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1. 发明申请

WO2018175648A1 GASTROINTESTINAL-PROTECTIVE FORMULATIONS FOR ORAL DELIVERY OF PROTEINS AND PEPTIDES 审中-公开
公开(公告)号：WO2018175648A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/023645
申请日：2018-03-21
申请人： BIODURO, LLC
发明人： WEST, James, Blair , SHI, Ke
IPC分类号： A61K39/395
摘要： Disclosed herein are processes for formulating a protein or a peptide for oral delivery, the process comprising the steps of: obtaining a powder containing the protein or peptide; obtaining an amount of an enteric polymer, wherein the enteric polymer is neutralized so that it is soluble in water; optionally obtaining at least one excipient; mixing the protein or peptide, the neutralized enteric polymer, and optionally the at least one excipient to obtain a First Dispersion; granulating the First Dispersion on a fluidized bed to obtain a Second Dispersion; whereby the protein or peptide in the Second Dispersion undergoes less than 50% proteolysis under gastric conditions.

2. 发明申请

WO2015142462A1 DYNAMIC MULTI ORGAN PLATE 审中-公开
标题翻译：动态多机构板
公开(公告)号：WO2015142462A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/016428
申请日：2015-02-18
申请人： IONTOX, LLC
发明人： MCKIM, James
IPC分类号： C12M3/00
CPC分类号： C12M23/12 , C12M21/08 , C12M23/58 , C12M29/00 , C12M29/04 , C12N5/0697
摘要： Disclosed herein are dynamic multi-organ plates comprising two or more wells, wherein the wells are configured for cell or tissue culture growth; at least one transwell tube in fluid communication with the two or more wells; and a pump in fluid communication with the at least one transwell tube.
摘要翻译：本文公开了包含两个或更多个孔的动态多器官板，其中所述孔被配置用于细胞或组织培养生长; 与所述两个或更多个孔流体连通的至少一个transwell管; 以及与所述至少一个transwell管流体连通的泵。

3. 发明申请

WO2013006757A2 RECONSTITUTION DEVICE 审中-公开
标题翻译：重新配置设备
公开(公告)号：WO2013006757A2
公开(公告)日：2013-01-10
申请号：PCT/US2012/045672
申请日：2012-07-06
申请人： NEXMED HOLDINGS, INC. , DAMAJ, Bassam , MARTIN, Richard , MUELLER, Michael
发明人： DAMAJ, Bassam , MARTIN, Richard , MUELLER, Michael
IPC分类号： A61J1/20
CPC分类号： A61J1/2093 , A61J1/2031 , A61J1/2051 , A61J2200/40 , A61J2200/72 , A61K31/137 , A61K31/5575 , B65D81/3211
摘要： The present invention relates to methods for reconstituting and relates to reconstitution devices suitable for reconstituting many different materials. Furthermore, the present invention includes methods of treatment and methods of use related to a reconstitution device or apparatus. Some embodiments are suitable for reconstituting small amounts of a pharmaceutical compositions and using the pharmaceutical composition for the treatment of sexual dysfunction.
摘要翻译：本发明涉及重构方法，涉及适用于重构许多不同材料的重建装置。此外，本发明包括与重构装置或装置有关的治疗方法和使用方法。一些实施方案适用于重组少量药物组合物并使用该药物组合物来治疗性功能障碍。

4. 发明申请

WO2012154776A1 COMBINATIONS OF TROSPIUM AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁和唾液的组合
公开(公告)号：WO2012154776A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/037010
申请日：2012-05-09
申请人： THERAVIDA, INC. , PABORJI, Mehdi , DUCHIN, Kenneth, L. , HERNANDEZ, Wendy, Jade Limayo , FLUGEL, Roger, S.
发明人： PABORJI, Mehdi , DUCHIN, Kenneth, L. , HERNANDEZ, Wendy, Jade Limayo , FLUGEL, Roger, S.
IPC分类号： A61K31/4178 , A61K31/46 , A61P13/10
CPC分类号： A61K31/46 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release trospium, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放蚤或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

5. 发明申请

WO2012154770A1 COMBINATIONS OF TOLTERODINE AND SALIVARY STIMULANTS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
标题翻译：用于治疗过敏性叶片的铁妥黄素和唾液酸凝胶的组合
公开(公告)号：WO2012154770A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/036997
申请日：2012-05-09
申请人： THERAVIDA, INC. , PABORJI, Mehdi , DUCHIN, Kenneth, L. , HERNANDEZ, Wendy, Jade Limayo , FLUGEL, Roger, S.
发明人： PABORJI, Mehdi , DUCHIN, Kenneth, L. , HERNANDEZ, Wendy, Jade Limayo , FLUGEL, Roger, S.
IPC分类号： A61K31/222 , A61K31/4178 , A61P13/10 , A61K9/00
CPC分类号： A61K31/137 , A61K31/4178 , A61K2300/00
摘要： Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of alleviating a side effect of treatment for overactive bladder in a patient suffering therefrom, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release tolterodine, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
摘要翻译：本文公开了包含治疗有效量的延长释放托特罗定或其药学上可接受的盐和治疗有效量的毛果芸香碱或其药学上可接受的盐的药物组合物。本文还公开了治疗患有膀胱过度活动症的患者的方法，所述方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托非罗定或其药学上可接受的盐和治疗有效量毛果芸香碱或其药学上可接受的盐。本文还公开了减轻患有其中的患者的膀胱过度活动症的副作用的方法，该方法包括鉴定有需要的患者，以及向患者施用治疗有效量的延长释放托特罗定或其药学上可接受的盐以及治疗有效量的毛果芸香碱或其药学上可接受的盐。

6. 发明申请

WO2012083261A1 BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION 审中-公开
标题翻译：用于胆固醇反应的血脑屏障穿刺
公开(公告)号：WO2012083261A1
公开(公告)日：2012-06-21
申请号：PCT/US2011/065655
申请日：2011-12-16
申请人： HUMAN BIOMOLECULAR RESEARCH INSTITUTE , CASHMAN, John, R. , KALISIAK, Jaroslaw
发明人： CASHMAN, John, R. , KALISIAK, Jaroslaw
IPC分类号： A01N33/24 , A61K31/15
CPC分类号： C07C251/40 , C07C257/12 , C07C257/14 , C07C257/18 , C07C279/12 , C07D233/24 , C07D239/06 , C07D249/04
摘要： The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
摘要翻译：本发明描述了能够穿过血脑屏障以防止有机磷农药和神经药物或其它亲电试剂通过再激活抑制的胆碱酯酶（即乙酰胆碱酯酶和丁酰胆碱酯酶）以及周围和中枢神经系统中的其它蛋白质的药剂。

7. 发明申请

WO2012019093A1 SYNTHETIC COMPOUNDS AND METHODS TO DECREASE NICOTINE SELF-ADMINISTRATION 审中-公开
标题翻译：合成化合物和降低非诺贝因自我管理的方法
公开(公告)号：WO2012019093A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046733
申请日：2011-08-05
申请人： HUMAN BIOMOLECULAR RESEARCH INSTITUTE , CASHMAN, John, R.
发明人： CASHMAN, John, R.
IPC分类号： A61K31/4436
CPC分类号： A61K31/4436 , A61K31/4427 , A61K31/4439
摘要： Methods and small molecule compounds for smoking and CNS disease harm reduction are provided. One example of a class of compounds that may be used is represented by the compound having the structure IA or IB in the form of free base or a pharmaceutically acceptable salt, hydrate or solvate thereof:
摘要翻译：提供了吸烟和CNS疾病减少的方法和小分子化合物。可以使用的一类化合物的一个实例由游离碱或其药学上可接受的盐，水合物或溶剂化物形式的具有结构1A或IB的化合物表示：

8. 发明申请

WO2011123836A3 PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT OF OVERACTIVE BLADDER 审中-公开
公开(公告)号：WO2011123836A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/031020
申请日：2011-04-01
申请人： THERAVIDA, INC. , PABORJI, Mehdi , TUOHY, III, Robert, V. , FREED, Peter, R.P. , FLUGEL, Roger, S.
发明人： PABORJI, Mehdi , TUOHY, III, Robert, V. , FREED, Peter, R.P. , FLUGEL, Roger, S.
IPC分类号： A61K9/14
摘要： Disclosed herein are pharmaceutical compositions comprising a plurality of first beads each comprising: a core; a first layer comprising pilocarpine or a pharmaceutically acceptable salt thereof; and a second layer comprising a first polymer. Also disclosed are pharmaceutical compositions comprising a plurality of second beads each comprising: a core; and a first layer comprising tolterodine or a pharmaceutically acceptable salt thereof. Further disclosed are pharmaceutical formulations comprising: a) a plurality of the first beads; b) a plurality of the second beads; or c) a plurality of the first beads and a plurality of the second beads.

9. 发明申请

WO2009055734A1 CONDENSED COMPOUNDS WITH ACTIVITY AT ESTROGEN RECEPTORS 审中-公开
标题翻译：在雌激素受体活性的浓缩化合物
公开(公告)号：WO2009055734A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081211
申请日：2008-10-24
申请人： ACADIA PHARMACEUTICALS INC. , OLSSON, Roger , HYLDTOFT, Lene , GUSTAFSSON, Magnus , LUND, Birgitte, Winther
发明人： OLSSON, Roger , HYLDTOFT, Lene , GUSTAFSSON, Magnus , LUND, Birgitte, Winther
IPC分类号： C07D307/91 , C07D307/93 , C07D333/80 , A61K31/343 , A61K31/381 , A61P19/00 , A61P9/00 , A61P25/00 , A61P35/00
CPC分类号： C07D307/93 , C07D307/91 , C07D333/80
摘要： Disclosed herein are compounds of Formula (I) as disclosed herein, methods of modulating the activity of an estrogen receptor and methods of treating a disorder associated with estrogen receptors.
摘要翻译：本文公开的是本文公开的式（I）的化合物，调节雌激素受体的活性的方法和治疗与雌激素受体相关的病症的方法。

10. 发明申请

WO2008141239A1 IMIDAZOL [1,2-A] PYRIDINES AND RELATED COMPOUNDS WITH ACTIVITY AT CANNABINOID CB2 RECEPTORS 审中-公开
标题翻译：咪达唑仑[1,2-A]吡啶类和相关化合物在CANNABINOID CB2受体上具有活性
公开(公告)号：WO2008141239A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/063328
申请日：2008-05-09
申请人： ACADIA PHARMACEUTICALS INC. , OLSSON, Roger , BURSTEIN, Ethan , KNAPP, Anne, Eeg , ESKILDSEN, Jorgen , CASTILLO, Joel
发明人： OLSSON, Roger , BURSTEIN, Ethan , KNAPP, Anne, Eeg , ESKILDSEN, Jorgen , CASTILLO, Joel
IPC分类号： C07D471/04 , C07D487/04 , A61P29/00 , A61P25/00 , A61K31/437 , A61K31/4985 , A61K31/519
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof; and methods of modulating the activity of a cannabinoid CB2 receptor comprising contacting a compound of Formula (I) or Formula (II) with the cannabinoid CB2 receptor. Said compounds are useful in the treatment of various condition and disorders such as pain, and neurodegenerative disorders.
摘要翻译：公开了式（I）或式（II）的化合物或其药学上可接受的盐，酯，酰胺或前药; 以及调节大麻素CB2受体的活性的方法，包括使式（I）或式（II）的化合物与大麻素CB2受体接触。所述化合物可用于治疗各种病症和病症，例如疼痛和神经变性疾病。

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