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    • 1. 发明申请
    • NOP RECEPTOR ANTAGONIST
    • NOP受体拮抗剂
    • WO2013051159A1
    • 2013-04-11
    • PCT/JP2011/073464
    • 2011-10-05
    • NIPPON SHINYAKU CO., LTD.OKANO, MasahikoOYAMA, Tatsuya
    • OKANO, MasahikoOYAMA, Tatsuya
    • C07D239/94A61K31/517A61P3/04A61P9/12A61P25/00A61P25/04A61P25/08A61P25/22A61P25/24A61P25/28A61P25/30A61P43/00
    • C07D239/94
    • A novel excellent non-opioid branch of the opioid peptide family of receptors antagonist is provided, which exhibit an analgesic effect on a varuous pains. The present invention is directed to a non-opioid branch of the opioid peptide family of receptors antagonist represented by the general formula [1] or a pharmaceutically acceptable salt thereof. In the general formula [1], R 1 represents hydrogen or the like, R 2 represents hydrogen or the like, R 3 and R 4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen, R 5 is combined with R 6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy, R 6 represents (1) alkyl, (2) cycloalkyl, (3) phenyl, (4) a 5- to 10-membered aromatic heterocyclic group containing 1 to 3 heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or (5) -N(R 61 )(R 62 ).
    • 提供了阿片类肽受体拮抗剂家族的优异的非阿片样物质分支,其对变性疼痛具有镇痛作用。 本发明涉及由通式[1]表示的受体拮抗剂阿片样肽家族的非阿片样物质分支或其药学上可接受的盐。 在通式[1]中,R 1表示氢等,R 2表示氢等,R 3和R 4相同或不同,表示氢,烷基,烷氧基或卤素,R 5与R 6一起表示亚烷基或代表 氢,羟基,烷基,苯基或烷氧基,R6表示(1)烷基,(2)环烷基,(3)苯基,(4)含有1至3个选自以下的杂原子的5至10元芳族杂环基: 的氮原子,氧原子和硫原子,或(5)-N(R61)(R62)。