)日：2014-10-23
申请号：PCT/IL2014/050343
申请日：2014-04-09
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD.
发明人： FUTERMAN, Anthony H. , VITNER, Einat , SALOMON, Ran
IPC分类号： A61K45/00 , A61K38/17 , A61P3/00 , A61P25/00
CPC分类号： A61K38/2006 , A61K45/06
摘要： The present invention provides compositions and methods for treating lysosomal storage disease characterized by elevation of RIP kinase in a subject in need thereof using at least one RIP kinase inhibitor.
摘要翻译：本发明提供用于治疗溶酶体贮积病的组合物和方法，其特征在于使用至少一种RIP激酶抑制剂在有需要的受试者中升高RIP激酶。

4. 发明申请

WO2014118782A2 METHODS AND SYSTEMS FOR REDUCING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT 审中-公开
标题翻译：用于减少受试者的一个机构的神经活动的方法和系统
公开(公告)号：WO2014118782A2
公开(公告)日：2014-08-07
申请号：PCT/IL2014/050109
申请日：2014-01-30
申请人： DIGMA MEDICAL LTD.
发明人： BEN-OREN, Ilan , HERSCHKOVITZ, Avia , WOLF, Tamir , YANIV, Irit
CPC分类号： A61B18/24 , A61B2018/00202 , A61B2018/00273 , A61B2018/00434 , A61B2018/00494 , A61B2018/00577 , A61B2018/00773 , A61B2018/00982 , A61B2018/20359 , A61B2018/2272
摘要： The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
摘要翻译：根据一些实施方案，本公开提供了用于选择性地减少，阻断或抑制受试者器官中的至少一部分神经活性的方法和系统。在优选实施方案中，所述方法和系统用于选择性阻断需要其的受试者的十二指肠中的至少一部分神经活性。根据一些实施例，通过使用激光辐射发生选择性阻塞。根据一些实施例，选择性阻塞包括对位于目标区域内的感觉神经的至少部分造成损伤，同时保持围绕感觉神经的组织的功能活动。根据一些实施例，感觉神经包括被配置为传送由通过十二指肠的食物触发的信号的神经元，例如但不限于神经激素信号。

5. 发明申请

WO2014118774A1 PHARMACEUTICAL COMPOSITIONS FOR ORAL TREATMENT OF DIABETES 审中-公开
标题翻译：用于口服糖尿病治疗的药物组合物
公开(公告)号：WO2014118774A1
公开(公告)日：2014-08-07
申请号：PCT/IL2014/050099
申请日：2014-01-29
申请人： OSHADI DRUG ADMINISTRATION LTD.
发明人： VOL, Alexander , GRIBOVA, Orna
IPC分类号： A61K38/28 , A61P3/10 , A61P3/08
CPC分类号： A61K38/28 , A61K9/0053 , A61K9/28 , A61K45/06 , A61K47/02 , A61K47/36 , A61K47/44
摘要： The present invention relates to pharmaceutical compositions for oral delivery comprising at least two bioactive proteins associated with glucose metabolism, selected from the group consisting of insulin, proinsulin and C-Peptide in a delivery vehicle adapted for oral administration that provides portal delivery of bioactive proteins. The exemplary pharmaceutical compositions comprise an oil-based matrix comprising solid particulate matter suspended therein, wherein the particulate matter comprises a polysaccharide non-covalently associated with silica particles having a hydrophobic surface, wherein the polysaccharide and silica particles are non-covalently associated with the at least two bioactive proteins. The present invention further provides therapeutic uses of said pharmaceutical compositions.
摘要翻译：本发明涉及用于口服递送的药物组合物，其包含至少两种与葡萄糖代谢相关的生物活性蛋白质，所述生物活性蛋白质选自胰岛素，胰岛素原和C-肽，其适于口服给药，其提供生物活性蛋白质的门静脉输送。示例性药物组合物包含悬浮在其中的固体颗粒物质的油基基质，其中所述颗粒物质包含与具有疏水性表面的二氧化硅颗粒非共价缔合的多糖，其中所述多糖和二氧化硅颗粒与所述多糖和二氧化硅颗粒非共价结合至少两种生物活性蛋白。本发明还提供了所述药物组合物的治疗用途。

6. 发明申请

WO2014108900A1 HIGHLY POTENT CELLULOLYTIC ENZYME PREPARATIONS AND PROCESSES FOR PRODUCING SAME 审中-公开
标题翻译：高纯度纤维素酶制剂及其生产方法
公开(公告)号：WO2014108900A1
公开(公告)日：2014-07-17
申请号：PCT/IL2014/050024
申请日：2014-01-09
申请人： DESIGNER ENERGY LTD.
发明人： MORAG, Ely , BARAK, Tal , KARPOL, Alon , ANBAR, Michael
IPC分类号： C12N9/42 , C12P7/10 , C12P19/14
CPC分类号： C12N11/16 , C12N9/2434 , C12N9/2445 , C12P19/02 , C12P19/14 , C12Y302/01021 , Y02P20/582
摘要： Compositions comprising unprocessed cell pellets of a cellulosome-producing microorganism grown on cellulosic biomass are provided. Further provided are methods for producing the compositions and uses thereof in hydrolysis of cellulosic substrates. In particular, the compositions advantageously contain extracellular beta-glucosidase, either expressed on the cells themselves or extrinsically added to the cell pellets.
摘要翻译：提供了包含在纤维素生物质上生长的产生纤维素酶的微生物的未处理的细胞团的组合物。进一步提供了用于生产组合物的方法及其在纤维素底物水解中的用途。特别地，组合物有利地含有细胞外β-葡糖苷酶，其在细胞本身上表达或者外源性加入到细胞团中。

7. 发明申请

WO2014068570A1 A SELF-PROPELLED SECURITY SYSTEM ON AN ADJACENT TO A FENCE TRACK 审中-公开
标题翻译：一个自相矛盾的安全系统
公开(公告)号：WO2014068570A1
公开(公告)日：2014-05-08
申请号：PCT/IL2013/050895
申请日：2013-11-03
申请人： MAGAL SECURITY SYSTEMS LTD.
发明人： SHAHAM, Avi , BEN-HAMOZEG, Yehonatan , SAAR, Avraham
IPC分类号： G08B13/194 , G08B13/196
CPC分类号： G08B13/19623 , G08B13/122
摘要： A self-propelled security system on an adjacent to a fence track, equipped with at least one imaging sensor and wherein the rail track on which the system's movable payload is propelled and the movable payload are both exposed to the fence side, and an anchoring means for anchoring, from time to time, the movable payload, and replacing the payload's battery with a new one within the anchoring means.
摘要翻译：一种在篱笆轨道附近的自推进安全系统，其配备有至少一个成像传感器，并且其中系统的可移动有效载荷被推进的轨道和可移动的有效载荷都暴露于栅栏侧;以及锚定装置用于不时地锚定可移动的有效载荷，并在锚定装置内用新的固定装置替换有效载荷的电池。

8. 发明申请

WO2014068568A1 LIGHT-SENSITIVE ION CHANNELS FOR INDUCTION OF CARDIAC ACTIVITY 审中-公开
标题翻译：用于诱导心脏病活动的敏感离子通道
公开(公告)号：WO2014068568A1
公开(公告)日：2014-05-08
申请号：PCT/IL2013/050893
申请日：2013-10-31
申请人： RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES
发明人： NUSSINOVITCH, Udi , GEPSTEIN, Lior
IPC分类号： A61K48/00 , A61K35/34 , A61P9/00
CPC分类号： A61K38/168 , A61K35/34 , A61K38/164 , A61K48/00 , A61K48/005 , A61K48/0075 , A61N5/062 , A61N2005/0626 , A61N2005/0662
摘要： The present invention relates to methods, kits and pharmaceutical compositions for inducing a controlled cardiac activity, thereby treating cardiac disease and disorders associated with reduced or suppressed cardiac activity.
摘要翻译：本发明涉及用于诱导受控心脏活动的方法，试剂盒和药物组合物，从而治疗与心脏活动减少或抑制相关的心脏疾病和病症。

9. 发明申请

WO2014064703A1 PHARMACEUTICAL LIQUID ADHESIVE COMPOSITIONS FOR TREATMENT OF ANORECTAL DISORDERS 审中-公开
标题翻译：用于治疗异位症的药物液体粘合剂组合物
公开(公告)号：WO2014064703A1
公开(公告)日：2014-05-01
申请号：PCT/IL2013/050870
申请日：2013-10-27
申请人： PERITECH PHARMA LTD.
发明人： LOZINSKY, Evgenia , EILAT, Eran
IPC分类号： A61L26/00 , A61K31/80 , C08L83/00
CPC分类号： A61L26/0076 , A61K9/0031 , A61K9/7015 , A61K31/137 , A61K31/167 , A61K31/245 , A61K31/4745 , A61K31/5375 , A61K45/06 , A61K47/24 , A61L26/0019 , A61L26/0066 , C08L83/04 , A61K2300/00
摘要： The present invention provides liquid adhesive compositions comprising a silicone film forming agent, a volatile solvent and a pharmaceutically active agent, and methods for preparing said compositions. The invention further provides methods for treating anorectal disorders comprising administering the liquid adhesive compositions to the mucous anal surface, kits comprising the liquid adhesive composition and a container-applicator device.
摘要翻译：本发明提供了包含硅酮成膜剂，挥发性溶剂和药物活性剂的液体粘合剂组合物以及制备所述组合物的方法。本发明还提供了治疗肛门直肠疾病的方法，包括将液体粘合剂组合物施用于粘液肛门表面，包含液体粘合剂组合物的试剂盒和容器涂抹器装置。

10. 发明申请

WO2014061023A1 MULTI-CAMERA ENDOSCOPE 审中-公开
标题翻译：多摄像机内窥镜
公开(公告)号：WO2014061023A1
公开(公告)日：2014-04-24
申请号：PCT/IL2013/050840
申请日：2013-10-17
申请人： ENDOCHOICE INNOVATION CENTER LTD.
发明人： LEVY, Avi
IPC分类号： A61B1/05 , A61B1/005 , A61B1/06
CPC分类号： A61B1/05 , A61B1/00091 , A61B1/00177 , A61B1/00181 , A61B1/015 , A61B1/0615 , A61B1/126 , G02B23/2423
摘要： There is provided herein a tip section of a multi-camera endoscope, the tip section comprising a front-pointing camera and a discrete front illuminator associated therewith two or more side-pointing cameras positioned at or in proximity to a distal end of said tip section, wherein each of said two or more side-pointing cameras having a discrete side illuminator associated therewith, and a working channel configured for insertion of a surgical tool.
摘要翻译：这里提供了一种多摄像机内窥镜的尖端部分，该尖端部分包括前置摄像机和与之相关联的两个或更多个侧面指向的摄像机的离散前照明器，所述两个或更多个侧面指向的摄像机位于或邻近所述尖端部分的远端，其中所述两个或更多个侧指摄像机中的每一个具有与其相关联的离散侧面照明器，以及被配置为插入外科手术工具的工作通道。

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