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1. 发明授权

US07326694B2 Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders 失效
公开(公告)号：US07326694B2
公开(公告)日：2008-02-05
申请号：US11420694
申请日：2006-05-26
申请人： Ernest G. Seidman , Yves Theoret
发明人： Ernest G. Seidman , Yves Theoret
IPC分类号： A61K31/70 , A61K31/52 , A61K31/415
CPC分类号： A61K31/52 , A61K31/522 , G01N33/564 , G01N33/94 , G01N2800/06 , G01N2800/065 , G01N2800/24 , G01N2800/245 , Y10T436/141111 , Y10T436/142222 , Y10T436/147777
摘要： The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes the step of determining the level of one or more 6-mercaptopurine metabolites in the patient having an immune-mediated gastrointestinal disorder.

2. 发明授权

US07189515B2 Human antibodies as detection reagents 有权
标题翻译：人抗体作为检测试剂
公开(公告)号：US07189515B2
公开(公告)日：2007-03-13
申请号：US10149737
申请日：2000-12-06
申请人： Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
发明人： Joe Buechler , Gunars Valkirs , Jeff Gray , Nils Lonberg
IPC分类号： G01N33/543
CPC分类号： C07K16/18 , C07K16/244 , C07K2317/21 , C07K2317/55 , G01N33/543 , Y02A50/55 , Y02A50/58 , Y10S435/962 , Y10S435/973 , Y10S436/809
摘要： The invention provides in vitro methods of detection using human antibodies. The methods are particularly useful for analyzing human samples containing HAMA or heterophilic antibodies. A human antibody can bind to an analyte in such samples without binding to HAMA or heterophilic antibodies present in the samples. The methods can be effected using a sandwich format among others.
摘要翻译：本发明提供使用人抗体的体外检测方法。该方法对于分析含有HAMA或异嗜性抗体的人类样品特别有用。人抗体可以结合这样的样品中的分析物而不与样品中存在的HAMA或异嗜性抗体结合。这些方法可以使用夹心形式等来实现。

3. 发明授权

US06972251B2 Method for fabricating copper damascene structures in porous dielectric materials 有权
标题翻译：在多孔电介质材料中制造铜镶嵌结构的方法
公开(公告)号：US06972251B2
公开(公告)日：2005-12-06
申请号：US10391538
申请日：2003-03-17
申请人： Xian Jie Ning
发明人： Xian Jie Ning
IPC分类号： H01L21/768 , H01L23/522 , H01L23/532 , H01L21/4763
CPC分类号： H01L23/5329 , H01L21/76807 , H01L21/7682 , H01L21/76885 , H01L23/5222 , H01L23/53228 , H01L2221/1036 , H01L2924/0002 , H01L2924/00
摘要： A method for manufacturing integrated circuit devices including metal interconnect structures. The method includes forming a first dielectric material overlying a surface of a semiconductor substrate. The method also includes forming a metal damascene structure in the first dielectric material, which surrounds the metal damascene structure. The method selectively removes the first dielectric material surrounding a portion of the metal damascene structure to expose the portion of the metal damascene structure. The method forms a porous dielectric material surrounding a vicinity of the exposed portion of the metal damascene structure, whereupon the porous dielectric material has a dielectric constant ranging from no greater than 2.6 but greater than 1.
摘要翻译：一种用于制造包括金属互连结构的集成电路器件的方法。该方法包括形成覆盖在半导体衬底的表面上的第一电介质材料。该方法还包括在围绕金属镶嵌结构的第一介电材料中形成金属镶嵌结构。该方法选择性地去除围绕金属镶嵌结构的一部分以暴露金属镶嵌结构部分的第一介电材料。该方法形成围绕金属镶嵌结构的暴露部分附近的多孔电介质材料，于是多孔电介质材料具有不大于2.6但大于1的介电常数。

4. 发明授权

US07471136B2 Temperature compensated self-refresh circuit 有权
标题翻译：温度补偿自刷新电路
公开(公告)号：US07471136B2
公开(公告)日：2008-12-30
申请号：US11148562
申请日：2005-06-09
申请人： Yun Seok Hong
发明人： Yun Seok Hong
IPC分类号： H01L35/00 , H01L37/00 , H03K3/42
CPC分类号： G11C11/406 , G11C11/40626 , G11C2211/4068
摘要： A temperature compensated self-refresh circuit maintains a stable current characteristic by maintaining a predetermined self-refresh cycle to cope with a process skew and a voltage change in a low power consumption memory product and by changing the self-refresh cycle only depending on temperature change. The temperature compensated self-refresh circuit is provided with a reference voltage generating unit adapted and configured to use an internal power voltage of a Widlar type so as to reduce a process skew and to have NMOS transistors with a LVT (Low Voltage Transistor) structure so as to have the same voltage as that of a temperature sense unit, thereby maintaining a predetermined cycle of an oscillating signal coping with the process skew.
摘要翻译：温度补偿自刷新电路通过保持预定的自刷新周期来保持稳定的电流特性，以应对低功耗存储器产品中的工艺偏差和电压变化，并且仅通过根据温度变化改变自刷新周期。温度补偿自刷新电路设置有参考电压产生单元，其被配置为使用Widlar类型的内部电源电压，以便减少处理偏斜并且具有LVT（低电压晶体管）结构的NMOS晶体管，因此具有与温度检测单元相同的电压，从而保持响应于处理偏斜的振荡信号的预定周期。

5. 发明授权

US07285534B2 Corticotropin-releasing hormone analogs and their uses 有权
标题翻译：促肾上腺皮质激素释放激素类似物及其用途
公开(公告)号：US07285534B2
公开(公告)日：2007-10-23
申请号：US11006296
申请日：2004-12-06
申请人： Edward Wei , Kurt Carlson
发明人： Edward Wei , Kurt Carlson
IPC分类号： A61K38/12 , A61K38/17 , C07K14/47
CPC分类号： C07K14/57509 , A61K38/00 , Y10S930/27
摘要： This invention provides members of the corticiotropin-releasing hormone superfamily and peptide analogs thereof wherein the 38th amino acid from the N-terminus is D-Nle, i.e. [D-Nle38]-CRH peptide. The peptide analogs can be used to treat proliferative disorders of the skin such as melanoma.
摘要翻译：本发明提供了促肾上腺皮质激素释放激素超家族和肽类似物的成员，其中N末端的第38位氨基酸是D-Nle，即[D-Nle 38 >] - CRH肽。肽类似物可用于治疗皮肤的增殖性疾病如黑素瘤。

6. 发明授权

US07094666B2 Method and system for fabricating strained layers for the manufacture of integrated circuits 有权
公开(公告)号：US07094666B2
公开(公告)日：2006-08-22
申请号：US11043477
申请日：2005-01-24
申请人： Francois J. Henley , Philip James Ong , Igor J. Malik , Harry R. Kirk
发明人： Francois J. Henley , Philip James Ong , Igor J. Malik , Harry R. Kirk
IPC分类号： H01L21/46 , H01L21/30
CPC分类号： H01L21/302 , H01L21/2007 , Y10T29/41
摘要： A method for forming a strained layer of semiconductor material, e.g., silicon, germanium, Group III/V, silicon germanium alloy. The method includes providing a non-deformable surface region having a first predetermined radius of curvature, which is defined by R(1) and is defined normal to the surface region. The method includes providing a first substrate (e.g., silicon wafer) having a first thickness. Preferably, the first substrate has a face, a backside, and a cleave plane defined within the first thickness. The method includes a step of overlying the backside of the first substrate on a portion of the surface region having the predetermined radius of curvature to cause a first bend within the thickness of material to form a first strain within a portion of the first thickness. The method provides a second substrate having a second thickness, which has a face and a backside. The method includes a step of overlying the face of the second substrate on a portion of the face of the first substrate to cause a second bend within the thickness of material to form a second strain within a portion of the second thickness. A step of joining the face of the second substrate to the face of the first substrate form a sandwich structure while maintaining the first bend in the first substrate and the second bend in the second substrate. Preferably, joining occurs using a low temperature process such as plasma activated bonding or the like.

7. 发明授权

US07084054B2 Method for making an opening for electrical contact by etch back profile control 有权
标题翻译：通过蚀刻回廓线控制制作电接触开口的方法
公开(公告)号：US07084054B2
公开(公告)日：2006-08-01
申请号：US10773565
申请日：2004-02-06
申请人： Han Ming Wu , Eric Kuang , Wei Ji Song
发明人： Han Ming Wu , Eric Kuang , Wei Ji Song
IPC分类号： H01L21/4763
CPC分类号： H01L21/76808 , H01L21/31138 , H01L21/31144
摘要： A method and apparatus for etchback profile control. The method includes performing a first etch through a first dielectric layer to form a first via and a second dielectric layer, filling the first via with a BARC material to form a first BARC layer, and performing a second etch on the first BARC layer to form a second BARC layer. The second etch has a first etch rate in a first peripheral region of the second BARC layer and a second etch rate in a first central region of the second BARC layer. The first peripheral region is located around a sidewall of the first via, and the first central region is located around a center of the first via. The first etch rate is larger than the second etch rate, and the first peripheral region is located higher than the first central region. A first top surface of the second BARC layer has substantially a first convex shape. Additionally, the method includes performing a third etch through a second dielectric layer to form a trench and a third BARC layer. The trench has a trench bottom surface, which is substantially free from any spike around a side surface of the third BARC layer. A second top surface of the third BARC layer has substantially a second convex shape. Moreover, the method includes removing the third BARC layer to form a second via.
摘要翻译：一种用于回蚀型材控制的方法和装置。该方法包括通过第一电介质层进行第一蚀刻以形成第一通孔和第二电介质层，用BARC材料填充第一通孔以形成第一BARC层，以及在第一BARC层上执行第二蚀刻以形成第二个BARC层。第二蚀刻在第二BARC层的第一外围区域具有第一蚀刻速率，在第二BARC层的第一中心区域具有第二蚀刻速率。第一周边区域位于第一通孔的侧壁周围，第一中心区域位于第一通孔的中心附近。第一蚀刻速率大于第二蚀刻速率，并且第一周边区域位于高于第一中心区域。第二BARC层的第一顶表面具有基本上第一凸形形状。另外，该方法包括通过第二介电层执行第三蚀刻以形成沟槽和第三BARC层。沟槽具有沟槽底表面，其基本上没有围绕第三BARC层的侧表面的任何尖峰。第三BARC层的第二顶表面具有基本上第二凸形形状。此外，该方法包括移除第三BARC层以形成第二通孔。

8. 发明授权

US07750605B2 Controlling an electrical signal sent to a sample load using a pulse modulated resistance 有权
标题翻译：使用脉冲调制电阻控制发送到采样负载的电信号
公开(公告)号：US07750605B2
公开(公告)日：2010-07-06
申请号：US11857679
申请日：2007-09-19
申请人： Charles W. Ragsdale
发明人： Charles W. Ragsdale
IPC分类号： H02J7/00
CPC分类号： C12N13/00 , A61N1/327 , C12M35/02 , H03K3/53
摘要： Systems, methods, apparatus, and circuits for controlling an electrical signal transmitted to a sample load are provided. The electrical signal produced by a capacitor is controlled via a control signal sent to a variable resistance device that is connected in parallel with the sample load. The variable resistance device includes a resistance and a switch in series. The control signal opens and closes the switch, thus providing a variable resistance based on the amount of time the switch is closed.
摘要翻译：提供了用于控制传输到样本负载的电信号的系统，方法，装置和电路。由电容器产生的电信号通过发送到与样本负载并联连接的可变电阻器件的控制信号进行控制。可变电阻装置包括电阻和串联的开关。控制信号打开和关闭开关，从而根据开关关闭的时间量提供可变电阻。

9. 发明授权

US07188095B2 System and method for managing a storage device 有权
标题翻译：用于管理存储设备的系统和方法
公开(公告)号：US07188095B2
公开(公告)日：2007-03-06
申请号：US10649172
申请日：2003-08-26
申请人： Nobuyuki Saika
发明人： Nobuyuki Saika
IPC分类号： G06F17/30
CPC分类号： G06F17/30067 , Y10S707/99931
摘要： A storage device system includes a storage control device with a file system for execution of data I/O processing relative to a storage device according to a data I/O request by means of file identifier assignment as sent from a host computer. A computer is connected between the host and the storage control device with a per-host accessible file storage region being reserved on the storage region of a storage device that the storage control device owns. The computer stores in a database a first correspondence established between a first ID which is added on a per-host basis and a file identifier which is added to a file that is stored in the file storage region and then compares to the first correspondence a correspondence between a first ID and a file identifier which is included in the data I/O request received from the host to thereby determine whether the received request is acceptable.
摘要翻译：存储设备系统包括具有文件系统的存储控制设备，该文件系统用于根据从主计算机发送的文件标识符分配，根据数据I / O请求执行相对于存储设备的数据I / O处理。计算机连接在主机和存储控制设备之间，其中每个主机可访问的文件存储区域被保留在存储控制设备所拥有的存储设备的存储区域上。计算机在数据库中存储在基于每个主机的基础上添加的第一ID和添加到存储在文件存储区域中的文件的文件标识符之间建立的第一对应关系，然后将其与第一个对应关系对应在从主机接收的数据I / O请求中包括的第一ID和文件标识符之间，从而确定所接收的请求是否可接受。

10. 发明授权

US07127013B2 Spacetime equalization in a wireless receiver 有权
标题翻译：无线接收机中的时间均衡
公开(公告)号：US07127013B2
公开(公告)日：2006-10-24
申请号：US10643155
申请日：2003-08-18
申请人： Gregory Steele , Richard D. J. van Nee
发明人： Gregory Steele , Richard D. J. van Nee
IPC分类号： H04L1/02
CPC分类号： H04B1/7093 , H04B7/0851 , H04B7/0854 , H04L25/03267
摘要： A wireless receiver receives signals at a plurality of antennas and the combined signal is compensated for channel distortion. In other aspects, a wireless receiver includes a minimum distance receiver applied to the output of a whitened-matched filter, which combines channel matched filtering and whitening, using one or more antennas.
摘要翻译：无线接收机在多个天线处接收信号，并且对信道失真进行补偿。在其他方面，无线接收机包括使用一个或多个天线来应用于白化匹配滤波器的输出的最小距离接收机，其组合信道匹配滤波和白化。

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