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1. 发明申请

WO2018102688A1 PHAGES TO TREAT BACTERIAL INFECTION ON SKIN 审中-公开
公开(公告)号：WO2018102688A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064223
申请日：2017-12-01
申请人： SMART PHAGE, INC.
发明人： SHIACH, Jacob
IPC分类号： A61K9/00 , A61K9/70 , A61K35/76 , A61P31/04 , A61P31/10
CPC分类号： A61K35/76 , A61K9/0014 , A61K9/08 , A61K9/70 , A61K9/7046 , A61P31/04 , A61P31/10 , C12N2795/00032
摘要： Methods and compositions having phage to prevent, inhibit or treat bacterial infection, e.g., on the dermis, are provided.

2. 发明申请

WO2017091622A1 METHOD AND DEVICE FOR NON-INVASIVE ROOT PHENOTYPING 审中-公开
标题翻译：用于非侵入性根表的方法和装置
公开(公告)号：WO2017091622A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063417
申请日：2016-11-22
申请人： HI FIDELITY GENETICS LLC
发明人： BENFEY, Philip , WINDLE, Jesse , GOLDMAN, Daniel , AGUILAR, Jeff , JOHNSON, Logan
IPC分类号： G01N27/22 , G01N33/24 , G01R27/26
CPC分类号： G01N33/0098 , G01N27/22 , G01N33/24
摘要： The present disclosure provides for an electronic sensor for detecting a root of a plant in soil, the electronic sensor that includes a first conductor plate configured to be disposed in soil, a switch, a power supply, and signal extractor. The switch is electrically coupled to the first conductor plate and is configured to switch between a first mode and a second mode. The power supply is electrically coupled to the switch and is configured to provide an electrical charge to the first conductor plate in the first mode of the switch. The signal extractor is electrically coupled to the switch and is configured to extract a signal response at the first conductor plate in the second mode of the switch. The present disclosure further provides a second conductor plate configured to be disposed in soil adjacent to and substantially parallel to the first conductor plate. The second conductor plate is electrically coupled to ground.
摘要翻译：本公开提供了一种用于检测土壤中的植物根部的电子传感器，所述电子传感器包括被配置为布置在土壤中的第一导体板，开关，电源以及信号提取器。开关电耦合到第一导体板并且被配置为在第一模式和第二模式之间切换。电源电耦合到开关并且被配置为在开关的第一模式中向第一导体板提供电荷。信号提取器电耦合到开关并且被配置为在开关的第二模式中在第一导体板处提取信号响应。本发明还提供了一种第二导体板，该第二导体板被配置为设置在与第一导体板相邻且基本平行的土壤中。第二个导体板电气连接到地。

3. 发明申请

WO2016172609A1 METHODS FOR PRODUCTION OF AROMATIC DICARBOXYLIC ACIDS AND DERIVATIVES THEREOF 审中-公开
标题翻译：生产芳香二羧酸及其衍生物的方法
公开(公告)号：WO2016172609A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/029020
申请日：2016-04-22
申请人： NOVOMER, INC.
发明人： FARMER, Jay, J. , SOOKRAJ, Sadesh, H.
IPC分类号： C07B37/12 , C07C51/353 , C07C67/333 , C07C69/82 , C07D493/08
CPC分类号： C07C51/235 , C07C63/16 , C07C63/24 , C07C63/26 , C07C67/34 , C07C67/39 , C07C69/82 , C07D493/08 , C07C69/80
摘要： Provided are methods for the production of isophthalic acid (IPA) and derivatives thereof. The methods are based on the addition of beta propiolactone to furfural or a derivative thereof. Provided are cost effective routes to biobased IPA and derivatives thereof, including terephthalic acid.
摘要翻译：提供了制备间苯二甲酸（IPA）及其衍生物的方法。所述方法是基于将β-丙内酯加入到糠醛或其衍生物中。提供了生物基IPA及其衍生物的成本效益路线，包括对苯二甲酸。

4. 发明申请

WO2016149169A1 (INDAZOL-4-YL)HEXAHYDROPYRROLOPYRROLONES AND METHOD OF USE 审中-公开
标题翻译：（INDAZOL-4-YL）十六氢吡咯烷酮及其使用方法
公开(公告)号：WO2016149169A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022262
申请日：2016-03-14
申请人： ABBVIE INC.
发明人： DAANEN, Jerome , DEGOEY, David A. , FROST, Jennifer M. , JINKERSON, Tammie , LATSHAW, Steve , SHI, Lei
IPC分类号： C07D487/04 , A61P25/00 , A61K31/416
CPC分类号： C07D487/04
摘要： Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein G Ar , L 1 , Z 1 and Z 2 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., Nayl.7 and/or Nayl.8. Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions for the treatment of pain.
摘要翻译：式（I）化合物及其药学上可接受的盐，酯，酰胺或放射性标记形式，其中如说明书中所定义的GAr，L1，Z1和Z2可用于治疗由电压门控钠通道预防或改善的病症或病症，例如Nayl.7和/或Nayl.8。公开了制备化合物的方法。还公开了式（I）化合物的药物组合物，以及使用这些化合物和组合物治疗疼痛的方法。

5. 发明申请

WO2016130993A1 PROCESS FOR PRODUCTION OF ACRYLIC ACID 审中-公开
标题翻译：丙烯酸生产工艺
公开(公告)号：WO2016130993A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017868
申请日：2016-02-12
申请人： NOVOMER, INC.
发明人： FARMER, Jay J.
IPC分类号： C07C51/09
CPC分类号： C07C51/09 , Y02P20/125 , C07C57/04
摘要： Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.
摘要翻译：提供了将β-丙内酯转化为丙烯酸的综合方法。还提供用于生产丙烯酸的系统。

6. 发明申请

WO2016130947A1 SYSTEMS AND PROCESSES FOR POLYMER PRODUCTION 审中-公开
标题翻译：聚合物生产的系统和工艺
公开(公告)号：WO2016130947A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017797
申请日：2016-02-12
申请人： NOVOMER, INC.
发明人： FARMER, Jay, J.
IPC分类号： G06Q30/02 , C08F122/02 , C07C51/09
CPC分类号： C08G63/08 , C07C51/09 , C07C57/04 , C08F4/30 , C08F120/06 , C08G2650/04
摘要： Disclosed are compositions, systems and methods related to a polypropiolactone composition comprising polypropiolactone polymers. Such polymers include polypropiolactone chains of Formula (I): [Formula should be inserted here] where n is an integer from 10 to about 1,000 and Y is either -H or a cation.
摘要翻译：公开了与包含聚内酯聚合物的聚内酯组合物相关的组合物，系统和方法。这样的聚合物包括式（I）的聚丙内酯链：[在此应插入式]其中n为10至约1,000的整数，Y为-H或阳离子。

7. 发明申请

WO2016069805A1 METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS USING AMINE CATALYSTS 审中-公开
标题翻译：使用氨催化剂生产燃料，汽油添加剂和润滑剂的方法
公开(公告)号：WO2016069805A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/057901
申请日：2015-10-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BP CORPORATION NORTH AMERICA INC.
发明人： SANKARANARAYANAPILLAI, Shylesh , SREEKUMAR, Sanil , TOSTE, F., Dean , BELL, Alexis, T. , GOKHALE, Amit, A. , GRIPPO, Adam
IPC分类号： C07C45/71 , C10L1/02 , B01J31/02
CPC分类号： C07C45/71 , B01J31/0237 , B01J31/0244 , C07C49/04 , C10L1/02 , C10L1/04
摘要： Provided herein are methods for producing ketone(s) from the condensation of methyl ketone(s) and alcohol(s) in the presence of an amine catalyst and a metal catalyst. Such amine catalysts may be supported, for example, on a silica-alumina support. Such ketones may be suitable for use in producing fuels, gasoline additives, and/or lubricants, or precursors thereof. The methyl ketone(s) and/or alcohol(s) may be obtained from renewable sources, such as by fermentation of biomass.
摘要翻译：本文提供了在胺催化剂和金属催化剂存在下由甲酮和醇缩合制备酮的方法。这种胺催化剂可以例如在二氧化硅 - 氧化铝载体上负载。这种酮可适用于生产燃料，汽油添加剂和/或润滑剂或其前体。甲基酮和/或醇可以从可再生来源获得，例如通过发酵生物质。

8. 发明申请

WO2016025865A1 METHODS OF PRODUCING ALKYLFURANS 审中-公开
标题翻译：生产碱性磷酸酶的方法
公开(公告)号：WO2016025865A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045330
申请日：2015-08-14
申请人： MICROMIDAS, INC.
发明人： HUCUL, Dennis, A. , HIRSCH-WEIL, Dimitri, A. , MASUNO, Makoto, Nathanael , BISSELL, John, Albert, II , WOOD, Alex, B. , ARAIZA, Robert, Joseph , HENTON, Daniel, R. , BROWNING, Shawn, M. , SMITH, Ryan, L.
IPC分类号： C07B31/00
CPC分类号： C07D307/36 , C07C2/865 , C07D307/38 , C07D307/44 , C07D307/48
摘要： Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example, 2,5-dimethylfuran may be produced by hydrogenation of (5-methylfuran-2-yl) methanol or 2-(chloromethyl)-5-methylfuran in the presence of a solid supported metal catalyst having an excess of either basic or acidic sites (as determined by chemisorption of CO2 or NH3). The process could further include a urea reagent (TMU, DMPU, TMI) and an alkyl benzene.
摘要翻译：本文提供了生产二烷基呋喃的方法，例如2,5-二甲基呋喃和其它烷基呋喃，如2-甲基呋喃。例如，2,5-二甲基呋喃可以通过在（5-甲基呋喃-2-基）甲醇或2-（氯甲基）-5-甲基呋喃的氢化下，在具有过量的碱性或碱性的固体负载型金属催化剂的存在下，酸性位点（通过化学吸附CO 2或NH 3测定）。该方法还可以包括尿素试剂（TMU，DMPU，TMI）和烷基苯。

9. 发明申请

WO2015138855A1 VECTORS AND METHODS FOR FUNGAL GENOME ENGINEERING BY CRISPR-CAS9 审中-公开
标题翻译：通过CRISPR-CAS9进行真菌基因组工程的方法和方法
公开(公告)号：WO2015138855A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020377
申请日：2015-03-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BP CORPORATION NORTH AMERICA INC.
发明人： RYAN, Owen , DOUDNA CATE, James, H. , NUNN, David, Neal, Jr.
IPC分类号： C12N15/63
CPC分类号： C12N15/81 , C12N15/80
摘要： The present disclosure provides expression vectors containing a nucleic acid encoding an RNA polymerase III promoter, a ribozyme, a CRISPR-Cas9 single guide RNA, and an RNA polymerase III terminator, where the ribozyme is 5 ' to the CRISPR-Cas9 single guide RNA, as well as ribonucleic acids encoded thereby. Further provided are fungal cells containing an expression vector described herein, as well as methods of fungal genome engineering through use of an expression vector described herein.
摘要翻译：本公开内容提供含有编码RNA聚合酶III启动子，核酶，CRISPR-Cas9单导向RNA和RNA聚合酶III终止子的核酸的表达载体，其中核酶为CRISPR-Cas9单导向RNA的5' 以及由此编码的核糖核酸。还提供了含有本文所述的表达载体的真菌细胞，以及通过使用本文所述的表达载体的真菌基因组工程的方法。

10. 发明申请

WO2014201291A1 METHODS FOR DETERMINING TOTAL BODY SKELETAL MUSCLE MASS 审中-公开
标题翻译：用于确定总身体肌肉质量的方法
公开(公告)号：WO2014201291A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/042186
申请日：2014-06-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED
发明人： HELLERSTEIN, Marc, K. , EVANS, William
IPC分类号： G01N33/70
CPC分类号： G01N33/70 , G01N2458/15
摘要： The present invention is based on the finding that enrichment of isotope-labeled creatinine in a urine sample following oral administration of a single defined dose of isotope-labeled can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and isotope-labeled creatinine in a single sample. The methods of the invention find use, inter alia , in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass.
摘要翻译：本发明是基于以下发现：在口服给予单一定义剂量的同位素标记的尿液样品中，同位素标记的肌酸酐的富集可以用于计算全身肌酸蛋白酶体积和全身肌肉骨骼质量学科。本发明还包括在单个样品中检测肌酐和同位素标记的肌酸酐的方法。本发明的方法尤其用于诊断与骨骼肌质量相关的障碍，以及筛选潜在的治疗剂以确定其对肌肉质量的影响。

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