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1. 发明申请

WO2010062705A1 CANCER DIAGNOSIS USING KI-67 审中-公开
标题翻译：使用KI-67进行癌症诊断
公开(公告)号：WO2010062705A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/062877
申请日：2009-10-30
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , BRUEY, Jean-Marie , ALBITAR, Maher
发明人： BRUEY, Jean-Marie , ALBITAR, Maher
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , G01N33/57426 , G01N2800/52 , G01N2800/56
摘要： The present invention provides methods and compositions for detection, diagnosis, prognosis, monitoring treatment and monitoring progression of cancer by detecting the level of Ki-67 protein in an individual.
摘要翻译：本发明通过检测个体中Ki-67蛋白的水平来提供用于检测，诊断，预后，监测治疗和监测癌症进展的方法和组合物。

2. 发明申请

WO2010045354A1 DETECTION OF NPM1 NUCLEIC ACID IN ACELLULAR BODY FLUIDS 审中-公开
标题翻译：在细胞体液中检测NPM1核酸
公开(公告)号：WO2010045354A1
公开(公告)日：2010-04-22
申请号：PCT/US2009/060672
申请日：2009-10-14
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , ALBITAR, Maher
发明人： ALBITAR, Maher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156
摘要： The present inventions relates to methods for detecting NPMl nucleic acid in acellular body fluid samples and determining whether the nucleic acid contains one or more mutations including insertions and deletions. The methods are useful for predicting prognosis of AML patients that have cells with mutations in the NPMl gene.
摘要翻译：本发明涉及在非细胞体液样品中检测NPM1核酸的方法，并确定核酸是否含有一个或多个突变，包括插入和缺失。该方法可用于预测具有NPM1基因突变的细胞的AML患者的预后。

3. 发明申请

WO2009143024A3 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
公开(公告)号：WO2009143024A3
公开(公告)日：2009-11-26
申请号：PCT/US2009/044178
申请日：2009-05-15
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , SPEVAK, Wayne , CHO, Hanna , SHI, Songyuan
发明人： IBRAHIM, Prabha, N. , SPEVAK, Wayne , CHO, Hanna , SHI, Songyuan
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P29/00 , A61P35/00 , A61P31/12
摘要： Compounds of Formula (I) which are active of Raf protein kinase and useful to treat melanoma, cancer, pain or polycystic kidney disease.

4. 发明申请

WO2009046334A1 MUTATED ACETOHYDROXYACID SYNTHASE GENES IN BRASSICA 审中-公开
标题翻译：在BRASSICA中的疏水性乙酰氧基合成酶基因
公开(公告)号：WO2009046334A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078798
申请日：2008-10-03
申请人： CIBUS LLC , SCHOPKE, Christian , GOCAL, Greg F. W. , WALKER, Keith , BEETHAM, Peter R.
发明人： SCHOPKE, Christian , GOCAL, Greg F. W. , WALKER, Keith , BEETHAM, Peter R.
IPC分类号： C12Q1/68 , C12N5/04 , A01H1/00
CPC分类号： C12N15/8274 , C12N9/88
摘要： Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are canola plants, cells, and seeds comprising the mutated genes.
摘要翻译：提供突变的乙酰羟酸合酶（AHAS）核酸和由突变的核酸编码的蛋白质。还提供了油菜植物，细胞和包含突变基因的种子。

5. 发明申请

WO2008011379A2 OXIDIZED APOA1 DETERMINATION BY MASS SPECTROMETRY 审中-公开
标题翻译：氧化APOA1通过质谱测定
公开(公告)号：WO2008011379A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/073607
申请日：2007-07-16
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , CAULFIELD, Michael, P.
发明人： CAULFIELD, Michael, P.
IPC分类号： G01N33/53
CPC分类号： G01N33/92 , G01N33/6893 , G01N2800/32
摘要： Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessment is based on the amount of oxidized and unoxidized apolipoprotein A-I in a biological sample obtained from a subject.
摘要翻译：提供了用于检测和定量蛋白质的方法，特别是载脂蛋白A-1及其氧化衍生物。还提供了用于评价受试者的心血管疾病风险的方法，其中所述评估基于从受试者获得的生物样品中的氧化和未氧化的载脂蛋白A-I的量。

6. 发明申请

WO2010075449A1 MASS SPECTROMETRY ASSAY FOR CONGENITAL ADRENAL HYPERPLASIA 审中-公开
标题翻译：大量光谱测定用于综合性ADRENAL HYPERPLASIA
公开(公告)号：WO2010075449A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/069305
申请日：2009-12-22
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , GHOSHAL, Amit , CLARKE, Nigel J. , GOLDMAN, Mildred M.
发明人： GHOSHAL, Amit , CLARKE, Nigel J. , GOLDMAN, Mildred M.
IPC分类号： G01N30/72 , G01N33/483 , A61K38/22 , B01D59/44
CPC分类号： G01N33/743 , C12Q1/6872 , G01N30/7233 , G01N33/6848 , G01N33/6851 , G01N33/689 , G01N2800/04 , H01J49/0031 , H01J49/004 , H01J49/165
摘要： Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
摘要翻译：提供了用于检测一种或多种CAH组分析物（即孕烯醇酮，17-OH孕烯醇酮，孕酮，17-OH孕酮，脱氢表雄酮（DHEA），雄烯二酮，睾酮，脱氧皮质酮，11-脱氧皮质醇和皮质醇）的量的方法质谱样品。该方法通常涉及将样品中的一种或多种CAH面板分析物离子化并量化产生的离子以确定样品中一种或多种CAH面板分析物的量。在检测到多个CAH面板分析物的量的方法中，在相同的样品注入中检测到多种分析物的量。

7. 发明申请

WO2007146712A3 THERAPY USING CYTOKINE INHIBITORS 审中-公开
公开(公告)号：WO2007146712A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/070547
申请日：2007-06-06
申请人： KEMIA, INC. , CROWLEY, Constance, A. , DELAET, Nancy G., J. , ERNST, Justin , GROVE, Carrie, Gail , HEPBURN, Bonnie , KING, Bernard , LARSON, Christopher, J. , MILLER, Stephen , PRYOR, Kent , SHUSTER, Lewis, J.
发明人： CROWLEY, Constance, A. , DELAET, Nancy G., J. , ERNST, Justin , GROVE, Carrie, Gail , HEPBURN, Bonnie , KING, Bernard , LARSON, Christopher, J. , MILLER, Stephen , PRYOR, Kent , SHUSTER, Lewis, J.
IPC分类号： A61K31/4965
摘要： The present invention relates to methods of treating, preventing, modifying and managing cytokine-mediated disorders or related disorders, which comprise the administration of a compound, such as a cytokine inhibitor, alone or in combination with known therapeutics. The invention also relates to pharmaceutical compositions and dosing regimens using the disclosed compounds. In particular, the invention relates to the use of compounds as disclosed herein, optionally in conjunction with other therapies, for the treatment of autoimmune diseases, inflammatory diseases, cardiovascular diseases, and cancer.

8. 发明申请

WO2010051214A8 COMPOSITIONS AND METHODS FOR DETECTING MUTATIONS IN JAK2 NUCLEIC ACID 审中-公开
公开(公告)号：WO2010051214A8
公开(公告)日：2010-05-06
申请号：PCT/US2009/061691
申请日：2009-10-22
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , ALBITAR, Maher , MA, Wanlong
发明人： ALBITAR, Maher , MA, Wanlong
IPC分类号： C12Q1/68 , G01N33/53
摘要： The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides compositions and methods useful for diagnosing hematopoietic diseases including, for example, myeloproliferative diseases. The invention also provides compositions and methods useful for determining a prognosis of an individual diagnosed as having a hematopoietic disease.

9. 发明申请

WO2009143018A2 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
标题翻译：化合物及其调节方法及其适应症
公开(公告)号：WO2009143018A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044151
申请日：2009-05-15
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , BREMER, Ryan , ZHANG, Jiazhong , NESPI, Marika , CHO, Hanna
发明人： IBRAHIM, Prabha, N. , BREMER, Ryan , ZHANG, Jiazhong , NESPI, Marika , CHO, Hanna
IPC分类号： C07D487/04 , A61K31/519 , A61P19/00 , A61P29/00 , A61P35/00 , A61P31/12
CPC分类号： C07D487/04 , A61K31/519
摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinases and/or Kit protein kinases, including rheumatoid arthiritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, Charcot Marie Tooth syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, ulcerative colitis, Crohn's disease, immune thrombocytopenic purpura, myelopreparation for autologous transplantation, transplant rejection, nephritis, nephropathy, type I diabetes, acute pain, inflammatory pain, neuropathic pain, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastomas, neurofibromatosis, osteolytic bone metastases, and giant cell tumors.
摘要翻译：其化合物及其盐，其制剂，其缀合物，其衍生物，其形式及用途。在某些方面和实施方案中，所述的化合物或其盐，其制剂，其缀合物，其衍生物，其形式在Fms蛋白激酶或Kit蛋白激酶中的至少一种上是有活性的。还描述了其用于治疗疾病和病症的方法，包括与Fms蛋白激酶和/或Kit蛋白激酶（包括类风湿性关节炎，骨关节炎，骨质疏松症，骨质疏松症，系统性硬化症，脱髓鞘疾病，多发性硬化症，Charcot玛丽牙综合征，肌萎缩性侧索硬化，阿尔茨海默病，帕金森病，溃疡性结肠炎，克罗恩病，免疫性血小板减少性紫癜，自体移植用骨髓制剂，移植排斥，肾炎，肾病，I型糖尿病，急性疼痛，神经性疼痛，乳腺癌，前列腺癌，胰腺癌，肺癌，卵巢癌，神经胶质瘤，成胶质细胞瘤，神经纤维瘤病，溶骨性骨转移和巨细胞肿瘤。

10. 发明申请

WO2009048873A4 DETECTION OF ATYPICAL PNEUMONIA 审中-公开
公开(公告)号：WO2009048873A4
公开(公告)日：2009-04-16
申请号：PCT/US2008/079080
申请日：2008-10-07
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , AYE, Michael , LEE, Ming-chou , KONG, Lilly I. , TABB, Michelle M. , CHEN, Fan , CHEN, Jules
发明人： AYE, Michael , LEE, Ming-chou , KONG, Lilly I. , TABB, Michelle M. , CHEN, Fan , CHEN, Jules
IPC分类号： C12Q1/68 , C07H21/00
摘要： Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.

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